Tag: M.W:200-300

303-26-4, 1-((4-Chlorophenyl)(phenyl)methyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 4 10 gr. (0.035 mole) of 1-[(4-chlorophenyl)phenylmethyl]piperazine, 8.8 gr. of ethyl 2-chloroethoxyacetate, 0.4. gr. of tetrabutylammonium iodide and 50 ml. of triethylamine were introduced into a pressure vessel and treated as described in example 1. 13.2 gr. of ethyl [2-[4-[(4-chlorophenyl)phenylmethyl]- 1-piperazinyl]ethoxy]acetate is obtained (90.8% yield).

303-26-4, 303-26-4 1-((4-Chlorophenyl)(phenyl)methyl)piperazine 9340, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Chemagis Ltd.; EP952153; (1999); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Example 37Te/t-butyl 4-(4-(6-chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-3H-imidazo[4,5- ?>]pyridin-2-yl)phenyl)piperazine-1-carboxylateTo a mixture of 5-chloro-4-(4-(4-chlorobenzyl)piperazin-1-yl)-3-nitropyridin-2-amine (prepared as described in example 37 of PCT/GB2006/004854; 0.042 g, 0.11 mmol) and EtOH (7 mL) was added te/t-butyl 4-(4-formylphenyl)piperazine-1-carboxylate (0.039 g, 0.14 mmol) followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.44 mL, 0.44 mmol). The reaction mixture was stirred at 80 0C for 20 h, then allowed to cool to room temperature and concentrated in vacuo. The residue was absorbed on silica gel, and the free-running powder was placed on a 10 g isolute silica column. Elution with ethyl acetate / dichloromethane (v:v; 1 :1), and then 2.5% methanol in ethyl acetate / dichloromethane (v:v; 1 :1 ) afforded the title compound as an off-white solid (0.023 g, 34%). 1H-NMR (500 MHz, DMSO-d6) 1.43 (s, 9H, OC(CHa)3), 2.58 (br t, 4H), 3.48 (br t, 4H), and 3.67 (br s, 4H) (piperazine N(CH2)2), 3.56 (s, 2H, NCH2-C6H4CI), 7.41 (m, 4H, C6H4CI), 7.06 (d, J = 8.8 Hz1 2H) and 8.03 (d, J = 7.7 Hz, 2H) (2,6-C6H4 and 3,5-C6H4), 8.04 (s, 1 H, imidazo[4,5-iotab]pyridine 5-H), 13.18 (br s, 1H, imidazo[4,5-/b]pyridine N-H);LC (Method B) – MS (ESI1 m/z): Rt = 4.45 min – 622, 624, 626 [(M+H)+, Cl2 isotopic pattern].

197638-83-8, As the paragraph descriping shows that 197638-83-8 is playing an increasingly important role.

Reference£º
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-38-0,2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.,5521-38-0

A stirred solution of 2-(4-(4-nitrophenyl)piperazin-1- yl)ethanol (1.2 g, 4.78 mmol) in ethanol (20 mL) washeated to 50 C. 10% palladium on carbon (0.254 g, 0.239 mmol) was added followed by portionwise addition of ammonium formate (1.506 g, 23.88 mmol) and the suspension was stirred for 1 hour. The suspension was filtered through Celite washing with fresh ethanol (20 mL) . Theethanol was removed in vacuo to give the title compound(1.10 g, 104 %) . ?H NMR (400 MHz, CDC13) : 3 6.81 (d, 2H),6.66 (d, 2H), 3.69 (t, 2H), 3.09 (t, 4H), 3.02 (br s,3H), 2.74 (t, 4H), 2.66 (t, 2H) . LCMS (Method C): =0.13 mi m/z = 222 [M+H].

As the paragraph descriping shows that 5521-38-0 is playing an increasingly important role.

Reference£º
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

6-Fluoro-2-methyl-3-(oxiran-2-yl)benzonitrile (12.0g, 67.7 mmol) and (S)-4-N-BOC-2-hydroxymethylpiperazine (22.0 g. 102 mmol) were suspended in ethanol (100 mL) then heated in a microwaye apparatus for 30 minutes at 150 C. The reaction mixture was cooled and eyaporated dryness. The residue was purified by MPLC chromatography through a 330g Redi-sep column eluting with 5%MeOH/95% EtOAc solyent system to yield the title compound. LC-MS : M+1= 394., 314741-40-7

The synthetic route of 314741-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DE JESUS, Reynalda, Keh; DING, Fa-xiang; DONG, Shuzhi; FRIE, Jessica; GU, Xin; JIANG, Jinlong; SHAHRIPOUR, Aurash; PIO, Barbara; TANG, Haifeng; WALSH, Shawn; WO2014/126944; (2014); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

438631-77-7, (R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,438631-77-7

DIPEA (5.15 mL, 29.46 mmol) was added to 695 7-bromo-4,5,6-trichloro-3-nitroquinoline (3.5 g, 9.82 mmol) and 272 1-(tert-butyl) 3-methyl (R)-piperazine-1,3-dicarboxylate (4.8 g, 19.64 mmol) in 78 THF (50 mL) at rt. The resulting solution was stirred at 80 C. for 2 days. The solvent was removed in vacuo. The crude product obtained was purified by flash silica chromatography (0 to 20% 57 EtOAc in 148 petroleum ether) to afford 697 1-tert-butyl 3-methyl (3R)-4-(7-bromo-5,6-dichloro-3-nitroquinolin-4-yl)piperazine-1,3-dicarboxylate (1.95 g, 35%) as a red solid; 1H NMR (400 MHz, DMSO, 30 C.) 1.44 (9H, s), 3.25-3.32 (3H, m), 3.50-3.60 (2H, m), 3.75-3.85 (2H, m), 3.98-4.04 (1H, m), 4.12-4.22 (2H, m), 7.80-7.95 (1H, m), 9.07 (1H, d); m/z: ES+ [M+H]+=563.

As the paragraph descriping shows that 438631-77-7 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

78818-15-2, Benzyl 3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

78818-15-2, Sodium hydride (60% dispersion in mineral oil, 281 mg, 7.0 mmol) was added to a solution of phenylmethyl 3-oxo-1-piperazinecarboxylate (1.5 g, 6.4 mmol) in dry dimethyl formamide (5 mL) and the mixture was stirred at room temperature for 30 minutes. 5-(Chloromethyl)-1-methyl-1H-1,2,4-triazole (WO0023449, 920 mg, 7.0 mmol) was added and the mixture was stirred at room temperature for 16 hours. The mixture was poured into water (150 mL) and extracted with diethyl ether (2¡Á100 mL). The combined organic fractions were dried (MgSO4) and the solvent was evaporated under reduced pressure to give the title compound as a pale oil (2 g, 94%). m/z (ES+) 330 (M+1).

78818-15-2 Benzyl 3-oxopiperazine-1-carboxylate 736777, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John; US2003/236250; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5521-38-0, 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5521-38-0

Reference Example 19b 2-[4-(4-amino-phenyl)-piperazin-1-yl]-ethanol 2-[4-(4-amino-phenyl)-piperazin-1-yl]-ethanol is prepared by catalytic hydrogenation of 2[4-(4-nitrophenyl)piperazine-1-yl]-ethanol (prepared as in Reference Example 19a) as described in Reference Example 13b

5521-38-0 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol 2763936, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Pierson, Edward; Sohn, Daniel; Haeberlein, Markus; Davenport, Timothy; Chapdelaine, Marc; Horchler, Carey; McCauley, John P.; US2003/13708; (2003); A1;; ; Patent; Chapdelaine, Marc; Davenport, Timothy; Haeberlein, Markus; Horchler, Carey; McCauley, John; Pierson, Edward; Sohn, Daniel; US2004/110745; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.692058-21-2,1-Boc-4-(2,2,2-trifluoroethyl)piperazine,as a common compound, the synthetic route is as follows.

Hydrogen chloride gas was bubbled through a solution of tert-butyl 4- (2, 2, 2-TRIFLUOROETHYLPIPERAZINE-1-CARBOXYLATE (8 g) in ethyl acetate (50 ml) during 1.5 hours. A precipitate formed as carbon dioxide gas was evolved. The precipitate was collected by filtration, washed with ethyl acetate and dried under vacuum. There was thus obtained 1- (2, 2, 2-trifluoroethyl) piperazine hydrochloride (7 g); NMR Spectrum : (DMSOd6 and CF3CO2D) 2.85 (m, 4H), 3.1 (m, 4H), 3.35 (q, 2H), 692058-21-2

The synthetic route of 692058-21-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/41829; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of /ert-butyl (2-oxoethyl)carbamate (4.89 g, 30.7 mmol) in 1,2- dichloroethane (50 mL) was added to a solution of l-(tert-butyl) 3-methyl piperazine- 1,3- dicarboxylate (5 g, 20.5 mmol) in l,2-dichloroethane (25 mL). The solution stirred at 25 C under nitrogen atmosphere for 30 min. Sodium triacetoxyborohydride (8.69 g, 41.0 mmol) was added, and the resulting mixture stirred at 25 C for 15 h. The reaction was quenched by the addition of water (50 mL) at 25 C. The resulting mixture was extracted with dichloromethane (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over anhydrous sodium sulfate, and the solids were filtered out. The filtrate was concentrated under vacuum. The residue was purified by silica gel chromatography (eluting with 1 : 1 ethyl acetate/petroleum ether) to afford l-ter/-butyl 3- methyl 4-(2-(/er/-butoxycarbonylamino)ethyl)piperazine-l,3-dicarboxylate as yellow oil (5.1 g, 64%). LCMS (ES, m/z): 388 [M+H]+.

129799-08-2, The synthetic route of 129799-08-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FORMA THERAPEUTICS, INC.; MARTIN, Matthew W.; BUCKMELTER, Alexandre Joseph; (158 pag.)WO2019/222468; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PIPERAZINE-L-CARBOXYLIC acid benzyl ester (1.03 g, 4. 68 mmol. 1.0 eq. ) and 4- TETRAIDROPIRANIL aldeide (0.8 mg, 7. 0 mmol, 1. 5 eq. ) are dissolved in 20 ml of anhydrous DCM. Na (OAC) 3BH (1. 48 g, 7.0 mmol, 1. 5 eq.) are added to this opalescent solution. The reaction is left under magnetic stirring and under a nitrogen atmosphere at room temperature for 2 hours. When the reaction is completed the solvent is removed by evaporation under reduced pressure. AcOEt (20 mL) and a IN solution OF NAOH (20 mL) are added and the biphasic system transferred to a separatory funnel. The phases are separated and the organic phase is washed with water and brine, dried on NASO,}, FILTERED and the solvent removed by evaporation under reduced pressure. 4- (Tetrahydro-pyran-4-ylmethyl)-piperazine-1-carboxylic acid benzyl ester (20) is obtained as a colourless oil (1. 3 g, 4. 08 mmol, yield = 87percent) H1 NMR (No., DMSO-D6, 300 MHZ) : 1.10 (qd, 2H, He, J= 6.3, 13.5 Hz) ; 1.59 (d, 2H, HD, J = 12. 6 Hz); 1.72 (M, 1H, HE) ; 2.30 (m, 4H, Hh); 2.63 (m, 2H, Hl); 3.23-3. 37 (m, 4H+2H, Hg + Hb), 3.80-3. 84 (M, 2H, Ha), 5.07 (s, 2H, PHCH2) ; 7.31-7. 40 (M, 5H, ArH)., 31166-44-6

31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MENARINI RICERCHE S.P.A.; WO2004/94412; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics