Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3022-15-9,Piperazine-2-carboxylic acid dihydrochloride,as a common compound, the synthetic route is as follows.

Intermediate 1 Preparation of N,N-Bis-Cbz-2-carboxypiperazine To a mixture of 2-carboxypiperazine dihydrochloride (5.08 g, 25 mmol), 1,3-dioxolane (45 ML), and water (30 ML) at 0 C. was added 50% aqueous sodium hydroxide (NaOH) (6 ML) dropwise.benzyl chloroformate (BzCOCl) (7.8 ML, 55 mmol) then was added to the resulting mixture dropwise in alternating portions with 50% aqueous sodium hydroxide (4 ML) in order to maintain a PH between 8-11.The temperature of the reaction was maintained below 15 C. during a 30-minute addition period.The resulting biphasic mixture was stirred at 0 C. for an additional 30 minutes, after which the reaction was acidified to PH 2 with 2 N hydrochloric acid (HCl), then diluted with ethyl acetate (100 ML).The organic layer was washed with brine (2*10 ML), and the aqueous phase was reextracted with ethyl acetate (20 ML).The combined organic extracts then were dried over sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure.The residue was purified by flash column chromatography, eluding with methylene chloride/methanol (40:1 to 10:1), to provide the bis-protected piperazine as a white solid (7.0 g, 70%): TLC Rf (10:1 methylene chloride/methanol)=0.55; 1H NMR (300 MHz, DMSO-d6) delta7.40-7.20 (m, 10H), 5.01-5.27 (m, 4H), 4.92-4.60 (m, 2H), 4.20-3.81 (m, 2H), 3.40-2.82 (m, 3H)., 3022-15-9

The synthetic route of 3022-15-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Orme, Mark W; Sawyer, Jason Scott; US2003/225093; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (R) -tert-butyl3-methylpiperazine-1-carboxylate (500 mg, 2.5 mmol) and triethylamine (700 mg,6.3 mmol) in DCM (10 mL) was added methylsulfamoyl chloride (0.39 mL,4.99 mmol) at 0 dropwise. The mixture was stirred at rt for 8 h, and washedwith water (10 mL ¡Á 3) . The combined organic layer were dried over anhydrousNa2SO4 and concentrated. The residue was purified bysilica gel chromatography eluted with Petroleum ether/EtOAc (v/v) 2/1 to give(R) -tert-butyl 3-methyl-4- (methylsulfonyl) piperazine-1-carboxylate as awhite solid (444 mg, 63) . 1H NMR (400 MHz, CDCl3): delta ppm 4.04-4.24 (m, 2H) , 3.82-3.98 (m, 1H) , 3.54 (d, J 12.7 Hz, 1H) ,3.14-3.21 (m, 1H) , 3.04-3.18 (m, 1H) , 2.87-3.00 (m, 1H) , 2.88 (s, 3H) , 1.48(s, 9H) , 1.26 (d, J 6.8 Hz, 3H) and MS-ESI: m/z 223.15 [M-55] +., 163765-44-4

The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
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502649-29-8, 1-Boc-3-Benzylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

502649-29-8, To a solution of tert-butyl 3-benzylpiperazine-1-carboxylate (300 mg, 1.09 mmol) in DCM (10 mL) was added TEA (330 mg, 0.45 mL, 3.26 mmol) and CbzCl (278 mg, 0.23 mL, 1.63 mmol). After the reaction mixture was then stirred at rt for 2 hrs. The mixture was diluted with water, and extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4 and concentrated to give crude product which was purified by column chromatography to give a product (368 mg) as an oil. The oil was dissolved in DCM (2 mL), then TFA (124 mg, 84 muL, 1.09 mmol) was added. The reaction mixture was stirred at rt overnight, then concentrated to give a crude compound 77a (385 mg) as an oil which is directly used in next step. MS: calc?d 311 (MH+), measured 311 (MH+).

As the paragraph descriping shows that 502649-29-8 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; LIU, Haixia; SHEN, Hong; ZHU, Wei; HU, Taishan; ZHANG, Zhiwei; DEY, Fabian; (91 pag.)WO2020/52738; (2020); A1;,
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55121-99-8,55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 257Preparation of 1-{4-[3-(1-methylethyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]phenyl}-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea. To a stirred solution of triphosgene (35 mg, 0.12 mmol) in CH2Cl2 (4 mL) was added 4-(3-isopropyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)aniline (50 mg, 0.14 mmol) at 25 C. The reaction mixture was stirred for 15 min and NEt3 (20 muL, 0.14 mmol) was added. Stirring was continued for 1 h and (4-aminophenyl)(4-methylpiperazin-1-yl)methanone (103 mg, 0.43 mmol) and NEt3 (200 muL, 1.4 mmol) were added and the reaction mixture was stirred for additional 1 hr. The solvents were removed in a N2 stream and the crude mixture was purified by semi-prep-HPLC (NH3-method) to give 1-{4-[3-(1-methylethyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]phenyl}-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea (43 mg, 39% yield), MS (ESI) m/z 585.4.

55121-99-8 (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone 231408, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Wyeth; US2009/181963; (2009); A1;,
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197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,6-dichloropyridine (1.0 equiv.) in THF (0.3 M) at -78 C under an atmosphere of nitrogen was added LDA (2M in heptanes, 1.7 equiv.) dropwise via an addition funnel. Upon stirring for 30 min at -78 C, tert-butyl 4-(4-formylphenyl)piperazine-1-carboxylate in THF (0.9M, 1.3 equiv.) was added dropwise. The reaction was stirred for 30 min, then quenched by the addition of sat. NH4Cl. The mixture was extracted with ethyl acetate and the organics were washed with brine, dried with magnesium sulfate, filtered, and concentrated. The crude material was dissolved in dry toluene (0.17M) and MnO2 (~ 85%, 20 equiv.) was added to the reaction. The solution was heated to reflux for 2 hours. The reaction was filtered through a pad of Celite while hot, and hot ethyl acetate was used to rinse the Celite pad. The filtrate was evaporated under vacuo and the material was purified via silica gel column chromatography eluting with ethyl acetate and hexanes (1:3) to afford the desired product in 51% yield for the two steps. LC/MS: 436.1/438.1, Rt: 3.53 min. H-NMR (300 MHz, CdCl3): 7.71-7.65 (m, 3H), 7.38 (d, J = 7.8, 1H), 6.84 (d, J=9, 2H), 3.61-3.58 (m, 4H), 3.43-3.93 (m, 4H), 1.49 (s, 9H).

197638-83-8, 197638-83-8 1-Boc-4-(4-Formylphenyl)piperazine 2795509, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Nishiguchi, Gisele A.; Atallah, Gordana; Bellamacina, Cornelia; Burger, Matthew T.; Ding, Yu; Feucht, Paul H.; Garcia, Pablo D.; Han, Wooseok; Klivansky, Liana; Lindvall, Mika; Bioorganic and Medicinal Chemistry Letters; vol. 21; 21; (2011); p. 6366 – 6369;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216144-45-5,4-(4-Methylpiperazin-1-yl)benzylamine,as a common compound, the synthetic route is as follows.

Stage 3: 6-[4-(4-methylpiperazin-1-yl)benzyl]-5H-quinazolino[3,2-a]quinazoline-5,12(61)-dione hydrochlorideA solution of methyl 2-(2-chloro-4-oxoquinazolin-3(4H)-yl)benzoate (170 mg) and [4-(4-methylpiperazin-1-yl)benzyl]amine (200 mg) in a THF/DCM/Et3N mixture (1 mL/1 mL/1 mL) is stirred for 4 days at ambient temperature then water and dichloromethane are added. After decantation and extractions, the combined organic phases are washed with salt water, dried over Na2SO4 then concentrated under reduced pressure at 40 C. Purification by flash chromatography on silica gel (eluent: dichloromethane/methanol 100:0 to 92:8) produces the expected compound in the form of the free base. The corresponding hydrochloride salt is formed by adding a 1N HCl solution in ethyl ether to the solution of the free base in ethyl acetate. The precipitate obtained is filtered and dried in order to produce the expected hydrochloride compound (85 mg, 36% yield from Stage 2).MS/LC: calculated MM=431.2; m/z=432.3 (MH+)NMR (1H, 400 MHz, DMSO-d6): delta2.83 (d, 3H), 3.12 (m, 4H), 3.48 (d, 2H), 3.81 (d, 2H), 5.55 (s, 2H), 6.98 (AB, 2H), 7.55 (m, 3H), 7.66 (m, 2H), 7.90 (m, 2H), 8.25 (AB, 1H), 8.31 (AB, 1H), 9.11 (AB, 1H), 10.75 (s, 1H)., 216144-45-5

216144-45-5 4-(4-Methylpiperazin-1-yl)benzylamine 2776493, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SOCIETE DE CONSEILS DE RECHERCHES ET D’APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.); US2010/144714; (2010); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.928025-56-3,(S)-tert-Butyl 3-ethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

928025-56-3, INTERMEDIATE 11 7-[(2S)-2-Ethylpiperazin- 1 -yll-3-methylisoxazolo[4,5 -d]pyrimidin-5-amine dihydrochioride Intermediate 10 (2.70 g, 16 mmol) was slurried in phosphorus oxychioride (33 mL) and DIPEA (5.3 mL) was added. The mixture was heated at reflux for 5 h. Upon cooling, the reaction mixture was concentrated in vacuo. The brown oil was partitioned between EtOAc and water. The organic layer was dried over Na2SO4 and concentrated. The resulting crude brown oil was dissolved in DMF (10 mL) and DIPEA (1.3 mL) wasadded, followed by (S)-tert-butyl 3-ethylpiperazine-1-carboxylate (0.96 g, 4.17 mmol).The reaction mixture was stirred at 70C overnight. The resulting solution wasconcentrated in vacuo, and the residue was purified by silica gel chromatography(gradient 40-100% EtOAc in isohexane). The resulting crude material was dissolved inEtOH, then 4M HC1 in 1,4-dioxane (10 mL) was added. The reaction mixture was stirredfor 2 h, then concentrated in vacuo, to give the title compound (1.0 g, 19% overall) as asticky brown solid. LCMS (ES+) MH 263, RT 0.76 minutes (method 1).

The synthetic route of 928025-56-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FORD Daniel James; HUANG Qiuya; NEUSS Judi Charlotte; REUBERSON James Thomas; VANDERHOYDONCK Bart; WO2015/193168; A1; (2015);,
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630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

630125-91-6, A mixture of 4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (7, 17.5 mg, 0.06 mmol), triethylamine (0.014 mL, 0.1 mmol), and p-nitrophenyl chloroformate (12.4 mg, 0.06 mmol) in 1,4-dioxane (5 mL) was heated at 60 C for 2 h. A solution of 6a (20 mg, 0.06 mmol) in 1,4-dioxane (5 mL) was slowly added thereto. The reaction mixture was heated at 90 C overnight. The reaction mixture was concentrated under reduced pressure and then partitioned between water (5 mL) and ethyl acetate (5 mL). The organic layer was separated and the aqueous layer was then extracted with ethyl acetate (3 ¡Á 3 mL). The combined organic extracts were washed with brine and dried over anhydrous Na2SO4. After evaporation of the organic solvent, the residue was purified by column chromatography (silica gel, hexane-ethyl acetate 3:1 v/v then switching to hexane-ethyl acetate 1:1 v/v) to yield compound 8g (6.0 mg, 15%).

As the paragraph descriping shows that 630125-91-6 is playing an increasingly important role.

Reference£º
Article; El-Gamal, Mohammed I.; Jung, Myung-Ho; Lee, Woong San; Sim, Taebo; Yoo, Kyung Ho; Oh, Chang-Hyun; European Journal of Medicinal Chemistry; vol. 46; 8; (2011); p. 3218 – 3226;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.

[00171]A mixture of 97 (0.30 g, 0.88 mmol), HBTU (0.50 g, 1.32 mmol), DIPEA (0.23 ml, 1.32 mmol) and DMF (2.5 ml) was stirred for a while, to which was then added 4-(4- ethylpiperazin-1-yl)aniline (0.27 g, 1.32 mmol) at room temperature and the mixture was stirred overnight. The residue was filtered by suction filtration to yield a red product. The residue was filtered without further purification to afford 37 (0.40 g, 85.92 %) as a red solid. 1H-NMR (300 MHz, DMSO-d6): ^1.01 (t, J= 7.2 Hz, 3H), 2.34 (q, J= 7.2 Hz, 2H), 3.07 (br, 4H), 5.01 (s, 2H), 6.89 (d, J= 9.0 Hz, 2H), 7.41 (d, J= 8.1 Hz, 2H), 7.56 (d, J= 9.0 Hz, 2H), 7.74 (t, J= 8.1 Hz, 1H), 7.77-7.88 (m, 3H), 7.95-7.98 (m, 2H), 8.09 (s, 1H), 9.98 (s, 1H).

115619-01-7, 115619-01-7 4-(4-Ethylpiperazin-1-yl)phenylamine 936738, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-ping; PAN, Shiow-lin; (102 pag.)WO2017/14788; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314741-39-4, (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

314741-39-4, To a solution of (S)-1-tert-butyl 3-methyl piperazine-1,3-dicarboxylate (500 mg, 2.05 mmol) in anhydrous dichloromethane (20 mL) at 0 C. was added triethylamine (311 mg 3.1 mmol) and acetyl chloride (0.16 mL, 2.25 mmol). The mixture was stirred for 30 minutes, and then the mixture was diluted with dichloromethane. The organic layer was washed with H2O, dried with MgSO4, filtered and concentrated under reduced pressure to provide the titled compound.

314741-39-4 (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 1501855, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Altenbach, Robert J.; Liu, Huaqing; Clapham, Bruce; Aguirre, Ana L.; Cowart, Marlon; Koenig, John R.; Sarris, Katerina; Scanio, Marc J.; Swinger, Kerren K.; Vasudevan, Anil; Villamil, Clara I.; Woller, Kevin R.; US2015/210720; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics