Tag: M.W:200-300

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 : DIPEA (879 mu, 5.17 mmol) was added to 5-bromo-2-chloropyrimidine Ex.10a (500 mg, 2.56 mmol) in acetonitrile (12 mL). Then, benzyl piperazine-1-carboxylate (500 mu, 2.56 mmol) was added to the mixture. The reaction mixture was stirred at r.t. for 60h. Water and EtOAc were added. The two phases were separated and the aqueous solution was extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered and the solution was concentrated to dryness. The crude material was purified by column chromatography on silica gel eluting with Heptane/EtOAc from [100:0] to [0:100]. The product fractions were combined and concentrated to dryness to afford benzyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate Ex.10a (858 mg, 88percent) as white solid.

31166-44-6, The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; GENFIT; DELHOMEL, Jean-Francois; PERSPICACE, Enrico; MAJD, Zouher; PARROCHE, Peggy; WALCZAK, Robert; BONNET, Pascal; FOGHA, Jade; (76 pag.)WO2018/138356; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Chloropyridine-2-carbonitrile (250 mg, 1.8 mmol) and tert-butyl (2S)-2- methylpiperazine-1-carboxylate (433 mg, 2.17 mmol) were added to a reaction tube with DIPEA (377 pi, 2.17 mmol) in DMF (2.5 ml). The tube was then sealed and the reaction stirred at 80 C for 20 hours. The reaction mixture was concentrated in vacuo and the residue was partitioned between EtOAc (25 ml) and sat aq NaHCO3 (25 ml). The organics were separated and the aqueous phase extracted with EtOAc (2 x 20 ml). The combined organics were washed with water (20 ml), brine (20 ml), dried over MgSO4 and filtered. The filtrate was concentrated in vacuo and the residue was purified via flash column chromatography (gradient of 0 – 100% EtOAc in heptane followed by 0-100% MeOH in EtOAc). The product-containing fractions were combined and concentrated in vacuo to give the title compound as a yellow oil (321 mg, 51 %).1HNMR(500 MHz, Chloroform-d) 7.51 (dd, J = 8.8, 7.2 Hz, 1H), 6.96 (d, J = 7.1 Hz, 1H), 6.76 (d, J = 8.8 Hz, 1H), 4.32 (s, 1H), 4.11 (s, 1H), 4.03 -3.88 (m, 2H), 3.36-3.19 (m, 2H), 3.11 – 2.98 (m, 1H), 1.48 (s,9H), 1.17 (d, J = 6.7 Hz, 3H).LCMS Method 2 – Tr = 1.23 mm (ES+) (M+H)+ 288.0, 169447-70-5

The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NAVITOR PHARMACEUTICALS, INC.; O’NEILL, David John; SAIAH, Eddine; KANG, Seong Woo Anthony; BREARLEY, Andrew; BENTLEY, Jonathan; (565 pag.)WO2018/89433; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,694499-26-8

General procedure: To amixture of substituted benzoic acid obtained in the last step (0.12 mmol) in 5mL DMF, 2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate (HATU, 0.18 mmol), ethyldiisopropylamine (DIPEA, 0.24 mmol)and 4-((4-methylpiperazin-1-yl)methyl)-3- (trifluoromethyl)aniline (0.1 mmol)was added. The resulting mixture was stirred at room temperature overnight. Thenthe reaction was extracted with ethyl acetate, washed with brine, dried overanhydrous Na2SO4, filtered and concentrated to give thecrude product, which was further purified by column chromatography to affordthe final compounds.

694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Han, Mei; Li, Shan; Ai, Jing; Sheng, Rong; Hu, Yongzhou; Hu, Youhong; Geng, Meiyu; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5679 – 5684;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Descriptions 150 (S)-tert-butyl 4-(5-chloro-2-methyl-3-nitrobenzyl)-2-methylpiperazine-1-carboxylate (DiSO)To a solution of 5-chloro-2-methyl-3-nitrobenzaldehyde (D143, 20 g) in DCM (260 mL), (S)-tertbutyl 2-methylpiperazine- 1 -carboxylate (24.08 g) was added. The mixture was stirred for 10 mm atroom temperture, sodium triacetoxyhydroborate (25.4 g) was added portionwise. The reaction mixtiure was stirred overnight at 20 C. The mixture was washed with brine, dried with anhydrous Na2SO4. Filtered, the filtrate was concentrated to give crude product, which was purified by column chromatography (silica gel, petroleum ether/EtOAc = 20:1) to afford the title compound (37 g) as white solid. MS (ESI): C18H26C1N3O4 requires 383; found 384 [M+Hf., 169447-70-5

The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DENG, Jing; LEI, Hui; MA, Xin; LIN, Xichen; WO2015/180612; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

694499-26-8, Pyridine (163 ul, 2.01 mmol) and 4-nitrophenyl chloroformate (Combi-Blocks, CatNo. OT-0341, CAS [7693-46-1]) (369 mg, 1.83 mmol) were added to the mixed solution comprising 4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (AK Scientific Co., CatNo. AK-83227, CAS [694499-26-8]) (500 mg, 1.83 mmol) and CH2Cl2 (10 ml), followed by stirring at room temperature for 3 hours. The reaction mixture was concentrated. The obtained residue was treated with diethyl ether. As a result, a target compound was obtained as a brown solid (611 mg, 76% yield). MS m/z: 439[M+H]

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference：
Patent; DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION; Choi, Hwan Geun; Son, Jung Beom; Kim, Shinae; Lee, Seungyeon; Ko, Eunhwa; Cho, Joongheui; Kang, Seock Yong; Kim, So Young; Park, Jin-Hee; Ko, Yi Kyung; Ryu, Hee Yoon; Kim, Nam Doo; Kim, Hyunkyoung; Lee, Younho; Lee, Sun-Hwa; Kim, Dayea; Lee, Sun Joo; Hong, Seongho; Min, Sang Hyun; Lee, Sungwoo; Choi, Dong Kyu; Bae, Jae Hyun; Hong, Eunmi; Jang, Tae-ho; Song, Jaeyoung; Kim, Sangbum; Yoon, Suk Kyoon; (108 pag.)US2019/315738; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound 9 (200mg, 0.8mmol), sodium iodine (289mg, 1.93mmol) and substituted amines (1.61mmol) in methanol (30mL) was stirred at 40C for 5h. After the reaction was completed (monitored by TLC), the solution was concentrated under vacuum. Then the crude residue was purified by column chromatography (dichloromethane/methanol), affording pure product 10., 208167-83-3

208167-83-3 tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate 22106269, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Liang, Yu-Kun; Yue, Zhi-Zhou; Li, Jia-Xin; Tan, Cun; Miao, Ze-Hong; Tan, Wen-Fu; Yang, Chun-Hao; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 505 – 515;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

Cbz lnt-1 a A mixture of 5-fjiioro-2-nitrobenzaldehyde (20 g, 118 mmol) in DMF (150 mL), benzyl 1-piperazine carboxylate (31.2 g, 142 mmol), and triethylamine (14.3 g,142 mmol) was heated to 80 °C for 15 hours. After cooling to room temperature, the reaction mixture was diluted with EtOAc (300 mL), washed with brine (3 x 150 mL), dried over Na2S04, filtered, and concentrated. The resulting thick oil was purified by a flash column, eiuting with 20percent EtOAc/hexanes to yield 36.2 g (86percent) of Int-la as a yellow solid., 31166-44-6

The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SCHERING CORPORATION; XIAO, Dong; PALANI, Anandan; ASLANIAN, Robert, G.; DEGRADO, Sylvia; HUANG, Xianhai; ZHOU, Wei; SOFOLARIDES, Michael; CHEN, Xiao; WO2011/75375; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

159532-59-9, (S)-1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a) A solution of lithium aluminium hydride in tetrahydrofuran (1M, 22.0 ml, 22.0 mmol) was added dropwise to a solution of (2S)-1- (TERT-BUTOXYCARBONYL) piperazine-2-carboxylic acid (see US5348955, 1.007 g, 4.38 mmol) in tetrahydrofuran (20 ml) cooled TO-15C. The mixture was allowed to warm to 15C over 1.5 hours and then heated at reflux for 3 hours. The mixture was cooled in an ice bath and then water (0.4 ML) was added dropwise followed by a dilute solution of sodium hydroxide (1M, 0.4 ml) and a further portion of water (1.2 ml). The mixture was stirred at room temperature for 0.5 hours and then allowed to stand overnight. The resultant precipitate was filtered and the residue was washed with diethyl ether. The filtrate was evaporated and the residue purified by silica gel chromatography eluting with a 10% mixture of methanol (containing 10% 7M ammonia in methanol) in dichloromethane to give [(2S)-L-METHYLPIPERAZIN-2-YL] methanol (0.3802 g, 67% yield): H-NMR (CDC13) : 3.88 (dd, 1H), 3.46 (dd, 1H), 2.79-2. 96 (m, 4H), 2.25-2. 35 (m, 1H), 2.33 (s, 3H), 2.00-2. 15 (m, 4H); 13C-NMR (CDC13) : 43.1, 46.3, 49.0, 56.2, 61.6, 63.6., 159532-59-9

159532-59-9 (S)-1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid 40419053, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/94410; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.159532-59-9,(S)-1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Lithium aluminium hydride (1M in THF, 19.5 ml) was added to a solution of (2S)-1- (tert-butoxycarbonyl) piperazine-2-carboxylic acid (1.5 g) in THF (20 ml) at 0C, then the reaction was warmed to room temperature and heated at 60C for 16 hours. The reaction was cooled to 0C and quenched by sequential addition of water (0.75 ml), sodium hydroxide (2N, 0.75 ml) and then water (1.5 ml). The resulting slurry was filtered and concentrated in vacuo and the residue purified by chromatography using DCM to 20% 7N ammonia in methanol in DCM to [(2S)-L-METHYLPIPERAZIN-2-YL] METIZANOL as a white solid (454 mg, 53%) ; NMR spectrum (DMSO-d6) 1. 83 (m, 1H), 1. 98 (dt, 1H), 2.14 (s, 3H), 2.31 (dd, 1H), 2.56 (m, 2H), 2. 68 (m, 1H), 2. 84 (dd, 1H), 3.23 (dd, 1H), 3.52 (dd, 1H).

159532-59-9, As the paragraph descriping shows that 159532-59-9 is playing an increasingly important role.

Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/26152; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.

A solution of methyl (Z)-3-((4-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl) chloromethylene)-2-oxoindoline-5-carboxylate (138 mg, 0.29 mmol), N-(4-aminophenyl)-N- methyl-2-(4-methylpiperazin-1-yl)acetamide (88 mg, 0.34 mmol) and TEA (0.8 muL, 0.10 mmol) in EtOH (0.8 mL) was stirred under refluxed for overnight. The reaction solvent was evaporated under reduced pressure, and the residue was purified by column chromatography with dichloromethane/ethanol (50/1, v/v) to obtain the final compound 101 (154 mg, 76% yield): 1H NMR (500 MHz, CDCl3) _ 12.03 (s, 1H), 10.04 (s, 1H), 7.73 (dd, J = 8.2, 1.6 Hz, 1H), 7.45 (d, J = 7.9 Hz, 2H), 7.39 (d, J = 8.2 Hz, 2H), 6.99 (d, J = 8,2 Hz, 3H), 6.84 (d, J = 8.7 Hz, 2H), 6.69 (d, J = 1.7 Hz, 1H), 3.95 (t, J = 7.0 Hz, 2H), 3.75 (s, 3H), 3.20 (s, 2H), 3.00 (t, J = 7.0, 2H), 2.45 (bs, 6H), 2.28 (s, 3H), 0.92 (s, 9H), 0.07 (s, 6H); 13C NMR (125MHz, CDCl3) _ 171.4, 169.5, 167.4, 157.3, 142.3, 139.9, 139.3, 138.5, 130.5, 130.1, 128.4, 128.3, 127.9, 126.2, 124.3, 123.2, 122.6, 120.7, 115.7, 109.0, 98.6, 64.3, 59.6, 54.9, 53.3, 51.7.

262368-30-9, 262368-30-9 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 21927707, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; DALBY, Kevin N.; EDUPUGANTI, Ramakrishna; TALIAFERRO, Juliana; LEE, Juhyeon; (0 pag.)WO2018/160967; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics