Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.639068-43-2,tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,639068-43-2

tert-Butyl 3,5-dimethylpiperazin-1-carboxylate (200.0 mg, 0.93 mmol) and 37percent formaldehyde (440.0 muL, 5.56 mmol) were dissolved in MeOH (5.0 mL), and NaBH4 (172.6 mg, 5.56 mmol) was slowly added thereto and stirred at room temperature for 12 hours. Brine was poured into the reaction mixture, and it was extracted with DCM (30.0 mL). The organic layer was dried over anhydrous Na2SO4, filtered and then distilled under reduced pressure. The residue was purified column chromatography (DCM:MeOH=95:5) on silica to obtain yellow liquid compound of tert-butyl 3,4,5-trimethylpiperazin-1-carboxylate (57.0 mg, 27percent).

639068-43-2 tert-Butyl 3,5-dimethylpiperazine-1-carboxylate 22219990, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; C&C RESEARCH LABORATORIES; Ho, Pil Su; Yoon, Dong Oh; Han, Sun Young; Lee, Won Il; Kim, Jung Sook; Park, Woul Seong; Ahn, Sung Oh; Kim, Hye Jung; US2014/315888; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 4d (4 g,14.44 mmol) was dissolved in 40 ml of dry pyridine and stirred at0 C under inert atmosphere. Cinnamoyl chloride 6b (4.45 g,17.33 mmol) was dissolved in 20 ml dry DCM and added dropwiseto above stirred solution at 0 C. The reaction mixture was stirredfor 3 h. After completion of the reaction, the reaction mixture wasdiluted with 40 ml water and 60 ml ethyl acetate followed by 2 NHCl to make it acidic. The organic layer was separated and againwashed with 2 N HCl followed by saturated bicarbonate solution(2 50 ml) and brine solution. The organic layer was dried overanhydrous sodium sulfate and was evaporated under reducedpressure. The crude product was recrystallized from ethyl acetateand hexane to afford 4.52 g of 7l. Light yellow solid; Yield 69.33%;216e218 C (charred); IR (KBr pellets, cm1): 3425, 3105, 1666,1604, 1544, 1514, 1427, 1342, 1220, 1141, 991, 844; 1H NMR(400 MHz, CDCl3) d (ppm): 1.43 (9H, s, CH3), 3.10 (4H, t, J 3.79 Hz),3.62 (4H, t, J 3.76 Hz), 6.71 (1H, d, J 16.5 Hz, PheCH]CHe), 6.98(2H, d, J 7.2 Hz, AreH), 7.29e7.87 (4H, m, AreH), 7.89 (1H, d,J 16.5 Hz, PheCH]CHe), 8.23 (2H, d, J 7.0 Hz, AreH), 9.24 (1H,s, CONH); 13C NMR (100 MHz, CDCl3) d (ppm): 28.76, 49.41, 51.48,78.50, 112.10, 118.03, 121.31, 123.72, 126.08, 129.45, 141.79, 142.11,145.21, 147.29, 157.22, 167.52; HReMS m/z: 453.2067 (M 1)., 170911-92-9

The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Patel, Kavitkumar N.; Telvekar, Vikas N.; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 43 – 56;,
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169447-86-3, (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compounds according to this embodiment are shown in Table 3, below. Synthesis of the relevant compounds is shown in FIGS. 1 1 A and 11 B., 169447-86-3

169447-86-3 (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate 17750441, apiperazines compound, is more and more widely used in various fields.

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Patent; UNIVERSITY OF SOUTH FLORIDA; YALE UNIVERSITY; WO2008/79945; (2008); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.140447-78-5,1-(2-N-Boc-Aminoethyl)piperazine,as a common compound, the synthetic route is as follows.

In a sealed tube, 8-bromo-7-fluoro-2-(methyloxy)-1 ,5-naphthyridine (1.1 g, 4.3 mmol), 1 ,1 -dimethylethyl [2-(1-piperazinyl)ethyl]carbamate (1 g, 4.3 mmol), Pd2dba3 (271 mg, 0.262 mmol), rac-Binap (163 mg, 0.262 mmol), Cs2CO3 (2.98 mg, 9.2 mmol) and 18- C-6 (115 mg, 0.436 mmol) in dioxane (22 ml_) were combined and flushed with N2. After 15min, the tube was sealed and heated to 1000C while stirring rapidly. After 12h, the solution was filtered, concentrated and the residue purified via column chromatography (silica,.1% MeOH in DCM (1% NH4OH)) yielding the title compound (725 mg, 41%) as an orange oil: LCMS (ES) m/e 406 (M+H)+., 140447-78-5

The synthetic route of 140447-78-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/81289; (2006); A2;,
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132710-90-8, 1-Boc-4-(3-hydroxypropyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,132710-90-8

The 6- {4-[4-(3-piperazin- 1 -ylpropoxy)phenyl]piperazin- 1 -yl} -3-(trifluoromethyl)-7,8- dihydro[l,2,4]triazolo[4,3-b]pyridazine used as starting material was prepared as follows:-; Preparation of tert-butyl 4-[3-(4-{4-[3-(trifluoromethyl)[l,2,4]triazolo[4,3- b]pyridazin-6-yl]piperazin-l-yl}phenoxy)propyl]piperazine-l-carboxylate; DIAD (3.24 mL, 16.47 mmol) was added dropwise to 4-{4-[3- (trifluoromethyl)[ 1 ,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin- 1 -yl}phenol (obtained as described in Example 16, preparation of starting materials) (5 g, 13.72 mmol), tert-butyl 4- (3-hydroxypropyl)piperazine-l-carboxylate (CAS 132710-90-8, 5.03 g, 20.59 mmol) and triphenylphosphine (5.40 g, 20.59 mmol) in THF (50 mL) at 00C under nitrogen. The resulting solution was stirred at ambient temperature for 16 hours. The reaction mixture was evaporated to dryness and redissolved in DCM (100 mL), and washed sequentially with 2M NaOH (100 mL) and saturated brine (100 mL). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, eluting with EtOAc. Pure fractions were evaporated to dryness to give tert-butyl 4-[3-(4-{4-[3-(trifluoromethyl)[l,2,4]t?azolo[4,3-b]pyridazin-6- yl]piperazin-l-yl}phenoxy)propyl]piperazine-l-carboxylate (3.66 g, 45%). IH NMR (399.9 MHz, CDC13) delta 1.46 (9H, s), 1.95 (2H, m), 2.40 (4H, m), 2.52 (2H, t), 3.21 (4H, m), 3.43 (4H, m), 3.78 (4H, m), 3.99 (2H, t), 6.87 (2H, d), 6.93 (2H, d), 7.11 (IH, d), 7.96 (IH, d); m/z = 591 [M+H]+.

As the paragraph descriping shows that 132710-90-8 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BRADBURY, Robert, Hugh; CARR, Gregory, Richard; RABOW, Alfred, Arthur; RAO KORUPOJU, Srinivasa; TUMMA, Harikrishna; WO2010/92371; (2010); A1;,
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120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Methyl-4-pyrimidin-2-yl-piperazine- 1 -carboxylic acid tert-butyl ester 100 mg 2-chloro-pyrimidine was added to 175 mg 2-Methyl-piperazine-l -carboxylic acid tert- butyl ester and this mixture was stirred for 2 h at 120 C to give 240 mg of the desired compound. Rt: 1.31 min (method B), (M+H)+: 279, 120737-78-2

120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; WELLENZOHN, Bernd; WO2013/83741; (2013); A1;,
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78551-60-7, tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78551-60-7

4 M HC1 in l,4-dioxane (150 mL, 600 mmol, 12 equiv) was added at room temperature to compound (14.5 g, 50 mmol, 1 equiv) and the mixture was stirred at room temperature for 2 hours, at which time LCMS indicated that the reaction was complete. The mixture was concentrated under reduced pressure and azeotroped with toluene (3 x 200 mL) to give l-benzylpiperazin-2-one hydrochloride (15.1 g, quantitative yield) as a viscous pale-yellow oil

As the paragraph descriping shows that 78551-60-7 is playing an increasingly important role.

Reference£º
Patent; CONATUS PHARMACEUTICALS, INC.; SPADA, Alfred, P.; TERNANSKY, Robert, J.; (0 pag.)WO2020/6341; (2020); A1;,
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197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl 4-[4-((hydroxyimino)methyl)phenyl]piperazinecarboxylate (Compound 32) A mixture of aldehyde 28 (10 mmol) and hydroxylamine hydrochloride (15 mmol) in MeOH (20 mL) with pyridine (2 mL) is stirred at r.t. for 12-15 h. The solvent is removed under vacuum, and the residue is distributed between EtOAc (100 mL) and water (30 mL). The organic layer is washed with 2% aq. citric acid (2*30 mL), water (30 mL), brine (30 mL), and dried (MgSO4). The solvent is evaporated and Compound 32 dried under vacuum.

197638-83-8, The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gordeev, Mikhail F.; Patel, Dinesh V.; Barbachyn, Michael R.; Gage, James R.; US2003/13737; (2003); A1;,
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314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step C: tert-butyl(3)-4-[2-( 5-cyano-2,4-difluorophenyl)-2-oxoethyl]-3-(hydroxymethyl)piperazine-1-carboxylate; A suspension of 5-(bromoacetyl)-2,4-difluorobenzonitrile (2.5 g, 9.6 mmol), tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate (2.1 g, 9.6 mmol) and DIEA (1.90 g, 14.4 mmol) in 50 mL ofTHF was stirred at 20C for 10 hours. The reaction mixture was poured into ice water and extracted with EtOAc (3×200 mL). The combined organic layers were washed with water and brine, dried andconcentrated. The residue was purified by column chromatography eluting with 5 % MeOH in DCM to afford the title compound., 314741-40-7

As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; WO2013/28474; (2013); A1;,
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278788-66-2, (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

278788-66-2, Into a 5-mL-pressure tube was added 183mg (l.Ommol) of 2,3-difluoro-5- (trifluoromethyl)pyridine, 216mg (l.Ommol) of 1,1-dimethylethyl (3i?)-3-(hydroxymethy I)-I- piperazinecarboxylate, 0.2mL DlEA and 1.OmL DMSO. The mixture was heated at 80 C for overnight. The resulting mixture were filtered and concentrated in vacuo. The residue was purified by using a Gilson preparative HPLC system with a Waters Xterra (C-18) column 100 mm by 50 mm ID, eluting with 20% B to 99% B in 10 min, where A = H2O and B = CH3CN pumped at 150 mL/min to yield 1,1-dimethylethyl (3i?)-4-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]-3- (hydroxymethyl)- 1 -piperazinecarboxylate as a solid. MS(ESI) 380 [M+H] +.To 20mg (0.053mmol) of 1,1-dimethylethyl (3i?)-4-[3-fluoro-5-(trifluoromethyl)-2- pyridinyl]-3-(hydroxymethyl)-l -piperazinecarboxylate was added 0.5mL DMSO and 20mg of tBuOK in a 5-mL-pressure tube. The mixture was heated at 110 C for overnight. The mixture was filtered and the solution was purified by using a Gilson preparative HPLC system with a Waters Xterra (C- 18) column 100 mm by 50 mm ID, eluting with 20% B to 99% B in 10 min, where A = H2O and B = CH3CN pumped at 150 mL/min to yield 1,1-dimethylethyl (6ai?)-3-(trifluoromethyl)- 6a,7,9,10-tetrahydropyrazino[l,2-rf]pyrido[3,2-][l,4]oxazine-8(6H)-carboxylate as a solid. MS(ESI) 360 [M+H]+.To 40mg of (0.1 lmmol) of 1,1-dimethylethyl (6alphai?)-3-(trifluoromethyl)-6alpha,7,9,10- tetrahydropyrazino[l,2-cr|pyrido[3,2-][l,4]oxazme-8(6H)-carboxylate was added ImL DCM and 0.5mL 50% of TFA in DCE. The mixture was stirred at rt for 6h and concentrated in vacuo (the extra TFA was removed by adding DCE and re-concentrating) to yield crude the TFA salt of (6ocR)- 3-(trifluoromethyl)-6,6alpha,7,8,9,10-hexahydropyrazino[l,2-rf]pyrido[3,2-A][l,4]oxazine. MS(ESI) 260 [M+H]1. The above TFA salt of (6alphai?)-3-(trifluoromethyl)-6,6alpha,7,8,9,10-hexahydropyrazino[l,2- rf]pyrido[3,2-ib][l,4]oxazine were dissolved in 1.OmL DCM and 0.3mL DIEA. Then lOOmg (mmol) of (S)-(+)-Camphotau sulfonylchloride in 0.5mL DCM was slowly added at 0 C. The mixture was stirred at rt for 2h. The resulting solution was concentrated in vacuo. The residue was purified by using a Gilson preparative HPLC system with a Waters Xterra (C- 18) column 100 mm by 50 mm ID, eluting with 20% B to 99% B in 10 min, where A = H2O and B = CH3CN pumped at 150 mL/minto yield (l?,4Z?)-7,7-dimethyl-l-({[(6 alphai?)-3-(trifluoromethyl)-6 alpha,7,9,10- tetrahydropyrazino[ 1 ,2-Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/76318; (2007); A2;,
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