Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.

A mixture of the compound of formula V (lOg) and N-(4-aminophenyl)-N-methyl-2-(4- methylpiperazin-l-yl)acetamide (formula IV) (7.89g) in DMF (50ml) was stirred at about 65-70C for 4h. The reaction mass was cooled to about 25-30C and stirred for lh. Reaction mass was filtered and solid was washed with methanol. The solid wet cake was added in methanol and stirred at about 25-30C. Reaction mass was cooled to about 0-5C and piperidine (6.2ml) was added under stirring. The reaction mass was heated to about 25-30C and stirred for 5h. The reaction mass was cooled to about 0-5C and stirred for lh. The reaction mass was filtered and solid was washed with cold methanol to obtain crude nintedanib. Yield: 12gm; HPLC purity: 99.96%; Imp B: 0.02%.

262368-30-9, The synthetic route of 262368-30-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLENMARK PHARMACEUTICALS LIMITED; NAIK, Samir; SRIVASTAVA, Sachin; PATIL, Pramod; PATIL, Premchand Bansilal; BHIRUD, Shekhar Bhaskar; (34 pag.)WO2019/48974; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-70-5,tert-Butyl 4-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

57260-70-5, The procedure described for the preparation of 2a was used with compound 10c (400 mg, 1.22 mmol), 13a (322 mg,1.83 mmol), K2CO3 (337 mg, 2.44 mmol), NaI (catalyst) and CH3CN(15 mL) to obtain 2c (296 mg, 52%) as light brown liquid. Rf = 0.56(n-hexane: EtOAc: MeOH = 2.5:1.5:1). 1H NMR (500 MHz, CDCl3): d7.38-7.23 (m, 15H), 5.86 (s, 1H), 4.61 (t, J = 7 Hz, 2H), 3.54 (s, 2H),2.48-2.00 (m, 10H), 2.07-2.02 (m, 2H), 1.52-1.49 (m, 2H); 13CNMR (125 MHz, CDCl3): d 167.8, 140.9, 138.2, 129.2, 128.7, 128.6,128.2, 127.1, 127.0, 63.1, 57.6, 53.2, 53.1, 53.0, 48.7, 27.4, 23.6.

57260-70-5 tert-Butyl 4-benzylpiperazine-1-carboxylate 584330, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Paudel, Suresh; Acharya, Srijan; Yoon, Goo; Kim, Kyeong-Man; Cheon, Seung Hoon; Bioorganic and Medicinal Chemistry; vol. 25; 7; (2017); p. 2266 – 2276;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To the stirred solution of 3-(3-oxo-2H-benzo[b][1,4]thiazin-4(3H)-yl)propanoic acid (100mg, 0.448 mol) in DMF, N-phenyl piperzine derivatives (0.538 mol) or 3-(4-phenylpiperazin-1-yl)propan-1-amine derivatives (0.538 mol) was added at room temperature, followed by the addition of EDC:HCl (102 mg) and HOBt (60.5 mg), the stirring was continued for 12h. After completion of the reaction (TLC analysis), small amount of ice cold water (10 mL) was added to the reaction mixture and then extracted with chloroform (2 x 10 mL). The chloroform layer was separated, dried over Na2SO4 and evaporated under vacuum to give corresponding derivatives 8a-i and 10a-g in good yields., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Venkatesh, Ramineni; Kasaboina, Suresh; Bidayat, Deepthi; Nikhil Kumar; Jain, Nishant; Tangeda, Saritha Jostna; Bantu, Rajashaker; Janardhan, Sridhara; Nagarapu, Lingaiah; Bioorganic and Medicinal Chemistry Letters; vol. 27; 2; (2017); p. 354 – 359;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 74 (2-Cyclopent-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone Following procedure E, (2-Cyclopent-1-enyl-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone is prepared from 2-cyclopent-1-enyl-5-methanesulfonyl-benzoic acid (Example H) and 1-(4-trifluoromethyl-phenyl)-piperazine: colourless foam, MS (ISP): 479.5 (M+H+).

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; Alberati-Giani, Daniela; Jolidon, Synese; Narquizian, Robert; Nettekoven, Matthias Heinrich; Norcross, Roger David; Pinard, Emmanuel; Stalder, Henri; US2005/59668; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

Compound BB-17-1 (7.0g, 31.78mmol) was dissolved in dilute hydrochloric acid (6M, 150mL) with stirring until homogeneous under nitrogen protectionskid slowly dropwise a solution of sodium nitrite (4N, 30 mL), then stirred at room temperature about one hour, 100mL of water was added with ethylacetate and extracted (100mL ¡Á 3).The combined organic phases were washed with saturated brine (20 mL), dried over anhydrous sodium sulfate, and under reduced pressure to removethe solvent, the resulting target compound BB-17-2 (7.5g, yield: 66%), was used directly in the next step without further purification.

31166-44-6, The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Changzhou Yin Sheng Pharmaceutical Co., Ltd.; Sichuan University; Zhang, Yang; Fu, Zhifei; Li, Jian; Chen, Shuhui; Wei, Yuquan; Tao, Xin; (65 pag.)CN105732602; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

66-1) 1-[2-(4-Fluorobenzenesulfonylamino)ethyl]-4-(t-butoxycarbonyl)piperazine The 1-(2-aminoethyl)-4-(t-butoxycarbonyl)piperazine (2.01 g) obtained in Example 58 and 4-fluorobenzene sulfonylchloride (2.05 g) were dissolved in tetrahydrofuran (20 ml), and triethylamine (2.4 ml) was added thereto, and the mixture was stirred overnight at room temperature. Water (50 ml) was added to the reaction mixture which was then extracted with ethyl acetate, and the organic layer was washed with water, dried, and evaporated. The residue was purified by Cromatorex NH silica gel column chromatography (hexane/ethyl acetate system), whereby the title compound (2.61g, 77percent) was obtained as a colorless oil., 192130-34-0

As the paragraph descriping shows that 192130-34-0 is playing an increasingly important role.

Reference£º
Patent; Eisai Co., Ltd.; EP1099692; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Benzyl carbonochloridate (6.43 mL, 45.03 mmol) was added to a solution of 1-tert-butyl 3-methyl piperazine-1,3-dicarboxylate (10 g, 40.94 mmol) and DIEA (14.30 mL, 81.87 mmol) in THF (100 mL) at 5C, and the mixture was stirred at room temperature for 14 hr. The reaction mixture was added to water and ethyl acetate. The organic layer was washed with aqueous ammonium chloride solution, dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (solvent gradient; 5?20% ethyl acetate/hexane) to give 1-benzyl 4-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate (16.2 g, 42.8 mmol, 105%) as white crystals. 1H NMR (300 MHz, CDCl3):delta 1.44(9H,s), 2.63-3.48(3H,m), 3.74(3H,s), 4.11(2H,s), 4.44-4.86(2H,m), 5.08-5.26(2H,m), 7.22-7.42(5H,m).

129799-08-2, The synthetic route of 129799-08-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; YAMAMOTO, Satoshi; SHIRAI, Junya; ODA, Tsuneo; IMADA, Takashi; KONO, Mitsunori; SATO, Ayumu; TOMATA, Yoshihide; OCHIDA, Atsuko; ISHII, Naoki; SASAKI, Yusuke; FUKASE, Yoshiyuki; YUKAWA, Tomoya; FUKUMOTO, Shoji; (200 pag.)EP3192791; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

This was obtained by stirring MA2-004 (0.698 g) and 4-(4-i170911-92-9, As the paragraph descriping shows that 170911-92-9 is playing an increasingly important role.

Reference£º
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas J.; LAWRENCE, Harshani R.; (293 pag.)WO2017/66428; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Intermediate 45: 1,1-dimethylethyl (3S)-4-ethyl-3-(hydroxymethyl)-1-piperazinecarboxylate 1,1-dimethylethyl (3S)-3-(hydroxymethyl)-1-piperazinecarboxylate (Commercial: e.g. Activate Scientific) (0.5 g, 2.312 mmol) and acetaldehyde (0.209 ml, 3.70 mmol) were dissolved in Methanol (10 ml) with molecular sieves and stirred at room temperature under nitrogen for 4 hours. Sodium borohydride (0.140 g, 3.70 mmol) was added and the reaction was stirred at room temperature for 18 hours. The reaction was quenched with 2M NaOH and the reaction was filtered through a celite column. The filtrate was extracted with ethyl acetate (*3). The combined organics were washed with water, dried using a hydrophobic frit and evaporated in vacuo to give the title compound as a colourless oil (0.546 g) LCMS (Method B): Rt=0.45 min, MH+=245

314741-40-7, As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; Atkinson, Francis Louis; Atkinson, Stephen John; Barker, Michael David; Douault, Clement; Garton, Neil Stuart; Liddle, John; Patel, Vipulkumar Kantibhai; Preston, Alexander G.; Shipley, Tracy Jane; Wilson, David Matthew; Watson, Robert J.; US2014/5188; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118753-66-5,tert-Butyl 4-aminopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a well-stirred solution of intermediate 5a (2.0 g,5.29 mmol) in ethanol (10 mL) was added 1-amino-4-methylpiperazine 9a (0.61 g, 5.29 mmol) and a drop of acetic acid,and the mixturewas stirred at 78 C for 2 h. The mixturewas cooledto room temperature and the resulting solid was collected byfiltration and purified by column chromatography to give the targetcompounds 6a-1 as a yellow solid in 75% yield. M.p: 228-230 C;, 118753-66-5

The synthetic route of 118753-66-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Yachuang; Ding, Xiudong; Yang, Yifeng; Li, Yingxiu; Qi, Yinliang; Hu, Feng; Qin, Mingze; Liu, Yajing; Sun, Lu; Zhao, Yanfang; European Journal of Medicinal Chemistry; vol. 185; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics