Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.303-26-4,1-((4-Chlorophenyl)(phenyl)methyl)piperazine,as a common compound, the synthetic route is as follows.

Example 2 10 gr. of (0.035 mole) of 1-[(4-chlorophenyl)phenylmethyl]piperazine, 8.06 gr. (0.0525 mole) of methyl 2-chloroethoxyacetate and 50 ml. of triethylamine were introduced into a pressure vessel and treated in a similar way as described in example 1. 12.5 gr. of methyl [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetate is obtained as reddish oil (88.7% yield)., 303-26-4

303-26-4 1-((4-Chlorophenyl)(phenyl)methyl)piperazine 9340, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Chemiagis, Ltd.; US6100400; (2000); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 26; 4-{2-[3-(2-Methylsulfanyl-pyrimidin-4-yl)- lH-pyrazolo[3,4-d]pyrimidin-6-ylamino]- ethyl}-piperazine-l-carboxylic acid tert-butyl ester; To a solution of 6-chloro-3-(2-methylsulfanyl-pyrimidin-4-yl)- lH-pyrazolo[3,4- d]pyrimidine (from Example 7 supra) (500 mg, 1.79 mmol) in 2-propanol (40 mL) was added tert-butyl 4-(2-aminoethyl)piperazine- l-carboxylate (613 mg, 1.97 mmol) followed by triethylamine (200 mg, 1.98 mmol). The reaction mixture was stirred at reflux for 15 hours and the solvent was then removed under reduced pressure. The residue was extracted with dichloromethane (3 x 30 mL), washed with water (5 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to afford 4-{2-[3-(2-methylsulfanyl-pyrimidin-4-yl)- lH-pyrazolo[3,4- d]pyrimidin-6-ylamino] -ethyl }-piperazine- l-carboxylic acid tert-butyl ester. (Yield 600 mg, crude). LC-MS: [M+H]+ 472.

192130-34-0, 192130-34-0 tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate 1514400, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; LIU, Wenjian; LUK, Kin-Chun Thomas; ZHANG, Xiaohu; WO2012/98068; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound (R) -3- methyl-piperazine-1-carboxylate (500mg, 2.5mmol), isobutyric acid (263mg, 3.0mmol),1- ethyl 3- (3-dimethylaminopropyl) carbodiimide hydrochloride (957mg, 5.0mmol) and N- hydroxy-7-azabenzotriazole(507mg, 3.7mmol) It was dissolved in dichloromethane (10 mL), and the conditions under 0 C,to this solution was added dropwise N, N- diisopropylethylamine (1.3mL, 7.49mmol), chamber Temperature for10H, add water (10mL ¡Á 3), dried over anhydrous Na 2 SO 4 organic phase was dried, the solvent was removedconcentrate was separated by column chromatography (developing Degreasing agent: Petroleumether / EtOAc(v / v) = 2/1), to give 670mg white solid: (R) -4- isobutyryl-3- methyl-piperazine-1-carboxylic acid tert Butyl,yield: 99%., 163765-44-4

The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methyl chloroformate (230 1iL, 3 mmol) was slowly added at 0C to a solution of tert-butyl (25)-2-methylpiperazine-i-carboxylate (300 mg, 1.5 mmol) and triethylamine (835 1iL, 6 mmol) in methylene chloride (6 mL). After stirring at r.t. for 1 h, reaction mixture wascarefully quenched by addition of water and the desired product was extracted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate and solvent was evaporated under reduced pressure. Cmde material was purified by Biotage IsoleraTM to give (5)-i -tert-butyl 4-methyl 2-methylpiperazine- 1 ,4-dicarboxylate (378 mg, 97%). LCMS calculated for C7H15N202 (M+H-Boc) m/z = 159.1; found: 159.1., 169447-70-5

As the paragraph descriping shows that 169447-70-5 is playing an increasingly important role.

Reference£º
Patent; INCYTE CORPORATION; VECHORKIN, Oleg; LI, Yun-Long; SOKOLSKY, Alexander; WANG, Anlai; ZHU, Wenyu; ZHUO, Jincong; (185 pag.)WO2017/59251; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3022-15-9,Piperazine-2-carboxylic acid dihydrochloride,as a common compound, the synthetic route is as follows.

N: l,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid 25. To an aqueous solution of Na2C03 (40 g, 380 mmol, in 200 mL of water) at room temperature was added piperazine-2- carboxylic acid dihydro chloride (either an enantiomeric mixture or a specific stereoisomer) (24; 10 g, 50 mmol), followed by di-ieri-butyl dicarbonate (41 g, 183 mmol) in tetrahydrofuran (200 mL). The reaction mixture was stirred at room temperature for 20 hours and then the volatiles were removed under reduced pressure. The resulting mixture was then extracted with diethyl ether (100 mL). The aqueous layer was treated with 3.0 M HC1 until it was slightly acidic (pH = 4) and then extracted with ethyl acetate (150 mL). The organic layer was washed with brine, dried over anhy. Na2SC>4, filtered, and concentrated to afford 16 g of the title compound as a white solid.

3022-15-9, 3022-15-9 Piperazine-2-carboxylic acid dihydrochloride 2723757, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong; WO2012/171506; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-81-3,1-Methyl-4-(4-nitrobenzyl)piperazine,as a common compound, the synthetic route is as follows.

70261-81-3, To the 500 mL single neck flask was added 8.5 g (36.2 mmol) of crude I-a,FeO (OH) / C catalyst 2.0 g and 95% ethanol 100 mL,Heating reflux,A mixture of 25 mL of hydrazine hydrate and 20 mL of 95% ethanol was slowly added dropwise,TLC detects the disappearance of the starting material (methanol: chloroform = 1:15).The filter cake was washed twice with hot ethanol (30 mL x 2)The solvent was evaporated under reduced pressure to give a white solid,And dried in vacuo to give 6.7 g of (I-b) in a yield of 90.3%.Products without further purification, directly into the next step.

70261-81-3 1-Methyl-4-(4-nitrobenzyl)piperazine 677795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; China Pharmaceutical University; Lu Shuai; Wang Yue; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (27 pag.)CN107245073; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

639068-43-2,639068-43-2, tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 3 7-(2,6-dimethylpiperazin-1-yl)-2-ethyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one This example is prepared by following the same procedures as described in Example 1 above except substituting tert-butyl 3,5-dimethylpiperazine-1-carboxylate for Boc-piperazine. 1H NMR (400 MHz, DMSO-d6) delta ppm 5.32 (s, 1H), 4.03 (d, J=9.78 Hz, 2H), 2.92 (q, J=7.43 Hz, 2H), 2.53-2.66 (m, 2H), 2.18-2.30 (m, 2H), 1.23 (t, J=7.43 Hz, 3H), 0.94 (d, 6H); LCMS: (electrospray +ve), m/z 294.2 (MH)+; HPLC: tR=2.86 min, UV254=100percent. HRMS (ESI): m/z calcd for C13H20N5OS [M+H]+ 294.1383. found 294.1382.

As the paragraph descriping shows that 639068-43-2 is playing an increasingly important role.

Reference£º
Patent; The United States of America, as Represented by the Secretary, Department of Health and Human Serv; The Rockefeller University; Icahn School of Medicine at Mount Sinai; Coller, Barry S.; Thomas, Craig; Filizola, Marta; McCoy, Joshua; Huang, Wenwei; Shen, Min; (43 pag.)US2015/374697; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,314741-40-7

Step A: tert-Butyl (3S)-4-[2-( 4-cyano-3 -methoxyphenyl )-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate: A Pyrex vessel was charged with magnetic stirringbar, (0.350 g, 2.00 mmol) of2-methoxy-4-(oxiran-2-yl) benzonitrile, (0.457 g, 2.20 mmol) oftert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate, and 6 mL ofEtOH. Then it was introduced in the microwave reactor and irradiated at 150 C for 3 hr. Then the mixture wascooled to room temperature and the solvent was evaporated and the resulting residue waspurified by column chromatography (silica gel, 1- 20% dichloromethane/MeOH) which affordedthe title compound as a mixture of two diastereomers (1 :1). LC/MS: (IE, mlz) [(M + 1)- t-But =336.1.

314741-40-7 (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate 24820294, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; WO2013/28474; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

27469-60-9, 4,4-Difluorobenzhydrylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0103] Pivaloyl chloride (4.3 ml, 34.9 mmol) was added dropwise over 15 mins. at room temperature to a solution of [(S)-(+)-L-(TERT-BUTOXYCARBONYL)-2-] piperidinecarboxylic acid (8 g, 34.89 mmol) and triethylamine (12.5 ml, 90 mmol) in methylene chloride (150 ml). After stirring for 1.5 hrs. , a solution of [1-] [BIS- (4, 4′-DIFLUORO-BENZHYDRYL)] piperazine (9.51 g, 33 mmol) in methylene chloride (100 ml) was added over 1.5 hrs. and the reaction stirred at room temperature overnight. The reaction was washed with IN sodium hydroxide (2 x 100 ml) and brine and the organic layer dried over anhydrous sodium sulfate. After removal of solvent, the crude product was purified by chromatography (Silica gel) eluting with methylene chloride/ethyl acetate (7/3) to afford 16.5 g (quantitative yield) of the desired product.

27469-60-9, 27469-60-9 4,4-Difluorobenzhydrylpiperazine 152932, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Vertex Pharmaceuticals Incorporated; WO2004/31148; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, molecular formula is , belongs to piperazines compound. In a document, author is Manasa, Kesari Lakshmi, Formula: C10H20N2O2.

Design and synthesis of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone conjugates: study on their apoptosis inducing ability and tubulin polymerization inhibition

A library of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone derivatives were designed, synthesized and screened for their in vitro cytotoxic activity against BT-474, HeLa, MCF-7, NCI-H460 and HaCaT cells by employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among all the synthesized analogues, compound 10ec displayed the highest cytotoxicity with the IC50 value of 0.99 +/- 0.01 mu M towards BT-474 cancer cell line. The target compound (10ec) was also evaluated for its tubulin polymerization inhibition study. Detailed biological studies such as acridine orange/ethidium bromide (AO/EB), DAPI and annexin V-FITC/propidium iodide staining assay suggested that compound 10ec induced the apoptosis of BT-474 cells. The clonogenic assay revealed that the inhibition of colony formation in BT-474 cells by 10ec in concentration-dependent manner. Moreover, the flow cytometric analysis revealed that 10ec induced apoptosis via cell cycle arrest at the sub-G1 and G2/M phase. In silico studies of sulfonyl piperazine-integrated triazole conjugates unveil that they possess drug-like properties. According to the molecular modelling studies, compound 10ec binds to the colchicine binding site of the tubulin.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 147081-29-6, in my other articles. Formula: C10H20N2O2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics