Tag: M.W:200-300

Recommanded Product: 16004-15-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Spectroscopic, structural and anticancer activity studies of (-)-cytisine halogenated N-benzyl derivatives.

(-)-Cytisine and its derivatives, characterized by high affinity to neuronal nicotinic acetylcholine receptors (nAChRs), have been shown to be important probes in the research of central nervous system disorders. In this work new halogenated N-benzylcytisine derivatives were obtained, and structurally characterized by NMR spectra and x-ray diffraction. Electron impact mass spectral (EIMS) fragmentations have been investigated and detailed fragmentation pathways have been proposed for all significant ions. For the first time it is shown that cytisine derivatives, under in vitro condition, exhibit promising antiproliferative activities against selected cell lines (A549, MV4-11, NCI-H358, MDA-MB-231, MCF-7, LoVo, HT-29, SK-N-MC). They exhibit lower cytotoxicity against normal murine fibroblasts then cisplatin, the commonly used anticancer drug. N-(4-iodobenzyl)cytisine revealed the strongest antiproliferative activity against lung (NCI-H358) and neuroepithelioma (SK-N-MC; IC50 below 10 μM) cancer cell lines among all compounds studied.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogs, published in 2021, which mentions a compound: 16004-15-2, Name is 1-(Bromomethyl)-4-iodobenzene, Molecular C7H6BrI, Reference of 1-(Bromomethyl)-4-iodobenzene.

Tyrosine sulfation is an important post-translational modification of peptides and proteins which underpins and modulates many protein-protein interactions. In order to overcome the inherent instability of the native modification, we report the synthesis of two sulfonate analogs and their incorporation into two thrombin-inhibiting sulfopeptides. The effective mimicry of these sulfonate analogs for native sulfotyrosine was validated in the context of their thrombin inhibitory activity and binding mode, as determined by X-ray crystallog.

There is still a lot of research devoted to this compound(SMILES：IC1=CC=C(CBr)C=C1)Reference of 1-(Bromomethyl)-4-iodobenzene, and with the development of science, more effects of this compound(16004-15-2) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3400-55-3, is researched, SMILESS is CC(Br)C(OCC)OCC, Molecular C7H15BrO2Journal, Article, Journal of the American Chemical Society called Improving the Fatigue Resistance of Diarylethene Switches, Author is Herder, Martin; Schmidt, Bernd M.; Grubert, Lutz; Paetzel, Michael; Schwarz, Jutta; Hecht, Stefan, the main research direction is photochromism diarylethene derivative substituent structure.Application In Synthesis of 2-Bromopriopionaldehydediethylacetal.

When applying photochromic switches as functional units in light-responsive materials or devices, an often disregarded yet crucial property is their resistance to fatigue during photoisomerization. In the large family of diarylethene photoswitches, formation of an annulated isomer as a byproduct of the photochromic reaction turns out to prevent the desired high reversibility for many different derivatives To overcome this general problem, we have synthesized and thoroughly investigated the fatigue behavior of a series of diarylethenes, varying the nature of the hetaryl moieties, the bridging units, and the substituents. By anal. of photokinetic data, a quantification of the tendency for byproduct formation in terms of quantum yields could be achieved, and a strong dependency on the electronic properties of the substituents was observed In particular, substitution with 3,5-bis(trifluoromethyl)phenyl or 3,5-bis(pentafluorosulfanyl)phenyl groups strongly suppresses the byproduct formation and opens up a general strategy to construct highly fatigue-resistant diarylethene photochromic systems with a large structural flexibility.

There is still a lot of research devoted to this compound(SMILES：CC(Br)C(OCC)OCC)Application In Synthesis of 2-Bromopriopionaldehydediethylacetal, and with the development of science, more effects of this compound(3400-55-3) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 16004-15-2, is researched, SMILESS is IC1=CC=C(CBr)C=C1, Molecular C7H6BrIJournal, Journal of Molecular Structure called Inhibition of acid corrosion in API 5L X52 steel with 1,2,3-triazole derivatized from benzyl alcohol: Experimental and theoretical studies, Author is Espinoza Vazquez, A.; Gonzalez-Olvera, R.; Moreno Cerros, D.; Negron Silva, G. E.; Figueroa, I. A.; Rodriguez Gomez, F. J.; Castro, M.; Miralrio, A.; Huerta, L., the main research direction is inhibition acid corrosion steel triazole derivatized benzyl alc.Related Products of 16004-15-2.

This work presents the synthesis of new triazoles derived from benzyl alc. to be used as corrosion inhibitors for API 5L X52 steel in HCl 1M medium. The results showed that all derivatives displayed a better inhibitory capacity than benzyl alc. Electrochem. impedance spectroscopy in conjunction with polarization curves revealed that compound 6 showed the highest inhibitory capacity of all derivatives with 94.2% inhibition efficiency at a concentration of 50 ppm. Furthermore, it was determined that compounds 3, 6 and 7 were inhibitors with anodic behavior and compounds 4 and 5 acted as mixed inhibitors. Benzyl alc. and all its synthesized derivatives fitted the Langmuir adsorption isotherm. The combined adsorption phenomenon was proposed according to the thermodn. parameter values obtained. Dispersion-corrected DFT studies, assuming the cluster approach, obtained free binding energies that matched well with exptl. determined standard adsorption free energies. The mixed physisorption-chemisorption observed was explained in terms of the electrostatic interactions and chem. bonding between the metal surface and the corrosion inhibitor. Finally, compound 6 obtained the largest charge transference to the metal cluster.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of [TpRu(CO)(PPh3)]2(μ-CH:CH-CH:CH-C6H4-CH:CH-CH:CH) from Wittig reactions, published in 2003-10-15, which mentions a compound: 18583-60-3, mainly applied to ruthenium hydride addition reaction phosphonium ethoxy alkyne; alkenylphosphonium ruthenium preparation Wittig condensation terephthaldicarboxaldehyde benzaldehyde; alkenylcarboxaldehyde ruthenium complex Wittig condensation benzyl phosphonium chloride; bimetallic ruthenium alkenylphosphonium containing metal alkenyl linkage preparation, Product Details of 18583-60-3.

Treatment of [Ru(CH:CHCH2PPh3)X(CO)(PPh3)2]+ (X = Cl, Br) with KTp (Tp = hydridotris(pyrazolyl)borate) and NaBPh4 produced [TpRu(CH:CHCH2PPh3)(CO)(PPh3)]BPh4. Reaction of RuHCl(CO)(PPh3)3 with HCCCH(OEt)2 produced Ru(CH:CHCH(OEt)2)Cl(CO)(PPh3)2, which reacted with KTp to give TpRu(CH:CHCHO)(CO)(PPh3). Treatment of [TpRu(CH:CHCH2PPh3)(CO)(PPh3)]BPh4 with NaN(SiMe3)2 and benzaldehyde produced TpRu(CH:CHCH:CHPh)(CO)(PPh3). The later complex was also produced when TpRu(CH:CHCHO)(CO)(PPh3) was treated with PhCH2PPh3Cl/NaN(SiMe3)2. The bimetallic complex [TpRu(CO)(PPh3)]2(μ-CH:CHCH:CHC6H4CH:CHCH:CH) was obtained from the reaction of [TpRu(CH:CHCH2PPh3)(CO)(PPh3)]BPh4 with NaN(SiMe3)2 and terephthaldicarboxaldehyde.

There is still a lot of research devoted to this compound(SMILES：[BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+])Product Details of 18583-60-3, and with the development of science, more effects of this compound(18583-60-3) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nicholson, Brian K. researched the compound: Potassiumtris(1-pyrazolyl)borohydride( cas:18583-60-3 ).Electric Literature of C9H10BKN6.They published the article 《The synthesis and x-ray structure of tris(pyrazolyl)borate(trimethyl)tin; a six-coordinate trialkyltin complex》 about this compound( cas:18583-60-3 ) in Journal of Organometallic Chemistry. Keywords: pyrazolylboratetrimethyltin preparation crystal structure; crystal structure tin pyrazolylborate complex; mol structure tin pyrazolylborate complex. We’ll tell you more about this compound (cas:18583-60-3).

Reaction between Me3SnCl and K[HB(pz)3] (pz = 1-pyrazolyl) afforded [HB(pz)3]SnMe3 (I) which was shown by a full x-ray structure determination to contain 6-coordinate Sn bonded to 3 Me groups and to 3 pz groups.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3400-55-3, is researched, Molecular C7H15BrO2, about Fe-Catalyzed Reductive Couplings of Terminal (Hetero)Aryl Alkenes and Alkyl Halides under Aqueous Micellar Conditions, the main research direction is iron catalyst reductive coupling heteroaryl alkene alkyl halide.Recommanded Product: 3400-55-3.

The combination of a vinyl-substituted aromatic or heteroaromatic and an alkyl bromide or iodide leads, in the presence of Zn and a catalytic amount of an Fe(II) salt, to a net reductive coupling. The new C-C bond is regiospecifically formed at rt at the β-site of the alkene. The coupling only occurs in an aqueous micellar medium, where a radical process is likely, supported by several control experiments A mechanism based on these data is proposed.

There is still a lot of research devoted to this compound(SMILES：CC(Br)C(OCC)OCC)Recommanded Product: 3400-55-3, and with the development of science, more effects of this compound(3400-55-3) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Heterocyclic vinyl eters. XVI. 2,5 Dimethyl-1,4-dithiadiene》. Authors are Parham, William E.; Mayo, Gwendolyn L. O.; Gadsby, Brian.The article about the compound:2-Bromopriopionaldehydediethylacetalcas:3400-55-3,SMILESS:CC(Br)C(OCC)OCC).Synthetic Route of C7H15BrO2. Through the article, more information about this compound (cas:3400-55-3) is conveyed.

cf. C.A. 53, 17133b. 2,5-Dimethyl-1,4-dithiadiene (I), the 1st example of an alkyl dithiadiene, was prepared Na2S.9H2O (559 g.) in 2800 cc. boiling 95% EtOH and 149 g. S refluxed 10 min., treated with 654 g. MeCHBrCH(OEt)2 at such a rate as to maintain reflux, refluxed 3 hrs., 500 cc. solvent removed, treated with 135 g. NaHCO3, distilled to collect 2.1 l. solvent, cooled, diluted with 1500 cc. H2O, and extracted with Et2O, the extract evaporated, and the residue kept in vacuo to constant weight gave 525-50 g. black oily residue, n26D 1.50; a 538-g. portion in 500 cc. dry Et2O diluted with 5 l. liquid NH3, treated with 200 g. Na during 1 hr. and then with 500 cc. liquid NH3, stirred 30-40 min., treated with 200 g. NH4Cl in small portions, and evaporated with stirring, the gummy residue kept at 32° overnight, stirred with 1 l. iced H2O, adjusted with concentrated HCl to pH 8-8.5 and then with CO2 to pH 7.8-8.0, the aqueous layer extracted with Et2O, and the combined organic layer and Et2O extract worked up gave 300 g. MeCH(SH)CH(OEt)2 (II), b9 60-78°, n27D 1.436-1.437. II (1.5 g.), NaOEt from 0.23 g. Na in 10 cc. EtOH, and 1.5 cc. BuBr refluxed 1.5 hrs., acidified with concentrated HCl, and treated with 2,4-(O2N)2C6H3NHNH2 gave 2,4-(O2N)2C6H3NHN:CHCH(SBu)Me, 110-11° (95% EtOH). p-MeC6H4SO3H.H2O (1.0 g.) in C6H6 dried azeotropically, treated with 49.2 g. II, refluxed 2 hrs., cooled, washed, dried, and distilled yielded 26.2 g. semisolid mixed isomers of 2,5-dimethyl-3,6-diethoxy-1,4-dithiane (III), b0.35 82-7°, n25D 1.5012; the solid portion of the mixture recrystallized from 95% EtOH gave the α-isomer, cubes, m. 119-20°. Powd. KMnO4 (47.4 g.) added in small portions to 23.6 g. mixed isomeric III in 162 g. glacial AcOH, the mixture kept 3 days at room temperature, the AcOH distilled the residue diluted with 160 cc. H2O, treated with SO2, and filtered, the tarry, yellow, semisolid residue dried in vacuo and extracted with EtOAc in a Soxhlet apparatus, and the extract worked up gave 5.22 g. tetroxide of III, needles, m. 190-1° (absolute EtOH). III (12.00 g.) and 0.1 g. P2O5 heated at 160°, 1.93 g. EtOH removed during 2 hrs., the residue cooled and diluted with Et2O, and the Et2O solution worked up gave 4.24 g. 3-ethoxy-2,5-dimethyl-1,4-dithi-5-ene (IV), b5.3 104-5°, b0.25 60-2°, n26.5D 1.5437. The solid isomeric III (3.66 g.) gave 1.03 g. IV. Al2O3 pellets (60 g.) heated 40-8 hrs. at 260° in a vertical tube under N, cooled to 213°, 5 cc. absolute EtOH passed at 10-12 drops/min. with about 0.5 l. N/min. through the tube, 30 g. III in 25 cc. absolute EtOH added at the same rate and finally 10 cc. absolute EtOH, and the pyrolyzate condensed in a Dry Ice trap, washed with 2% aqueous NaOH and saturated aqueous NaCl, dried, and distilled yielded 6.9 g. I, b2.8 72-8°, n25D 1.56, and 8.2 g. IV, b2.0 91-106°, n26.5D 1.5329-1.5258. Similar pyrolytic runs on Al2O3, conditioned at 316-60° with a N flow of 0.3-0.5 l./min., at 204-310° gave yields of I and IV varying from 0-38 and 0-64%, resp.; at temperatures above 270° neither I nor IV were obtained. I (about 5 g.) in 1:1 Et2O-petr. ether chromatographed on Al2O3 gave pure I, pale yellow oil, b2.0 61-2°, n26D 1.5754. IV purified similarly gave an almost colorless oil, b2.4 90-2.5°, n26.9D 1.5383. IV (22.5 g.) passed at 227° over 60 g. Al2O3 pellets (conditioned at 360°) gave 7.1 g. unchanged IV, n26D 1.534, and 5.0 g. I, n26D 1.568. I (0.400 g.) in glacial AcOH treated at 70° with 2.5 cc. 30% H2O2 during 1.5 hrs., kept 18 hrs. at 70° and 1 hr. at 10°, and filtered from 0.35 g. product, the filtrate evaporated to dryness, the residue dissolved in 2 cc. glacial AcOH, treated with a few drops 30% H2O2, heated 0.5 hr. on the steam bath, and filtered, and the combined residues (0.57 g.) recrystallized from 95% EtOH gave tetroxide of I, m. 218-21° with sublimation. I (4.35 g.), b2.3 62-4°, n27.3D 1.5702, refluxed under a stream of N 1 hr. gave 0.88 g. 2,4-dimethylthiophene (V), n27.8D 1.5057, b. 90-138°, the residue distilled yielded 0.27 g. liquid, b2 55°, n27D 1.5218, and 2.13 g. black residue. V (0.75 g.) in 1.0 cc. C6H6 and 1.36 g. Ac2O treated at 60° with 4 drops 85% H2PO4, refluxed 2.5 hrs., cooled, diluted with 2.5 cc. H2O, kept overnight, and extracted with Et2O, the extract washed, dried, and evaporated, the residue refluxed 2 hrs. with 1 g. NH2OH.HCl, 5 cc. C5H5N, and 5 cc. absolute EtOH and evaporated at room temperature in vacuo, the residual oil triturated with 5 cc. H2O, and the resulting solid recrystallized from 95% EtOH gave a mixture, m. 55-68°, of a material, m. about 65°, and a material, m. about 120°, which could not be separated chromatographically; the mixture kept 14 days at room temperature in a sublimation apparatus gave a small amount of oxime of V, m. 118-23° (aqueous EtOH). p-MeC6H4SO3H (0.2 g.), 44.0 g. BuOH, and 12.0 g. IV refluxed 24 hrs., cooled, diluted with 150 cc. Et2O, and worked up gave 2.5 g. unchanged IV, and 7.3 g. 3-butoxy-2,5-dimethyl-1,4-dithi-5-ene, pale yellow oil, b0.45 81-91°, n28D 1.52; it reacted rapidly with O. I (1.89 g.) in 15 cc. petr. ether treated rapidly with 1.75 g. AlCl3, diluted with H2O, and stirred overnight, and the gray tarry precipitate triturated with 95% EtOH left a gray solid, (C6H8S2)x, m. 140-50°, insoluble in EtOH and Et2O. I (1.48 g.) in 125 cc. Ac2O treated with 1.3 cc. nitrating solution gave 0.30 g. amorphous brown solid. I (3.2 g.) in 25 cc. CCl4 treated at 0° with 1.6 g. Cl gave a CHCl3-insoluble black tar, and a CHCl3-soluble oil, b2.2 70° to b0.2 80°, which rapidly decomposed to a black tar and HCl. I (1.40 g.) in 130 cc. Ac2O treated with 1.6 g. Br gave 0.36 g. brown amorphous solid, m. 40-70° (the solid contained Br but decomposed upon attempted recrystallization), and 0.95 g. unidentified Et2O-soluble oil which gave no solid on oxidation with H2O2 in AcOH at 70°. I (1.5 g.), 1.4 g. Ac2O, and 2 drops 85% H3PO4 heated at 100° yielded 0.6 g. unchanged I and 0.22 g. orange oil, n25D 1.5850, which showed a CO absorption. I (1.00 g.) and a solution prepared from 58 g. HgCl2, 12 g. 33% aqueous NaOAc, and 54 g. 95% EtOH gave 1.35 g. solid, m. 100-30°, which digested with hot EtOH and filtered hot gave a solid, m. 85-100° (EtOH). Similar runs in the absence of NaOAc gave impure amorphous solids, m. above 285° and 100-200° (decomposition), resp.

There is still a lot of research devoted to this compound(SMILES：CC(Br)C(OCC)OCC)Synthetic Route of C7H15BrO2, and with the development of science, more effects of this compound(3400-55-3) can be discovered.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Bromopriopionaldehydediethylacetal, is researched, Molecular C7H15BrO2, CAS is 3400-55-3, about Alkylation of disodiopentane-2,4-dione with halo acetals.Recommanded Product: 2-Bromopriopionaldehydediethylacetal.

NaCH2COCHNaCOMe with RCH2CH(OR1)2 (I; R = Br, R1 = Me, Et, CH2) gave 49, 46, and 38% (R1O)2CH(CH2)2COCH2COMe, resp. Similarly Br(CH2)2CH(OEt)2 and Cl(CH2)2CH(OCH2)2 gave dioxooctanal acetals. The lack of reactivity between I (R = Cl, R1 = Me, Et, CH2) and NaCH2COCHNaCOMe was explained by steric hindrance and the leaving group ability of Cl.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Nallagonda, Rajender; Musaev, Djamaladdin G.; Karimov, Rashad R. published the article 《Light-Promoted Dearomative Cross-Coupling of Heteroarenium Salts and Aryl Iodides via Nickel Catalysis》. Keywords: dihydropyridine aryl preparation regioselective; aryl iodide pyridinium dearomative cross coupling nickel iridium photocatalyst.They researched the compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2 ).Synthetic Route of C7H6BrI. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:16004-15-2) here.

Herein, the coupling of aryl iodides, e.g., Ph iodide with pyridinium and related heteroarenium salts, e.g., I catalyzed by Ni/bpp and an Ir photocatalyst using Zn as a terminal reductant was reported. This methodol. tolerates a wide range of functional groups and allows the coupling of aryl and heteroaryl iodides, thus significantly expanding the scope of nitrogen heterocycle scaffolds, e.g., II that could be prepared through dearomatization of heteroarenes. The reaction products have been further functionalized to prepare various nitrogen heterocycles. Initial mechanistic studies indicate that the reaction described herein goes through a unique mechanism involving dimers of dihydroheteroarenes.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics