With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5
Preparation of Compound 177 (Method D) 2-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2- yl]ethynyl]carbazol-9-yl]-N-[2-(4-methylpiperazin-l-yl)ethyl]acetamide To a stirred solution of 2-(4-methylpiperazin-l-yl)ethanamine (7.7 mg, 0.054 mmol) and Et3N (20 mu) in DMF (0.3 mL) is added a premixed solution of Compound 176 and HATU (23 mg, 0.061 mmol) in DMF (0.4 mL). Reaction mixture is stirred at RT for 3 h and the mixture is purified directly by reverse phase HPLC to afford the title compound (16 mg, 40percent yield). NMR (400 MHz, CD3OD) delta 8.38 (brs, 1H), 8.11 (d, J = 8.1 Hz, 2H), 7.63 (s, 2H), 7.36 (dd, J = 8.1, 1.2 Hz, 2H), 5.04 (s, 2H), 4.90 (d, J = 2.1 Hz, 2H), 4.03 (dd, J = 3.2, 2.2 Hz, 2H), 3.96 (dd, J = 9.3, 3.3 Hz, 2H), 3.91 – 3.81 (m, 4H), 3.73 (dd, J = 11.3, 5.8 Hz, 2H), 3.63 (t, J = 9.4 Hz, 2H), 2.64 (s, 3H), 2.46 (t, J = 6.0 Hz, 2H). XH NMR (400 MHz, DMSO-D6) delta 8.17 (d, J = 8.1 Hz, 2H), 8.08 (t, J = 5.6 Hz, 1H), 7.64 (s, 2H), 7.30 – 7.25 (m, 2H), 5.06 (s, 2H), 4.76 (d, J = 2.0 Hz, 2H), 3.83 (s, 2H), 3.77 – 3.65 (m, 4H), 3.63 – 3.55 (m, 2H), 3.46 (dd, J = 11.7, 6.2 Hz, 2H), 3.39 (t, J = 9.3 Hz, 2H), 3.16 (dd, J = 12.1, 6.2 Hz, 2H), 2.40 – 2.16 (m, 10H), 2.11 (s, 3H). ESI-MS m/z calc. 722.3163, found 723.71 (M+l)+.
The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; RAMTOHUL, Yeeman, K.; DAS, Sanjoy, Kumar; CADILHAC, Caroline; REDDY, Thumkunta, Jagadeeswar; VAILLANCOURT, Louis; GALLANT, Michel; LIU, Bingcan; DIETRICH, Evelyne; VALLEE, Frederic; MARTEL, Julien; POISSON, Carl; WO2014/100158; (2014); A1;,
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