Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-66-2,(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To the solution of tert-butyl (3R)-3-(hydroxymethyl)piperazine-l-carboxylate (1044 mg, 4.83 mmoi) in N,N-Diisopropylethylamine (2.57 mL, 14.48 mmoi) and DMF (7 niL) was added (E)- 2-cyano-4,4-dimethyl-pent-2-enoic acid (1109.1 mg, 7.24 mmoi) followed by HATU (486.6 mg, 5.79 mmoi). The mixture was stirred at rt for 1 h. The mixture was diluted with DCM and water and partitioned. The organic layer was dried with MgSOa and concentrated. The cmde mixture was purified by column chromatography to obtain tert-butyl (3R)-4-[(E)-2-cyano-4,4-dimethyl-pent-2-enoyl]-3- (hydroxymethyl)piperazine-l-carboxylate (1340 mg) as an oil., 278788-66-2

The synthetic route of 278788-66-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PRINCIPIA BIOPHARMA INC.; LOU, Yan; OWENS, Timothy, Duncan; BRAMELD, Kenneth, Albert; GOLDSTEIN, David, Michael; (230 pag.)WO2018/136401; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

694499-26-8, To a solution of 3-(4-bromophenyl)propionic acid (42 mg, 0.18 mmol) in anhydrous N,N-dimethylformamide (2 mL) was treated HATU (139 mg, 0.36 mmol) andthe mixture was stirred at room temperature for 30 minutes. A solution of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)-aniline (50 mg, 0.18 mmol) and triethylamine (37 mg, 0.36 mmol) in anhydrous N,N-dimethylformamide (1.0 mL) was added. The reaction mixture was stirred at room temperature for 2 hours and partitioned between H20 (50 mL) and ethyl acetate (50 mL). The aqueous layer was extracted withethyl acetate (50 mL x 2). The combined organic extracts were washed with brine (100 mL), dried over sodium sulfate and concentrated in vacuum. The residue was purified by flash chromatography (Redisep silica gel, 9:1 dichloromethane/methanol) to afford 3 -(4- bromophenyl)-N- {4- [(4-methylpiperazin- 1 -yl)methyl] -3 -(trifluoromethyl)phenyl } -propanamide. ESI MS: m/z 486.05.

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR); CHERIAN, Joseph; DURAISWAMY, Athisayamani Jeyaraj; NACRO, Kassoum; WO2014/88519; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

655225-01-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.655225-01-7,tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of N-(l-((lH-pyrazol-3-yl)methyl)-3-ethyl-lH-indazol-4-yl)imidazo[l,2- a]pyridine-3-carboxamide (40.0 mg; 0.104 mmol) in dry DMF (0.5 mL) was added tert-butyl4- (2-bromoethyl)piperazine-l -carboxylate (30.4 mg; 0.104 mmol) and cesium hydroxide hydrate (17.4 mg; 0.104 mmol). The mixture was stirred under a nitrogen atmosphere for 30 minutes. The mixture was filtered, washing with methanol and ethyl acetate, and the solvent was removed under reduced pressure. The residue (a mixture of two regioisomers) was purified by preparative thin layer chromatography on silica, eluting with 10percent methanol in dichloromethane. The desired isomer tert-butyl 4-(2-(3-((3-ethyl-4-(imidazo[l,2-a]pyridine- 3-carboxamido)- lH-indazol- 1 -yl)methyl)- lH-pyrazol- 1 -yl)ethyl)piperazine- 1 -carboxylate was isolated (21.5 mg) along with some of the alternate isomer.

655225-01-7 tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate 15946441, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; BRADLEY, Michael; DELISLE, Robert Kirk; HENNINGS, D. David; KENNEDY, April L.; MARMSATER, Fredrik P.; MEDINA, Matthew; MUNSON, Mark C.; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian; WO2011/79076; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5521-39-1, Example 39 6-Methoxy-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid {4-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-phenyl}-amide This compound was prepared from 6-methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride (Reference Example 2) and 2-[4-(4-amino-phenyl)-piperazin-1-yl]-ethanol (Reference Example 19) as prepared in Example 12, yielding a yellow solid. (80 mg=60%). mp=211.5-212.2 (dec.), MS-base peak at m/z=492 by positive ion and m/z=490 by negative ion CI

The synthetic route of 5521-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chapdelaine, Marc; Davenport, Timothy; Haeberlein, Markus; Horchler, Carey; McCauley, John; Pierson, Edward; Sohn, Daniel; US2004/110745; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

262368-30-9, N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of methyl (Z)-3-(chloro(4-methoxyphenyl)methylene)-2-oxoindoline-5-carboxylate (100 mg, 0.29 mmol), N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide (88 mg, 0.34 mmol) and TEA (0.08 mL, 0.59 mmol) in EtOH (1.0 mL) was stirred under refluxed for overnight. The reaction solvent was evaporated under reduced pressure, and the residue was purified by column chromatography with dichloromethane/ethanol (50/1, v/v) to obtain the final compound 96 as a yellow solid (164 mg, 99% yield): 1H NMR (500 MHz, DMSO-d6) _ 11.91 (s, 1H), 11.12 (s, 1H), 7.59 (dd, J = 8.2, 1.7 Hz, 1H), 7.43 (d, J = 8.6 Hz, 2H), 7.15 (d, J = 8.8 Hz, 3H), 6.94 (d, J = 8.2 Hz, 1H), 6.90 (d, J = 8.4 Hz, 2H), 6.65 (d, J = 1.5 Hz, 1H), 3.87 (s, 3H), 3.65 (s, 3H), 3.07 (bs, 3H), 2.87 (bs, 2H), 2.65 (bs.4H); 13C NMR (125 MHz, DMSO-d6) _ 170.4, 166.4, 160.7, 156.8, 140.4, 139.1, 130.2, 127.8, 125.4, 124.15, 124.09, 123.4, 121.2, 119.6, 115.0, 108.8, 97.8, 57.7, 55.5, 52.6, 51.5, 49.1; HRMS (ESI-TOF) m/z calcd for C32H35N5O5 [M + Na+] 592.2530, found 592.2531.

262368-30-9, As the paragraph descriping shows that 262368-30-9 is playing an increasingly important role.

Reference£º
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; DALBY, Kevin N.; EDUPUGANTI, Ramakrishna; TALIAFERRO, Juliana; LEE, Juhyeon; (0 pag.)WO2018/160967; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-66-2,(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To asolution of 5-(bromoacetyl)-2-fluorobenzonitrile (13.1 g, 0.054 mol) in DMF (160 mL) was added tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate (13.1 g, 0.065 mol) and K2CO3 (11.77 g, 0.075mol), and the mixturewas stirred at RTfor 3 h. The mixture was washed with water, and extracted with EtOAc. The organic layer waswashed with brine, dried over Na2SO4 and concentrated in vacuum to give the title compound which was used forthe next step without further purification.

278788-66-2, As the paragraph descriping shows that 278788-66-2 is playing an increasingly important role.

Reference£º
Patent; Merck Sharp & Dohme Corp.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; (128 pag.)EP2744499; (2016); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 3-iodo-4-methylbenzoyl chloride obtained above in dry DCM (10mL) at 0C was added Et3N (0.28mL, 2.0mmol) and 4-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) aniline (328mg, 1.2mmol). The mixture was stirred at room temperature for 5h, and then the solvent was removed under reduced pressure. The residue was purified by using column chromatography to afford the corresponding product 6-1 (439mg, 2 steps yield: 85%)., 694499-26-8

694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Yang; Peng, Xia; Guan, Xiaocong; Lu, Dong; Xi, Yong; Jin, Shiyu; Chen, Hui; Zeng, Limin; Ai, Jing; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 122 – 132;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-(Thiophen-2-yl)pentanoic acid (72 mg, 0.39 mmol), HOBt (58 mg, 0.43 mmol), TBTU (138 mg, 0.43 mmol), anhydrous triethylamine (86 ??, 0.62 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol) and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 25 % yield. H NMR (300 MHz, CDCI3) ? 7.49 (d, 2H), 7.09 (dd, 1 H), 6.89-7.01 (m, 3H), 6.79-6.84 (m, 1 H), 3.76 (t, 2H), 3.59 (t, 2H), 3.23 (t, 4H), 2.85 (t, 2H), 2.37, (t, 2H), 1.74-1.82 (m, 4H). MS (+ESI) calcd for C20 H23 F3 N2 O m/z: [M + H]+ , 396.1468; found 397.1556 [Diff(ppm) = -3.75]., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound ferf-butyl (3R)-3-methylpiperazine-1-carboxylate (25g, 124.8 mmol) was dissolved in DMSO (50 mL). To reaction mixture was added 6-chloronicotinonitrile (19 g, 137.3 mmol), K2CO3 (32.7g, EPO 235.9 mmol) and Cu(MeCN)4PF6 (0.42 g, 1.12 mmol) then warmed to 140 0C for 4h. The solution was cooled to 25 0C and diluted with EtOAc (200 mL) then partitioned between aqueous HCI (3 X 50 mL 0.1 N) and saturated aqueous sodium bicarbonate (2 X 50 mL). The organic layer was dried over sodium sulfate, filtered through silica (50 mL) and concentrated. The residue was purified by crystallizing from 20 mL of warm EtOAc after standing for 2h at 25 0C. The mother liquor was decanted, the solid rinsed with EtOAc (2 x 10 mL) and placed under high vacuum for 2h that afforded the title compound 23(0 as a white crystalline solid (32.6 g, 96%). HPLC Rt: 3.444 (95.4%). 1H NMR (400MHz, CDCI3) delta: 8.42 (s, 1 H), 7.63 (dd, J = 9.1 , 2.3 Hz, 1 H), 6.56 (d, J = 9.1 Hz, 1 H), 5.30 (s, 1 H), 4.53 (bs, 1 H), 4.13 (bs, 1 H), 3.94 (bs, 1 H), 3.26-3.21 (m, 2H), 2.99 (bs, 1 H), 1.49 (s, 9H), 1.20 (d, J = 6.8 Hz, 3H). LCMS (ESI): mlz: 303.3., 163765-44-4

The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER INC.; WO2006/106423; (2006); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55121-99-8, Compound 6 A flask was charged with intermiediate 1 (150mg, 0.5 mmol), l-(4-aminobenzoyl)-4-m ethyl piperazine (109 mg, 0.5 mmol), TFA (50uL), isopropanol (3mL). The reaction was heated to 100C for 4h. The reaction mixture was basified with a saturated aqueous sodium bicarbonate solution and then was extracted with DCM/ (10 mlx3). The combined organic was washed by brine, dried over sodium sulfate and concentrated. The crude product was purified with flash chromatography (0-10% MeOH-in DCM) to afford the desired product as light yellow solids (160 mg, 66% yield). 1H MR (400 MHz, DMSO-d6) delta 11.36 (br, 1H), 10.17 (br, 1H), 8.34 (s, 1H), 7.63 (d, J = 8.8 Hz, 2H), 7.39 (d, J = 8.8 Hz, 2H), 7.13 (d, J = 8.4 Etazeta, IotaEta), 6.96 (t, J = 7.6 Hz, 1H), 6.24 (s, 1H), 3.80-3.40 (br, 4H), 2.40 (s, 3H), 2.36-2.24 (br, 4H), 2.19 ( s, 3H); ESI-MS: calcd for (C26H24FN702) 485, found 486 (MH+).

55121-99-8 (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone 231408, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NANTBIOSCIENCE, INC.; TAO, Chunlin; POLAT,, Tulay; WEINGARTEN, Paul; NALLAN, Laxman; ARP, Forrest; WANG, Qinwei; HO, David; (129 pag.)WO2016/138527; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics