Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.

17.6 g of N- (4-aminophenyl) -N, 4-dimethyl-1-piperazineacetamide was addedMethyl N-acetyl-3- [methoxy (phenyl) methylene] -2-oxoindoline-6-carboxylate19g was added to DMF15 mL and 75 mL of methanol,Reflux reaction 1.5h or more.The reaction solution was added with 9.4 g of N-methylpiperazine,Reaction 1h,Cooling,Filtration to 5 C.Nidanibu products25.1g.250 ml of nidadibugar methanol was recrystallized,The purity of purified nidadipine was 99.58%

262368-30-9, 262368-30-9 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 21927707, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Ruiyang Pharmaceutical Co., Ltd.; Miao Dezu; Hu Qingwen; Cong Chao; Wang Hongguang; Yu Zhibo; (9 pag.)CN106748960; (2017); A;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Example 7 tert-Butyl 4-(4-(6-bromo-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H- imidazo[4,5-jb]pyridin-2-yl)phenyl)piperazine-1-carboxylateTo a mixture of 5-bromo-4-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3- nitropyridin-2-amine (0.90 g, 0.22 mmol, 1 eq), EtOH (3.8 mL) and DMF (0.52 mL), tert-butyl-4-(4-formylphenyl)tetrahydro-1-(2H)pyrazine carboxylate (0.069 g, 0.24 mmol, 1.1 eq) was added followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.66 mL, 0.66 mmol). The reaction mixture was heated at 85 C for 24 h, then allowed to cool to room temperature and diluted with DCM and a few drops of aqueous NH3 until complete dissolution was observed. This solution was deposited on two preparative silica TLC plates and eluted with DCM/MeOH (v/v; 94:6). The title compound was obtained after trituration with diethyl ether as an off-white solid (0.025 g, 15%); 1H-NMR (500Mz, DMSO-Cf6): delta 1.42 (s, 9H, C(CH3J3), 2.59-2.67 (m, 4H, piperazine N(CH2)2), 3.23-3.29 (m, 4H, piperazine N(CH2)2), 3.43-3.52 (m, 4H, piperazine N(CH2)2), 3.60-3.70 (m, 6H), 7.07 (d, J = 9.0 Hz, 2H, ArH, C6H4), 7.70- 7.75 (m, 1 H, py 4-H), 8.13 (d, J = 9.0 Hz, 2H, ArH, C6H4), 8.18 (s, 1 H, imidazo[4,5- jb]pyridine 5-H), 8.45-8.48 (m, 1 H, py 2-H ), 8.50 (d, 1 H, J = 3.0 Hz, py 6-H)1 13.28 (brs, 1 H, imidazo[4,5-iotab]pyridine N-H); LC (Method B) – MS (ESI, m/z) 4.59 min – 651/653 [(M+H)+, Br isotopic pattern]. ESI-HRMS: Found: 651.2200, calculated for C3IH37FBrN8O2 (M+H)+: 651.2201.

197638-83-8, The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
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Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2,3-dichloro-1,4-naphthoquinone (0.37 g, 1.60 mmol) and 4-(4- methylpiperazin-1-yl)aniline (0.3 g, 1.46 mmol) was dissolved in EtOH (5 ml). The reaction was stirred and refluxed for 16 h. The residue was purified by flash column over silica gel (dichloromethane: methanol= 29: 1) to afford 77 (0.10 g, 17.30 %).1H NMR (300 MHz, CDCl3): delta 1.15 (t, J = 6.0 Hz, 3H), 2.48 (t, J= 6.0 Hz, 2H), 2.63 (t, J= 6.0 Hz, 4H), 3.26 (t, J= 6.0 Hz, 4H), 6.89 (d, J= 9.0 Hz, 2H), 7.03 (d, J= 8.7 Hz, 2H), 7.65-7.70 (m, 2H), 7.77-7.79 (m, 1H), 8.10- 8.13 (m, 1H), 8.18-8.20 (m, 1H).

115619-01-7, 115619-01-7 4-(4-Ethylpiperazin-1-yl)phenylamine 936738, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-ping; PAN, Shiow-lin; (44 pag.)WO2017/20030; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.192130-34-0,tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

In THF (50 mL) were dissolved 4-((3-chloro-4-methoxybenzyl)amino)-2-(5-azaspiro [2.4]heptan-5-yl)pyrimidine-5-carboxylic acid (1.0 g, 2.58 mmol), tert-butyl 4-(2-aminoethyl)piperazine-1-carboxylate (709 mg, 3.1 mmol) and HATU (1.18 g, 3.09 mmol). DIEA (1 mL, 5.16mmol) was added. The reaction was conducted at ambient temperature for 8 h. The solvent was removed, and DCM (50 mL) was added for resolution. The DCM phase was washed with water (50 mLx3). The organic phase was dried, concentrated and purified by silica gel column chromatography (DCM / methanol = 150/1) to give tert-butyl 4-(2-(4-((3-chloro-4-methoxybenzyl)amino)-2-(5-azaspiro[2.4]heptan-5-yl) pyrimidine-5-formamido)ethyl)piperazine-1-carboxylate as a white solid (910 mg, 59 percent yield)., 192130-34-0

As the paragraph descriping shows that 192130-34-0 is playing an increasingly important role.

Reference£º
Patent; Xuanzhu Pharma Co., Ltd.; WU, Frank; WANG, Aichen; EP2886540; (2015); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-39-4,(S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

(d) [2S]-4-t-Butoxycarbonyl-2-hydroxymethylpiperazine A solution of Example 1(c) in dry tetrahydrofuran (40 ml) at 0 C. was treated with lithium aluminum hydride (0.50 g) and the mixture was stirred at 0 C. for 1.5 hours. The cooled solution was treated dropwise with a solution of 2M sodium hydroxide until a white precipitate had formed. Dichloromethane and anhydrous sodium sulfate were added and the solution was filtered and evaporated to give a pale yellow oil (3.0 g). MS (+ve ion electrospray) m/z 217 (MH+).

314741-39-4, The synthetic route of 314741-39-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SmithKline Beecham Corporation and SmithKline Beecham p.l.c.; US2003/203917; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

4-[(4-methyl-1-piperidinyl) methyl] -3- (trifluoromethyl) -benzeneamine (360 mg, 1.33 mmol),N, N-Diisopropylethylamine (273 muL, 1.60 mmol),Dissolve DMAP (1.2 mg, 0.01 mmol) in THF (5.0 mL),3,5-Dibromo-4-methyl- benzoyl chloride (500 mg, 1.6 mmol) was added and stirred at room temperature for 2 hours.Add water and extract with ethyl acetate,It concentrated under reduced pressure with an evaporator.Silica gel column chromatography of the obtained residueThe compound 3 was purified by (chloroform: methanol = 10: 1).(540.0 mg, 0.98 mmol, 73.8%, pale yellow solid) were obtained., 694499-26-8

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kyoto University; Arkray Corporation; Saji, Hideo; Kimura, Hiroyuki; Matsuda, Hirokazu; Nakanishi, Shuichi; (27 pag.)JP2019/64986; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 0.342 g of 4-(4-ethylpiperazine-1-yl)phenylamine (4d;0.00167 mol) in a dry round bottom flask was added 10 mL 98%ethanol. Then 0.265 g of ethyl 2,4-dioxo-6-methylcyclohexanecarboxylate(E164; previously synthesized in our lab)23 was added. The reactionmixture was refluxed for about 6 h and a total of 5 mL additionalethanol was added. The reaction was monitored by thin layer chromatography(dichloromethane: methanol 85/15). After 6 h, the heatwas turned off and reaction continued to stir at room temperatureovernight. After reaction was completed, the reaction was adsorbed ona silica gel and purified by automated flash chromatography (dichloromethane:methanol 75/25) to yield a yellow semi-solid (54)(0.154 g, 30%).1H NMR (300 MHz, d-CDCl3): delta (ppm) 1.099-1.176 (t,3H), 1.276-1.355 (t, 3H), 1.951 (d, 3H), 2.392-2.547 (q, 2H),2.498-2.641 (t, 4H), 3.211-3.244 (t, 4H), 4.239-4.287 (q, 2H), 5.403(s, 1H), 6.873-6.903 (d, 2H), 7.039-7.069 (d, 2H). HRMS (ESI): m/z,Calcd. for C22H31N3O3 [M+H]+: 386.2433, found 386.2564.

115619-01-7, As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.

Reference£º
Article; Ghoneim, Ola M.; Bill, Ashley; Dhuguru, Jyothi; Szollosi, Doreen E.; Edafiogho, Ivan O.; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 3890 – 3898;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.928025-56-3,(S)-tert-Butyl 3-ethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

[Step 1] tert-Butyl (3S)-3-ethyl-4-methylpiperazine-1-carboxylate To a solution of tert-butyl (3S)-3-ethyl piperazine-1-carboxylate (2.0 g) in dichloromethane (20 ml), a 37% aqueous solution of formalin (3.4 ml) was added at room temperature. The reaction solution was ice-cooled and sodium triacetoxyborohydride (3.0 g) was added thereto. After that, the temperature of the reaction solution was gradually returned to room temperature and the reaction solution was stirred for 4 hours. To the reaction solution, a 1 N aqueous solution of sodium hydroxide (50 ml) was added. The reaction solution was stirred and dichloromethane and water were added, and the layers were separated. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by silica gel column chromatography (0-10% methanol/dichloromethane) to obtain the title compound (2.14 g) as an oily substance. 1H-NMR (CDCl3) delta: 4.04-3.69 (2H, m), 3.05 (1H, t, J=11.0 Hz), 2.90-2.53 (2H, m), 2.29 (3H, s), 2.24-2.13 (1H, m), 1.94-1.85 (1H, m), 1.74-1.62 (1H, m), 1.49-1.30 (10H, m), 0.92 (3H, t, J=7.9 Hz). MS (ESI/APCI) m/z: 229 [M+H]+

928025-56-3, 928025-56-3 (S)-tert-Butyl 3-ethylpiperazine-1-carboxylate 24820542, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; Ota, Masahiro; Inoue, Hidekazu; Kawai, Junya; Ohki, Hitoshi; Toki, Tadashi; (25 pag.)US2019/284198; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of tert-butyl 3-(2-chloropyrimidin-4-yl)-5-fluoro-lH-indole-l- carboxylate (400 mg, 1.15 mmol) in dioxane (1 mL), were added cesium carbonate (2.25 g, 6.90 mmol), XANTPetaOS (39.8 mg, 0.069 mmol), l-(4-Amino-phenyl)-piperazine-4-carboxylic acid tert-butyl ester (604 mg, 1.72 mmol), and bis(dibenzylideneacetone)palladium (0) (21.1 mg, 0.023 mmol). The reaction mixture vial was capped and heated to 1000C for 12 hr. The reaction mixture was cooled, diluted with H2O, and extracted with EtOAc. The organic layer was collected, dried with MgSO4, filtered, and concentrated under reduced pressure. Column chromatography (100 % Hex to 100% EtOAc produced tert-butyl 3-[2-({4-[4-(tert- butoxycarbonyl)piperazin- 1 -yl]phenyl} amino)pyrimidin-4-yl]-5-fluoro- li/-indole- 1 -carboxylate. LRMS m/z (M+H) Calcd: 589.3, found: 589.3.

170911-92-9, The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK & CO., INC.; WO2007/149427; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Octanoic acid (62 ??, 0.39 mmol), HOBt (58 mg, 0.43 mmol), TBTU (138 mg, 0.43 mmol), anhydrous triethylamine (87 ??, 0.63 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 63 % yield. H NMR (300 MHz, CDCI3) ? 7.48 (d, 2H), 6.91 (d, 2H), 3.77 (t, 2H), 3.62 (t, 2H), 3.24-3.30 (m, 4H), 2.34 (t, 2H), 1.61-1.71 (m, 2H), 1 .29-1.34 (m, 8H), 0.86-0.91 (m, 3H). MS (+ESI) calcd for C19 H27 F3 N2 O m/z: [M + H]+ , 357.2148; found 357.2136 [Diff(ppm) = -3.36].

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics