Tag: M.W:200-300

169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of HOBT (0.777 g, 5.07 mmol), EDC (0.972 g, 5.07 mmol), TEA (0.707 mL,5.07 mmol) and 3-methoxy-4-nitrobenzoic acid (lg, 5.07 mmol) in DMF (20 mL) was added(S)-tert-butyl 2-methylpiperazine-1-carboxylate (1.016 g, 5.07 mmol). The reaction wasstirred at room temperature for 3 hours. The mixture was partitioned between ethyl acetate(50 mL) and water (25 mL). The organic layer was washed with water (25 mL), saturatedNaHCO3 (25 mL) and brine (25 mL), dried over Na2SO4 and evaporated in vacuum to givethe title compound D42 (1 .78g, 3.61 mmol, 71.2 % yield) as orange oil.LCMS: 380[M+H]. tR=l.325. (LCMS condition 2)

169447-70-5, The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DING, Xiao; LIU, Qian; LONG, Kai; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; XU, Qiongfeng; EDGE, Colin Michael; WO2015/113451; (2015); A1;,
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170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2-chloro-6-(2-chlorophenyl)-7-methyl-5H-pyrano[2,3-d]pyrimidin-5-one (45 mg, 0.15 mmol), tert-butyl 4-(4- aminophenyl)piperazine-1-carboxylate (41 mg, 0.15 mmol) and DIPEA (51 1JL, 0.29 mmol) in anhydrous DMF (1 mL) washeated to 100 C under a nitrogen atmosphere for 60 mm. The reaction mixture was allowed to cool to RT, diluted with water (5 mL) and extracted into ethyl acetate (3 x 5 mL) . The combined organic phases were washed with 1:1 water/brine (3 x 5 mL), dried over Na2SO4, filtered, andconcentrated to dryness under reduced pressure to givethe title compound (42 mg, 52%) as a yellow solid. ?H NMR(500 MHz, CDC13) : 6 9.18 (s, 1H) , 8.07 (br s, 1H) , 7.53(br d, 2H), 7.47-7.51 (m, 1H), 7.31-7.37 (m, 2H), 7.21-7.25 (m, 1H), 6.96 (d, 2H), 3.59 (t, 4H), 3.12 (t, 4H),2.19 (s, 3H), 1.49 (s, 9H) . LCMS (Method A): = 1.56mi m/z = 548, 550 [M+H].

170911-92-9, 170911-92-9 tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 11011301, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; O’DOWD, Colin Roderick; BURKAMP, Frank; BELL, Mark Peter; WO2015/19037; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-39-4,(S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

A mixture of (S)-tert-butyl methyl piperazine- 1,3 -dicarboxylate (366 mg, 1.5 mmol) and HC1 in MeOH (20 mL, 2.9 M) was stirred at RT for 1 h. Themixture was concentrated in vacuo to yield the crude product (270 mg) as a yellow solid which was used directly in next step without further purification.

314741-39-4, The synthetic route of 314741-39-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARAXES PHARMA LLC; JANES, Matthew, Robert; PATRICELLI, Matthew, Peter; LI, Liansheng; REN, Pingda; LIU, Yi; (397 pag.)WO2016/44772; (2016); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-39-1,2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of compound 7, 8, or 9 (1 equiv) in 1-butanol was added compounds 12(1.1 equiv) and p-toluenesulfonic acid (1 equiv). The mixture was placed in a pressure flask, and heated to 100C for 15h. The reaction mixture was quenched by saturated Na2CO3 aqueous solution, and then was extracted with DCM and the organic phase was washed with water, dried over anhydrous Na2SO4. The combined organic layer was concentrated under reduced pressure and was further purified by flash column chromatography using dichloromethane/methanol as eluent to afford product H1-H14, Y1-Y14, or L1-L14 as a pale yellow solid., 5521-39-1

The synthetic route of 5521-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hou, Yunlei; Zhu, Liangyu; Li, Zhiwei; Shen, Qi; Xu, Qiaoling; Li, Wei; Liu, Yajing; Gong, Ping; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 690 – 709;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.655225-01-7,tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

655225-01-7, To a solution of Intermediate 20 (1.10 g, 90percent purity, 2.84 minol) in DMF (6.6 mL) was added atr.t. sodium hydride (60percent on mineral oil, 136 mg, 3.41 minol) and tetra-N-butylaminonium iodide(105 mg, 0.28 minol). Then the mixture was cooled to 0¡ãC and tert-butyl 4-(2- bromoethyl)piperazine-1-carboxylate (1.00 g, 3.41 minol) was added. The mixture then stirred for 14 h at r.t. and the reaction was quenched by the addition of water. Resulting mixture was extracted with dichloromethane (3 x) and the combined organic extracts were washed with brineand filtered through a phase separator filter to give the crude product which was directly used in the synthesis of Example 111 without further purification. Besides 50 mg of the crude product was purified by preparative HPLC to give 24 mg (0.04 minol) of the pure title compound.HPLC: Instrument: Waters Autopurification MS SingleQuad; Colum: Waters XBrigde C18 Sp lOOx3Omin; eluent A: water + 0.2 vol percent aqueous aminonia (32percent), eluent B: acetonitrile;gradient: 0-5.5 min 5-100percent B; flow 70 mI/min; temperature: 25 ¡ãC; DAD scan: 210-400 nm.1H-NMR (400 MHz, DMSO-d6): 6 [ppm] = 8.64 (s, IH), 8.62 (s, IH), 8.51 (d, IH), 7.77-7.71 (m,2H), 7.70-7.65 (m, 2H), 7.44 (d, IH), 4.83 (br d, 4H), 4.10 (dt, IH), 3.70-3.60 (m, IH), 3.42-3.36(m, IH), 3.23 (brs, 4H), 2.75-2.64 (m, 2H), 2.56 (t, 2H), 2.41-2.30 (m, 4H), 1.37 (s, 9H), 1.10 (d,3H).LC-MS (Method 6): R = 1.09 min; MS (ESipos): mz = 562 [M¡ÂH].

The synthetic route of 655225-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; GIESE, Anja; QUANZ-SCHOEFFEL, Maria; MUeLLER, Thomas; GUeNTHER, Judith; BOeHNKE, Niels; GRIEBENOW, Nils; BARAK, Naomi; BOeMER, Ulf; NEUHAUS, Roland; OSMERS, Maren; KOPITZ, Charlotte Christine; KAULFUSS, Stefan; REHWINKEL, Hartmut; WEISKE, Joerg; BADER, Benjamin; CHRISTIAN, Sven; HILLIG, Roman; (426 pag.)WO2018/86703; (2018); A1;,
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120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2-(5-chloro-2,4-dimethoxyphenyl)-7-(4-(2-chloropyrimidin-4- yl)piperazin-l-yl)imidazo[ l,2-a|pyridine 311 (200 mg, 0.41 mmol) and tert-butyl 2- methylpiperazine-1-carboxylate (164 mg, 0.824 mmol) was heated at 125 C in a microwave reactor for 3 h. The reaction mixture was diluted with water; the precipitate was collected by filtration, washed with water and dried. The crude compound was purified by combi-flash companion (silica gel, NH4OH/CH3OH CH2CI2) to provide tert-butyl 4-(4-{4-[2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl}pyrimidin-2-yl)-2-methylpiperazine-1-carboxylate 312j (125 mg, 47%) as an off-white solid. lH NMR (300 MHz, DMSO-d6): delta 8.36 (d, ./ = 7.5 Hz, i l l). 8.17 (s, 1H), 8.03 (s, 1H), 7.92 (d, J = 6 Hz, I H), 6.87-6.84 (m, 2H), 6.71 (s, 1H), 6.18 (d, J = 6 Hz, IH), 4,51 (dd, J = 13.2, 20.7 Hz, 2H), 4.18 (bs, IH), 4.01 (s, 3H), 3.93 (s, 3H), 3 ,78-3.68 (m, 4H), 3.33-3.12 (m, 4H), 3.07-2.99 (m, 2H), 2.90-2.81 (m, IH), 1.42 (s, 9H), 1.05 (d, ./ 6.6 I zeta. 3H); HPLC (Method 1) 96.1% (AUC), fR – 13.0 min.; ESI+APCI MS rn/z 649 M + l |, 120737-78-2

120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; CHAKRABARTI, Anjan; RAWAT, Manish; RAI, Sanjay; SATYANARAYANA, Arvapalli, Venkata; DUAN, Zhiyong; TALUKDAR, Arindam; RAVULA, Srinivas; DECORNEZ, Helene; (491 pag.)WO2017/58503; (2017); A1;,
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414910-15-9, tert-Butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,414910-15-9

TFA (965 muL) was added to a solution of intermediate 11 (210 mg) in anhydrous DCM (1 mL). The solution was stirred at r.t. for 2 hours, then it was concentrated in vacuo. The residue was diluted in a saturated potassium carbonate solution (10 mL) and extracted with AcOEt (2¡Á20 mL). The combined organic extracts were dried and concentrated in vacuo to give the title compound (110 mg) as an oil. [0244] T.I.c.: AcOEt, Rf=0.14. [0245] IR (CDCl3, cm-1): 1626 (CO). [0246] NMR (CDCl3): delta (ppm) 3.7 (bs, 1H); 3.63 (bd, 4H); 2.88 (bd, 4H); 1.72 (m, 1H); 0.99 (m, 2H); 0.75 (m, 2H). [0247] MS (ES/+): m/z=155 [M+H]+.

414910-15-9 tert-Butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate 968936, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Alvaro, Giuseppe; Di Fabio, Romano; Maragni, Paolo; Tampieri, Marsia; Tranquillini, Maria Elvira; US2004/14770; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

31166-44-6, To a solution of benzyl piperazine-1 -carboxylate (1 .10 g, 4.99 mmol) and 1 -bromo-3-diethoxyphosphoryl-propane (1 .29 g, 4.99 mmol) in CH3CN (40.00 mL) was added K2003 (1 .38 g, 9.98 mmol). The reaction mixture was stirred at 75 00 overnight and then EtOAc (50 mL) and water (30 mL) were added. The layers were separated, and the aqueous phase was extracted again with EtOAc (20 mLx2). The combined organic phases were washed with brine (40 mL), dried over anhydrous Mg504, filtered andconcentrated. The residue was purified by flash column chromatography on silica gel to afford Compound 15.la (EtOAc/MeOH=50:1) to afford (1.80 g, 4.52 mmol, 91percent yield) as an oil. 1H NMR (400 M, ODd3), oe7.35 (m, 5H), 5.13 (s, 2H), 4.12 (m, 4H), 3.52 (m, 4H), 2.42 (m, 6H), 1.78 (m, 4H), 1.32 (m, 6H).

31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; UNITY BIOTECHNOLOGY, INC.; BACKES, Bradley; W. VON GELDERN, Thomas; CHEN, Bing; (121 pag.)WO2017/101851; (2017); A1;,
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630125-91-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.630125-91-6,4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

To a solution of 4-bromo-2- (difluoromethyl) aniline (100 mg 0.450 mmol) in THF (10 mL) was added triphosgene (46.8 mg 0.158 mmol) . The resulting mixture was stirred at 70 . After 30 min LCMS analysis showed the starting material was disappeared. The solvent was removed in vacuo to give 4-bromo-2- (difluoromethyl) -1-isocyanatobenzene (110mg 0.417 mmol 93yield) . To a solution of 4- ( (4-ethylpiperazin-1-yl) methyl) -3- (trifluoromethyl) aniline (153 mg 0.532 mmol) Et3N (0.124 mL 0.887 mmol) and DMAP (10.84 mg 0.089 mmol) in THF (10 mL) was added a solution of 4-bromo-2- (difluoromethyl) -1-isocyanatobenzene (110 mg 0.444 mmol) in THF (10 mL) . The resulting mixture was stirred at 70 . After LCMS analysis showed the starting material was disappeared. The solvent was removed in vacuo. The residue was purified by preparative TLC (DCM/MeOH 10/1) to yield a solid of 1- (4-bromo-2- (difluoromethyl) phenyl) -3- (4- ( (4-ethylpiperazin-1-yl) methyl) -3- (trifluoromethyl) phenyl) urea (130 mg 0.172 mmol 38.9yield) 1HNMR(400 MHz CD3OD) delta 7.86 (s 1H) 7.75 (d J 8.8 Hz 1H) 7.67-7.63 (m 4H) 7.03-6.76 (m 1H) 3.67 (s 2H) 3.20-3.18 (m 2H) 2.96 (m 8H) 1.30 (m 3H) ES-LCMS m/z 535.1 537.1 (M+H)

The synthetic route of 630125-91-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
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196811-66-2, tert-Butyl 4-carbamothioylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of 4-thiocarbamoyl-piperazine-1 -carboxylic acid tert-butyl ester (13.3 mmol) in ethanol (60 ml) was added 4-(2-bromoacetyl)-benzoic acid (13.3 mmol) and 4- methylmorpholine (13.9 mmol). The reaction was heated at reflux for 2.5 h. The reaction was concentrated in vacuo and the solid washed with water (200 ml) to yield the title compound as a white solid (3.9 g). 1 H NMR (400MHz, CDCI3) 1.45 (9H, s), 3.58 (8H, m), 4.86 (1 H, s), 6.95 (1 H,s), 7.97 (2H, d, J 8 Hz), 8.1 (2H, d, J 8Hz).

196811-66-2, 196811-66-2 tert-Butyl 4-carbamothioylpiperazine-1-carboxylate 12093220, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MEDIVIR AB; WO2007/6714; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics