859518-35-7, tert-Butyl 3-cyanopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,859518-35-7
To a solution of ten-butyl 3-cyanopiperazine-1-carboxylate (21.1 g, 0.1mol) and aqueous formaldehyde (24 g. 37% in water) in THF was added sodiumcyanoborohydride (315 g, 0.5 rnol) in small portions. The reaction mixture was agedat ambient temperature overnight then diluted with water and extracted with ethylacetate. The organic phase was washed with saturated aqueous sodium chloride,dried over anhydrous sodium sulfate. filtered, and concentrated under vacuum. Thecrude product was purified by column chromatography to provide the title compound.1H NMR (400MHz, MeOD) o 4.23-4.18 (m, 1H), 4.01-3.97 (br, 1H), 3.92-3.90 (br,1 H), 2.92-2.89 (br, 1 H). 2.88-2.87 (br, 1 H), 2.65-2.62 (m, 1 H), 2.378 (s, 3H), 2.36-2.33 (m, 1H), 1.47 (s, 9H).
859518-35-7 tert-Butyl 3-cyanopiperazine-1-carboxylate 53487922, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; ORTHO-CLINICAL DIAGNOSTICS, INC; JANSSEN PHARMACEUTICA NV; HRYHORENKO, Eric; SANKARAN, Banumathi; DECORY, Thomas, R.; TUBBS, Theresa; COLT, Linda; REMMERIE, Bart, M.; SALTER, Rhys; DONAHUE, Matthew, Garrett; GONG, Yong; WO2014/31656; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics