Structure–activity relationships of piperazine scaffolds in CNS drugs
A review of substitution patterns in recent CNS agents, and the balance between basicity, lipophilicity and receptor selectivity.
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Chemistry · Pharmacy · Heterocycles
Piperazine
A six-membered nitrogen heterocycle whose conformational flexibility and hydrogen-bonding behaviour make it a privileged scaffold in medicinal chemistry.
Literature notes
Latest articles
Recent reading and experimental notes on piperazine scaffolds, heterocyclic synthesis and medicinal chemistry.
Green synthetic routes and catalyst selection for heterocyclic amines
Comparing catalytic hydrogenation and photoredox routes for selectivity, cost and scalability.
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Hydrogen-bonding networks in piperazine derivatives from crystal structures
Using single-crystal diffraction data to examine how substituents alter ring conformation and intermolecular interactions.
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Research directions
Research directions
Four long-term interests connecting synthesis, structure and drug design.
Drug Synthesis
Route design, catalysis and process scale-up for piperazine and heterocyclic scaffolds.
Heterocyclic Chemistry
Reactivity, conformation and substituent effects in six-membered nitrogen heterocycles.
Medicinal Chemistry
Structure–activity relationships, pharmacokinetic properties and fragment-based design.
Analytical Characterization
NMR, MS and crystallography in structure elucidation.