Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Ethyl-7-r(2S)-4-(tgrt-butoxycarbonyl)-2-(hydroxymethvDpiperazin-l-vn-l- cyclopropyl-6-fluoro-8-formyl-4-oxo-l,4-dihvdroquinoline-3-carboxylate (3)tert-Butyl-(3S)-3-(hydroxymethyl)piperazine-l-carboxylate (1) (0.543 g,0.00251 mol) and N-methylpyrrolidinone (20 mL) were added to a 40 mL vial. Ethyl- 1 -cyclopropyl-6,7-difluoro-8-formyl-4-oxo- 1 ,4-dihydroquinoline-3-carboxylate (2) (0.807 g, 0.00251 mol) and N,N-diisopropylethylamine (1.31 mL, 0.00753 mol) were added and the reaction was heated at 50 C overnight. The reaction was checked by HPLC and LC/MS and was shown to be -50% complete. The heat was increased to 75 C overnight. HPLC showed the reaction to be -85% complete with an impurity forming. The reaction was stopped and the mixture was diluted with water. The aqueous was extracted with ethyl acetate (3 x 150 mL). The combined organic layers were washed with water (3 x 50 mL) and brine (25 mL). The organic layer was then dried with sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by silica gel chromatography on 120 g of silica gel using 15% to 50% acetone in dichloromethane as the eluent to afford 800 mg (62%) of the desired product (3) as a yellow solid. MS ES+ 518.2 m/z for [C26H32FN307+H]+; MS ES” 516.2 m/z for [C26H32FN307-H], 314741-40-7

314741-40-7 (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate 24820294, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ACHAOGEN, INC.; WAGMAN, Allan, Scott; MOSER, Heinz, Ernst; MCENROE, Glenn, A.; AGGEN, James, Bradley; LINSELL, Martin, Sheringham; GOLDBLUM, Adam, Aaron; SIMONS, Lloyd, J.; BELLIOTTI, Thomas, R.; HARRIS, Christina, R.; POEL, Toni-Jo; MELNICK, Michael, J.; GASTON, Ricky, D.; GRIFFIN, John, H.; WO2011/31740; (2011); A1;,
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169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1 14 (1.60 g, 6.91 mmol) in toluene (21.1 mL) under an argon atmosphere was added (S)-/eri-butyl 2-methylpiperazine-l -carboxylate (1 15, 1.38 g, 6.91 mmol, AK Scientific, Inc., Union City, CA), sodium teri-butoxide (0.73 g, 7.60 mmol, Sigma-Aldrich), and 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (i.e., “X-Phos,” 0.49 g, 1.04 mmol, Sigma-Aldrich). The mixture was degassed under argon and thentris(dibenzylideneacetone) dipalladium (Pd2(DBA)3, 0.63 g, 0.69 mmol, Sigma-Aldrich) was added to form a reaction mixture. The reaction mixture, heated in an oil bath maintained at temperature within the range of from 80C to 85C, was stirred for 1.5 hours. Thereafter, the mixture was cooled to a temperature of about 25C, poured onto cold water, and extracted with EtOAc. The organic layer was separated, washed with brine, and concentrated to an oil which was chromatographed on a silica gel column eluted with 10:90 EtOAc:hexanes and 20:80 EtOAc:hexanes to provide 1.71 g of 1 16 as a solid (63% yield). NMR (CDC13) delta: 1.25 (3H, d, J=6.80Hz), 1.46 (3H, s), 1.48 (9H, s), 1.53 (3H, s), 2.89 (1H, dt, J=3.29, 13.59Hz), 3.09 ( 1 H, dd, J=3.73, 12.06Hz), 3.23 (1H, dt, J=2.85, 13.59Hz), 3.69 (1H, t, J=7.89Hz), 3.83 (1 H, d, J=12.72Hz), 3.92 (1 H, d, J=13.81Hz), 4.01 (1H, d, J=12.90Hz), 4.27 (1H, t, J=6.14Hz), 4.31 (1H, brs), 5.01 (1H, t, J=7.24Hz), 7.30 (1H, d, J=1.97Hz), 7.95 (1H, s). LC/MS (M+1): m/z = 396.

169447-70-5, As the paragraph descriping shows that 169447-70-5 is playing an increasingly important role.

Reference£º
Patent; PURDUE PHARMA L.P.; Shionogi & Co. Ltd.; TAFESSE, Laykea; ANDO, Shigeru; KUROSE, Noriyuki; WO2012/176061; (2012); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7365-45-9,2-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid,as a common compound, the synthetic route is as follows.

General procedure: In a typical procedure, 10 mL zinc acetate solution (200 mM) was mixed with 20 mL HEPES solution (200 mM pH 7.4). A microwave and ultrasonic wave combined reactor (XH-300A, Beijing Xianghu Technology Co., Ltd.) provided continuous and homogeneous ultrasonic wave and microwave irradiation for the mixed solutions. Firstly, the mixture was continuously sonicated for 5 min by ultrasonic processor with a power of 1000 W. Then the mixed solution was heated to 110 C within 3 min and kept at this temperature for 17 min under microwave heating combined with discontinuous ultrasonic irradiation (1 s sonication and 2 s interruption) with a power of 500 W. After cooling down to room temperature naturally, the product was collected by centrifugation and washed with deionized water and absolute alcohol for 5 times, then dried in a desiccator for further characterization (S1). Other ZnO samples (S2-S15) were also prepared under identical conditions by varying Zn/HEPES moral ratio, pH value of HEPES solution and Zn precursor. The detailed procedure is same as described above and all the experimental parameters are listed in Table 1., 7365-45-9

The synthetic route of 7365-45-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Qin; Li, Hui; Wang, Runming; Li, Guangfang; Yang, Hao; Chen, Rong; Journal of Alloys and Compounds; vol. 567; (2013); p. 1 – 9;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.192130-34-0,tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a mixture of 61 (131 mg, 0.303 mmol, 1.0 equiv), Pd2dba3 (27 mg, 0.0303 mmol, 0.10 equiv), 2-Dicyclohexylphosphino-2′, 4′, 6′-tri-1-propyl-1,1′-biphenyl (17 mg, 0.036 mmol, 0.12 equiv), and NaOtBu (58 mg, 0.606 mmol, 2.0 equiv) was added toluene (5 mL) which was first purged with argon. After 1 min of vigorous stirring, tert-butyl 4-(2-aminoethyl)piperazine-1-carboxylate (63 muL, 0.606 mmol, 2.0 equiv) was added and the mixture was heated to 90¡ã C. After starting material was consumed as indicated by TLC, the solvent was removed in vacuo. The resulting residue was taken up in EtOAc (50 mL) and washed with water and brine. After drying with MgSO4 and concentration in vacuo, the crude mixture was purified by silica gel chromatography (10percent MeOH:CH2Cl2) to afford amine 10v [MS (MH+) 625; Calculated 624.3 for C36H44N6O4] and amine 15 [MS (MH+) 398; Calculated 397.2 for C25H23N3O2]., 192130-34-0

As the paragraph descriping shows that 192130-34-0 is playing an increasingly important role.

Reference£º
Patent; Nunes, Joseph J.; Martin, Matthew W.; White, Ryan; McGowan, David; Bemis, Jean E.; Kayser, Frank; Fu, Jiasheng; Liu, Jinqian; Jiao, Xian Yun; US2006/46977; (2006); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.196811-66-2,tert-Butyl 4-carbamothioylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

a) 4-(Dimethylaminomethylene-thiocarbamoyl)-piperazine-l-carboxylic acid tert-butyl ester; A mixture of 122 mmol N,N-dirnethylformamide dimethyl acetal and 6.11 mmol 4- thiocarbamoyl-piperazine-1-carboxylic acid tert-butyl ester (prepared from tert-butyl 1- piperazinecarboxylate, lj’-thiocarbonyldiimidazole and ammonia according to the procedure of J. Med. Chem. 1998, 41, 5037-5054) was heated at 110 0C for 3 h. The reaction mixture was then concentrated in vacuo and the residue was resuspended in ethyl acetate/ tetrahydrofuran ( 1:1) and washed with brine. The organic phase was dried over sodium sulphate and concentrated in vacuo to afford the title compound as a light yellow crystalline solid (yield 95%). MS (m/e): 301.4 (M+H+, 100%)., 196811-66-2

The synthetic route of 196811-66-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2006/72436; (2006); A1;,
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Piperazines – an overview | ScienceDirect Topics

170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 32 (500 mg, 1.66 mmol) in s-butanol (5 mL) were added tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (498 mg, 1.82 mmol) and TFA (760 mg, 6.64 mmol) at room temperature. The resulting reaction mixture was stirred at 100 C for 12 h. It was then diluted with 10% MeOH in CH2Cl2 (100 mL) and washed with saturated sodium bicarbonate solution. The organic layer was dried over Na2SO4 and concentrated in vacuo. Column chromatography (3% MeOH in CHCl3) to afford 33 (400 mg, 44%) as a pale yellow solid.1H NMR (400 MHz, DMSO-d6) delta ppm 9.56 (s, 1H), 9.40 (s, 1H), 8.45 (d, J = 5.2 Hz, 1H), 7.58 (d, J = 9.2 Hz, 2H), 7.44 (s, 1H), 7.24 (d, J = 5.2, Hz, 1H), 6.95 – 6.88 (m, 3H), 5.45 (s, 1H), 4.58 (d, J = 3.2 Hz, 2H), 3.48 – 3.45 (m, 4H), 3.04 – 3.02 (m, 4H), 2.37 – 2.33 (m, 1H), 1.42 (s, 9H), 1.06 – 1.04 (m, 4H).LC-MS (MeCN, pH 3): [M+H]+ = 542, rt = 1.62 mins, purity = > 95%.

170911-92-9, 170911-92-9 tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 11011301, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Large, Jonathan M.; Birchall, Kristian; Bouloc, Nathalie S.; Merritt, Andy T.; Smiljanic-Hurley, Ela; Tsagris, Denise J.; Wheldon, Mary C.; Ansell, Keith H.; Coombs, Peter J.; Kettleborough, Catherine A.; Whalley, David; Stewart, Lindsay B.; Bowyer, Paul W.; Baker, David A.; Osborne, Simon A.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 19; (2019);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

393781-70-9, (R)-1-Boc-2-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 3 – ((2,4-dioxo -3,4-dihydrochinazolines having antiviral properties -1 (2H)-yl) methyl) benzoic acid (250 mg, 0 . 80mmol), EDC (307 mg, 1 . 6mmol), HOBT (217 mg, 1 . 6mmol) and DIEA (162 mg, 1 . 60mmol) into the reaction bottle in, addition of about 3 ml of the dissolution of water-free DMF, r.t. The lower stirring 15 min, then dropwise (R)-N-Boc-2-ethyl piperazine (258 mg, 1 . 20mmol) in the DMF solution to the reaction solution, r.t. The lower stirring overnight, the reaction solution is poured into 100 ml water, using 100mLDCM extraction, an organic layer for sequentially 1MHCl (100 ml), saturated NaCl (100 ml) and water (100 ml) washing, vacuum concentration, silica gel column chromatography, to obtain 236 mg solid, yield 58.1%., 393781-70-9

The synthetic route of 393781-70-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Institute Of Materia Medica Chinese Academy Of Medical Sciences; Xu, Bailing; Chen, Xiaoguang; Yao, Haiping; Ji, Ming; Jin, Jing; Zhou, Jie; Wang, Ke; Zhao, Dalong; (55 pag.)CN105461697; (2016); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

55121-99-8, To a stirred solution of triphosgene (0.373 mg, 1.258 lmol) in anhydr. THF (20 ml) was added 7d (S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline (1.200 mg, 2.097 lmol) at 25 C. The reaction mixture wasstirred for 5 min and NEt3 (45 mL, 0.33 mmol) were added and the reaction mixture was stirred for additional 1 h. Then 9a 4-amino-N-(2-(dimethylamino)ethyl)-N-methylbenzamide (1.392 mg, 6.29 lmol) was added and stirred for another 0.5 h and NEt3 (406 mL, 2.91 mmol) was added and the mixture was stirred over night. The solvents were removed in a N2 stream and the crude mixture was purified by semi-prep-HPLC to obtain 3 as an off white solid (665 mg, 53%).

The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Dehnhardt, Christoph M.; Venkatesan, Aranapakam M.; Chen, Zecheng; Delos-Santos, Efren; Ayral-Kaloustian, Semiramis; Brooijmans, Natasja; Yu, Ker; Hollander, Irwin; Feldberg, Larry; Lucas, Judy; Mallon, Robert; Bioorganic and Medicinal Chemistry Letters; vol. 21; 16; (2011); p. 4773 – 4778;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3022-15-9,Piperazine-2-carboxylic acid dihydrochloride,as a common compound, the synthetic route is as follows.,3022-15-9

Piperazine-2-carboxylic acid dihydrochloride (10.0 g, 49.2 mmol) was dissolved in H2O (125 mL) and 1,4-dioxane (200 mL), and the solution was brought to pH 11 with 50% NaOH in H2O. Benzyl chloroformate (14 mL, 98 mmol) was added while maintaining the pH at 11 with 50% NaOH in H2O. After 1 h, an additional portion of benzyl chloroformate (2 mL, 14 mmol) was added. After 30 min, the solution was extracted with Et2O (3 x 100 mL). The aqueous layer was brought to pH 2 with concentrated HCl and extracted with EtOAc (3 x 200 mL). The combined EtOAc extracts were dried over Na2SO4, filtered, and concentrated under reduced pressure to give 18.9 g (96%) of the desired product as a thick oil. The material was used without further purification. LC-MS: RT = 9.250 min; [M+H]+ = 421.1.

As the paragraph descriping shows that 3022-15-9 is playing an increasingly important role.

Reference£º
Patent; CRITICAL THERAPEUTICS, INC.; WO2007/146066; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

70261-81-3, 1-Methyl-4-(4-nitrobenzyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70261-81-3, Nickel chloride hexahydrate (45.7 g, 192 mmol) was added to a solution of Compound 46a2 (17.9 g, 87.4 mmol) in methanol (250 mL). Twenty portions of sodium borohydride (500 mg each, 264 mmol total) were then added to the reaction mixture over a period of about 2 hr. The mixture was then carefully diluted at 0 C. with concentrated HCl to give a transparent green solution. The mixture was subsequently washed with ethyl ether. The cooled aqueous layer was adjusted to pH 10 with NH4OH (28%) and then extracted with EtOAc. The combined organic layers were dried over MgSO4, then filtered and evaporated in vacuo to give 4-(4-methyl-piperazin-1-ylmethyl)-phenylamine Compound 46a (17.6 g) as a yellow foam. 1H NMR (DMSO-d6) delta 6.91 (d, J=8.2 Hz, 2H); 6.50 (d, J=8.2 Hz, 2H); 4.94 (br s, 2H); 3.28 (s, 2H); 2.44-2.26 (m, 8H); 2.19 (s, 3H).

As the paragraph descriping shows that 70261-81-3 is playing an increasingly important role.

Reference£º
Patent; Connolly, Peter J.; Johnson, Sigmond G.; Pandey, Niranjan B.; Middleton, Steven A.; US2006/58341; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics