Tag: M.W:300-400

149057-19-2, 4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-((benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid 587a (25 g, 69 mmol) in EtOH (50 mL) was added HCl.EtOH (35%, 50 mL). The mixture was stirred at 25 C. for 4 hours. The mixture was evaporated to afford product as white solid (18 g, 100%). MS (ESI): mass calcd. for C13H16N2O4 264.11, m/z found 265.1 [M+H]+., 149057-19-2

The synthetic route of 149057-19-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VenatoRx Pharmaceuticals, Inc.; BURNS, Christopher J.; COBURN, Glen; LIU, Bin; YAO, Jiangchao; BENETATOS, Christopher; BOYD, Steven A.; CONDON, Stephen M.; HAIMOWITZ, Thomas; US2019/375708; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

350684-49-0, tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,4-dichloro-5-(trifluoromethyl)pyrimidine(0.46 mL,3.4 mmol) in DCE (12 mL) and tBuOH (12 mL) was added 4mL ZnCl2 solution (1M in diethyl ether). The mixture was stirredunder ice bath for 1 h. Then the mixture was added compound21(1.04 g, 3.4 mmol in 3mL DCE: tBuOH 1:1) and stirred foranother 1.5 h under ice bath. Then the mixture was added Et3N(0.52 mL, 3.7 mmol) dropwise. The mixture was concentrated undervacuum and extracted with dichloromethane (20 mL x 3). Theorganic phase was washed with brine (15mL x 3) and dried overanhydrous Na2SO4 and concentrated under vacuum. The crude product was purified by column chromatography to get compound 12 as white solid (0.76 g, 46%). Mp: 182-183 C. 1H NMR (400 MHz,DMSO-d6) delta 10.90 (s, 1H), 8.85 (s, 1H), 7.82 (d, J = 8.0 Hz, 2H), 7.45 (d,J = 8.4 Hz, 2H), 3.40 (s, 8H), 1.42 (s, 9H).13C NMR (100 MHz,DMSO-d6) delta 168.96, 160.37, 158.08 (d, J = 5.0 Hz),157.73, 153.81,139.80, 130.26, 128.07, 119.55, 112.32-111.32 (m), 79.14, 43.49, 42.90, 27.99., 350684-49-0

As the paragraph descriping shows that 350684-49-0 is playing an increasingly important role.

Reference£º
Article; Su, Yue; Li, Ridong; Ning, Xianling; Lin, Zhiqiang; Zhao, Xuyang; Zhou, Juntuo; Liu, Jia; Jin, Yan; Yin, Yuxin; European Journal of Medicinal Chemistry; vol. 177; (2019); p. 32 – 46;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228780-72-0,1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine,as a common compound, the synthetic route is as follows.

(0142) A mixture of Compound 18A (1.7 g), Compound 3E (1.8 g), and HK2PO4 (1.21 g) in dimethylsulfoxide (20 ml) at 135 C. was stirred for 24 hours. The reaction was cooled, diluted with ether (400 ml), and washed with 3¡Á1M NaOH, and brine, and concentrated. The crude product was chromatographed on silica gel with 10-50% ethyl acetate/hexanes., 1228780-72-0

The synthetic route of 1228780-72-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AbbVie Inc.; Catron, Nathaniel; Lindley, David; Miller, Jonathan M.; Schmitt, Eric A.; Tong, Ping; US10213433; (2019); B2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Let¡¯s face it, organic chemistry can seem difficult to learn, Safety of 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, Especially from a beginner¡¯s point of view. Like 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, molecular formula is C9H14N4O3, belongs to amides-buliding-blocks compound. In a document, author is Zhang, Gui-Hong, introducing its new discovery.

1D/3D Co(II)-based coordination polymers: protective effect on alzheimer’s disease by inhibiting neurons apoptosis and A beta accumulation

By using a mixed-ligand method, two new Co(II)-based coordination polymers with the chemical formula of [Co(L)(2,2 ‘-bipy)](n)(1, 2,2 ‘-bipy = 4,4 ‘-bipyridine) and [Co(L)(phen)](n)(2, phen = 1,10-phenanthroline) have been successfully synthesized by the solvothermal reaction of 1,4-bis(3-carboxylbenzyl)piperazine acid (H2L) and different N-donor co-ligands with the metal salt Co(NO3)center dot 6H(2)O. Furthermore, a grinding method was used to prepare the nanoparticles of the two coordination polymers with average size distribution around 350 and 200 nm. The protective activity against the Alzheimer’s disease (AD) was assessed and the specific mechanism was discussed at the same time. First of all, the ELISA detection assay was conducted and the content of the Amyloid (A beta) in the brain was determined after compounds1and2treatment. In addition to this, the Annexin V-FITC/PI staining was performed and the protective activity of compounds1and2on neurons was evaluated.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, molecular formula is C13H20Cl2N2O2. In an article, author is Pal, Avishek,once mentioned of 106261-49-8.

Probing the charged nature and ion-exclusion mechanism of fluorine-enriched non-ionogenic polyamide derived thin film composite nanofiltration membranes

A thin film composite (TFC) nanofiltration (NF) membrane comprising a novel fluorine-enriched polyamide (FPA) as a skin layer polymer has been developed by in situ interfacial polycondensation between a cyclo-aliphatic diamine monomer, piperazine, and an acyclic fluorodiacyl chloride monomer, tetrafluorosuccinyl chloride. Instrumental investigations carried out by FTIR and XPS showed that the structure of FPA is devoid of intra- as well as inter-molecular H-bonds, which seems to be a rare finding in NF type membranes with decent performances. Stereoelectronic effects of the FPA structure, owing to the configurational mobility of polymer chains, electron-withdrawing ability of fluorine and lack of cohesive non-covalent type interactions, strongly influenced the surface morphology, topography and hydrophilicity of the TFC-NF membranes. The active skin layer of the membranes exhibited uniform charge-atmosphere in spite of not having any fixed charged groups in the polymer structure constituting it. Zeta potential measurement of the membranes revealed low values (-4.4 to -7 mV), indicating their low surface charge. However, a high Donnan-exclusion was observed towards a solute with multivalent anion (Na2SO4, solute rejection: 87-93%) as opposed to that with monovalent anion (NaCl, solute rejection: 23-26%), with a solvent flux as high as 54 L m(-2) h(-1) at 15 bar transmembrane pressure. The current class of TFC-NF membranes with unique physicochemical attributes thus provides a promising scope for a variety of nanofiltration applications.

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Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, Formula: C17H19Cl2N3S, begins with the direct observation of nature¡ª in this case, of matter.111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, SMILES is [H]Cl.[H]Cl.C12=CC=CC=C1N=C(N3CCNCC3)C4=CC=CC=C4S2, belongs to piperazines compound. In a document, author is Jiang, Jin-Ke, introduce the new discover.

Crystal structure of catena-poly[aqua(mu(6)-piperazine-1,4-bisethanesulfonato-kappa(6) N:N ‘:O:O ‘:O ”:O ”’)(mu(2)-pyrazinyl-kappa N-2:N ‘)disilver(I) sesquihydrate], C12H30Ag2N4O11S2

C12H30Ag2N4O11S2, monoclinic, I2/a (no. 15), a = 12.2643(8) angstrom, b = 7.1481(4) angstrom, c =26.2858(16) angstrom, beta = 93.119(6)degrees, V = 2301.0(2) angstrom(3), Z = 4, R-gt(F) = 0.0186, WRref(F-2) = 0.0462, T = 298(2) K.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 111974-74-4. Formula: C17H19Cl2N3S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reference of 5625-37-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, SMILES is O=S(CCN1CCN(CCS(=O)(O)=O)CC1)(O)=O, belongs to piperazines compound. In a article, author is Okitsu, Takashi, introduce new discover of the category.

A dearomative ipso-iodocyclization/desymmetrization sequence leading to optically active tricyclic piperazine scaffolds

Dearomative ipso-iodocyclization of 4-(1-ethoxyethoxy)-N-propargylanilines leading to 1-azaspiro[4.5]deca-3,6,9-trien-8-ones has been developed. This reaction is characterized by the yield of fewer toxic byproducts and is conducted by a more user-friendly protocol compared to other reported methods. The synthetic application of these spiro products was demonstrated by transformation of the iodo component into other functionalities. The desymmetrization of the resulting cyclohexadienones was also achieved by the diastereoselective aza-Michael addition of internal amino acid moieties to yield tricyclic piperazine scaffolds with two newly formed contiguous chiral centers.

Reference of 5625-37-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 5625-37-6.

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Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is , belongs to piperazines compound. In a document, author is Tang, Yuanyuan, HPLC of Formula: C8H18N2O6S2.

Enhancing the permeance and antifouling properties of thin-film composite nanofiltration membranes modified with hydrophilic capsaicin-mimic moieties

Enhancing the water permeance and improving the antifouling performance of developing thin film composite (TFC) nanofiltration (NF) membranes remains a great challenge for practical applications. In this work, a novel TFC membrane was fabricated by introducing a new capsaicin derivative (propyl 2-(acrylamidomethyl)-3,4,5-trihydroxybenzoate, PAMTB) into a polyamide (PA) layer during interfacial polymerization for the NF process. The abundant hydroxyl groups in the PAMTB molecules can compete with the amino group in piperazine (PIP) to react with acyl chloride in trimesoyl chloride (TMC), facilitating the formation of a smooth and hydrophilic membrane surface with an enlarged pore size to promote water permeance. Compared to the control TFC membrane, the PAMTB-incorporated membrane exhibited increased water flux from 80 L m-2h-1 to 115 L m-2h-1 and a steady rejection of above 98.0% with 2.0 g L-1 Na2SO4 as the feed solution under a pressure of 5.0 bar. Different measurement methods demonstrated that the TFC-PAMTB membrane exhibited superior antifouling properties and long-term stability. In particular, the permeation flux recovery was approximately 100% after simple hydraulic washing with HA solution as the foulant. This work introduced a new approach to exploit capsaicin-mimic moieties in water treatment applications.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5625-37-6, in my other articles. HPLC of Formula: C8H18N2O6S2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, SMILES is Cl.Cl.CN1CCN(CC1)CC2=CC=C(C(=O)O)C=C2, in an article , author is Sandoval, Jose A., once mentioned of 106261-49-8, Quality Control of 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride.

Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells

Glioblastoma (GBM) is an aggressive tumor of the brain, with an average post-diagnosis survival of 15 months. GBM stem cells (GBMSC) resist the standard-of-care therapy, temozolomide, and are considered a major contributor to tumor resistance. Mammalian target of rapamycin Complex 1 (mTORC1) regulates cell proliferation and has been shown by others to have reduced activity in GBMSC. We recently identified a novel chemical series of human-safe piperazine-based brain-penetrant mTORC1-specific inhibitors. We assayed the piperazine-mTOR binding strength by two biophysical measurements, biolayer interferometry and field-effect biosensing, and these confirmed each other and demonstrated a structure-activity relationship. As mTORC1 is altered in human GBMSC, and as mTORC1 inhibitors have been tested in previous GBM clinical trials, we tested the killing potency of the tightest-binding piperazines and observed that these were potent GBMSC killers. GBMSCs are resistant to the standard-of-care temozolomide therapy, but temozolomide supplemented with tight-binding piperazine meclizine and flunarizine greatly enhanced GBMSC death over temozolomide alone. Lastly, we investigated IDH1-mutated GBMSC mutations that are known to affect mitochondrial and mTORC1 metabolism, and the tight-binding meclizine provoked ‘synthetic lethality’ in IDH1-mutant GBMSCs. In other words, IDH1-mutated GBMSC showed greater sensitivity to the coadministration of temozolomide and meclizine. These data tend to support a novel clinical strategy for GBM, i.e., the co-administration of meclizine or flunarizine as adjuvant therapy in the treatment of GBM and IDH1-mutant GBM.

Interested yet? Read on for other articles about 106261-49-8, you can contact me at any time and look forward to more communication. Quality Control of 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, molecular formula is , belongs to piperazines compound. In a document, author is Shen, Ke, Category: piperazines.

Salt-tuned fabrication of novel polyamide composite nanofiltration membranes with three-dimensional turing structures for effective desalination

High performance thin-film nanofibrous composite (TFNC) membranes with Turing structures were constructed by interfacial polymerization (IP) of trimesoyl chloride (TMC) and piperazine (PIP) tuned with high content salt (NaCl) in aqueous phase onto a polyacrylonitrile (PAN) nanofibrous mat for nanofiltration (NF). The concentration of salt in aqueous phase played a key role in the structural transition of polyamide (PA) membrane surfaces with two type Turing structures from the crossed ridge networks to crowed nodular arrays. The introduction of NaCl induced the uneven distribution of the IP reaction and could fine-tune the hydrophilicity and compactness of the formed ultrathin PA layer. The skillful manipulation of IP by regulating the NaCl content in aqueous phase enabled a great improvement in NF performance. Under 0.5 MPa, the flux of the optimized TFNC membrane (20.0 wt% NaCl in aqueous phase) reached 129.0 L m(-2) h(-1) (Na2SO4 rejection was 99.1%) which was approximately 2.5 times greater than that of the original membrane fabricated without salt addition. Moreover, the resultant membrane exhibited excellent stability and anti-fouling properties for long-term use. This approach is easy to be connected with commercialized IP technology to prepare high-performance NF membranes.

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Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics