Tag: M.W:200-300

1217599-13-7, (R)-1-Boc-2-Isobutylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a vial containing (R) -tert-butyl 2-isobutylpiperazine-1-carboxylate (17-a) (50.8 mg, 0.210 mmol, commerically available from Matrix Scientific, Cairo, Egypt) , were added compound 10-d (48.3 mg, 0.220 mmol) , DMF (2.0 mL) and DIEA (100 mul, 0.57 mmol) . The mixture was stirred at RT for 19 h. The mixture was then filtered and purified by preparative, reverse-phase HPLC (eluting with ACN/water with 0.1%TFA) to afford (R) -tert-butyl 4- (5-cyano-2- (1-methyl-1H-pyrazol-4-yl) pyrimidin-4-yl) -2-isobutylpiperazine-1-carboxylate (17-b) as the TFA salt. MS (ESI) Calc?d for C22H32N7O2[M+1]+, 426; found, 426., 1217599-13-7

The synthetic route of 1217599-13-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; MCGOWAN, Meredeth A.; KATZ, Jason D.; CHRISTOPHER, Matthew; ZHOU, Hua; WITTER, David James; LI, Chaomin; LAMPE, John; METHOT, Joey L.; ACHAB, Abdelghani A.; XU, Shimin; FRADERA, Xavier; (123 pag.)WO2019/119206; (2019); A1;,
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288251-82-1, 5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 17 N-[3-cyano-4-(4-methylpiperazin-1-yl)phenyl]benzo[b]thiophene-2-carboxamide By the reaction and treatment in the same manner as in Example 6 using benzo[b]thiophene-2-carboxylic acid (1.3 g) and 5-amino-2-(4-methylpiperazin-1-yl)benzonitrile (1.6 g), the title compound (1.0 g) was obtained. melting point: 263-264¡ã C. 1H-NMR (270 MHz, DMSO-d6)delta:2.24 (3H, s), 3.13-3.14 (4H, m), 3.34-3.35 (4H, m), 7.21 (1H, d, J=9.2 Hz), 7.47-7.51 (2H, m), 7.90-7.93 (1H, m), 8.00-8.08 (2H, m), 8.09 (1H, d, J=2.6 Hz), 8.32 (1H, s), 10.64 (1H, s).

288251-82-1, 288251-82-1 5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile 17609581, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Ushio, Hiroyuki; Naito, Youichiro; Sugiyama, Naoki; Kawaguchi, Takafumi; Ohtsuki, Makio; Chiba, Kenji; US2003/203909; (2003); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16154-62-4,1-(2-Chloro-4-nitrophenyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.

[3-Chloro-4-(4-methyl-1-piperazinyl)phenyl]amine: 1-(2-chloro-4-nitrophenyl)-4- methylpiperazine (13.5 g, 52.8 mmol) was dissolved in Methanol (200 mL), and treated with platinum(IV) oxide (0.120 g, 0.528 mmol). The reaction was evacuated and back filled with H2 twice, then stirred for 48 hours under an H2 atmosphere. The crude mixture was filtered through a pad of celite, washed with MeOH, and concentrated to give the title compound as an orange solid (12 g, 100%). 1H NMR (400 MHz, METHANOL-^) delta ppm 2.35 (s, 3 H) 2.62 (br. s., 4 H) 2.95 (br. s., 4 H) 6.63 (dd, J=8.53, 2.76 Hz, 1 H) 6.75 – 6.81 (m, 1 H) 6.90 – 6.97 (m, 1 H); MS (m/z) 226 (M+H+)., 16154-62-4

16154-62-4 1-(2-Chloro-4-nitrophenyl)-4-methylpiperazine 2837294, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; CASILLAS, Linda, N.; CHAKRAVORTY, Subhas, J.; EIDAM, Patrick; HAILE, Pamela, A.; HUGHES, Terry, Vincent; LAKDAWALA SHAH, Ami; LEISTER, Lara, Kathryn; MILLER, Nathan, Andrew; RAHMAN, Attiq; SEHON, Clark, A.; WANG, Gren, Z.; ZHANG, Daohua; WO2011/120026; (2011); A1;,
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128019-59-0, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of piperazine-1,3-dicarboxylic acid 1-tert-butyl ester (4.5 g, 19.565 mmol, 1.0 eq) in DCM (125 mL) was added TEA (5.93 g, 58.70 mmol, 3.0 eq) and CbzCl (5 g, 29.35 mmol, 3.0 eq). The mixture was stirred at r.t. for 4 h. The reaction was monitored by LC-MS and TLC. The mixture was concentrated and the resulting residue was purified by chromatography on silica gel column (PE/EA = 5/1) to give (S)-1-((benzyloxy)carbonyl)-4- (tert-butoxycarbonyl)piperazine-2-carboxylic acid (5 g, 70%) as a white solid., 128019-59-0

The synthetic route of 128019-59-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LIFESCI PHAMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (241 pag.)WO2017/98328; (2017); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

A vial was charged with (S)-tert-butyl 3-(hydroxymethyl)piperazine-l-carboxylate (321.4 mg, 1.441 mmol) and (S)-2-(methoxymethyl)oxirane (162.4 mg, 1.788 mmol) in ethanol (2.5 mL). The mixture was heated at 120 C for 30 min using microwave. The mixture was cooled to room temperature, concentrated to remove all of solvent. The residue was purified with flash column chromatography on silica gel using 1-10% methanol in dichloromethane to afford the final product as colorless oil (379.3 mg) in 86% yield. 1H NMR (500 MHz, Chloroform-;/) delta 3.88 (m, l H), 3.82 (m, 1H), 3.66 (dd, J = 13, 3 Hz, 1H), 3.64 (br, 1 H), 3.50 – 3.47(m, 2H), 3.41 (dd, J= 9.7, 3.8 Hz, 1H), 3.37 (s, 3H), 3.30 (dd, J = 9.7, 6.2 Hz, 1H), 3.25 (br, lH), 2.90 (br, 1 H), 2.80 (t, J = 11.5 Hz, 2H), 2.46 (br, 1H), 2.35 (m, 2H), 1.43 (s, 9H). MS for C|4H28N205: 305.2 (MH+)., 314741-40-7

314741-40-7 (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate 24820294, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NEKTAR THERAPEUTICS (INDIA) PVT. LTD.; NEKTAR THERAPEUTICS; SHARMA, PANKAJ; KHATRI, VIJAY KUMAR; GU, XUYUAN; SONG, YUAN; SHEN, MICHAEL LIXIN; SAUTHIER, JENNIFER RIGGS; ANAND, NEEL K.; KOZLOWSKI, ANTONI; ODINECS, ALEKSANDRS; RILEY, TIMOTHY A.; REN, ZHONGXU; MU. YONGQI; SHEN, XIAOMING; YUAN. XUEJUN; AURRECOECHEA, NATALIA; O’MAHONY, DONOGH JOHN ROGER; WO2015/92819; (2015); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-78-2,tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Example 13A tert-butyl (2S)-2-methyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-carboxylate The product from Example 1D (200 mg, 0.59 mmol) was subjected to the conditions described in Example 11, substituting (S)-tert-butyl 2-methylpiperazine-1-carboxylate for 4-(piperidin-4-yl)morpholine to give the titled compound (232 mg, 75%)., 120737-78-2

120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AbbVie Inc.; Bogdan, Andrew; Cowart, Marlon D.; DeGoey, David A.; Jinkerson, Tammie K.; Koenig, John R.; Kort, Michael E.; Liu, Bo; Matulenko, Mark A.; Nelson, Derek W.; Patel, Meena V.; Peltier, Hillary; Scanio, Marc J.; Wakefield, Brian D.; US2015/218102; (2015); A1;,
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Piperazines – an overview | ScienceDirect Topics

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0512] Benzyl piperazine-1-carboxylate 23 (27 .3 mL,142.2 mmol) was dissolved in dry THF (313.1 mL) andoxetan-3-one (12.29 g, 10.93 mL, 170.6 mmol) was added.The resulting solution was cooled in an ice-bath. NaBH(Oac )3 (59.99 g, 284.4 mmol) was added portionwise over 30mins, about a quarter was added. Mixture removed from icebath, allowed to warm to room temperature then continuedadding the NaBH(Oac )3 portionwise over 30 mins. On completeaddition, an exotherm from 22¡ã C. slowly to 32¡ã C. wasobserved, whereby the mixture was subsequently cooled onan ice bath until an internal of 22¡ã C. was reached. The icebath was removed and the reaction mixture’s internal tempwas steady at 22¡ã C. The mixture was stirred at room temperatureovernight. [0513] The resulting white suspension was quenched byaddition of 2M sodium carbonate solution (approx 150 mL)(pH=8) and concentrated under reduced pressure to removeTHF. Product was then extracted with EtOAc (3×250 mL).Organics were combined, dried over MgS04 , filtered andconcentrated under reduced pressure to leave product 24 as awhite solid (32.7 g 83percent yield). 1H NMR (500 MHz, DMSOd6)o 7.39-7.30 (m, 5H), 5.07 (s, 2H), 4.52 (t, 2H), 4.42 (t,2H), 3.43-3.39 (m, 5H) and 2.22 (t, 4H). MS (ES+) 276.8., 31166-44-6

As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.

Reference£º
Patent; Charrier, Jean-Damien; Davis, Christopher John; Fraysse, Damien; Etxebarria I Jardi, Gorka; Pegg, Simon; Pierard, Francoise; Pinder, Joanne; Studley, John; Zwicker, Carl; Sanghvi, Tapan; Waldo, Michael; Medek, Ales; Shaw, David Matthew; Panesar, Maninder; Zhang, Yuegang; Alem, Naziha; US2015/158872; (2015); A1;,
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Piperazines – an overview | ScienceDirect Topics

300543-56-0, (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2 g of R-I- ( (4-chlorophenyl) (phenyl) methyl) piperazine and 0.88 g of diglycolic acid anhydride were dissolved in 10 ml of dimethylsulphoxide . To the solution 20 ml of tetrabutylammo- nium bromide were added. The solution was stirred for another 10 hours until the reaction was completed. The solution was diluted with 67 ml of water and 15 ml of isopropyl acetate were added. The phases were separated and the water layer was reextracted with isopropyl acetate. The organic layer was mixed with demineralised water (40 ml) and the pH of the suspension was adjusted to 10 with 2 M NaOH. The layers were separated and to the water phase 40 ml of isopropyl acetate were added. The pH of the suspension was adjusted to 3.5. The layers were separated and the water phase was reextracted twice with isopropylacetate . The organic phase was rinsed with water and evaporated to dryness. 2.5 g of product (HPLC (area) was 98.5 %) ) was crystallised. The product was dried at vacuum at 500C., 300543-56-0

As the paragraph descriping shows that 300543-56-0 is playing an increasingly important role.

Reference£º
Patent; KRKA, tovarna zdravil, d.d., Novo Mesto; WO2009/150147; (2009); A1;,
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Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A dichloromethane solution (6mL) of an appropriate piperazine (1 eq) and triethylamine (3 eq) was added drop wise to a suspension of 2-chloro-N-(5-nitrothiazol-2-yl)acetamide (1) in 5mL CH2Cl2 and the reaction was kept at room temperature under a nitrogen atmosphere and stirring for 48h. The reaction solvent was evaporated and the residue was redissolved in ethyl acetate. The inorganic salts were filtered away and the residue was chromatographed on preparative TLC silica gel plates with ethyl acetate/petroleum ether as eluent to obtain the desired pure product as a powder or crystals. Purity was also checked by HPLC and it was ?95%. Orange powder (55%): mp 173-175C; 1H NMR (400MHz, (CDCl3) delta: 8.33 (s, 1H), 7.51 (d, J=8.4Hz, 2H), 6.96 (d, J=8.4Hz, 2H), 3.40 (s, 2H), 3.38 (t, J=5.2Hz, 4H), 2.82 (t, J=5.2Hz, 4H). HRESIMS calcd for C16H16N8O4S m/z [M+H]+ 416.1010, found 416.1005, 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Papadopoulou, Maria V.; Bloomer, William D.; Rosenzweig, Howard S.; Wilkinson, Shane R.; Szular, Joanna; Kaiser, Marcel; European Journal of Medicinal Chemistry; vol. 117; (2016); p. 179 – 186;,
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694499-26-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

General procedure: To amixture of substituted benzoic acid obtained in the last step (0.12 mmol) in 5mL DMF, 2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate (HATU, 0.18 mmol), ethyldiisopropylamine (DIPEA, 0.24 mmol)and 4-((4-methylpiperazin-1-yl)methyl)-3- (trifluoromethyl)aniline (0.1 mmol)was added. The resulting mixture was stirred at room temperature overnight. Thenthe reaction was extracted with ethyl acetate, washed with brine, dried overanhydrous Na2SO4, filtered and concentrated to give thecrude product, which was further purified by column chromatography to affordthe final compounds.

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference£º
Article; Han, Mei; Li, Shan; Ai, Jing; Sheng, Rong; Hu, Yongzhou; Hu, Youhong; Geng, Meiyu; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5679 – 5684;,
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Piperazines – an overview | ScienceDirect Topics