With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.,5625-67-2
Example 29 Step 1: Piperazin-2-one (1 g, 10 mmol) was dissolved in CH2CI2 (40 ML), and BOC20 (2.4 g, 11 MMOL, 1.1 eq), ET3N (2.02 g, 20 mmol, 2 eq) and DMAP (0.024 g, 0.2 mmol, 2 mol%) were added. After the mixture was stirred at RT for 16 h, it was acidified with 1 N HCI. The organic layer was separated, washed with saturated NAHC03, brine, dried (NA2SO4), and concentrated in vacuo to give the product (1.8 g, 90%) as a white solid.’H NMR (CDC13, 300 MHz) 8 6. 70 (1 H, bs), 4.08 (2H, s), 3.62 (2H, t, J = 6. 0 Hz), 3.37 (2H, m), 1.46 (9H, s).
5625-67-2 Piperazin-2-one 231360, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC; WO2005/16876; (2005); A2;,
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