Tag: M.W:200-300

55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55121-99-8, Example No. 131Preparation of 5- (3-methoxyphenyl) -N- (4- ( (4-methylpiperazin-l- yl) methyl) phenyl) -IH-pyrazolo [4 , 3-d] pyrimidin-7-amine7-chloro-2- (4-methoxybenzyl) -5- (3-methoxyphenyl) -2H- pyrazolo [4 , 3 -d] pyrimidine (0.16 mmol) and 4 -Amino-phenyl) – (4 – methyl-piperazin-l-yl) -methanone (0.3 mmol 2 eq. , ) were suspended in MeOH (dry, 3mL) in a microwave vial (2-5mL) , HCl in dioxane (4M, 3 drops) was added. The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140 C. The reaction mixture was concentrated and dissolved in THF (dry) LiAlH4 powder was added (excess, 2 by 2 eq) until completion of reaction is observed (by LCMS) . The reaction was quenched with water (lmL per gram LiAlH4) , then NaOH (ca. 15% aq. , lmL per g LiAlH ) , water (3mL per gram LiAlH4) . The mixture was filtered, washed with THF, MeOH, MeCN (ca. 10ML each) . The reaction mixture was concentrated and purified by semi-preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 429.27 g/molHPLC-MS: analytical method Art: 2.239 min – found mass: 430 (m/z+H)

The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; TRAUBE, Nadine; WO2012/143144; (2012); A1;,
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192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(i) tert-Butyl 4-(2-(5-(tert-butyl)-2-methoxy-3-(3-(4-((2-(phenylamino)pyridin-4-yl)oxy)- naphthalen-1-yl)ureido)benzamido)ethyl)piperazine-1-carboxylateA stirred mixture of 5-(tert-butyl)-2-methoxy-3-(3-(4-((2-(phenylamino)pyridin-4- yl)oxy)naphthalen-1-yl)ureido)benzoic acid, HCI (see Example 14(iii) above; 80 mg, 0.130 mmol), tert-butyl 4-(2-aminoethyl)piperazine-1-carboxylate (59.8 mg, 0.261 mmol) and triethylamine (72.7 muIota_, 0.522 mmol) in DCM (4 mL) was cooled in an ice-bath. 50 wtpercent T3P in EtOAc (93 muIota_, 0.157 mmol) was added, the ice-bath was removed and the reaction mixture allowed to warm to rt and stirred for 36 h. The reaction mixture was partitioned between sat. aq. NaHCC>3 (10 mL) and DCM (10 mL). The aqueous phase was back extracted with fresh DCM (10 mL). The combined organic extracts were washed with water (20 mL), brine (20 mL), dried (MgSC ), filtered and concentrated in vacuo onto silica gel. The crude product was purified by chromatography on the Companion (12 g column, 1-5percent MeOH in DCM) to afford the sub-title compound (52 mg) as a pink/brown solid.LCMS m/z 788 (M+H)+(ES+); 786 (M-H)”(ES”)

192130-34-0, The synthetic route of 192130-34-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; BAKER, Thomas Matthew; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; RIGBY, Aaron; WO2015/92423; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 17 3-Methyl-5-[2-[4-[4-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2-oxazolidinone This compound was prepared according to the procedure of Example 2. A mixture of 3.5 g (0.015 mol) of 1-(4-trifluoromethylphenyl)piperazine (Emka-Chemie), 2.5 g (0.015 mol) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 5.3 g (0.05 mol) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 mL of 1-butanol gave 3.7 g (69%) of white solid, mp 116-117 C. (2-propanol). Anal. Calculated for C17 H22 F3 N3 O2: C, 57.14; H, 6.20; N, 11.76. Found: C, 56.74; H, 6.24; N, 11.55., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; A. H. Robins Company, Incorporated; US5086055; (1992); A;,
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76003-29-7, 1-Boc-3-Oxopiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the product of Step 4 (10.0 g, 50.0 mmol) in anhydrous DMF(250 ml) in an ice-water bath were added sodium hydride (2.40 g, 60.0 mmol) andbenzyl chloride (6.60 g, 52.5 mmol). The mixture was stirred at RT for 4.5 h. Thereaction was quenched with water (10 ml), diluted with CH2CI2 (500 ml), and washed with water (2x250ml). The organic layer was extracted with saturated NH4CI (200 ml),dried (MgSO4), concentrated, and purified by column chromatography (gradientMeOH/CH2CI2 0-5%) to give the product (10.7 g, 74%). 1H-NMR (CDCI3): 6=7.2-7.3(m, 5H), 4.57 (s, 2H), 4.10 (s, 2H), 3.53 (m, 2H), 3.19 (m, 2H), 1.41 (s, 9H), 76003-29-7

76003-29-7 1-Boc-3-Oxopiperazine 3157178, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SCHERING CORPORATION; WO2006/14762; (2006); A1;,
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31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of tetrahydro-pyran-4-carboxylic acid (0.477 g, 2.27 mmol, 1.0 eq. ) EDCA (0.480 g, 2.50 mmol, 1.1 eq. ) and HOBt (0. 340 g, 2. 50 mmol, 1.1 eq. ) in THF/DMF (8 mL/2 mL) is kept under magnetic stirring at room temperature for about I hour. PIPERAZINE-L-CARBOXYLIC acid benzyl ester (0.438 mL, 2.27 mmol, 1. 0 eq. ) is then added and the resulting reaction mixture is left to react for 14 hours. AcOEt (10 mL) and a 10percent solution OF NAHCO3 (10 mL) are added and the phases are separated. The organic phase is then washed with water (2×10 mL) and brine (10 mL), dried on N2aSO4, filtered and the solvent removed by evaporation under reduced pressure. 4-(Tetrahydr-pyran-4-carbonyl)- piperazine-1-carboxylic acid benzyl ester (32) is obtained as an ivory coloured solid (0. 613 g, I. 85 mmol, yield = 81percent) which does not require further purification. HPLC (method A): Rt=7.71 min., 31166-44-6

The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MENARINI RICERCHE S.P.A.; WO2004/94412; (2004); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.

tert-Butyl4-(4-(6-chloro-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H- imidazo[4,5-?>]pyridin-2-yl)phenyl)piperazine-1-carboxylateTo a mixture of 5-chloro-4-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3- nitropyridin-2-amine (0.100 g, 0.27 mmol, 1 eq), EtOH (4.7 mL) and DMF (0.63 mL), terf-butyl-4-(4-formylphenyl)tetrahydro-1-(2H)pyrazine carboxylate (0.087 g, 0.3 mmol, 1.1 eq) was added followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.82 mL, 0.82 mmol). The reaction mixture was heated at 85C for 24 h, then allowed to cool to room temperature and diluted with DCM and a few drops of aqueous NH3 until complete dissolution was observed. This solution was deposited on two preparative silica TLC plates and eluted with DCM/MeOH (v/v; 94:6). The title compound was obtained after trituration with diethyl ether as an off-white solid (0.050 g, 30%); 1H-NMR (500Mz, DMSO-c/6): delta 1.43 (s, 9H, C(CH3J3), 2.59-2.67 (m, 4H, piperazine N(CH2)2), 3.45-3.52 (m, 4H, piperazine N(CH2J2), 3.66 (s, 2H, NCH2), 3.65-3.74 (m, 4H, piperazine N(CH2)2), missing 4H piperazine N(CH2)2 under solvents peaks, 7.07 (d, J = 9.5 Hz, 2H, ArH, C6H4), 7.64-7.74 (m, 1 H, py 4-H)1 8.01- 8.07 (m, 3H, ArH and imidazo [4,5-]pyridine 5-H), 8.44-8.47 (m, 1 H), 8.49 (d, J = 2.5 Hz, 1H, py 6-H), 13.19 (br s, 1H, imidazo[4,5-b]pyridine N-H); LC (Method B) – MS (ESI, m/z) 4.51 min – 607/609 [(M+H)+, Cl isotopic pattern]; ESI-HRMS: Found: 607.2743, calculated for C31H36CIFN8O2 (M+H)+: 607.2707.

197638-83-8, As the paragraph descriping shows that 197638-83-8 is playing an increasingly important role.

Reference£º
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
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Piperazines – an overview | ScienceDirect Topics

70261-81-3, 1-Methyl-4-(4-nitrobenzyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70261-81-3, A suspension of 1-methyl-4-(4-nitrobenzyl)piperazine (1.0 g, 4.25 mmol), Pd/C (200 mg) in EtOH (20 mL) was stirred at room temperature under H2 (1 atm) for 6 h, then filtered, removed the solvent to give 4-((4-methylpiperazin-1- yl)methyl)aniline as light brown solid (785 mg), yield 90%. LC/MS (ESI) m/z = 206 (M + H)+.

70261-81-3 1-Methyl-4-(4-nitrobenzyl)piperazine 677795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; THE BROAD INSTITUTE, INC.; DANA-FARBER CANCER INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; GRAY, Nathanael, S.; LIANG, Yanke; CHOI, Hwan, Geun; SUNDBERG, Thomas; SHAMJI, Alykhan; XAVIER, Ramnik; FISHER, David E.; (251 pag.)WO2018/9544; (2018); A1;,
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187669-60-9, 1-(4-(Methylsulfonyl)phenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: Synthesis of N -(( E )-5-Hydroxyadamantan-2-yl)-6-(4-(4-(methylsulfonyl)phenyl)piperazin-1-yl)picolinamide [233] 6-Bromo-N-((E)-5-hydroxyadamantan-2-yl)picolinamide(60 mg, 0.171 mmol), 1-(4-(methylsulfonyl)phenyl)piperazine (49 mg, 0.205 mmol), Pd2(dba)3 (3.1 mg, 0.003 mmol), xantphos (5.9 mg, 0.010 mmol), and sodium-tert-butoxide (25 mg, 0.257 mmol) were suspended in toluene (3 ml), and then the resulting liquid was stirred at 100oC under nitrogen stream for 4 hours. Distilled water (10 ml) was added to the resulting reaction liquid, followed by extraction with MC (15 ml x 2). The organic layer was dried over anhydrous sodium sulfate, followed by filtration and concentration, and then the residue thus obtained was subjected to MPLC (4% MeOH/MC), to obtain 34 mg of pale yellow solid (39%). MS (ESI): 511[M+H]+

187669-60-9, The synthetic route of 187669-60-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SK Chemicals Co.,Ltd.; RYU, Je Ho; KIM, Shin Ae; RYU, Keun Ho; KIM, Jae Sun; KIM, Nam Ho; HAN, Hye Young; KIM, Yong Hyuk; YOUN, Won-No; LEE, Yoon-Jung; SON, Hyun Joo; LEE, Bong-yong; PARK, Sung Hoon; LEE, Ju Young; LEE, Hyun Jung; JUNG, Hoe Chul; SHIN, Young Ah; LEE, Jung A; LEE, Bo Ram; SA, Joon Ho; WO2011/139107; (2011); A2;,
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192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A microwave vial was charged with 4-(4-benzylphenylamino)-6-fluoro-1 ,7- naphthyridine-3-carbonitrile (0.100 g, 0.282 mmol), 1-N-BOC-4-(2- aminoethyl)piperazine and 2 mL THF, crimp-sealed, and heated in a microwave reactor at 180 0C for 35 minutes, until TLC analysis (5percent MeOH in CH2CI2) showed disappearance of the 6-fluoronaphthyridine. This process was repeated with 3 additional aliquots of the fluoronaphthyridine (0.12O g, 0.100 g, 0.10O g), and the contents of all 4 vials were then combined, partitioned between 50 mL each EtOAc and brine, and worked up as described above for the synthesis of WAY-191220. The crude product was purified by flash chromatography over silica gel (5percent MeOH in CH2CI2) and lyophilized to give pure 4-(4-benzylphenylamino)-6-(2-(1 -N-BOC- piperazin-4-yl)ethylamino)-1 ,7-naphthyridine-3-carbonitrile (0.151 g, 23percent yield): 1H NMR (400 MHz, DMSO-D6) t 1.39 (s, 9 H) 2.34 – 2.44 (m, 4 H) 2.57 (t, J=6.6 Hz, 2 H) 3.21 – 3.42 (m, 6 H) 3.99 (s, 2 H) 6.59 (t, J=5.3 Hz, 1 H) 7.03 (s, 1 H) 7.14 – 7.34 (m, 9 H) 8.22 (s, 1 H) 8.81 (s, 1 H) 9.56 (s, 1 H)., 192130-34-0

The synthetic route of 192130-34-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WYETH; WO2006/124944; (2006); A1;,
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Piperazines – an overview | ScienceDirect Topics

1403898-64-5, (2R,5R)-tert-Butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 10: (2R,5R)-2-Hydroxymethyl-5-methyl-piperazine-1 ,4-dicarboxylic acid 1 – benzyl ester 4-ferf-butyl esterTo (2R,5R)-5-hydroxymethyl-2-methyl-piperazine-1 -carboxylic acid ie f-butyl ester (21 g, 90 mmol) in THF (210 mL) at 3-4 C (ice bath) was added 1 M aqueous NaOH (99.5 mL) and benzyl chloroformate (12.9 mL, 90.43 mmol). After stirring for 1 h at the same temperature, the mixture was left to stir for another 1 h and then warmed to RT. The organic layer was separated and the aqueous phase extracted with EtOAc (2 x 50 mL). The combined organic extracts were washed with saturated brine solution (150 mL), then dried over sodium sulfate, filtered and concentrated. The crude oil was purified by column chromatography on silica gel (gradient elution, 0 – 100%, EtOAc/petrol), to give the title compound (26 g) as a pale yellow oil, used directly in Preparation 1 1 . 1H NMR (Me-d3-OD): 7.47-7.15 (5H, m), 5.26-5.07 (2H, m), 4.25 (2H, s), 4.04-3.88 (1 H, m), 3.83 (1 H, d), 3.61 (2H, bs), 3.31 -3.09 (2H, m), 1 .48 (9H, s), 1.14 (3H, t)., 1403898-64-5

The synthetic route of 1403898-64-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTEX THERAPEUTICS LIMITED; WOOLFORD, Alison Jo-Anne; HOWARD, Steven; BUCK, Ildiko Maria; CHESSARI, Gianni; JOHNSON, Christopher Norbert; TAMANINI, Emiliano; DAY, James Edward Harvey; CHIARPARIN, Elisabetta; HEIGHTMAN, Thomas Daniel; FREDERICKSON, Martyn; GRIFFITHS-JONES, Charlotte Mary; WO2012/143726; (2012); A1;,
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Piperazines – an overview | ScienceDirect Topics