Tag: M.W:200-300

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2. Preparation of 4-[4-(4-trifluoromethyl-phenyl)-piperazin-l- yl]-butyric acid ethyl ester intermediate.Ethyl-4-bromobutyrate (390 mg, 2.00 mmol) and triethylamine (280 muL; 2.00 mmol) were added to a solution of l-(4-trifluoromethylphenyl)-piperazine (460 mg; 2.00 mmol) in tetrahydrofuran (3 mL). Potassium iodide (332 mg; 2.00 mmol) was added and the resulting suspension is irradiated in a mono-mode microwave oven for 2 hours at 1000C. The suspension is then diluted with dichloromethane (15 mL) and washed twice with water (5 mL). The organic phase is then dried over sodium sulphate and is concentrated under reduced pressure to afford the desired product (660 mg; 1.96 mmol)., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; INTERVET INTERNATIONAL B.V.; CHASSAING, Christophe Pierre Alain; MEYER, Thorsten; WO2010/115688; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 4d (3 g,10.83 mmol) was dissolved in 40 ml of dry pyridine and stirred at0 C under inert atmosphere. Cinnamoyl chloride 6a (2.16 g,13 mmol) was dissolved in 20 ml dry DCM and added dropwise toabove stirred solution at 0 C. The reaction mixture was stirred for 3 h. After completion of the reaction, the reaction mixture wasdiluted with 40 ml water and 60 ml ethyl acetate followed by 2 NHCl to make it acidic. The organic layer was separated and againwashed with 2 N HCl followed by saturated bicarbonate solution(2 50 ml) and brine solution. The organic layer was dried overanhydrous sodium sulfate and was evaporated under reducedpressure. The crude product was recrystallized from ethyl acetateand hexane to afford 3.25 g of 7d. Off-white solid; Yield 73.86%; mp186-188 C; IR (KBr pellets, cm1): 3335, 3106, 2976, 2822, 1689,1624, 1521, 1423, 1232, 1173, 971, 827, 763; 1H NMR (400 MHz,CDCl3) d (ppm): 1.41 (9H, s, CH3), 3.12 (4H, t, J 4.15 Hz), 3.71 (4H, t,J 4.12 Hz), 6.75 (1H, d, J 14.8 Hz, PheCH]CHe), 7.09e7.45 (9H,m, AreH), 7.71 (1H, d, J 14.8 Hz, PheCH]CHe), 8.61 (1H, s,CONH); 13C NMR (100 MHz, CDCl3) d (ppm): 28.37, 51.48, 80.43,118.47, 121.14, 121.38, 127.97, 128.83, 129.84, 134.74, 141.93, 154.43,164.33; HR-MS m/z: 407.2267 (M)., 170911-92-9

As the paragraph descriping shows that 170911-92-9 is playing an increasingly important role.

Reference£º
Article; Patel, Kavitkumar N.; Telvekar, Vikas N.; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 43 – 56;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.140447-78-5,1-(2-N-Boc-Aminoethyl)piperazine,as a common compound, the synthetic route is as follows.

Compound 10 10- { 3 -[4-(N-Boc-2 -amino)ethylpiperazinyl] propyl } -2- dimethylsulfamidolphenothiazineTo a stirred solution of the phenothiazine chloro derivative 9 (382 mg, 1.0 mmol), potassium carbonate (500 mg,3.62 mmol), and l-(2-N-Boc- aminoethyl)piperazine (229 mg, 1.0 mmol) in methyl ethyl ketone (20 mL) was added sodium iodide (150 mg, 1 mmol). The reaction mixture was stirred for 24 h at reflux under an atmosphere of argon. The reaction mixture was filtered, and the filtrate was concentrated under vacuum. The residue was partitioned between ethyl acetate (20 mL) and brine (10 mL). The organic layer was dried over anhydrous sodium sulphate, filtered, and evaporated. The resulting residue was purified by silica gel chromatography (9:1 CH2Cl2:MeOH) to give 10 (410 mg, 71%) as a foam. MS(ESI): m/z 576 (M+H)., 140447-78-5

140447-78-5 1-(2-N-Boc-Aminoethyl)piperazine 1514401, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; IMMUNE CONTROL, INC.; WO2008/27521; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

EXAMPLE 30B 7-chloro-5-(2-methoxy-4-(4-methy lpiperazin- l-yl)pheny lamino)py rido[3.4-i/]py ridazin- 4(3H)-one To a solution of EXAMPLE 7K (120 mg, 0.56 mmol) in dioxane (10 mL) was added EXAMPLE 30A (136 mg, 0.6 ] mmol) and NN-diisopropy lethylamine (724 mg, 5.6 mmol) and the mixture was stirred at 120C in a sealed tube for 16 hours. The mixture was cooled to ambient temperature, poured into water (50 mL) and extracted with ethy l acetate (3 * 50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, concentrated and purified by flash chromatography on si lica gel (200-300 mesh) eluting with 50/1 dichlomethane/methanol to give the title compound. MS : 401 (M + IT)., 122833-04-9

The synthetic route of 122833-04-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

639068-43-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.639068-43-2,tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of compound 13a-b, 17a-b (1.0 mmol) inCH3CN (20 mL) were added N-Boc-piperazine (180.9 mg,0.9 mmol), K2CO3 (205.9 mg, 1.5 mmol), KI (166.0 mg, 1.0 mmol)and 18-crown-6 (26.4 mg, 0.1 mmol) at room temperature. Themixture was stirred overnight at 80 C and filtered. The filtrate wasdiluted by DCM and washed by brine. The organic layer was concentrated for next step. To a stirred solution of the abovecompounds in DCM (20 mL) was added TFA (3 mL) at room temperature.The mixture was stirred for 3e4 h and concentrated toafford the crude products 15a-o and 19a-f in a yield of 35%e42%. Toa stirred solution of above crudes in anhydrous MeOH (10 mL) wasadded BTZ core compound 11 (403.2 mg, 1.0 mmol) and Et3N(0.2 mL, 1.5 mmolj) at room temperature. The mixture was stirredfor 1e3 h at 40 C and concentrated. The residue was purified bysilica gel column (DCM: MeOH 20: 1) to give 1a-f and 2a-e (25%e41% for two steps).

The synthetic route of 639068-43-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Apeng; Lv, Kai; Tao, Zeyu; Gu, Jian; Fu, Lei; Liu, Mingliang; Wan, Baojie; Franzblau, Scott G.; Ma, Chao; Ma, Xican; Han, Bing; Wang, Aoyu; Xu, Shijie; Lu, Yu; European Journal of Medicinal Chemistry; vol. 181; (2019);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a stirred solution of tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (27-1)( 400.0 mg, 1.44 mmol) in DMF (1.0 mL) were added 3-bromopiperidine-2,6-dione (1-2) (552 mg,5 2.88 mmol) and DIPEA (795 J.L, 4.31 mmol) and the reaction mixture was stirred at roomtemperature for 16 hours. It was diluted with saturated aqueous NaHC03 solution and extractedwith 20% IP A/DCM. Organic layer was dried over sodium sulfate and concentrated. Crudematerial was purified by column chromatography using (0%-2% MeOH/DCM) to afford tert-butyl4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperazine-1-carboxylate (27-3) (300 mg, 772J.mol,10 53.6 %) as offwhite solid. LC/MS (ES+): m/z 389 [M+H]+, 170911-92-9

As the paragraph descriping shows that 170911-92-9 is playing an increasingly important role.

Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Christoper, G.; HENDERSON, James, A.; LIANG, Yanke; HE, Minsheng; DUPLESSIS, Martin; CHEN, Chi-Li; (791 pag.)WO2018/237026; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The mixture of 2,4,5-trifluorobenzonitrile (1.0 g, 6.4 mmol), (S)-tert-butyl 2- methylpiperazine-1-carboxylate (1.53 g, 7.6 mmol) and K2C03 (2.64 g, 19.1 mmol) in MeCN (20 mL) were stirred at 80 C for 16 h. The mixture was then filtered, washed with MeCN (5 mL x 2), concentrated, and purified by chromatography (PE:EtOAc = 2:3) to afford (S)-tert-butyl 4-(2- cyano-4,5-difluorophenyl)-2-methylpiperazine-1-carboxylate (1.8 g, 84%) as a white solid. MS (EI+, m/z): 338.2 [M+H]t

169447-70-5, As the paragraph descriping shows that 169447-70-5 is playing an increasingly important role.

Reference£º
Patent; NAVITOR PHARMACEUTICALS, INC.; O’NEILL, David John; SAIAH, Eddine; KANG, Seong Woo Anthony; BREARLEY, Andrew; BENTLEY, Jonathan; (565 pag.)WO2018/89433; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

182181-38-0, 3-Fluoro-4-(piperazin-1-yl)benzonitrile is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Combine 1-(4-cyano-2-fluorophenyl)piperazine (1.57 g, 7.6 mmol) and Et3N (1.28 ml, 9.2 mmol) in CH2Cl2 (10 ml) and add Boc2O (1.67 g, 7.6 mmol). Stir 1 h and wash with satd. NaHCO3. Dry (MgSO4) and concentrate to obtain the crude carbamate as a yellow solid., 182181-38-0

182181-38-0 3-Fluoro-4-(piperazin-1-yl)benzonitrile 596113, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Schering Corporation; US2004/220194; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129799-15-1, Methyl 1-Boc-piperazine-2-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In 9 parallel batches, A mixture of tert-butyl 2-methyl piperazine-l,2-dicarboxylate (1.0 g, 4.09 mmol), (4-fluorophenyl)boronic acid (1.72 g, 12.28 mmol), Copper(II) acetate (1.5 g, 8.19 mmol), pyridine (647 mg, 8.19 mmol) and sodium bicarbonate (688 mg, 8.19 mmol) in dichloromethane (50 ml) was stirred at ambient temperature under 02 (balloon) for 60 h, at which time LCMS indicated the reaction had gone to completion. The combined solutions were concentrated under reduced pressure. The residue was dissolved in ethyl acetate (50 mL), washed with water (2 x 40 mL) and concentrated. The crude product was purified by silica gel chromatography column (Hexanes/ethyl acetate = 5: 1) to give the title compound (9.8 g, yield 79%) as a brown oil. NMR (400 MHz, CDC13): delta 6.91 -6.80 (m, 2 H), 6.80-6.62 (m, 2 H), 4.86-4.68 (m, 1 H), 4.05-3.88 (m, 2 H), 3.77 (s, 3 H), 3.37-3.15 (m, 2 H), 2.90-2.86 (m, 1 H), 2,77-2.68 (m, 1 H), 1.49-1.40 (m, 9 H). LCMS M/Z (M+H) 338., 129799-15-1

The synthetic route of 129799-15-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; BELLON, Steven, F.; BURDICK, Daniel, J.; COTE, Alexandre; CRAWFORD, Terry; DAKIN, Les, A.; HSIAO-WEI TSUI, Vickie; HEWITT, Michael, Charles; LEBLANC, Yves; MAGNUSON, Steven, R.; NASVESCHUK, Christopher, G.; ROMERO, F., Anthony; TANG, Yong; TAYLOR, Alexander, M.; WANG, Shumei; (251 pag.)WO2016/77375; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

325145-35-5, (S)-tert-Butyl 2-ethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 15 as Boc-Protected ER-890963 To a solution of 14 (13.9 g, 31.77 mmol) and TEA (8.86 mL, 63.541 mmol) in DMA (89 mL) at rt was added dropwise commercially available (S)-tert-butyl 2-ethylpiperazine-1-carboxylate (7.49 g, 34.95 mmol) over 5-min period. The reaction mixture was stirred at 110¡ã C. for 12 h to completion after which time the reaction was cooled to rt. The reaction was concentrated to remove DMA followed by dilution with DCM (30 mL). The resultant organic solution was washed two times with water (30 mL each), brine (30 mL), and dried over MgSO4. The crude was filtered, concentrated in vacuo, and purified over silica gel (SNAP 340 g eluting 10percent to 30percent EtOAc in heptene, TLC heptane/EtOAc=3/1, rt=0.6) gave 5-((2S,6R)-2-(((S)-4-(3,3-dimethylbutanoyl)-3-ethylpiperazin-1-yl)methyl)-6-methylmorpholino)quinoline-8-carbonitrile or Boc-protected ER-890963 (12.27 g, 24.15 mmol, 76percent yield) as yellow powder after concentration of the combined desired fractions and drying in vacuo., 325145-35-5

As the paragraph descriping shows that 325145-35-5 is playing an increasingly important role.

Reference£º
Patent; CARLSON, ERIC; HANSEN, HANS; HAWKINS, LYNN; ISHIZAKA, SALLY; MACKEY, MATTHEW; SCHILLER, SHAWN; OGAWA, CHIKAKO; DAVIS, HEATHER; US2015/105370; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics