Tag: M.W:200-300

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Bromopriopionaldehydediethylacetal, is researched, Molecular C7H15BrO2, CAS is 3400-55-3, about A Flexible Strategy for the Regiocontrolled Synthesis of Pyrazolo[1,5-a]pyrazines, the main research direction is pyrazolopyrazine preparation; pyrazole alkylation formylation cyclization reductive amination.Safety of 2-Bromopriopionaldehydediethylacetal.

A four-step protocol for the synthesis of pyrazolo[1,5-a]pyrazines was developed. Com. available pyrazoles were alkylated and formylated in a regiocontrolled manner to give pyrazole-5-aldehydes bearing 2,2-dialkoxyethyl substitution on N-1. Efficient conditions for the subsequent deprotection and cyclization of these intermediates allowed access to pyrazolo[1,5-a]pyrazines with multiple substitution patterns. The versatility of the pyrazole-5-aldehyde intermediates was further demonstrated through a deprotection and double-reductive amination sequence to give 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazines.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

HPLC of Formula: 18583-60-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Potassiumtris(1-pyrazolyl)borohydride, is researched, Molecular C9H10BKN6, CAS is 18583-60-3, about Nitrosyl, Nitro, and Nitrato Complexes of Palladium(IV). The First Structurally Characterized Mononuclear Nitrosyl Complex of Palladium. Author is Campora, Juan; Palma, Pilar; del Rio, Diego; Carmona, Ernesto; Graiff, Claudia; Tiripicchio, Antonio.

A series of PdIV-(NOx) complexes (x = 1, nitrosyl; x = 2, nitro; x = 3, nitrate) has been synthesized. The nitrosyl derivative [cyclic] [Pd(CH2CMe2-o-C6H4)(κ3-Tp)(NO)] is the first palladium mononuclear derivative to be structurally characterized by x-ray diffraction methods.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Boron-pyrazole chemistry. II. Poly(1-pyrazolyl)-borates, published in 1967, which mentions a compound: 18583-60-3, mainly applied to BORATE POLYPYRAZOLYL BORON PYRAZOLES; POLYPYRAZOLYL BORATE BORON PYRAZOLES; PYRAZOLYL BORATE DIHYDROBIS; BORATE PYRAZOLYL DIHYDROBIS; DIHYDROBIS PYRAZOLYL BORATE; PYRAZOLYL BORATE HYDROTRIS; BORATE PYRAZOLYL HYDROTRIS; TETRAKIS PYRAZOLYL BORATE; PYRAZOLYL BORATE TETRAKIS; UNINEGATIVE BIDENTATE LIGANDS; LIGANDS BIDENTATE UNINEGATIVE; UNINEGATIVE TRIDENTATE LIGANDS; TRIDENTATE LIGANDS UNINEGATIVE; LIGANDS TRIDENTATE UNINEGATIVE; BORON PYRAZOLES POLYPYRAZOLYL BORATE; HYDROTRIS PYRAZOLYL BORATE; PYRAZOLES BORON POLYPYRAZOLYL BORATE; BIDENTATE LIGANDS UNINEGATIVE; BORATE PYRAZOLYL TETRAKIS, Recommanded Product: 18583-60-3.

cf. preceding abstract Alkali metal dihydrobis(1-pyrazolyl)borates, hydrotris(1-pyrazolyl)borates, and tetrakis(1-pyrazolyl)borates have been prepared from alkali metal borohydrides and pyrazole. The first 2 are parent compounds, each representing a new class of chelating agents. Dihydrobis(1-pyrazolyl)borates are uninegative bidentate ligands and react with divalent transition metal ions forming square-planar or tetrahedral chelates, while hydrotris(1-pyrazolyl)borates are uninegative tridentates yielding octahedral coordination compounds A study of the solvent- and cation-dependence in the N.M.R. spectra of poly(1-pyrazolyl)borate ions permitted assignment of the 3-H and 5-H doublets. All alkali metal poly(1-pyrazolyl)borates (I, Z = metal or onium ion) can be converted to isolable free acids of moderate stability. The synthesis and properties of representative compounds are described. 27 references.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Onishi, Masayoshi; Nagaoka, Nobutaka; Hiraki, Katsuma; Itoh, Kei published the article 《Syntheses, properties and crystal structures of several new bis(polypyrazolylborato)lanthanoid(III) complexes》. Keywords: crystal structure neodymium pyrazolylborate pyrazole aqua; lanthanide pyrazolylborate pyrazole quinolinolato aqua preparation; neodymium pyrazolylborate pyrazole quinolinolato aqua preparation; lutetium pyrazolylborate pyrazole quinolinolato aqua preparation; ytterbium pyrazolylborate pyrazole quinolinolato aqua preparation.They researched the compound: Potassiumtris(1-pyrazolyl)borohydride( cas:18583-60-3 ).Quality Control of Potassiumtris(1-pyrazolyl)borohydride. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:18583-60-3) here.

Lanthanoid(III) chlorides MCl3·6H2O (M = Lu, Nd, Yb) in THF were treated with K tris(1-pyrazolyl)hydroborate K(BHpz3) (pz = 1-pyrazolyl) in a (1/1) molar ratio at -78°, and [MCl(BHpz3)2(L)] (L = Hpz for M = Lu and Nd; L = H2O for M = Yb) were isolated. In the presence of N-methylpyrazole (N-CH3pz), similar reaction procedures gave [MCl(BHpz3)2(N-CH3pz)], of which further treatment with Na 8-quinolinolate Na(quin) afforded the stable complexes [M(BHpz3)2(quin)] quant. From single crystal x-ray structural analyses, distorted square-antiprismatic geometry was determined for [NdCl(BHpz3)2(L)] (L = Hpz and H2O). Compared with N-CH3pz adduct formation, Hpz coordination to Lu and Nd was fairly strong, owing to the H bonding formed between the Cl atom on Nd and the acidic 1-N proton in the coordinated Hpz.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Potassiumtris(1-pyrazolyl)borohydride, is researched, Molecular C9H10BKN6, CAS is 18583-60-3, about A plutonium-based single-molecule magnet.Recommanded Product: Potassiumtris(1-pyrazolyl)borohydride.

The magnetic properties of the 5f5 [tris(tri-1-pyrazolylborato)plutonium(III)] complex were studied by a.c. susceptibility measurements, showing it to be the 1st Pu single-mol. magnet; its magnetic relaxation slows down with decreasing temperature through a thermally activated mechanism followed by a quantum tunnelling regime <5 K. As far as I know, this compound(18583-60-3)Recommanded Product: Potassiumtris(1-pyrazolyl)borohydride can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application of 16004-15-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about External Catalyst-Free Oxidation of Benzyl Halides to Benzoic Acids Using NaOH/TBHP in Water.

An efficient and metal-free methodol. for the oxidation of benzyl halides to benzoic acids using an inexpensive and green oxidant (TBHP) in aqueous basic medium has been developed. This protocol offers an excellent way to avoid adding catalysts and involves the use of an in-situ generated halide ion as catalyst. It is also the first report on the oxidation of benzyl iodides to benzoic acids. A series of carboxylic acids were prepared from benzyl halides in high yields under mild reaction conditions by this method which does not require chromatog. purification Gram scale reactions for the synthesis of the carboxylic acids in good yields have been successfully carried out using benzyl chloride, bromide and iodide. As an industrial application, the synthesis of a key monomer used for the synthesis of polyethylene terephthalate (PET), i. e., terephthalic acid (PTA), has also been accomplished in good yields.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Inorganic Chemistry called MIIIDyIII3 (M = FeIII, CoIII) Complexes: Three-Blade Propellers Exhibiting Slow Relaxation of Magnetization, Author is Xu, Gong-Feng; Gamez, Patrick; Tang, Jinkui; Clerac, Rodolphe; Guo, Yun-Nan; Guo, Yang, which mentions a compound: 18583-60-3, SMILESS is [BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+], Molecular C9H10BKN6, Electric Literature of C9H10BKN6.

[DyIII(HBpz3)2]2+ moieties (HBpz3- = hydrotris(pyrazolyl)borate) and a 3d transition-metal ion (FeIII or CoIII) were rationally assembled using a dithiooxalato dianion ligand into 3d-4f [MDy3(HBpz3)6(dto)3]·4MeCN·2CH2Cl2 [M = Fe (1), Co (2)] complexes. Single-crystal x-ray studies reveal that three eight-coordinated DyIII centers in a square antiprismatic coordination environment are connecting to a central octahedral trivalent Fe or Co ion forming a propeller-type complex. The dynamics of the magnetization in the two isostructural compounds, modulated by the nature of the central MIII metal ion, are remarkably different despite their analogous d.c. magnetic properties. The slow relaxation of the magnetization observed for 2 mainly originates from isolated Dy ions, since a diamagnetic CoIII metal ion links the magnetic DyIII ions. In the case of 1, the magnetic interaction between S = 1/2 FeIII ion and the three DyIII magnetic centers, although weak, generates a complex energy spectrum of magnetic states with low-lying excited states that induce a smaller energy gap than for 2 and thus a faster relaxation of the magnetization.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Name: 2,3-Dichloro-5-iodopyridine. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,3-Dichloro-5-iodopyridine, is researched, Molecular C5H2Cl2IN, CAS is 97966-01-3, about Synthesis and Structure-Activity Relationships of 3,8-Diazabicyclo[4.2.0]octane Ligands, Potent Nicotinic Acetylcholine Receptor Agonists. Author is Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Jianquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D..

A series of potent neuronal nicotinic acetylcholine receptor (nAChR) ligands based on a 3,8-diazabicyclo[4.2.0]octane core have been synthesized and evaluated for affinity and agonist efficacy at the human high affinity nicotine recognition site (hα4β2) and in a rat model of persistent nociceptive pain (formalin model). Numerous analogs in this series exhibit picomolar affinity in radioligand binding assays and nanomolar agonist potency in functional assays, placing them among the most potent nAChR ligands known for the hα4β2 receptor. The 3,8-diazabicyclo[4.2.0]octanes (1R,6S)-I [R = H, Cl, Me, R1 = Cl; R = Br, Cn, R1 = Br] and (1S,6R)-I [R = H, R1 = Cl] exhibit equivalent or greater affinity for the hα4β2 receptor relative to epibatidine, and like epibatidine, many exhibit robust analgesic efficacy in the rat formalin model of persistent pain.

From this literature《Synthesis and Structure-Activity Relationships of 3,8-Diazabicyclo[4.2.0]octane Ligands, Potent Nicotinic Acetylcholine Receptor Agonists》,we know some information about this compound(97966-01-3)Name: 2,3-Dichloro-5-iodopyridine, but this is not all information, there are many literatures related to this compound(97966-01-3).

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Organometallic Chemistry called Synthesis of a tris(pyrazolyl)borate-stabilized molybdenum alkylidene and its hydrolysis products. Crystal structures of TpMo(CH2C(Me)2Ph)(NAr)(O) and [TpMo(NAr)(O)]2O, Author is Vaughan, William M.; Abboud, Khalil A.; Boncella, James M., which mentions a compound: 18583-60-3, SMILESS is [BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+], Molecular C9H10BKN6, Name: Potassiumtris(1-pyrazolyl)borohydride.

The synthesis of a tris(pyrazolyl)borate-stabilized molybdenum(VI) imido alkylidene complex, TpMo(CHC(Me)2Ph)(NAr)(OTf) (1) [Ar = 2,6-i-Pr2-C6H3, Ph = C6H5, OTf = OSO2CF3], has been achieved by addition of potassium hydridotris(1-pyrazolyl)borate (KTp) to Mo(CHC(CH3)2Ph)(NAr)(OTf)2(DME). Stirring compound 1 over alumina in the presence of H2O gave TpMo(CH2C(Me)2Ph)(NAr)(O) (2). Alternatively, compound 1 was converted to 2 by the addition of CsOH·H2O in THF. A single crystal of [TpMo(NAr)(O)]2O (4) was isolated from a solution of 2. Compounds 2 and 4 have been characterized by x-ray crystallog. and the bonding considerations about the molybdenum atoms are discussed.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromopriopionaldehydediethylacetal(SMILESS: CC(Br)C(OCC)OCC,cas:3400-55-3) is researched.Recommanded Product: (1S)-(-)-Camphanic acid. The article 《Enolate additions to a chiral 3-hydroxypropionate 2,3-dication equivalent. Enantioselective synthesis of β,δ-dihydroxy esters》 in relation to this compound, is published in Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:3400-55-3).

The use of optically active dicarbonyl cyclopentadienyliron(vinyl ether) BF4 salts, (e.g. (5R)-(dicarbonyl-η-cyclopentadienyliron)-5,6-dihydro-5-methyl-1,3-dioxin tetrafluoroborate), as enantioselective 3-hydroxypropionate 2,3-dication equivalent is outlined. They are readily available by exchange etherification of the dimethoxyethylene analog, and these were transformed to enantiomeric dicarbonyl (η-cyclopentadienyliron)(η2-1-methoxypropene) BF4 5 and ent-5. Complex 5 was converted to the corresponding p-methoxybenzyloxy vinyl ether complex by exchange etherification. Condensation of this salt with a number of terminal and nonterminal enolates yields adducts, which are then transformed by redox-promoted alkoxycarbonylation, followed by alc. deprotection, to optically active 2-methyl-3-hydroxy-5 keto esters. 1,3-Reduction of these ketols can be effected to give either syn- or anti-1,3-diols and thence their related pentanolides (e.g. (2R*,3S*,4R*,5S*)-5-ethyl-3-hydroxy-2,4-dimethyl-5-pentanolide).

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics