Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-86-3,(S)-tert-Butyl 2-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of the free carboxylic acid (1 equiv.) in dry dichloromethane (0.05 M solution) (S)-lambdaM -Boc-2-benzylpiperazine (1.05 equiv.), EDCI (1.1 equiv.), HOBt (1.1 equiv.) and DIPEA (2 equiv.) were added at room temperature. The reaction was stirred overnight, the solvent evaporated under reduced pressure and the crude material purified by flash chromatography.; (S)-fert-butyl-2-benzyl-4-[5-/so-butyl-6-(3-/so-butyl-1W-pyrazol-5- yl)pyridazine-3-carbonyl]piperazine-1-carboxylate 12b: Rf = 0.21 (CH2CI2/Me0H = 98:2)., 169447-86-3

169447-86-3 (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate 17750441, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2009/25751; (2009); A1;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

A solution of 2-chloro-9-cyclopentyl-7-ethyl-purin-8-one (Method 5) (0.1 g), 2-methoxy- 4-(4-methylpiperazin-l-yl)aniline (Compound 46-3, page 138 in WO 04/080980) (0.16 g) and 4-toluenesulphonic acid (0.13 g) in 2-propanol (2 mL) was heated at 1900C for Ih by microwave. After cooling the mixture was concentrated in vacuo and purified by FCC using 0-5% of (10:1 MeOetaxonc. aq. NH3) in DCM to afford the title compound (0.05 g, 31%) as a pale yellow foam; 1H NMR: (CDCl3) 1.34 (3H, t), 1.68 (2H, m), 2.33 (2H, m), 2.36 (3H, s), 2.60 (4H, m), 3.17 (4H, m), 3.87 (2H, q), 3.89 (3H, s), 4.81 (IH, tt), 6.55 (IH, dd), 6.57 (IH, s), 7.30 (IH, s), 7.86 (IH, s), 8.25 (IH, d); m/z: MH+ 453; EAA: 0.220; EAA2: 0.0538.

122833-04-9, The synthetic route of 122833-04-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/24824; (2009); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

694499-26-8, To a stirred solution of methyl XXX (0.150 g, 0.46 mmol) and V (0.191 g, 0.70 mmol) in methanol(5 mL) was added acetic acid in catalytic amount, reaction mass was allowed to stir at RT for 30 min thenNaCNBH4 was added to the reaction mass and allowed to stirred at RT for overnight. After completion ofreaction RM was evaporated under vacuum to obtain crude which was diluted with water and product wasextracted with ethyl acetate (30 mL X 3) and brine washing was given to organic layer and dried overanhydrous Na2SO4 and evaporated under vacuum and purified though reverse phase HPLC to obtaincompound 12 (0.06 g, 22%).LCMS: 579 [M+1]+1HNMR (400 MHz, DMSO) delta 10.0 (s, 1H), 8. 2 (s, 1H), 7.9 (t, 3H), 7.5 (m, 2H), 7.4 (m, 1H), 7.3 (m, 2H),7.2 (d, 2H), 7.1 (d, 2H), 4.2 (s, 1H), 3.5 (s, 3H), 2.5 (s, 1H), 2.4 (m, 6H), 2.3 (m, 4H), 2.2 (s, 3H).

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
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7365-45-9,7365-45-9, 2-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a typical procedure, 10 mL zinc acetate solution (200 mM) was mixed with 20 mL HEPES solution (200 mM pH 7.4). A microwave and ultrasonic wave combined reactor (XH-300A, Beijing Xianghu Technology Co., Ltd.) provided continuous and homogeneous ultrasonic wave and microwave irradiation for the mixed solutions. Firstly, the mixture was continuously sonicated for 5 min by ultrasonic processor with a power of 1000 W. Then the mixed solution was heated to 110 C within 3 min and kept at this temperature for 17 min under microwave heating combined with discontinuous ultrasonic irradiation (1 s sonication and 2 s interruption) with a power of 500 W. After cooling down to room temperature naturally, the product was collected by centrifugation and washed with deionized water and absolute alcohol for 5 times, then dried in a desiccator for further characterization (S1). Other ZnO samples (S2-S15) were also prepared under identical conditions by varying Zn/HEPES moral ratio, pH value of HEPES solution and Zn precursor. The detailed procedure is same as described above and all the experimental parameters are listed in Table 1.

7365-45-9 2-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid 23831, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Li, Qin; Li, Hui; Wang, Runming; Li, Guangfang; Yang, Hao; Chen, Rong; Journal of Alloys and Compounds; vol. 567; (2013); p. 1 – 9;,
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Piperazines – an overview | ScienceDirect Topics

169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a dried flask was added (S)-tert-butyl 2-methylpiperazine-1-carboxylate (52.3 mg, 0.261 mmol),rac-benzyl ((2S,3R,4R)- I -acetyl-6-bromo-2-cyclopropyl-3-methyl- 1,2 ,3,4-tetrahydroquinolin-4-yl)carbamate (for a preparation see Intermediate 13, 99.5 mg, 0.218 mmol), sodium tert-butoxide (41.8 mg, 0.435 mmol), Pd2(dba)3 (9.96 mg, 10.88 pmol) and DavePhos (8.56 mg, 0.022 mmol) under nitrogen. To this was added 1,4-dioxane (2 mL), and the solution was stirred and degassed with nitrogen for -15 mm. The mixture was heated to 90 C overnight. The mixture was allowed tocool to rt, filtered through a 2.5 g celite cartridge, washed through with ethyl acetate and concentrated in vacuo. The residue was taken up in dichloromethane, loaded onto a 25 g silica flash column, and eluted in 10%-50% ethyl acetate in cyclohexane. The appropriate fractions were collected and concentrated in vacuo to afford a yellow oil (48.4 mg, 0.084 mmol, 38.6%). This was a mixture of diastereoisomers. LCMS (2 mm formic): Rt = 1 .29 mi [MH] = 577., 169447-70-5

The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; AMANS, Dominique; ATKINSON, Stephen John; HARRISON, Lee Andrew; HIRST, David Jonathan; LAW, Robert Peter; LINDON, Matthew; PRESTON, Alexander; SEAL, Jonathan Thomas; WELLAWAY, Christopher Roland; WO2014/140076; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3022-15-9,Piperazine-2-carboxylic acid dihydrochloride,as a common compound, the synthetic route is as follows.

Example 172 [4- (3-CHLORO-5-HYDROXYMETHYL-PYRIDIN-2-YL)-1- [5-TRIFLUOROMETHYL-7- (3,] 4,5- [TRIFLUORO-PHENYL)-LH-BENZOIMIDAZOL-2-YL]-PIPERAZINE-2-CARBOXYLIC ACID] methylamide. (a) Piperazine-1,2, 4-tricarboxylic acid 1,4-dibenzyl ester. Benzyl chloro formate (3.1 mL, 22 mmol, Aldrich) was added dropwise over a period of 5 min to a mixture of piperazine-2-carboxylic acid dihydrochloride (2.03 g, 10 mmol, Aldrich) and [NA2C03] (4.24 g, 40 mmol) in water (10 mL) with stirring at [0 C.] The mixture was stirred at [0 C] for 1 h, 2N [HC1] (10 mL) was added and the mixture was extracted with EtOAc (3 x 40 mL). The combined organic extracts were washed with water (10 mL) and brine (20 mL), dried over Na2S04, and filtered. The filtrate was evaporated in vacuo to give the title compound as a gum, which was used for the next step without additional purification. MS (ESI, pos. ion) m/e: 399 (M+1)., 3022-15-9

3022-15-9 Piperazine-2-carboxylic acid dihydrochloride 2723757, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AMGEN INC.; WO2004/35549; (2004); A1;,
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Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Thienylacetic acid (54 mg, 0.39 mmol), HOBt (58 mg, 0.43 mmol), TBTU (138 mg, 0.43 mmol), anhydrous triethylamine (87 ??, 0.63 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 20 % yield. H NMR (300 MHz, CDCI3) ? 7.47 (d, 2H), 7.19 (dd, 1 H), 6.88-6.97 (m, 4H), 3.96 (s, 2H), 3.79 (t, 2H), 3.66 (t, 2H), 3.24 (t, 2H), 3.15 (t, 2H). MS (+ESI) calcd for C17 H17 F3 N2 02 S m/z: [M + H]+ , 355.1086; found 355.1084 [Diff(ppm) = -0.56].

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.928025-56-3,(S)-tert-Butyl 3-ethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,928025-56-3

To a solution of tert-butyl (S)-3-ethylpiperazine-1-carboxylate (150 mg, 0.700 mmol) and 4,4′-(chloromethylene)bis(fluorobenzene) (0.131 mL, 0.700 mmol) in acetonitrile (2 mL) was added DIPEA (0.244 mL, 1.400 mmol). The reaction mixture was heated to 80 C for 2 h. and diluted with water. The mixture was extracted twice with ethyl acetate (20 mL). The organic layer was separated, dried over Na2SO4 and evaporated to dryness. The crude was purified by ISCO (Column: 24 g RediSep silica, Solvent run: 0-50 % EtOAc in petroleum ether). The product was eluted at 30 % EtOAc in petroleum ether to afford tert-butyl (S)-4-(bis(4-fluorophenyl)methyl)-3- ethylpiperazine-1-carboxylate (50 mg, 8.8 % yield); LCMS: m/z = 417.4 (M+H); rt 2.39 min. Method: AQUITY UPLC BEH C18 (3.0 x 50 mm) 1.7 ^m, Mobile phase A:10 mM ammonium acetate:acetonitrile (95:5) Mobile phase B: 10 mM ammonium (1077) acetate:acetonitrile (5:95), Flow: 0.7 mL/min

The synthetic route of 928025-56-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; VELAPARTHI, Upender; CHUPAK, Louis S.; DARNE, Chetan Padmakar; DING, Min; GENTLES, Robert G.; HUANG, Yazhong; KAMBLE, Manjunatha Narayana Rao; MARTIN, Scott W.; MANNOORI, Raju; MCDONALD, Ivar M.; OLSON, Richard E.; RAHAMAN, Hasibur; JALAGAM, Prasada Rao; ROY, Saumya; TONUKUNURU, Gopikishan; VELAIAH, Sivasudar; WARRIER, Jayakumar Sankara; ZHENG, Xiaofan; TOKARSKI, John S.; DASGUPTA, Bireshwar; REDDY, Kotha Rathnakar; RAJA, Thiruvenkadam; (0 pag.)WO2020/6018; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

655225-01-7, tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

655225-01-7, A mixture of 4-bromo-6-hydroxypyrazolo[l,5-a]pyridine-3-carbonitrile (Intermediate PI, 200 mg, 0.840 mmol) in DMA (4.20 mL) was treated sequentially with K2CCb(s) (348 mg, 12.1 mmol) and tert-butyl 4-(2-bromoethyl)piperazine-l -carboxylate (493 mg, 1.68 mmol), then stirred for 3 h at 60 ¡ãC. After cooling to ambient temperature, the mixture was diluted with brine. The resulting suspension was filtered, and the solids were rinsed with water (5x). The solids the were collected, dissolved in DCM and concentrated in vacuo to cleanly afford the title compound (239 mg, 63percent yield). MS (apci) m/z = 452.0 (M+H).

655225-01-7 tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate 15946441, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
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154590-35-9, tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Cool in ice a solution of the product of Preparation 13, Step 3 (1.50 g, 5.1 mmol) in THF (40 ml). Add DIPEA (1.08 ml, 6.2 mmol), then 2-chloroethyl chloroformate (0.76 g, 5.3 mmol). Stir 3 h and partition with ether and satd. NaHCO3. Dry (MgSO4) and concentrate to obtain the carbamate as a brown solid, 154590-35-9

154590-35-9 tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 16203630, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Schering Corporation; US2004/220194; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics