Tag: M.W:300-400

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is , belongs to piperazines compound. In a document, author is Zhang, Dandan, Category: piperazines.

Photocatalytic degradation of ofloxacin by perovskite-type NaNbO3 nanorods modified g-C3N4 heterojunction under simulated solar light: Theoretical calculation, ofloxacin degradation pathways and toxicity evolution

Graphitic carbon nitride (g-C3N4) is widely used as a visible-light-driven photocatalyst but limited by the rapid photoexcited electron-hole pairs recombination rate. To promote the photocatalytic activity of g-C3N4, a class of heterojunction photocatalysts, perovskite-type sodium niobate (NaNbO3) nanorods modified g-C3N4 (SNCN), was fabricated through a two-step hydrothermal and thermal polymerization method in this study. X-ray powder diffraction (XRD), transmission electron microscope (TEM) and X-ray photoelectron spectroscopy (XPS) demonstrated the successful decoration of NaNbO3 onto g-C3N4, as well as the formation of material interface with high reactivity. The optimal material (SNCN-3) exhibited an extremely high degradation efficiency of ofloxacin (OFL) under simulated solar light, as the kinetic rate constant (k) was 29.6 and 10.4 times of that for the neat g-C3N4 and NaNbO3, respectively. Energy band structure analysis indicated that SNCN-3 was a type II heterojunction. Moreover, surface photovoltage (SPV), photoluminescence (PL) and transient photocurrent response measurements confirmed SNCN-3 had the highest electron-hole separation efficiency compared with NaNbO3, g-C3N4 and the other SNCN composites. Quenching tests indicated that O-center dot(2)- and holes were the primary reactive species for OFL degradation. Density functional theory (DFT) calculation on further revealed the atoms of OFL with high Fukui index (f(0)) preferred to be attacked by the produced radicals. Cleavage of piperazine moiety and substitution of F were the key OFL degradation pathways. In addition, the reduced toxicity of transformation products after photocatalysis verified the proposed technique was a green method. This work provided the promising application of g-C3N4/NaNbO3 heterojunction photocatalysts for degradation of antibiotic pollutants in water.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5625-37-6, in my other articles. Category: piperazines.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, molecular formula is C17H19Cl2N3S, belongs to piperazines compound. In a document, author is Chen, Hong, introduce the new discover, COA of Formula: C17H19Cl2N3S.

Novel piperazine-containing oligomer as flame retardant and crystallization induction additive for thermoplastics polyurethane

In flame-retarding polymer field, it is very difficult to achieve simultaneous outstanding flame retardancy and excellent mechanical properties, thus causing the serious lack of high-performance flame-retarded polymers. In this work, a novel piperazine-containing additive with phosphorus and alkynyl, named poly (2-butyne-1,4-diol piperazine bisphosphonate) (PPBPP), was designed to fabricate flame-retarding high-performance thermoplastics polyurethane (TPU). Experimental results showed that 3.0 wt% PPBPP endowed TPU with a UL-94 V-0 rating in burning test, and the melt dripping of TPU disappeared at 12.0 wt% PPBPP. More importantly, mechanical properties of flame-retarding TPU/PPBPP remarkably recovered with increasing the PPBPP, and the elongation at break for TPU containing 12 wt% PPBPP reached 812.1%, be almost equivalent to that of pure TPU, which is totally different that occurred in traditional flame-retarding TPU system. The study on mechanical recovery mechanism demonstrated that the PPBPP-induced crystallization of TPU made up for the destruction of PPBPP to hydrogen bonding in the hard segment domain of TPU and the following mechanical loss of matrix, leading to the remarkable recovery in mechanical properties of flame-retarding TPU. The study on the flameretardant mechanism illustrated that alkynyl in PPBPP underwent crosslinking process during heating, and the formed network structure joined the charring of phosphorus-nitrogen flame retardant and effectively promoted the condensed-phase flame-retardant efficiency of PPBPP and anti-melt dripping performance of TPU/PPBPP. This work proposed an efficient route for fabricating flame-retarding high-performance TPU, namely, introduction of piperazine groups into functional flame retardant compensates for the damage of additive to mechanical properties via the induced crystallization and then achieves simultaneously flame retardation and high performance of TPU.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 111974-74-4. COA of Formula: C17H19Cl2N3S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, HPLC of Formula: C17H19Cl2N3S, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, molecular formula is C17H19Cl2N3S. In an article, author is Shinde, Ravindra R.,once mentioned of 111974-74-4.

Synthesis and antimicrobial activity of 2-(4-(benzo[d]thiazol-5-ylsulfonyl)piperazine-1-yl)-N-substituted acetamide derivatives

A new series of 2-(4-(benzo[d]thiazol-5-ylsulfonyl)piperazin-1-yl)-N-substituted acetamide(5a-5k)compounds have been synthesized, and these compounds were characterized with spectral data like IR, NMR, and Mass spectroscopy. All compounds were evaluated in vitro for their efficacy as antimicrobial against Gram-positive and Gram-negative pathogenic bacterial strains such asStaphylococcus aureus, Bacillus subtilis, Escherichia coliandPseudomonas aeruginosausing ciprofloxacin as a standard and fungal strains likeCandida albicansandAspergillus fumigatusas compared with standard drug Clotrimazole, and Molecular docking study shows that all these compounds were having good to excellent correlation binding energy as compared with binding energy of standard drugs.

If you¡¯re interested in learning more about 111974-74-4. The above is the message from the blog manager. HPLC of Formula: C17H19Cl2N3S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, molecular formula is C13H20Cl2N2O2, belongs to piperazines compound. In a document, author is Zhao, Bingtao, introduce the new discover, HPLC of Formula: C13H20Cl2N2O2.

Process simulation, optimization and assessment of post-combustion carbon dioxide capture with piperazine-activated blended absorbents

High efficiency, large capacity, and low energy consumption have become an important challenge in performances of post-combustion carbon dioxide (CO2) capture and regeneration. Blended absorbents have shown great potential but their process simulation, modeling, and optimization have not been known definitively. This work developed the blended aqueous absorbents based on piperazine (PZ) activators: PZ-activated methyldiethanolamine (MDEA), potassium carbonate solution (K2CO3), and aqueous ammonia (NH3 center dot H2O) to improve their techno-economic performances. The whole process simulation was conducted using a validated rate-based model under given a CO2 capture efficiency of 85%. In this process, the key factors including the molar concentration of the absorbent, PZ molar ratio, CO2 load of lean liquid, lean-liquid temperature, flue-gas temperature, and rich-liquid temperature, were employed for the design of experiment using response surface methodology. A series of nonlinear regression equations were developed using the flow rate of absorbents, the reboiler heat duty (in the units of gigajoules per ton of CO2), and the cooling-water flow rate as the multi-objective function. Subsequently, the optimal Pareto solution set and compromise solutions were determined using the multi-objective genetic algorithm and finally, their performances were assessed using the fuzzy close-degree algorithm. It was found that the optimal operating parameters can be determined effectively according to the proposed approach. For each PZ-activated blended absorbents, the trade-off effect exists between absorbent flow rate, reboiler heat duty, and cooling water consumption. The absorbents having optimal techno-economic performance were recommended to be PZ-activated MDEA, followed by PZ-activated K2CO3 and PZ-activated NH3 center dot H2O when considering the regeneration energy consumption. The results may provide a positive reference for process design and optimization of the industrial post-combustion CO2 capture system. (C) 2020 Elsevier Ltd. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 106261-49-8. HPLC of Formula: C13H20Cl2N2O2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is C8H18N2O6S2, belongs to piperazines compound. In a document, author is Khan, Shahan Zeb, introduce the new discover, Recommanded Product: 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid.

Structural features, anticancer, antioxidant and anti-acetylcholinesterase studies of [(DTCs)(PAr3)PdCl]

Four new [(DTCs)(PAr3)PdCl] complexes have been synthesized, where DTCs = sodium 4-diphenylmethylpiperazine-1-carbodithioate(1), sodium4-(3-methoxyphenyl)piperazine-1-carbodithioate (2), sodium4-(2-pyrimidyl)piperazine-1-carbodithioate (3, 4); ArR3 = diphenyl-p-tolylphosphine (1, 2), 1,4-bis(diphenylphosphino) butane (3). These complexes have been characterized by CHNS analysis, FT-IR, NMR {H-1, C-13 and P-31}, and X-ray crystallography (for complex 1 and 2). Single crystal analysis revealed that the Pd is chelated by dithiocarbamate ligand forming a four-membered chelate ring, whereas PAr3 and Cl are coordinated in monodentate fashion. The Hirshfeld Surface and Fingerprint analysis have been used to investigate the intermolecular interactions and molecular shape of crystal structures (1&2), respectively. The anticancer activities of (1-4) were evaluated using Staurosporine as a standard against various human cancer cell lines, i.e. LU, MCF7, Hepa-IcIc-7, PC-3, and MDA-MB-231. The compound 3 was found to be the most active against the tested cancer cell lines with IC50 values of 0.9 +/- 0.2-18.3-3.0 mu M owing to its cationic nature that facilitates safe carriage thus causing electrostatic interaction with the negatively charged DNA. The highest antioxidant activity is shown by compound 3 against DPPH used as a free radical. Furthermore, all the complexes (1-4) caused a mixed type of inhibition against acetylcholinesterase. Thus, these compounds represent a class of potential therapeutic agents and can be used for the treatment of Alzheimer’s disease.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 5625-37-6. Recommanded Product: 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

1001180-21-7, (R)-tert-Butyl 4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 9:; Triethylamine (4.33 ml, 31.1 mmol; degassed with nitrogen 30 minutes prior to use) and formic acid (1.36 ml, 36.1 mmol; degassed with nitrogen 30 minutes prior to use) were added to a solution of (R)-tert-butyl 4-(5-methyl-7-oxo-6,7-dihydro-5H- cyclopenta[d]pyrimidin-4-yl)piperazine-l -carboxylate (9.75 g, 29.3 mmol) in DCM (210 mL; degassed with nitrogen 30 minutes prior to use). The mixture was stirred for 5 minutes, then a Ru catalyst (0.0933 g, 0.147 mmol) was added. The reaction was stirred under positive nitrogen pressure overnight (18 hours). The reaction mixture was concentrated to dryness and dried on high vacuum. The impure material was flashed on Biotage 65M loaded 1:1 DCM:ethyl acetate 500 mL flushed, then 1 :4 DCM:ethyl acetate until product (2nd spot), then gradient to neat ethyl acetate, then 25:1 DCM:MeOH eluted rest of product. The fractions were combined and concentrated on a rotary evaporator. The residue was concentrated again from DCM/hexanes to give a mixture of tert-butyl 4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine- 1-carboxylate (major) and tert-butyl 4-((5R,7S)-7-hydroxy-5-methyl-6,7-dihydro-5H- cyclopenta[d]pyrimidin-4-yl)piperazine-l -carboxylate (minor) (9.35 g, 95.3% yield) as a beige foam. LC/MS (APCI+) m/z 335 [M+H]+. IH NMR (CDC13) shows 88% de by integration of carbinol methine.

1001180-21-7, The synthetic route of 1001180-21-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; MITCHELL, Ian, S.; BLAKE, James, F.; XU, Rui; KALLAN, Nicholas, C.; XIAO, Dengming; SPENCER, Keith, Lee; BENCSIK, Josef, R.; LIANG, Jun; SAFINA, Brian; ZHANG, Birong; CHABOT, Christine; DO, Steven; WO2008/6040; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.113028-17-4,Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate,as a common compound, the synthetic route is as follows.

30 g of ethyl 6-fluoro-7-piperazine-1-methyl-4-oxo- [1,3] thiazepino [3,2-a] 120ml concentration of 1mol / L of potassium hydroxide solution dissolved, And stirred at room temperature for 5 hours. The solution was neutralized with a 20% (v/v) acetic acid solution and the pH was adjusted to 7-8 and stirred well. The precipitate was collected by filtration, and the precipitate was washed three times with deionized water and acetonitrile, respectively. The precipitate was then dried in vacuo at 60 C to give 6-fluoro-7-piperazine-1-methyl-4-oxo- [1,3] thiazacyclo [3,2-a] 3-carboxylic acid 29g, 90% yield. The obtained 6-fluoro-7-piperazine-1-methyl-4-oxo- [1,3] thiazepino [3,2-a] quinoline-3-carboxylic acid was 99.1% pure.

113028-17-4, 113028-17-4 Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 10249018, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Zhaoke Pharmaceutical (Hefei) Co., Ltd.; Li Xiaoyi; Dai Xiangrong; Zhou Guanqun; (20 pag.)CN107383069; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

112257-12-2, tert-Butyl 4-(2-bromoacetyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound D_1 (477 mg, 3 mmol), compound G_1 (1 ¡¤ 38 g, 4.5 mmol), 15 mL of acetonitrile was added to a 50 mL single-mouth flask, and the mixture was heated under argon atmosphere. The mixture was heated under reflux, followed by TLC. Acetonitrile, the residue was dissolved with as little CH2CI2 as possible. A large amount of ether was added to precipitate a solid. The solid was carefully sucked out into an Erlenmeyer flask. It was necessary to allow ether to remain on the surface. The ether was immediately blown dry with argon, and the cone was dried. The bottle is sealed with a sealing membrane and kept out of the air. The product was a pink solid 700 mg (compound H-1) with a yield of 50%., 112257-12-2

112257-12-2 tert-Butyl 4-(2-bromoacetyl)piperazine-1-carboxylate 15829155, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; East China University of Science and Technology; Qian Xuhong; Xu Yufang; Jia Xiaotong; Zhu Weiping; Yang Youjun; (14 pag.)CN107619397; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

1072027-36-1, 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 4a-4c (1mmol) suspended in methanol (1mL) was added 4M HCl in dioxane (5mL) and the reaction mixture was stirred for 24hat room temperature. The precipitate was filtrated, washed with diethyl ether (2¡Á5mL), and dried to obtain 5a-5c, which were used for the next step without further purification.

1072027-36-1, The synthetic route of 1072027-36-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Yang; Yin, Yanzhen; Zhang, Zhen; Li, Carrie J.; Zhang, Hui; Zhang, Daoguang; Jiang, Changying; Nomie, Krystle; Zhang, Liang; Wang, Michael L.; Zhao, Guisen; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 543 – 551;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

162046-66-4, 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 3 4-[4-(4′-{2-[(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-biphenyl-4-ylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester To a solution of 4-(4-(tert-butoxycarbonyl)piperazin-1-yl)benzoic acid (24.7 mg, 0.081 mmol) in dichloromethane (0.89 mL, 14 mmol) and N,N-dimethylformamide (0.4 mL, 6 mmol) was added N,N-diisopropylethylamine (0.071 mL, 0.407 mmol) and methyl chloroformate (0.006 mL, 0.081 mmol). The reaction mixture was stirred for 15 min at room temperature, then ((S)-1-{(S)-2-[4-(4′-amino-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (25.0 mg, 0.054 mmol) was added and the mixture was allowed to stir overnight. The reaction mixture was concentrated and then dissolved in DCM (5 mL) and washed with saturated aqueous sodium bicarbonate (2 mL). The organic layer was concentrated. Approximately 15 mg of the crude material was concentrated, dissolved in 1:1 acetic acid:water (1.5 mL), and purified by preparative HPLC to provide the trifluoroacetic acid salt of the title compound (7.3 mg). (m/z): [M+H]+ calcd for C42H51N7O6 750.39 found 750.4., 162046-66-4

162046-66-4 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid 2795508, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; THERAVANCE, INC.; US2012/114600; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics