Tag: M.W:200-300

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bromomethyl)-4-iodobenzene(SMILESS: IC1=CC=C(CBr)C=C1,cas:16004-15-2) is researched.Category: quinoxaline. The article 《One pot synthesis of isocyano-containing, densely functionalised gem-difluoroalkenes from α-trifluoromethyl alkenes, alkyl halides and TosMIC》 in relation to this compound, is published in Organic Chemistry Frontiers. Let’s take a look at the latest research on this compound (cas:16004-15-2).

A base-promoted one-pot, three-component reaction of TosMIC with α-trifluoromethyl alkenes and alkyl halides for the synthesis of isocyano- containing, densely functionalized gem-difluoroalkenes were reported. This protocol displayed broad scope and excellent functional group compatibility. The products were used as precursors to various medicinally relevant fluorine- or heterocycle-containing compouds.

Here is a brief introduction to this compound(16004-15-2)COA of Formula: C7H6BrI, if you want to know about other compounds related to this compound(16004-15-2), you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 16004-15-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Spectroscopic, structural and anticancer activity studies of (-)-cytisine halogenated N-benzyl derivatives.

(-)-Cytisine and its derivatives, characterized by high affinity to neuronal nicotinic acetylcholine receptors (nAChRs), have been shown to be important probes in the research of central nervous system disorders. In this work new halogenated N-benzylcytisine derivatives were obtained, and structurally characterized by NMR spectra and x-ray diffraction. Electron impact mass spectral (EIMS) fragmentations have been investigated and detailed fragmentation pathways have been proposed for all significant ions. For the first time it is shown that cytisine derivatives, under in vitro condition, exhibit promising antiproliferative activities against selected cell lines (A549, MV4-11, NCI-H358, MDA-MB-231, MCF-7, LoVo, HT-29, SK-N-MC). They exhibit lower cytotoxicity against normal murine fibroblasts then cisplatin, the commonly used anticancer drug. N-(4-iodobenzyl)cytisine revealed the strongest antiproliferative activity against lung (NCI-H358) and neuroepithelioma (SK-N-MC; IC50 below 10 μM) cancer cell lines among all compounds studied.

Here is a brief introduction to this compound(16004-15-2)Recommanded Product: 16004-15-2, if you want to know about other compounds related to this compound(16004-15-2), you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogs, published in 2021, which mentions a compound: 16004-15-2, Name is 1-(Bromomethyl)-4-iodobenzene, Molecular C7H6BrI, Reference of 1-(Bromomethyl)-4-iodobenzene.

Tyrosine sulfation is an important post-translational modification of peptides and proteins which underpins and modulates many protein-protein interactions. In order to overcome the inherent instability of the native modification, we report the synthesis of two sulfonate analogs and their incorporation into two thrombin-inhibiting sulfopeptides. The effective mimicry of these sulfonate analogs for native sulfotyrosine was validated in the context of their thrombin inhibitory activity and binding mode, as determined by X-ray crystallog.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3400-55-3, is researched, SMILESS is CC(Br)C(OCC)OCC, Molecular C7H15BrO2Journal, Article, Journal of the American Chemical Society called Improving the Fatigue Resistance of Diarylethene Switches, Author is Herder, Martin; Schmidt, Bernd M.; Grubert, Lutz; Paetzel, Michael; Schwarz, Jutta; Hecht, Stefan, the main research direction is photochromism diarylethene derivative substituent structure.Application In Synthesis of 2-Bromopriopionaldehydediethylacetal.

When applying photochromic switches as functional units in light-responsive materials or devices, an often disregarded yet crucial property is their resistance to fatigue during photoisomerization. In the large family of diarylethene photoswitches, formation of an annulated isomer as a byproduct of the photochromic reaction turns out to prevent the desired high reversibility for many different derivatives To overcome this general problem, we have synthesized and thoroughly investigated the fatigue behavior of a series of diarylethenes, varying the nature of the hetaryl moieties, the bridging units, and the substituents. By anal. of photokinetic data, a quantification of the tendency for byproduct formation in terms of quantum yields could be achieved, and a strong dependency on the electronic properties of the substituents was observed In particular, substitution with 3,5-bis(trifluoromethyl)phenyl or 3,5-bis(pentafluorosulfanyl)phenyl groups strongly suppresses the byproduct formation and opens up a general strategy to construct highly fatigue-resistant diarylethene photochromic systems with a large structural flexibility.

There is still a lot of research devoted to this compound(SMILES：CC(Br)C(OCC)OCC)Application In Synthesis of 2-Bromopriopionaldehydediethylacetal, and with the development of science, more effects of this compound(3400-55-3) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 16004-15-2, is researched, SMILESS is IC1=CC=C(CBr)C=C1, Molecular C7H6BrIJournal, Journal of Molecular Structure called Inhibition of acid corrosion in API 5L X52 steel with 1,2,3-triazole derivatized from benzyl alcohol: Experimental and theoretical studies, Author is Espinoza Vazquez, A.; Gonzalez-Olvera, R.; Moreno Cerros, D.; Negron Silva, G. E.; Figueroa, I. A.; Rodriguez Gomez, F. J.; Castro, M.; Miralrio, A.; Huerta, L., the main research direction is inhibition acid corrosion steel triazole derivatized benzyl alc.Related Products of 16004-15-2.

This work presents the synthesis of new triazoles derived from benzyl alc. to be used as corrosion inhibitors for API 5L X52 steel in HCl 1M medium. The results showed that all derivatives displayed a better inhibitory capacity than benzyl alc. Electrochem. impedance spectroscopy in conjunction with polarization curves revealed that compound 6 showed the highest inhibitory capacity of all derivatives with 94.2% inhibition efficiency at a concentration of 50 ppm. Furthermore, it was determined that compounds 3, 6 and 7 were inhibitors with anodic behavior and compounds 4 and 5 acted as mixed inhibitors. Benzyl alc. and all its synthesized derivatives fitted the Langmuir adsorption isotherm. The combined adsorption phenomenon was proposed according to the thermodn. parameter values obtained. Dispersion-corrected DFT studies, assuming the cluster approach, obtained free binding energies that matched well with exptl. determined standard adsorption free energies. The mixed physisorption-chemisorption observed was explained in terms of the electrostatic interactions and chem. bonding between the metal surface and the corrosion inhibitor. Finally, compound 6 obtained the largest charge transference to the metal cluster.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of [TpRu(CO)(PPh3)]2(μ-CH:CH-CH:CH-C6H4-CH:CH-CH:CH) from Wittig reactions, published in 2003-10-15, which mentions a compound: 18583-60-3, mainly applied to ruthenium hydride addition reaction phosphonium ethoxy alkyne; alkenylphosphonium ruthenium preparation Wittig condensation terephthaldicarboxaldehyde benzaldehyde; alkenylcarboxaldehyde ruthenium complex Wittig condensation benzyl phosphonium chloride; bimetallic ruthenium alkenylphosphonium containing metal alkenyl linkage preparation, Product Details of 18583-60-3.

Treatment of [Ru(CH:CHCH2PPh3)X(CO)(PPh3)2]+ (X = Cl, Br) with KTp (Tp = hydridotris(pyrazolyl)borate) and NaBPh4 produced [TpRu(CH:CHCH2PPh3)(CO)(PPh3)]BPh4. Reaction of RuHCl(CO)(PPh3)3 with HCCCH(OEt)2 produced Ru(CH:CHCH(OEt)2)Cl(CO)(PPh3)2, which reacted with KTp to give TpRu(CH:CHCHO)(CO)(PPh3). Treatment of [TpRu(CH:CHCH2PPh3)(CO)(PPh3)]BPh4 with NaN(SiMe3)2 and benzaldehyde produced TpRu(CH:CHCH:CHPh)(CO)(PPh3). The later complex was also produced when TpRu(CH:CHCHO)(CO)(PPh3) was treated with PhCH2PPh3Cl/NaN(SiMe3)2. The bimetallic complex [TpRu(CO)(PPh3)]2(μ-CH:CHCH:CHC6H4CH:CHCH:CH) was obtained from the reaction of [TpRu(CH:CHCH2PPh3)(CO)(PPh3)]BPh4 with NaN(SiMe3)2 and terephthaldicarboxaldehyde.

There is still a lot of research devoted to this compound(SMILES：[BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+])Product Details of 18583-60-3, and with the development of science, more effects of this compound(18583-60-3) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nicholson, Brian K. researched the compound: Potassiumtris(1-pyrazolyl)borohydride( cas:18583-60-3 ).Electric Literature of C9H10BKN6.They published the article 《The synthesis and x-ray structure of tris(pyrazolyl)borate(trimethyl)tin; a six-coordinate trialkyltin complex》 about this compound( cas:18583-60-3 ) in Journal of Organometallic Chemistry. Keywords: pyrazolylboratetrimethyltin preparation crystal structure; crystal structure tin pyrazolylborate complex; mol structure tin pyrazolylborate complex. We’ll tell you more about this compound (cas:18583-60-3).

Reaction between Me3SnCl and K[HB(pz)3] (pz = 1-pyrazolyl) afforded [HB(pz)3]SnMe3 (I) which was shown by a full x-ray structure determination to contain 6-coordinate Sn bonded to 3 Me groups and to 3 pz groups.

There is still a lot of research devoted to this compound(SMILES：[BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+])Electric Literature of C9H10BKN6, and with the development of science, more effects of this compound(18583-60-3) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Nucleophilic and Radical Heptafluoroisopropoxylation with Redox-Active Reagents, published in 2021-10-11, which mentions a compound: 16004-15-2, mainly applied to heptafluoroisopropyl ether preparation; hydroxylamine oxidative heptafluoroisopropyl silver heptafluoroisopropylation; conformation; heptafluoroisopropoxylation; nucleophilic reactions; radical reactions; redox-active reagents, Electric Literature of C7H6BrI.

The practical and efficient heptafluoroisopropoxylation reactions through the invention of a series of redox-active N-OCF(CF3)2 reagents e.g., I were described. These reagents were readily prepared from the oxidative heptafluoroisopropylation of hydroxylamines e.g., II with AgCF(CF3)2. The substitutions on the nitrogen atom significantly affected the properties and reactivities of N-OCF(CF3)2 reagents. Accordingly, two types of N-OCF(CF3)2 reagents including I and III were used as OCF(CF3)2 anion and radical precursors, resp. This protocol enables the direct heptafluoroisopropoxylation of a range of substrates, delivering the corresponding products in moderate to excellent yields.

If you want to learn more about this compound(1-(Bromomethyl)-4-iodobenzene)Electric Literature of C7H6BrI, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(16004-15-2).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Osorio, Liseth S.; Ionta, Marisa; Demuner, Antonio J.; de Sousa, Bianca L.; Ferraz, Guilherme O.; Varejao, Eduardo V. V.; Ferreira-Silva, Guilherme A.; Pilau, Eduardo J.; Silva, Evandro; dos Santos, Marcelo H. published an article about the compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2,SMILESS:IC1=CC=C(CBr)C=C1 ).Formula: C7H6BrI. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:16004-15-2) through the article.

In the present study, a series of novel triazole compounds, e.g., I were obtained by conjugation between hydnocarpic acid and functionalized azides via copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC). Hydnocarpic acid and its derivatives were tested against estrogen-pos. breast carcinoma (MCF-7), hepatocellular carcinoma (HepG2), and non-small cell lung cancer (A549) cell lines. The compound I displayed promising antiproliferative activity against A549 cells. It was demonstrated that this compound selectively inhibited the viability of A549 cell cultures. Furthermore, compound I inhibited the clonogenic capacity of A549 cells, and this effect was associated to its ability to inhibit cell cycle progression at G1 phase. These findings indicate that compound I is a promising antitumor agent on A549 cells and support further studies to evaluate the mol. mechanisms underlying its antiproliferative activity. In addition, hydnocarpic acid should be considered as a promising chem. prototype to obtain novel antineoplastic agents.

If you want to learn more about this compound(1-(Bromomethyl)-4-iodobenzene)Formula: C7H6BrI, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(16004-15-2).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Safety of 1-(Bromomethyl)-4-iodobenzene. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Chemo-, regio- and stereoselective synthesis of monofluoroalkenes via a tandem fluorination-desulfonation sequence. Author is Yang, Ren-Yin; Xu, Bo.

A widely applicable approach for the synthesis of Z-monofluoroalkenes ArC(F):CHR [R = Ph, 2-naphthyl, 3-BrC6H4, etc., Ar = Ph, 4-NCC6H4, 4-O2NC6H4, etc.] from readily available alkyl triflones and NFSI was reported. The reaction proceeded under mild conditions, affording the mono-fluorinated alkenes in good to excellent yields with excellent chemo-, regio-, and stereoselectivity. The mechanism might involve electrophilic fluorination of triflones followed by the highly stereoselective concerted bimol. elimination (E2) of CF3SO2H.

If you want to learn more about this compound(1-(Bromomethyl)-4-iodobenzene)Safety of 1-(Bromomethyl)-4-iodobenzene, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(16004-15-2).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics