Category: piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235865-77-6,2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.

A solution of 2 – ((lH-pyrrolo [2,3-b] pyridin-5-yl) oxy) -4- (4 – ((4′-chloro-5,5-dimethyl- 5,6-tetrahydro- [1,1′-biphenyl] -2-yl) methyl) piperazin-1-yl) benzoic acid (see Example 1, step 14) (60 mg, 0.105 mmol, 1.0 eq) (40 mg, 0.114 mmol, 1.09 eq) was added to DCM (10 mL) followed by EDCI (40 mg, 0.209 mmol, 1.99 eq) and 4 (4 mL), 2-nitro-4-sulfamoylphenyl trifluoromethanesulfonate (26mg, 0.213mmol, 2.03eq), room temperature reaction 3h, TLC point plate analysis, the basic reaction of acid raw materials, directly to the reaction liquid spin dry, column, PE / EA (v / v) = 1/1 Eluting with a pale yellow solid product 52 mg, yield 53.9%, 1235865-77-6

The synthetic route of 1235865-77-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sunshine Lake Pharma Co.,Ltd.; Kou, Yuhui; Hu, Bolin; Jiang, Haigang; Ye, Jiuyong; Liu, Zhiqiang; Xie, Hongming; Zhang, Yingjun; (42 pag.)CN106565706; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.140447-78-5,1-(2-N-Boc-Aminoethyl)piperazine,as a common compound, the synthetic route is as follows.

In a sealed tube, 8-bromo-7-fluoro-2-(methyloxy)-1 ,5-naphthyridine (1.1 g, 4.3 mmol), 1 ,1 -dimethylethyl [2-(1-piperazinyl)ethyl]carbamate (1 g, 4.3 mmol), Pd2dba3 (271 mg, 0.262 mmol), rac-Binap (163 mg, 0.262 mmol), Cs2CO3 (2.98 mg, 9.2 mmol) and 18- C-6 (115 mg, 0.436 mmol) in dioxane (22 ml_) were combined and flushed with N2. After 15min, the tube was sealed and heated to 1000C while stirring rapidly. After 12h, the solution was filtered, concentrated and the residue purified via column chromatography (silica,.1% MeOH in DCM (1% NH4OH)) yielding the title compound (725 mg, 41%) as an orange oil: LCMS (ES) m/e 406 (M+H)+., 140447-78-5

The synthetic route of 140447-78-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/81289; (2006); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

132710-90-8, 1-Boc-4-(3-hydroxypropyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,132710-90-8

The 6- {4-[4-(3-piperazin- 1 -ylpropoxy)phenyl]piperazin- 1 -yl} -3-(trifluoromethyl)-7,8- dihydro[l,2,4]triazolo[4,3-b]pyridazine used as starting material was prepared as follows:-; Preparation of tert-butyl 4-[3-(4-{4-[3-(trifluoromethyl)[l,2,4]triazolo[4,3- b]pyridazin-6-yl]piperazin-l-yl}phenoxy)propyl]piperazine-l-carboxylate; DIAD (3.24 mL, 16.47 mmol) was added dropwise to 4-{4-[3- (trifluoromethyl)[ 1 ,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin- 1 -yl}phenol (obtained as described in Example 16, preparation of starting materials) (5 g, 13.72 mmol), tert-butyl 4- (3-hydroxypropyl)piperazine-l-carboxylate (CAS 132710-90-8, 5.03 g, 20.59 mmol) and triphenylphosphine (5.40 g, 20.59 mmol) in THF (50 mL) at 00C under nitrogen. The resulting solution was stirred at ambient temperature for 16 hours. The reaction mixture was evaporated to dryness and redissolved in DCM (100 mL), and washed sequentially with 2M NaOH (100 mL) and saturated brine (100 mL). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, eluting with EtOAc. Pure fractions were evaporated to dryness to give tert-butyl 4-[3-(4-{4-[3-(trifluoromethyl)[l,2,4]t?azolo[4,3-b]pyridazin-6- yl]piperazin-l-yl}phenoxy)propyl]piperazine-l-carboxylate (3.66 g, 45%). IH NMR (399.9 MHz, CDC13) delta 1.46 (9H, s), 1.95 (2H, m), 2.40 (4H, m), 2.52 (2H, t), 3.21 (4H, m), 3.43 (4H, m), 3.78 (4H, m), 3.99 (2H, t), 6.87 (2H, d), 6.93 (2H, d), 7.11 (IH, d), 7.96 (IH, d); m/z = 591 [M+H]+.

As the paragraph descriping shows that 132710-90-8 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BRADBURY, Robert, Hugh; CARR, Gregory, Richard; RABOW, Alfred, Arthur; RAO KORUPOJU, Srinivasa; TUMMA, Harikrishna; WO2010/92371; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Methyl-4-pyrimidin-2-yl-piperazine- 1 -carboxylic acid tert-butyl ester 100 mg 2-chloro-pyrimidine was added to 175 mg 2-Methyl-piperazine-l -carboxylic acid tert- butyl ester and this mixture was stirred for 2 h at 120 C to give 240 mg of the desired compound. Rt: 1.31 min (method B), (M+H)+: 279, 120737-78-2

120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; WELLENZOHN, Bernd; WO2013/83741; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

Preparation of Compound 177 (Method D) 2-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2- yl]ethynyl]carbazol-9-yl]-N-[2-(4-methylpiperazin-l-yl)ethyl]acetamide To a stirred solution of 2-(4-methylpiperazin-l-yl)ethanamine (7.7 mg, 0.054 mmol) and Et3N (20 mu) in DMF (0.3 mL) is added a premixed solution of Compound 176 and HATU (23 mg, 0.061 mmol) in DMF (0.4 mL). Reaction mixture is stirred at RT for 3 h and the mixture is purified directly by reverse phase HPLC to afford the title compound (16 mg, 40percent yield). NMR (400 MHz, CD3OD) delta 8.38 (brs, 1H), 8.11 (d, J = 8.1 Hz, 2H), 7.63 (s, 2H), 7.36 (dd, J = 8.1, 1.2 Hz, 2H), 5.04 (s, 2H), 4.90 (d, J = 2.1 Hz, 2H), 4.03 (dd, J = 3.2, 2.2 Hz, 2H), 3.96 (dd, J = 9.3, 3.3 Hz, 2H), 3.91 – 3.81 (m, 4H), 3.73 (dd, J = 11.3, 5.8 Hz, 2H), 3.63 (t, J = 9.4 Hz, 2H), 2.64 (s, 3H), 2.46 (t, J = 6.0 Hz, 2H). XH NMR (400 MHz, DMSO-D6) delta 8.17 (d, J = 8.1 Hz, 2H), 8.08 (t, J = 5.6 Hz, 1H), 7.64 (s, 2H), 7.30 – 7.25 (m, 2H), 5.06 (s, 2H), 4.76 (d, J = 2.0 Hz, 2H), 3.83 (s, 2H), 3.77 – 3.65 (m, 4H), 3.63 – 3.55 (m, 2H), 3.46 (dd, J = 11.7, 6.2 Hz, 2H), 3.39 (t, J = 9.3 Hz, 2H), 3.16 (dd, J = 12.1, 6.2 Hz, 2H), 2.40 – 2.16 (m, 10H), 2.11 (s, 3H). ESI-MS m/z calc. 722.3163, found 723.71 (M+l)+.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; RAMTOHUL, Yeeman, K.; DAS, Sanjoy, Kumar; CADILHAC, Caroline; REDDY, Thumkunta, Jagadeeswar; VAILLANCOURT, Louis; GALLANT, Michel; LIU, Bingcan; DIETRICH, Evelyne; VALLEE, Frederic; MARTEL, Julien; POISSON, Carl; WO2014/100158; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,103-76-4

A solution of 3,7-dichloro-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one (200 mg, 0.66 mmol), 1-(2-hydroxyethyl)piperazine (117 mg, 0.90 mmol, Aldrich) and triethylamine (0.27 mL, 1.94 mmol) in THF (3 mL) was stirred at room temperature for one hour. The reaction was partitioned between ethyl acetate and water. The layers were separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate, and solvent was removed at reduced pressure to give 7-chloro-3-[4-(2-hydroxyethyl)piperazin-1-yl]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one. (218 mg, 83% yield). 1H NMR (CDCl3) delta 8.48 (1H), 7.34 (1H), 4.33-4.30 (2H), 4.04-4.00 (4H), 3.76-3.72 (2H), 3.69-3.65 (2H), 3.38-3.34 (2H), 2.67-2.64 (4H), 2.62-2.58 (2H), 1.55-1.48 (2H), 0.87-0.82 (3H).

The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US2007/249615; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

78551-60-7, tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78551-60-7

4 M HC1 in l,4-dioxane (150 mL, 600 mmol, 12 equiv) was added at room temperature to compound (14.5 g, 50 mmol, 1 equiv) and the mixture was stirred at room temperature for 2 hours, at which time LCMS indicated that the reaction was complete. The mixture was concentrated under reduced pressure and azeotroped with toluene (3 x 200 mL) to give l-benzylpiperazin-2-one hydrochloride (15.1 g, quantitative yield) as a viscous pale-yellow oil

As the paragraph descriping shows that 78551-60-7 is playing an increasingly important role.

Reference£º
Patent; CONATUS PHARMACEUTICALS, INC.; SPADA, Alfred, P.; TERNANSKY, Robert, J.; (0 pag.)WO2020/6341; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl 4-[4-((hydroxyimino)methyl)phenyl]piperazinecarboxylate (Compound 32) A mixture of aldehyde 28 (10 mmol) and hydroxylamine hydrochloride (15 mmol) in MeOH (20 mL) with pyridine (2 mL) is stirred at r.t. for 12-15 h. The solvent is removed under vacuum, and the residue is distributed between EtOAc (100 mL) and water (30 mL). The organic layer is washed with 2% aq. citric acid (2*30 mL), water (30 mL), brine (30 mL), and dried (MgSO4). The solvent is evaporated and Compound 32 dried under vacuum.

197638-83-8, The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gordeev, Mikhail F.; Patel, Dinesh V.; Barbachyn, Michael R.; Gage, James R.; US2003/13737; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59878-57-8, Examples 35-92; General Procedure for Examples 35-92; A solution of 3-{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-propionaldehyde (intermediate 2) (0.037 g, 0.1 mmol) in DCE (0.5 ml) was added to the appropriate amine (0.1 mmol) followed by a freshly prepared solution of pyridine-borane complex (25 ul, 8M in pyridine, 0.2 mmol) and acetic acid (25 ul) in EtOH (0.5 ml). The reaction was then shaken overnight, concentrated and the residue purified by preparative HPLC.

59878-57-8 1-(Cyclopropylcarbonyl)piperazine 2064235, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Aebi, Johannes; Green, Luke; Mattei, Patrizio; Ricklin, Fabienne; Roche, Olivier; Zahm, Peter; US2007/249589; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step C: tert-butyl(3)-4-[2-( 5-cyano-2,4-difluorophenyl)-2-oxoethyl]-3-(hydroxymethyl)piperazine-1-carboxylate; A suspension of 5-(bromoacetyl)-2,4-difluorobenzonitrile (2.5 g, 9.6 mmol), tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate (2.1 g, 9.6 mmol) and DIEA (1.90 g, 14.4 mmol) in 50 mL ofTHF was stirred at 20C for 10 hours. The reaction mixture was poured into ice water and extracted with EtOAc (3×200 mL). The combined organic layers were washed with water and brine, dried andconcentrated. The residue was purified by column chromatography eluting with 5 % MeOH in DCM to afford the title compound., 314741-40-7

As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; WO2013/28474; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics