With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122323-88-0,Methyl piperazine-2-carboxylate dihydrochloride,as a common compound, the synthetic route is as follows.
2-(4-(Bromomethyl)phenyl)-1 ,1 ,1 ,3,3,3-hexafluoropropan-2-ol (4.61 mmol,1.553g), potassium carbonate (13.82mmol, 1.91 Og) and methyl piperazine-2-carboxylate dihydrochloride (4.61 mmol, 1 g) were combined and stirred at room temperature overnight in acetonitrile (25mL). The reaction mixture was filtered and the solid washed with ethyl acetate. The organic was concentrated under reduced pressure. The resulting residue was purified by silica column chromatography (eluant dichloromethane/methanol/ammonia 95/5/0.5) to afford the title compound (464mg).MS (ESI) m/z 401.1 [M+H]+
122323-88-0, As the paragraph descriping shows that 122323-88-0 is playing an increasingly important role.
Reference：
Patent; N.V. ORGANON; WO2009/138438; (2009); A1;,
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