Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128102-16-9,(R)-4-Benzyl 1-Boc-2-methylpiperazine-4-carboxylate,as a common compound, the synthetic route is as follows.

10% palladium carbon (223 mg) was dissolved in ethanol (5 mL) in a solution of 4-benzyl 1-tert-butyl 2-methylpiperazine-1,4-dicarboxylate (2.23 g, 6.68 mmol) in ethanol (10 mL) . The inside of the reaction vessel was replaced with hydrogen and stirred at room temperature for 3 hours. The reaction solution was filtered through celite and concentrated to give the title compound (1.28 g, 96%). Transparent oil, 128102-16-9

As the paragraph descriping shows that 128102-16-9 is playing an increasingly important role.

Reference：
Patent; Yakult Honsha Corporation; Abe, Atsuhiro; Mae, Satoyuki; Yamazaki, Ryuta; Sawaguchi, Yuichi; Sugimoto, Takuya; Sasai, Toshio; Nishiyama, Hiroyuki; Nagaoka, Masato; Matsuzaki, Ken; Kurita, Akinobu; Matsui, Makoto; Shingeyama, Takahide; (208 pag.)JP6378918; (2018); B2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

1228780-72-0, 1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1228780-72-0, Example 30H ethyl 2-(1H-indol-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)benzoate EXAMPLE 30A (330 mg), EXAMPLE 30G (335 mg), and HK2PO4 (191 mg) were stirred in dimethylsulfoxide (5 mL) at 140 C. for 24 hours. The reaction was diluted with ethyl acetate, washed three times with water, washed with brine, dried over Na2SO4, filtered, and concentrated. The crude product was chromatographed on silica gel with 30% ethyl acetate/hexanes.

The synthetic route of 1228780-72-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ABBOTT LABORATORIES; US2010/184750; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112984-60-8,6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

Synthesis of 6-Fluoro-7-{4-[2-hydroxy~3~(2-methyl-5-nitro~imidazol-l- yl) -propyl J-piperazin-1 -yl}-l -methyl-4-oxo-4H-2-thia-8b-aza- cyclobuta[a]naphthalene-3-carboxylic acid (2): To a stirred solution of 6-Fluoro- 1 -methyl -4-oxo-7-piperazin- 1 -yl-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3- carboxylic acid, (III) (0.2g, 0.57mmol) in acetone (15ml) was added potassium carbonate (0.1 Ig, 0.19mmol) dissolved in water (5ml), followed by addition of epoxy ornidazole,(II)(0.15g, O.S2mmol). The reaction mixture was heated at 50 C for 20 hr. After completion, the reaction mixture was evaporated and extracted twice with dichloromethane. The combined organic layer was dried over sodium sulphate and evaporated to obtain the crude mass. The crude mass was purified by column chromatography by eluting with 10-12% methanol/dichloromethane mixture to obtain the pure compound (2), i.e., Compound 91 from Table 1, with 25-30% isolated yield. 1H-NMR (400 MHz, DMSO) 5ppm: 2.12 (3H, d, J – 6.4 Hz, CH3), 2.46 (3H, s, CH3), 2.58-2.60 (2H, t, J = 5.6 Hz CH2N ), 2.66 (4H, m, 2 x CH2), 3.2 (4H, m, 2 x CH2), 3.9-4.1 (2H, m, 2 x CH2N), 4.63 (1H, d, J= 14 Hz, CHOH), 5.15 (1H, d, J = 5.2 Hz -OH), 6.39 (1 H, d, J = 6.4 Hz, CHSN) 6.93 (1H, d, J = 7.2 Hz , Ar-H), 7.79 (1H, d, J = 14 Hz, Ar-H), 8.04 (1H, s, Ar-H). ESI-MS (m z): 532.95(M+H).

112984-60-8, The synthetic route of 112984-60-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; VYOME BIOSCIENCES PVT. LTD.; SENGUPTA, Shiladitya; CHAWRAI, Suresh Rameshlal; GHOSH, Shamik; GHOSH, Sumana; JAIN, Nilu; SADHASIVAM, Suresh; BUCHTA, Richard; BHATTACHARYYA, Anamika; WO2015/114666; (2015); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

150407-69-5, (S)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

11.2 g (34.9 mmol) TBTU and 5.5 mL (39.6 mmol) triethylamine were added to a mixture, cooled to 0 C., of 12.2 g (32.8 mmol) 1-benzyl-4-tert-butyl(S)-piperazine-1,2,4-tricarboxylate and 30 mL EtOH in 150 mL THF, stirred for another 30 min at this temperature and then stirred for 68 h at RT. 600 mL diethyl ether were added to the reaction mixture, it was combined with 200 mL saturated NaHCO3 solution, the aqueous phase was separated off, the organic phase was washed with saturated NaCl solution and dried over Na2SO4. After elimination of the desiccant and solvent the residue was purified by chromatography (silica gel, gradient PE/EtOAc 4:1 to 7:3). Yield: 11.35 g (88% of theory) ESI-MS: (M+H)+=393 Rf=0.38 (Polygram-silica gel, PE/EtOAc 3:1), 150407-69-5

As the paragraph descriping shows that 150407-69-5 is playing an increasingly important role.

Reference：
Patent; Mueller, Stephan Georg; Rudolf, Klaus; Lustenberger, Philipp; Schaenzle, Gerhard; Santagostino, Marco; Stenkamp, Dirk; Arndt, Kirsten; Doods, Henri; US2007/49581; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

182618-86-6, 1-Boc-4-(4-Nitrophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. 4-(4-Amino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester To a suspension of 1-fluoro-4-nitrobenzene (1.4 mL, 13 mmol) and potassium carbonate (2.5 g, 18 mmol) in DMSO (10 mL) was added 1-Boc-piperazine (2.75 g, 14.8 mmol). The mixture was stirred at 100 C. for 2 hours. After cooing down, the mixture was diluted with water (50 mL) and extracted with EtOAc (3*50 mL). The combined organic layers were washed with brine, dried with sodium sulfate (Na2SO4), and concentrated in vacuo to afford a yellow solid. Recrystallization from EtOAC/hexanes gave 4.0 g of 1-(4-Boc-piperazin-1-yl)-4-nitrobenzene, which was reduced via hydrogenation to give the title compound (purple solid, 3 g). 1H NMR (400 MHz, CDCl3) delta (ppm): 6.68 (d, J=8.8 Hz, 2H), 6.64 (d, J=8.8 Hz, 2H), 3.56 (t, J=5.0 Hz, 4H), 2.96 (t, J=5.0 Hz, 4H), 1.46 (s, 9H).

182618-86-6, 182618-86-6 1-Boc-4-(4-Nitrophenyl)piperazine 3380696, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Player, Mark R.; Huang, Hui; Hutta, Daniel A.; US2007/60577; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

112984-60-8, 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

28 grams of ulifloxacin dissolved at room temperatureIn a 14 ml volume ratio of 5:1 acetic acid in acetonitrile,Dissolve and filter at 10CThen add 16ml of 10M hydrochloric acid to the filtrate.And stirred at 10 C for 4 hours to complete the reaction.After filtration, the precipitate was collected and washed with acetonitrile and dried under vacuum at 20C.The collected crystals were dissolved in methanol,After heating and stirring, cool in an ice bath and stir to crystallize.Precipitated crystals were collected and vacuum dried at 20C.That is, ulifloxacin hydrochloride crystal A is obtained.

112984-60-8, As the paragraph descriping shows that 112984-60-8 is playing an increasingly important role.

Reference：
Patent; Zhaoke Pharmaceutical (Hefei) Co., Ltd.; Li Xiaoyi; Dai Xiangrong; Zhou Guanqun; (18 pag.)CN107501298; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

182618-86-6, 1-Boc-4-(4-Nitrophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. 4-(4-Amino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester To a suspension of 1-fluoro-4-nitrobenzene (1.4 mL, 13 mmol) and potassium carbonate (2.5 g, 18 mmol) in DMSO (10 mL) was added 1-Boc-piperazine (2.75 g, 14.8 mmol). The mixture was stirred at 100 C. for 2 hours. After cooing down, the mixture was diluted with water (50 mL) and extracted with EtOAc (3*50 mL). The combined organic layers were washed with brine, dried with sodium sulfate (Na2SO4), and concentrated in vacuo to afford a yellow solid. Recrystallization from EtOAC/hexanes gave 4.0 g of 1-(4-Boc-piperazin-1-yl)-4-nitrobenzene, which was reduced via hydrogenation to give the title compound (purple solid, 3 g). 1H NMR (400 MHz, CDCl3) delta (ppm): 6.68 (d, J=8.8 Hz, 2H), 6.64 (d, J=8.8 Hz, 2H), 3.56 (t, J=5.0 Hz, 4H), 2.96 (t, J=5.0 Hz, 4H), 1.46 (s, 9H).

182618-86-6, 182618-86-6 1-Boc-4-(4-Nitrophenyl)piperazine 3380696, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Player, Mark R.; Huang, Hui; Hutta, Daniel A.; US2007/60577; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

112984-60-8, 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

28 grams of ulifloxacin dissolved at room temperatureIn a 14 ml volume ratio of 5:1 acetic acid in acetonitrile,Dissolve and filter at 10CThen add 16ml of 10M hydrochloric acid to the filtrate.And stirred at 10 C for 4 hours to complete the reaction.After filtration, the precipitate was collected and washed with acetonitrile and dried under vacuum at 20C.The collected crystals were dissolved in methanol,After heating and stirring, cool in an ice bath and stir to crystallize.Precipitated crystals were collected and vacuum dried at 20C.That is, ulifloxacin hydrochloride crystal A is obtained.

112984-60-8, As the paragraph descriping shows that 112984-60-8 is playing an increasingly important role.

Reference：
Patent; Zhaoke Pharmaceutical (Hefei) Co., Ltd.; Li Xiaoyi; Dai Xiangrong; Zhou Guanqun; (18 pag.)CN107501298; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

181955-79-3, 1,4-Di-Boc-piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1 ,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid (2.5g, 7.56 mol) in acetonitrile (25 mL) was CS2CO3 (3.93g, 12.06 mol) with stirring at RT. After 15 min, Mel (2.34g, 16.48 mol) was added. The reaction mixture was stirred at rt for 14h. The reaction was monitored by TLC. When SM was finished, reaction mixture was filtered through celite pad and filtrate was concentrated. Column chromatography of crude material afforded product 1 ,4-di-tert-butyl 2-methyl piperazine-l,2,4-tricarboxylate (29) as white solid (2.35g, 90%). NMR: delta (, 400 MHz, CDC13): 1.45 (18H, s), 2.6-3.5 (4H, m), 3.74 (3H, s), 3.8-5.0 (3H, m)., 181955-79-3

181955-79-3 1,4-Di-Boc-piperazine-2-carboxylic acid 11255979, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; CEPHALON, INC.; BRESLIN, Henry J.; CURRY, Matthew A.; GINGRICH, Diane E.; LEARN, Keith S.; OTT, Gregory R.; WAGNER, Jason C.; WO2013/116291; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.350684-49-0,tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: The mixture of compound 10a-10e (3.24 mmol), compound 9(1.04 g, 3.4 mmol), Pd(OAc)2 (0.11 g, 0.5 mmol), Xantphos (0.28 g,0.5 mmol), and K3PO41.38 g, 6.48 mmolin DMF (8 mL) was heated 22 h at 125 C under argon followed by cooling to roomtemperature.The mixture was extracted with dichloromethane(20 mL x 3), the combined organic phase was washed with water(15mL x 2), dried over anhydrous Na2SO4 and concentrated toafford the crude product. The crude product was purified by columnchromatography to obtain compounds 11a-11e., 350684-49-0

As the paragraph descriping shows that 350684-49-0 is playing an increasingly important role.

Reference：
Article; Su, Yue; Li, Ridong; Ning, Xianling; Lin, Zhiqiang; Zhao, Xuyang; Zhou, Juntuo; Liu, Jia; Jin, Yan; Yin, Yuxin; European Journal of Medicinal Chemistry; vol. 177; (2019); p. 32 – 46;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics