Tag: M.W:200-300

Recommanded Product: 16004-15-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders.

Peroxisome proliferator-activated receptor alpha (PPARα) is expressed in retinal Müller cells, endothelial cells, and in retinal pigment epithelium; agonism of PPARα with genetic or pharmacol. tools ameliorates inflammation, vascular leakage, neurodegeneration, and neovascularization associated with retinal diseases in animal models. As such, PPARα is a promising drug target for diabetic retinopathy and age-related macular degeneration. Herein, we report proof-of-concept in vivo efficacy in an streptozotocin-induced vascular leakage model (rat) and preliminary pharmacokinetic assessment of a first-generation lead 4a (A91). Addnl., we present the design, synthesis, and evaluation of second-generation analogs, which led to the discovery of 4u and related compounds that reach cellular potencies <50 nM and exhibit >2,700-fold selectivity for PPARα over other PPAR isoforms. These studies identify a pipeline of candidates positioned for detailed PK/PD and pre-clin. evaluation.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Organic Chemistry called Reaction of 3-substituted imidazo[1,2-a]pyridines with bromine(1+) and the alleged 5-bromo-substituted product, Author is Hand, E. Smakula; Paudler, William W., which mentions a compound: 3400-55-3, SMILESS is CC(Br)C(OCC)OCC, Molecular C7H15BrO2, Reference of 2-Bromopriopionaldehydediethylacetal.

The reaction of 3-methylimidazo[1,2-a]pyridine with N-bromosuccinimide (I) gave products formed by apparent nucleophilic substitution at the 2-position. I in CHCl3 gave II and III, while I in CCl4 or Br2 in CHCl3 gave II exclusively. Mechanisms and differences in product formation are discussed; evidence is presented that the previously reported I product was in fact 3-bromo-5-methylimidazo[1,2-a]pyridine, rather than the alleged 5-bromo-3-Me derivative IV. IV was prepared by diazotization of 5-amino-3-methylimidazo[1,2-a]pyridine in the presence of HBr and by condensation of MeCHBrCHO (or its acetal) with 2-amino-6-bromopyridine.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2 ) is researched.Synthetic Route of C7H6BrI.Yang, Ren-Yin; Gao, Xinyan; Gong, Kehao; Wang, Juan; Zeng, Xiaojun; Wang, Mingwei; Han, Junbin; Xu, Bo published the article 《Synthesis of ArCF2X and [18F]Ar-CF3 via Cleavage of the Trifluoromethylsulfonyl Group》 about this compound( cas:16004-15-2 ) in Organic Letters. Keywords: aryldifluoromethylene compound preparation. Let’s learn more about this compound (cas:16004-15-2).

A versatile synthesis of ArCF2X and [18F]Ar-CF3 type compounds from readily available ArCF2SO2CF3 has been developed. Diverse nucleophiles, including weak nucleophiles such as halides (18F-, Cl-, Br-, and I-), RSH, and ROH, could react with ArCF2SO2CF3 efficiently to give the corresponding difluoromethylene products. The control experiments and the Hammett plot indicated that the reaction might proceed through a difluorocarbocation intermediate generated from the steric hindrance-assisted cleavage of the trifluoromethylsulfonyl group.

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Canty, Allan J.; Jin, Hong; Roberts, Andrew S.; Traill, Peter R.; Skelton, Brian W.; White, Allan H. published the article 《Synthetic and structural studies of methyl- and phenylpalladium(II) complexes of poly(pyrazol-1-yl)borates, and the η3-allylpalladium(II) complex Pd(η3-C3H5){(pz)3BH-N,N’}》. Keywords: crystal structure pyrazolylborate palladium complex; mol structure pyrazolylborate palladium complex; borate pyrazolyl palladium complex.They researched the compound: Potassiumtris(1-pyrazolyl)borohydride( cas:18583-60-3 ).Electric Literature of C9H10BKN6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:18583-60-3) here.

The poly(pyrazol-1-yl)borate complexes PdMe{(pz)3BR-N,N’}(PPh3) (R = H, pz) are formed on the reaction of [PdMe(SMe2)(μ-I)]2 with K[(pz)3BR] in the presence of PPh3 and TlPF6, and the phenylpalladium(II) analogs are formed directly from PdIPh(tmeda) (tmeda = N,N,N’,N’-tetramethylethylenediamine) and K[(pz)3BR] in the presence of PPh3. X-ray diffraction studies of PdR{(pz)4B-N,N’}(PPh3) (R = Me, Ph) and PdPh{(pz)3BH-N,N’}(PPh3) reveal square planar geometry for Pd with the poly(pyrazol-1-yl)borate ligands in bidentate mode. The structure of Pd(η3-C3H5){(pz)3BH-N,N’} also was determined, and it contains a bidentate tris(pyrazol-1-yl)borate group with the η3-allyl group forming a dihedral angle of 125.5(2.1)° with the PdN2 plane. In both PdPh{(pz)3BH-N,N’}(PPh3) and Pd(η3-C3H5){(pz)3BH-N,N’} the uncoordinated pyrazole group lies above the coordination plane.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 18583-60-3, is researched, SMILESS is [BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+], Molecular C9H10BKN6Journal, Article, Journal of the American Chemical Society called Metal-to-Metal Electron Transfer in Co/Fe Prussian Blue Molecular Analogues: The Ultimate Miniaturization, Author is Koumousi, Evangelia S.; Jeon, Ie-Rang; Gao, Qian; Dechambenoit, Pierre; Woodruff, Daniel N.; Merzeau, Pascal; Buisson, Lionel; Jia, Xiaolu; Li, Dongfeng; Volatron, Florence; Mathoniere, Corine; Clerac, Rodolphe, the main research direction is cobalt iron cyano pyrazolylborate heterodinuclear preparation structure electron transfer; Prussian Blue analog cobalt iron pyrazolylborate cyanido bridged heterodinuclear; crystal structure cobalt polypyridyl iron cyano pyrazolylborate heterodinuclear complex.Category: piperazines.

Co/Fe Prussian Blue analogs are known to display both thermally and light induced electron transfer attributed to the switching between diamagnetic {FeIILS(μ-CN)CoIIILS} and paramagnetic {FeIIILS(μ-CN)CoIIHS} pairs (LS = low spin; HS = high spin). A dinuclear cyanido-bridged Co/Fe complex, [{(Tp)Fe(CN)3}{Co(PY5Me2)}] (PY5Me2 = 2,6-bis(1,1-bis(2-pyridyl)ethyl)pyridine; Tp = hydridotris(pyrazol-1-yl)borate), the smallest {Fe(μ-CN)Co} moiety at the origin of the remarkable phys. properties of these systems, was designed by a rational building-block approach. Combined structural, spectroscopic, magnetic and photomagnetic studies reveal that a metal-to-metal electron transfer that can be triggered in solid state by light, temperature and solvent contents, is observed for the first time in a dinuclear complex.

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Synthetic Route of C7H15BrO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Bromopriopionaldehydediethylacetal, is researched, Molecular C7H15BrO2, CAS is 3400-55-3, about A modified Bischler synthesis of some tetracyclic indole derivatives.

Indoles I (RR1 = CH:CH, X = H2, CH2CH2, CH:CH, S) were obtained in 69-83% yield by cyclizing I (R = CH2CHO, R1 = H) on a mol. sieve. I (R = CH2CHO, R1 = H) were obtained by treating I (R = R1 = H) with BrCH2CH(OEt)2 and hydrolyzing I [R = CH2CH(OEt)2, R1 = H] with 4-MeC6H4SO3H. I (R = CH2CHO, R1 = H, X = bond) did not cyclize but dimerized.

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Recommanded Product: Potassiumtris(1-pyrazolyl)borohydride. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Potassiumtris(1-pyrazolyl)borohydride, is researched, Molecular C9H10BKN6, CAS is 18583-60-3, about Reactivity of an anionic Pd(ii) metallacycle with CH2X2 (X = Cl, Br, I): formal insertion of methylene into a Pd-Caryl bond. Author is Campora, Juan; Palma, Pilar; del Rio, Diego; Lopez, Jorge A.; Valerga, Pedro.

Whereas the reaction of the anionic palladium metalacycle [cyclic] [K{Pd(CH2CMe2-o-C6H4)(κ2-Tp)}] with CH2Cl2 leads to the isolation of the stable Pd(iv) chloromethyl complex [cyclic] [Pd(CH2CMe2-o-C6H4)(κ3-Tp)(CH2Cl)], the analogous reactions with CH2Br2 and CH2I2 give rise to the six membered metalacycles [cyclic] [Pd(CH2CMe2-o-C6H4(CH2))(κ3-Tp)X] (X = Br or I), as a result of the formal insertion of CH2 into the Pd-Caryl bond. The crystal structure of the bromomethyl complex was determined

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhurnal Obshchei Khimii called Chlorination and bromination of acetaldehyde and lower homologs, Author is Shchukina, M. N., which mentions a compound: 3400-55-3, SMILESS is CC(Br)C(OCC)OCC, Molecular C7H15BrO2, Product Details of 3400-55-3.

Chlorination of AcH at 16-18° proceeds through a substance composed of 2 moles ClCH2CHO, 1 mole AcH, and 1 mole HCl, which on distillation dissociate and gives 60% ClCH2CHO. Prolonged chlorination of AcH at 70-80° gives mainly Cl2CHCHO, while at 80-90° chloral forms mainly, with some MeCHClCCl2CHO. Bromination of AcH and homologs proceeds at a lower temperature than the chlorination and gives 1,2-di-Br alcs. as primary products; further action is slow and requires a higher temperature The mechanism of chlorination and bromination must be regarded as consisting of proton addition to give an intermediate which has a hydroxycarbenium structure in one of the equilibrium states; the presence of the incomplete electron octet explains the ease of halogenation and the polymerization tendency; the difficulty of continued reaction is explained by decreased weight of the carbenium structure after introduction of 1 Br atom. Passage of dry Cl into 44 g. AcH leads to a temperature rise despite cooling and is best done at 16-18°, as an initially preset -5° temperature leads to violent action delayed 2-10 min.; HCl evolution starts after 24 g. Cl is taken up. When a 3 mols. AcH:2 mols. Cl ratio is reached, Cl is no longer absorbed; 13-14 g. HCl is recovered and the product, 78-84 g., is a fuming colorless liquid, whose analysis confirms the above-given complex. Distillation gives 13 g. HCl, 8 g. AcH, 47 g. ClCH2CHO, b. 80-6° (2,4-dinitrophenylhydrazone, m. 158-9°), and 10 g. residue of trichloroparaldehyde, m. 83-4°. On standing 24 hrs. the complex seps. into 2 layers: upper, aqueous HCl; and bottom, ClCH2CHO.H2O, b. 88-93°, b20-1 23-5°. Addition of 44 g. of the complex to 50 g. thiourea in water, followed by 28 g. NaHCO3 and heating 2 hrs. at 85-90°, gave 48-50% 2-aminothiazole, m. 96° (from benzene). If the chlorination is continued 12 hrs. with gradual heating to 70-80°, there is obtained 90 g. product, which on distillation gives 57.5% Cl2CHCHO, b. 88-90°, yielding, with 2,4-(O2N)2C6H3NHNH2 the corresponding glyoxal derivative, m. 315°; on standing, Cl2HCCHO gives a solid polymer which dissociates on distillation Similar chlorination carried further 8 hrs. at 80°, 12 hrs. at 80-90°, and 8 hrs. at 90° (Cl absorption stops) gave 120 g. crude product yielding on distillation 50% chloral, followed by 9.5 g. trichlorobutyraldehyde, m. 78° (b. about 150°); addition of Fe chloride (from 3 g. Fe and HCl) gives a somewhat lower yield of chloral. Bromination was conducted as described earlier (Stepanov, et al., C.A. 21, 731) and is facilitated by illumination; the induction period is 2-3 min. and the addition of Br must be halted until the initial action subsides. When 1 mol. Br is added at 5°, the addition stops and addition of alcs. to this primary product gives α-bromoacetals; in this manner the di-Et acetals of BrCH2CHO, MeCHBrCHO, EtCHBrCHO, and Me2CHCHBrCHO were obtained in 69-73% yields (no data). Addition of a 2nd Br requires 6-7 hrs. at 25-40°; passage of dry N or CO2 is used to remove the HBr prior to isolation of the products; treatment with P2O5 and distillation gave 55% Br2CHCHO, b. 137-40°, 48% MeCBr2CHO, b730 128-30° (with semicarbazide-HCl this gives methylglyoxal disemicarbazone, m. 252-3°, and with HC(OEt)3 79% MeCBr2CH(OEt)2, b14 96-8°, d154 1.5513, n15D 1.4783), and 61% EtCBr2CHO, b40 85° (di-Et acetal, d154 1.645, n15D 1.4875), from the corresponding aldehydes.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 18583-60-3, is researched, SMILESS is [BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+], Molecular C9H10BKN6Journal, Journal of Organometallic Chemistry called Synthesis of organometallic hydrotris(pyrazol-1-yl)boratoruthenium(II) complexes, Author is Hill, Anthony F., the main research direction is ruthenium pyrazolylborato.Recommanded Product: Potassiumtris(1-pyrazolyl)borohydride.

The reactions of K[HB(pz)3] (pz = pyrazol-1-yl) with the coordinatively unsaturated σ-vinyl complexes [Ru(CR:CHR)Cl(CO)(PPh3)2] (R = H, Me, C6H5) proceed with loss of a chloride and a phosphine ligand to provide the compounds [Ru(CR:CHR)(CO)(PPh3){HB(pz)3}] in high yield. Similar treatment of the complex [Ru(C6H4Me-4)Cl(CO)(PPh3)2] leads to the related σ-aryl derivative [Ru(C6H4Me-4)(CO)(PPh3){HB(pz)3}] while the complex [RuClH(CO)(PPh3)3] treated successively with diphenylbutadiyne and K[HP(pz)3] provides the unusual derivative [Ru{C(CCPh):CHPh}(CO)(PPh3){HB(pz)3}].

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Polyhedron called Synthesis of a cyano-bridged Fe2Mn linear unit and a Fe2Mn2 square unit by using the [fac-Fe{HB(pz)3}(CN)3]- building block, Author is Kim, Jinkwon; Han, Sujin; Cho, In-Ku; Choi, Ki Young; Heu, Min; Yoon, Seokwon; Suh, Byoung Jin, which mentions a compound: 18583-60-3, SMILESS is [BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+], Molecular C9H10BKN6, Recommanded Product: Potassiumtris(1-pyrazolyl)borohydride.

Mononuclear (LH2)[Fe{HB(pz)3}(CN)3]2·2H2O·2MeOH (2) (L = C-meso-3,14-dimethyl-2,6,13,17-tetraazatricyclo[16.4.0.07,12]docosane) and two cyano-bridged bimetallic complexes [{Fe{HB(pz)3}(CN)3}2Mn(MeOH)4]·2MeOH (3) and [Mn2Fe2{HB(pz)3}2(CN)6(2,2′-bipyridine)2](ClO4)2·4MeCN (4) were prepared and their structures and magnetic properties studied. A crystal structure anal. of complex 2 revealed a H bonded dimeric structure of two [Fe{HB(pz)3}(CN)3]- anions and two H2O mols. The structure of 3 consists of a neutral FeIII-MnII-FeIII mol. and two crystal MeOH mols. The Mn ion is coordinated by two [Fe{HB(pz)3}(CN)3]- moieties through cyanide bridging ligands with trans geometry, resulting in a linear trinuclear structure. Reaction of the 2,2′-bipyridine ligand with complex 3 gave complex 4. The crystal structure of 4 consists of a discrete tetranuclear square Fe2Mn2 complex, two perchlorate anions and four MeCN solvent mols. The Mn ions are surrounded by two 2,2′-bipyridine ligands and bridged by two [Fe(tbp)(CN)3]- moieties through cyanide bridging ligands to form a cyclic tetranuclear structure. The magnetic properties of 3 and 4 are dominated by a weak antiferromagnetic interaction of low-spin FeIII (S = 1/2) and high-spin MnII (S = 5/2). The FeIII-MnII coupling constant J is -5.90(9) or -7.6(2) cm-1 for 3 and -2.29(3) cm-1 for 4.

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