Tag: M.W:200-300

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 20-mL screw-cap vial, 100 mg (0.3 mmol) 2-(2-chlorophenyl)-1-(4-chlorophenyl)- 1H imidazole-4-carboxylic acid, 87 mg (0.33 mmol) TFFH, and 5.0 equiv. PS-DIEA (loading level: 3.50 mmol/g, 429 mg, 1.5 mmol) were heated in 8 mL 1,2-dichloroethane at 35C overnight. The formation of acyl fluoride was monitored by LC-MS. To the mixture, 1.1 equiv. (76 mg, 0.33 mmol) 1-(4-trifluormethylphenyl)-piperazine was added and the reaction continued overnight. The mixture was filtered through a filter tube (polypropylene frit), and the filtrate was evaporated under reduced pressure. The crude product was redissolved in 1 mL MeOH and purified by preparative HPLC to give 45.9 mg of 1-{ [2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4- yl]carbonyl}-4-[4-(trifluoromethyl)phenyl]piperazine as the trifluoroacetate salt (yellow oil, 23% yield). ?H NMR (400 MHz, CD3COCD3) No. 7.95 (s, 1 H), 7.60 (m, 1 H), 7.30-7.50 (m, 7 H), 7.25 (d, 2 H), 7.05 (d, 2 H), 4.5 (bs, 2 H), 3.80 (bs, 2 H), 3.35 (m, 4 H) ; LC-MS m/z 545.3 (MH+), retention time 4.21 min (method 2), 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2005/99705; (2005); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.

Thus, in a first step and in accordance with what is described in WO 01/27081, 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone is prepared as follows. 10.5 g (30.0 mmol) 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone (prepared as described in WO 01/27081) and 8.60 g (33.0 mmol) N-[(4-methyl-piperazin-1-yl)-methylcarbonyl]-N-methyl-p-phenylendiamine (prepared as described in WO 01/27081) are dissolved in 80 ml dimethylformamide and mixed for 1 hour at 80C. After cooling, 6.50 ml piperidine is added and the whole is further mixed for 2 hours at room temperature. Water is added, the liquid over the resulting precipitate is sucked up, and the precipitate is washed again with a low quantity of water. The residue is suspended in 200 ml methanol, the liquid is sucked up, and the remaining residue washed with cold water and diethylether. The resulting product is vacuum dried at 110 C. [] Recovered product:12.4 g (77% of theoretical value)IR-spectroscopy:1610, 1655, 1711 cm-1 Tsmp. =253CMolecular formula: C31H33N5O4 Electrospray-mass spectrometry: m/z = 540 [M+H]+ [] Element analysis: calculatedC 68.99H 6.16N 12.98foundC 68.32H 6.29, 262368-30-9

262368-30-9 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 21927707, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Boehringer Ingelheim Pharma GmbH & Co.KG; EP1473043; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-81-3,1-Methyl-4-(4-nitrobenzyl)piperazine,as a common compound, the synthetic route is as follows.

70261-81-3, Nitrobenzyl bromide and N- methyl piperazine after the substitutionreaction, and then get by stannous chloride reduction.

As the paragraph descriping shows that 70261-81-3 is playing an increasingly important role.

Reference£º
Patent; CHINA PHARMACEUTICAL UNIVERSITY; YANG, ZHAO; WANG, ZHIXIANG; FANG, ZHENG; GUO, KAI; WEI, PING; (23 pag.)CN103739550; (2016); B;,
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169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Preparation of tert-butyl (2S)-4-[[2-fluoro-4-(morpholin-4-yl)phenyl]methyl]-2- methylpiperazine-l-carboxylate [00251] A 100-mL round-bottom flask was charged with 2-fluoro-4-(morpholin-4- yl)benzaldehyde (0.800 g, 3.82 mmol, 1.00 equiv), tert-butyl (2S)-2-methylpiperazine-l- carboxylate (0.840 g, 4.20 mmol, 1.10 equiv), and 1,2-dichloroethane (20 mL). The mixture was stirred for 30 min at room temperature. Sodium triacetoxyborohydride (2.40 g, 1 1.3 mmol, 3.00 equiv) was added. The resulting solution was stirred overnight at room temperature, diluted with 0 (10 mL), and extracted with dichloromethane (3 x 10 mL). The organic layers were combined and washed with brine (50 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was chromatographed on a silica gel column with ethyl acetate/petroleum ether (25/75) to provide 1.40 g (93% yield) of ter/-butyl (2S)-4-[[2-fluoro-4-(morpholin-4-yl)phenyl]methyl]-2-methylpiperazine-l-carboxylate as a white solid. LCMS (ESI, m/z): 394 [M+H]+., 169447-70-5

The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABIDE THERAPEUTICS; THE SCRIPPS RESEARCH INSTITUTE; CISAR, Justin, S.; GRICE, Cheryl, A.; JONES, Todd, K.; WANG, Dong-Hui; WEBER, Olivia; CRAVATT, Benjamin, F.; NIPHAKIS, Micah, J.; COGNETTA, Armand; CHANG, Jae Won; WO2013/142307; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Step A: tert-Butyl (3S)-4- [2- (4-cyano-3-methoxyphenyl)-2-hydroxyethyl1 -3-(hydroxymethyl)piperazine- 1 -carboxylate: A Pyrex vessel was charged with magnetic stirring bar, (0.350 g, 2.00 mmol) of 2-methoxy-4-(oxiran-2-yl) benzonitrile, (0.457 g, 2.20 mmol) oftert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate, and 6 mL of EtOH. Then it was introduced in the microwave reactor and irradiated at 150 C for 3 hr. Then the mixture was cooled to room temperature and the solvent was evaporated and the resulting residue was purified by column chromatography (silica gel, 1- 20% dichloromethane/MeOH) which afforded the title compound as a mixture of two diastereomers (1:1). LC/MS: (IE, m/z) [(M + 1) – t-Bu] =336.1., 314741-40-7

As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DEJESUS, Reynalda, Keh; FRIE, Jessica, L.; PIO, Barbara; TANG, Haifeng; WALSH, Shawn, P.; WO2014/99633; (2014); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-70-5,(S)-tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Step 2: (S)-tert-butyl 2-methyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indol-5-yl)piperazine-1-carboxylate To a solution of 5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole (2 g, 6.13 mmol) and (S)-tert-butyl-2-methylpiperazine-1-carboxylate (1.23 g, 6.13 mmol) in toluene (20 mL) was added Pd2(dba)3 (281 mg, 0.31 mmol), BINAP (381 mg, 0.613 mmol), and t-BuONa (1.17 g, 12.26 mmol). The mixture was stirred at 80 C. for 5 hrs under nitrogen. The resulting mixture was concentrated in vacuo and the residue was purified by column chromatography on silica gel to give (S)-tert-butyl-2-methyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indol-5-yl)piperazine-1-carboxylate (645 mg, 1.45 mmol, 16.5%) as a yellow liquid. ESI-MS (EI+, m/z): 446.4 [M+H]+., 169447-70-5

The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Navitor Pharmaceuticals, Inc.; O’Neill, David John; Saiah, Eddine; Kang, Seong Woo Anthony; Brearley, Andrew; Bentley, Jonathan; (136 pag.)US2019/389843; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 69 (0.2 g, 0.57 mmol), 4-(2-amino-ethyl)-piperazine-l-carboxylic acidtert-butyl ester (0.26 g, 1.13 mmol) and DIEA (0.20 mL, 1.14 mmol) in 1-butanol (5 mL) washeated to 120¡ãC for 1.5 h. After concentration, the residue was purified by silica gelchromatography using 2-5percent MeOH/DCM, to give 4-[2-(5,6-diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-ethyl]-piperazine-l-carboxylic acid tert-butyl ester 71 (0.20 g). Compound 71 wassubjected to 20 mL of 20percent TFA/DCM at rt for 2 h, then the reaction was concentrated almostto dryness under reduced pressure, and purified by silica gel column chromatography using0.1percent MeOH/DCM containing ImL ammonium hydroxide, to give 72 (0.15 g). MS: 400.2(M+l). ‘HNMRtDMSO-dg) ppm 8.36 (s, 1H), 7.61-7.33 (m, 10H), 5.49 (t, 1H, J=4.48Hz),3.45 (dd, 2H, Jr=5.10Hz, J2=5.84Hz), 2.33 (t, 2H, J=5.80Hz), 2.13 (br, 4H), 1.95 (br, 1H)(note: some peaks overlapped with water peak in DMSO-de). ‘HNMR (CCla-d) ppm 8.43 (s,1H), 7.60-7.50 (m, 6H), 7.50-7.26 (m, 4H), 5.39 (t, 1H), 3.54 (dd, 2H, J^S.OSHz, J2=6.20Hz),2.73 (t, 4H, J=4.71Hz), 2.44 (t 2H, J=5.91Hz), 2.28 (br, 4H), 1,87 (br, 1H).

192130-34-0, As the paragraph descriping shows that 192130-34-0 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; WO2006/4658; (2006); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

3-(2-Furyl)propanoic acid (54 mg, 0.39 mmol), HOBt (58 mg, 0.43 mmol), TBTU (138 mg, 0.43 mmol), anhydrous triethylamine (87 ??, 0.63 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 31 % yield. H NMR (300 MHz, CDCI3) ? 7.48 (d, 2H), 7.31 (s, 1 H), 6.89 (d, 2H), 6.28 (t, 1 H), 6.04 (d, 1 H), 3.77 (t, 2H), 3.58 (t, 2H), 3.21-3.26 (m, 4H), 3.00 (t, 2H), 2.69 (t, 2H). MS (+ESI) calcd for C18 H19 F3 N2 02 m/z: [M + H]+ , 353.1471 ; found 353.1461 [Diff(ppm) = – 2.83].

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1188265-73-7,tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

tert-butyl 3-(2-hydroxyethyl) piperazine-1-carboxylate (6.91 g, 30.0 mmol) and 5-(2-bromoacetyl)-4-methylisobenzofuran-1(3H)-one (6.73 g, 25 mmol) were dissolved in tetrahydrofuran (100 mL) then added Hunig?sbase (8.73 mL, 50.0 mmol) and stirred at RT overnight. The reaction was poured into brine and extracted with EtOAc(2x). The combined organic layer was dried over Na2SO4, filtered and evaporated to dryness. The crude productwas chromatographed through an ISCO Redi-Sep 330g column and eluted with 5% MeOH /DCM solvent systemto the title compound. LC-MS (IE, m/z): 419 [M + 1]+., 1188265-73-7

1188265-73-7 tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate 53407692, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Merck Sharp & Dohme Corp.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; (128 pag.)EP2744499; (2016); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

55121-99-8, General Procedure for Synthesis of Examples 8 – 42; EPO EPO EPO The starting pyrimidyl chloride (54 mg, 0.15 mmol) was placed in a 2-5 mL microwave reaction vessel from Personal Chemistry, suspended in iPrOH (2 mL), and treated with concentrated HCI (0.075 mL) and an aniline monomer (0.3 mmol). The vial was sealed and the reaction was heated in the Smith Synthesizer at 170 0C for 20 minutes. The cap was removed and Et3N (0.5 mL) and CH2CI2 (2 mL) were added. The solvent was evaporated and the residue purified by reverse phase mass directed prep HPLC [conditions: 4 x 20 mm Phenomenex Luna C18(2) 3 micron column, eluted with 10-100% Methanol (0.075% Formic Acid) / Water (0.1% Formic Acid), 3 minute gradient time, 4 minute run, 2 ml/minute]. The appropriate fractions were combined and concentrated to give the final products. Compounds with greater than 80% purity by peak area were submitted for screening and are shown in the table below.

55121-99-8 (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone 231408, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/18941; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics