Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

55121-99-8, Step 2.2: {4-[7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino]-phenyl}-(4-methyl-piperazin-1-yl)-methanone (2) In a sealed tube, 2-chloro-7-(3,5-difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidine (50.0 mg, 0.130 mmol), (4-Amino-phenyl)-(4-methyl-piperazin-1-yl)-methanone (42.1 mg, 0.182 mmol), KOtBu (21.1 mg, 0.182 mmol) and SK-CC02-A (12.5 mg, 0.020 mmol, Pd catalyst 2-(Dimethylaminomethyl)-ferrocen-1-yl-palladium(II)-chlorid Dinorbornylphosphin Complex, Fluka No. 44696) are suspended in THF (2 ml) under Ar. The reaction mixture is stirred at 80 C. for 1.5 h, cooled to rt, and then filtered through a Celite plug. The filtrate is concentrated under reduce pressure. The residue is purified by reverse phase prep-HPLC (Waters) to afford the title compound (2) as a white solid. HPLC: tR=0.89 min (Method A); MS-ES: (M+H)+=548.

As the paragraph descriping shows that 55121-99-8 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; US2009/203688; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

76003-29-7, 1-Boc-3-Oxopiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

76003-29-7, A mixture of 1 ,1 -dimethylethyl 3-oxo-1 -piperazinecarboxylate (0.489 g, 2.44 mmol), 3-bromothiophene (0.332 g, 2.036 mmol), copper(l) iodide (0.019 g, 0.102 mmol), potassium carbonate (0.563 g, 4.07 mmol) and trans-N,N-dimethyl-cyclohexane-1 ,2- diamine (0.029, 0.204 mmol) in 1 ,4-dioxane (5 mL) was heated at reflux under nitrogen for 24 hours. After cooling to room temperature, the reaction mixture was filtered through silica ge. eluting with DCM:EtOAc/1 :1 , The filtrate was concentrated and the residue was purified by silica gel chromatography to afford 1 ,1 -dimethylethyl 3-oxo-4-(3-thienyl)-1 – piperazinecarboxylate (0.305 g, 53%) as a white solid.

76003-29-7 1-Boc-3-Oxopiperazine 3157178, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John, G.; CHONG, Pek, Yoke; FANG, Jing; GARRIDO, Dulce, Maria; PEAT, Andrew, James; PRICE, Daniel, J.; SHOTWELL, John, Brad; TAI, Vincent; ZHANG, Huichang; WO2011/41713; (2011); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53788-49-1,tert-Butyl 4-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

53788-49-1, Example 2 Preparation of Intermediate 4-(4-chloro-pyrimidin-2-yl)-piperazine-1-carboxylic Acid Tert-Butyl Ester (I-2a): To a suspension of 2,4-dichloropyrimidine (1.00 g, 6.71 mmol) in 13.4 mL of toluene was added 4-methyl-piperazine-1-carboxylic acid tert-butyl ester (1.34 g, 6.71 mmol). The reaction was heated to reflux overnight, then cooled to room temperature and concentrated in vacuo. The residue was taken up in 20 mL of water and extracted with ethyl acetate (2*40 mL). The combined organic layers were washed with brine (25 mL), then dried over sodium sulfate, filtered, and concentrated in vacuo to an off-white solid. Flash column chromatography (silica gel, gradient elution from 5% ethyl acetate-hexanes to 20% ethyl acetate-hexanes) yielded 1.14 g of the title compound (I-2a). 1H NMR (400 MHz, CDCl3) delta 8.15 (d, 1H); 6.52 (d, 1H); 3.80 (m, 4H); 3.48 (m, 4H); 1.47 (s, 9H). MS (APCI+) Calc: 298, Found: 299.1 (M+1).

The synthetic route of 53788-49-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chiang, Phoebe; Novomisle, William A.; Welch JR., Willard M.; US2003/105106; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-38-0,2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.

5521-38-0, General procedure: The substituted nitro compound 11 (1 equiv in a mixture of EtOH-H2O, 95:5, 20mL) was treated with 10% Pd-carbon (5% w/w). The reaction was subjected to hydrogenation under hydrogen gas at room temperature and the reaction was monitored by TLC. After completion of the reaction, the mixture was filtered through a Celite bed and concentrated in a vacuum to afford product 12.

5521-38-0 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol 2763936, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Hou, Yunlei; Zhu, Liangyu; Li, Zhiwei; Shen, Qi; Xu, Qiaoling; Li, Wei; Liu, Yajing; Gong, Ping; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 690 – 709;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70261-82-4, General procedure: 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzoic acid (8.95g, 31mmol) was stirred in a solvent of 58 dimethyl formamide (25mL).The reaction solution was added with 59 HATU (12.98g, 34.1mmol), 72 DIPEA (10.26mL, 62.0mmol) and 104 3-(trifluoromethyl)aniline (5g, 31mmol), followed by stirring for about 8h at room temperature. The reaction mixture was diluted with ethyl acetate and washed with a saturated aqueous sodium bicarbonate solution and saline. The organic layer thus obtained was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting mixture was concentrated to give the crude 132 product, which was purified by silica gel column chromatography.

The synthetic route of 70261-82-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Qi; Dai, Yang; Ji, Yinchun; Shi, Huanyu; Guo, Zuhao; Chen, Danqi; Chen, Yuelei; Peng, Xia; Gao, Yinglei; Wang, Xin; Chen, Lin; Jiang, Yuchen; Geng, Meiyu; Shen, Jingkang; Ai, Jing; Xiong, Bing; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 671 – 689;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

692058-21-2,692058-21-2, 1-Boc-4-(2,2,2-trifluoroethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(lH-Indazol-4-yl)-4-mophiholin-4-yl-6-[4-(2,2,2-trifluoro-ethyl’)-piperazin-l- ylmethyl]-thieno[3,2-dlpyrimidine (90).Prepared via 2-Chloro-4-morpholin-4-yl-6-[4-(2,2,2-trifluoro-ethyl)- piperazin-l-ylmethyl]-thieno[3,2-d]pyrimidine, prepared from l-(2,2,2-trifluoro- ethyl)-piperazine.Amine preparation: to BOC-piperazine (4g) in DCM (4OmL) was added trifluoroacetic anhydride (6.06mL) and triethylamine (3.29mL). After stirring overnight the reaction mixture was diluted with diluted with DCM, washed with sodium bicarbonate solution, dried (MgSO4) and the solvent removed in vacuo to yield 4-(2,2,2-trifluoro-acetyl)-piperazine-l-carboxylic acid tert-butyl ester (6.06g).To 4-(2,2,2-trifluoro-acetyl)-piperazine-l-carboxylic acid tert-butyl ester (6.06g) in dry THF (6OmL) was added borane dimethyl sulfide complex (4.5ml) and EPO the reaction mixture was heated to reflux. After 2 h the reaction mixture was cooled to O0C and MeOH was carefully added, followed by water. The organics were extracted into ethyl acetate, dried (MgSO4) and the solvent removed in vacuo to yield 4-(2,2,2-trifluoro-ethyl)-piperazine-l-carboxylic acid tert-butyl ester (4.46g). Treatment with HCl in DCM/MeOH yielded the desired compound, which was isolated as the hydrochloride salt.1H NMR (400MHz, CDCl3): 2.56 (4H, m), 2.69 (4H, m), 2.93 (2H, q), 3.79 (2H, s), 3.85 (4H, m), 4.02 (4H, m), 7.23 (IH, s), 7.44 (IH, d), 7.52 (IH, d), 8.21 (IH, d), 8.94 (IH, s).

As the paragraph descriping shows that 692058-21-2 is playing an increasingly important role.

Reference£º
Patent; PIRAMED LIMITED; WO2006/46031; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.,70261-82-4

General procedure: To a solution of 2 (0.3 g, 0.68 mmol), HATU (0.26 g, 0.68 mmol)and DIPEA (0.24 mL, 1.36 mmol) in dry CH2Cl2 (10 mL) were stirred for20 min at room temperature, the substituted anilines or benzylamines (0.68 mmol) was added slowly. The reaction mixture was stirred for 5 hat room temperature. The resulting mixture was diluted by H2O(10 mL), and extracted by EtOAc (3¡Á10 mL). The combined organiclayers were washed with brine and dried over anhydrous MgSO4, filtered,and concentrated under reduced pressure. The residue was recrystallized from the solution of MeOH-H2O (1:1) to give the amides3a-n in good yields of 80.2-88.5%.

As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.

Reference£º
Article; Qiu, Yinda; Xiao, Zhongxiang; Wang, Yanyan; Zhang, Dingfang; Zhang, Wenxin; Wang, Guangbao; Chen, Wenbin; Liang, Guang; Li, Xiaokun; Zhang, Yali; Liu, Zhiguo; Bioorganic and Medicinal Chemistry; vol. 27; 20; (2019);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.

A suspension of />-iodo-aniline (918mg, 4.8mmol), 3-oxo-piperazine-l-carboxylic acid tert-butyl ester (960mg, 4.2mmol) (7R,2R)-cyclohexane-l,2-diamine (0.05mL, 0.42mmol), copper (I) iodide (14.9mg,0.0042mmol) and K2CO3 (1.19g, 2.04mmol) in dioxane (4mL), is purged with nitrogen for 5 min in a reaction tube. The tube is sealed and the reaction mixture is heated at 1190C for 15 hours. After cooling to room temperature, the reaction mixture is filtered through a silica cartridge washing with ethyl acetate (4OmL). The filtrate is concentrated in vacuo to afford the title compound as a brown liquid (1.06g, 87%). LCMS: Rt 0.88min (91%)., 76003-29-7

The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GALAPAGOS N.V.; WO2007/138072; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 77 (2-Cyclohex-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone Following procedure E, (2-Cyclohex-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone is prepared from 2-cyclohex-1-enyl-5-methanesulfonyl-benzoic acid (Example G) 1-(4-trifluoromethyl-phenyl)-piperazine: colourless solid, MS (ISP): 493.2 (M+H+).

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Alberati-Giani, Daniela; Jolidon, Synese; Narquizian, Robert; Nettekoven, Matthias Heinrich; Norcross, Roger David; Pinard, Emmanuel; Stalder, Henri; US2005/59668; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 6a-p (1.0mmol) and K2CO3 in acetone (10mL) was added 6-(bromomethyl)-5-chloro-2-(thiophen-2-yl)-7,8-dihydroquinoline 5 (1mmol) at room temperature under stirring for 12h (monitored by TLC), After completion the reaction mixture was evaporated and extracted with ethylacetate and water, the organic layer was separated dried over anhydrous Na2SO4. and evaporated under vacuum. The resulting crude product was purified by silica gel column chromatography by using EtOAc/hexane as eluent.

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Marvadi, Sandeep Kumar; Krishna, Vagolu Siva; Sriram, Dharmarajan; Kantevari, Srinivas; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 171 – 178;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics