Tag: M.W:200-300

169447-70-5,169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a solution containing 5-fluoro-2-methyl-3-nitrobenzene (D24, 10 g) and (S)-2-methylpiperazine-1-carboxylic acid tert-butyl ester (12.03 g) in DCM (120 mL) was added acetic acid (3.28 g) dropwise. The mixture was stirred at room temperature for one hour. Sodium triacetoxyborohydride (23.15 g) was added to the ice bath. The mixture was stirred overnight at room temperature,The reaction was stopped using saturated NaHC03 solution. The organic layer was dehydrated with anhydrous Na2SO4, filtered, and concentrated in vacuo to give the title compound (22.17 g) as a slurry.

The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; LEI, HUI; MA, XIN; REN, FENG; LIN, XICHEN; MARQUIS, ROBERT W., JR; (139 pag.)TW2017/14884; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.655225-01-7,tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

tert-Butyl 4-(2-((4-chloro-5-iodo-2-methoxyphenyl)amino)ethyl)piperazine-1-carboxylate To a stirred solution of 4-chloro-5-iodo-2-methoxyaniline (968 mg, 3.42 mmol) in anhydrous THF (20 mL) at 0¡ã C., NaH (60percent in mineral oil, 205.2 mg, 5.13 mmol) was added and the resulting mixture was stirred at reflux under nitrogen for 1 h. To this mixture, tert-butyl-4-(2-bromoethyl)piperazine-1-carboxylate (500 mg, 1.71 mmol) was added and the resulting mixture was stirred at room temperature for 15 h. The mixture was concentrated in vacuo and the residue was partitioned between ethyl acetate and brine. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (10-30percent ethyl acetate/petroleum ether) to afford the desired product (180 mg, 21percent yield) as a solid., 655225-01-7

655225-01-7 tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate 15946441, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao; US2014/288045; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129799-15-1,Methyl 1-Boc-piperazine-2-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of Methyl 1-Boc-piperazine-2-carboxylate (1.837 g, 7.52 mmol), bromobenzene (0.728 ml, 6.84 mmol), Pd2(dba)3 (0.063 g, 0.068 mmol), DavePhos (0.032 g, 0.082 mmol) and Cs2CO3 (3.34 g, 10.25 mmol) in1,4-Dioxane (15 ml, solvent was degassed for 40 min before using) with molecular sieves (4 A) was heated to 85 C and stirred under argon for 24 hrs. After cooling to room temperature, the mixture was filtered through a plug of celite and concentrated to a yellow oil which was purified via flash chromatography (5%EtOAc/Hexanes) to give a yellow viscous liquid Methyl1-Boc-4-phenylpiperazine-2-carboxylate (2 g, 91 % yield)., 129799-15-1

129799-15-1 Methyl 1-Boc-piperazine-2-carboxylate 2756818, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Zhao, Huanyu; Prosser, Anthony R.; Liotta, Dennis C.; Wilson, Lawrence J.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 21; (2015); p. 4950 – 4955;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-70-5,(S)-tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Add to the reaction flask6-bromo-3-aldehyde pyridine (2.43 g, 13 mmol) and(S) -2-methylpiperazine-1-carboxylic acid tert-butyl ester(2) (3.4 g, 17 mmol) and dichloromethane (30 mL)Sodium triacetoxyborohydride (4.3 g, 20 mmol) was added in portions.The mixture was stirred at room temperature for 12 hours, water (10 mL) was added,Dichloromethane extraction (20 mL x 3).The organic phase was washed with saturated Na2CO3 solution (40 mL)Saturated brine (40 mL), dried over anhydrous sodium sulfate, filtered,Concentrated under reduced pressure. The residue was purified by column chromatography (DCM / MeOH = 20: 1)The resulting residue was purified to give the title compound (2.2 g, white solid)Yield 45%., 169447-70-5

As the paragraph descriping shows that 169447-70-5 is playing an increasingly important role.

Reference£º
Patent; Gan & Lee Pharmaceuticals; Liu, Wenjian; Yin, Lei; Li, Heng; (94 pag.)CN106608879; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of (3 ?)-3-methyl-6-(2- methyloxiran-2-yl)-3,4-dihydro-lH-isochromen-l-one (598 mg, 2.74 mmol) and tert-butyl (35)- 3 -(hydroxymethyl)piperazine-l -carboxylate (770 mg, 3.56 mmol dissolved in EtOH (15mL) was heated in a sealed tube to 110C for 14 hours. The reaction was cooled and concentrated to give crude product which was purified via MPLC (30-80%) EtOAc/Hexane) to give the title compound as a mixture of diastereomers: LC-MS: (M+l)+ 435;, 314741-40-7

The synthetic route of 314741-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PIO, Barbara; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; WALSH, Shawn; WO2013/90271; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

118753-66-5, tert-Butyl 4-aminopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 6-chloro-2-naphthoic acid (0.100 g, 0.48 mmol, 1.0 equiv) in DMF (05 mL) was added HATU (0.368 g, 0.97 mmol, 2.0 equiv) at RT and stirred for 10 minutes. Then tert-butyl 4-aminopiperazine- 1 -carboxylale (0.097 g, 0.48 mmol, 1.0 equiv) was added followed by the addition of DIPEA (0.2 mL, 1.45 mmol, 3.0 equiv). The resulting reaction mixture was allowed to stir at RT for overnight. Product formation was confirmed by LCMS. the reaction mixture was diluted with water (50 mL) and extracted with EtOAc (50 mL c 2). The combined organic layer was washed with water (30mL), brine solution (30 mL >< 2), dried over anhydrous sodium sulfate and concentrated under reduced pressure, to obtain tert-butyl 4~(6- chloro-2-naphtliamido)piperazine-l -carboxylale (0.160 g, 85 % Yield) as an off-white solid. LCMS 390.2 [M+H]+: NMR (400MHz, DMSO-de) d 9.69 (s, 1 H), 8.39 (s, 1 H), 8.18 - 8.03 (m, 2 H), 7.97 (t, ./= 9.0 Hz, 1 H), 7.90 (d, ./= 8.8 Hz, 1 H), 7.60 (d, J 7.0 Hz, 2 H), 3 44 (br. s., 3 H), 2.94 - 2.84 (m, 4 H), 1 .53 - 1.32 (m, 9 H)., 118753-66-5

As the paragraph descriping shows that 118753-66-5 is playing an increasingly important role.

Reference£º
Patent; PRAXIS BIOTECH LLC; DELGADO OYARZO, Luz Marina; URETA DIAZ, Gonzalo Andres; PUJALA, Brahmam; PANPATIL, Dayanand; BERNALES, Sebastian; CHAKRAVARTY, Sarvajit; (0 pag.)WO2019/236710; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

259808-67-8, 1-Boc-3,3-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 190a tert-Butyl 3,3-Dimethyl-4-(6-nitropyridin-3-yl)piperazine-1-carboxylate 190a A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer and a reflux condenser was charged with 5-bromo-2-nitropyridine (5.6 g, 28.0 mmol), tert-butyl 3,3-dimethyl-4-piperazine-1-carboxylate (3.0 g, 14.0 mmol), cesium carbonate (9.1 g, 28 mmol), and 1,4-dioxane (50 mL). After bubbling nitrogen through the resulting solution for 30 min, Binap (870 mg, 1.4 mmol) and tris(dibenzylideneacetone)-dipalladium(0) (1.2 g, 1.4 mmol) were added. The reaction mixture was subjected to three cycles of vacuum/argon flush and stirred at 120 C for 24 h. After this time the reaction was cooled to room temperature, filtered and the filtrate was partitioned between ethyl acetate (200 mL) and water (50 mL). The aqueous layer was separated and extracted with ethyl acetate (3 * 50 mL). The combined organic layers were washed with brine (50 mL) and dried over sodium sulfate. The drying agent was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by silica-gel column chromatography eluting with 5:1 petroleum ether/ethyl acetate to afford 190a (1.27 g, 27%). LCMS: [M+H]+ 337.2.

259808-67-8, As the paragraph descriping shows that 259808-67-8 is playing an increasingly important role.

Reference£º
Patent; F.Hoffmann-La Roche AG; CRAWFORD, James John; ORTWINE, Daniel Fred; WEI, BinQing; YOUNG, Wendy B.; EP2773638; (2015); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

120737-78-2, Under an argon atmosphere,tert-butyl 2-methylpiperazine-1-carboxylate(1.28 g, 6.40 mmol), 1-bromo-3-fluoro-4-iodobenzene (2.31 g, 7.68 mmol), copper iodide (122 mg, 0.640 mmol)Triopotassium phosphate (4.08 g, 25.6 mmol),Ethylene glycol (716 muL, 12.8 mmol) inA solution of 1-butanol (6 mL) was stirred at 100 C. for 16 h.Water was added to the reaction solution, and the mixture was extracted with ethyl acetate.The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, filtered, and the solvent was distilled off. The resulting residue was purified by silica gel column chromatography (hexane / ethyl acetate) to give the title compound (767 mg, 32%).Clear oil

120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Yakult Honsha Corporation; Abe, Atsuhiro; Mae, Satoyuki; Yamazaki, Ryuta; Sawaguchi, Yuichi; Sugimoto, Takuya; Sasai, Toshio; Nishiyama, Hiroyuki; Nagaoka, Masato; Matsuzaki, Ken; Kurita, Akinobu; Matsui, Makoto; Shingeyama, Takahide; (208 pag.)JP6378918; (2018); B2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21091-98-5,(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone,as a common compound, the synthetic route is as follows.

To 1.67 g (6.70 mmol) of the product prepared in step 2.1 partially dissolved in 50 mL of methanol are added, under an inert atmosphere, 71 mg of 10% palladium-on-charcoal. The reaction mixture is stirred at room temperature under 3 bar of hydrogen for 2 hours 30 minutes and then filtered through Celite. After evaporating to dryness, 1.5 g of the expected product are obtained in the form of an orange oil, which is used as obtained in the following step. Quantitative yield., 21091-98-5

21091-98-5 (4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone 716396, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SANOFI; US2012/277220; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8,694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 90.1 : 7-(6-Chloro-pyrimidi?-4-yloxy)-isoquinoli?e-4-carboxylic acid [4-(4-methyl- piperazi?-1-ylmethyl)-3-trifluoromethyl-phenvn-amide; A mixture of 1.95 g (5.5 mMol) 7-(6-chloro-pyrimidin-4-yloxy)-isoquinoline-4-carboxylic acid (Step 93.2), 1.5 g (5.49 mMol) 4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl- phenylamine and 6.42 ml (46.2 mMol) triethylamine in 50 ml dry DMF is heated under an argon atmosphere at 50 C. A solution of 5.4 ml (8.2 mMol) propylphosphonic anhydride is then added. After 2 h, the reaction mixture is poured onto an aqueous solution of NaHCO3 and stirred at 0 0C for 1 h. The suspension is then filtered (hyflo) and the solid residue is dissolved in CH2CI2/MeOH 5:1. The solvent is evaporated off under reduced pressure to afford a crude product which is purified by reversed phase MPLC (Bchi system), yielding, after neutralisation with saturated aqueous NaHCO3, the title compound as a orange solid.

694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2006/59234; (2006); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics