Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1589082-06-3,(S)-tert-Butyl 3-(cyanomethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

A reaction mixture of tert-butyl (3S)-3-(cyanomethyl)piperazine-1-carboxylate (850 mg, 3.77 mmol) and HCl/dioxane (4 M, 20 mL) was stirred at 15¡ã C. for 1 hour. Upon completion, the solvent was removed under vacuum to give 2-[(2S)-piperazin-2-yl]acetonitrile (740 mg, 3.74 mmol, 99.0% yield, 2HCl) as a white solid. 1H NMR (400 MHz, METHANOL-d 4) delta=4.04-3.90 (m, 1H), 3.81-3.70 (m, 2H), 3.69-3.61 (m, 2H), 3.53-3.36 (m, 2H), 3.13 (d, J=6.4 Hz, 2H)., 1589082-06-3

The synthetic route of 1589082-06-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mirati Therapeutics, Inc.; Array BioPharma Inc.; Blake, James F.; Burgess, Laurence E.; Chicarelli, Mark Joseph; Christensen, James Gail; Cook, Adam; Fell, Jay Bradford; Fischer, John P.; Marx, Matthew Arnold; Mejia, Macedonio J.; Savechenkov, Pavel; Vigers, Guy P.A.; Smith, Christopher Ronald; Rodriguez, Martha E.; US2019/144444; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

128019-59-0, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 10; Piperazine-1, 2,4-tricarboxylic acid 4-tert-butyl ester 1- (9H-fluoren-9-ylmethyl) ester; A solution of 9-fluorenylmethyl chloroformate (2.72 g, 10.5 mmol) in 1,4-dioxane (19 mL) was added drop-wise to a solution of piperazine-1, 3-dicarboxylic acid 1-tert-butyl ester (2.20 g, 9.6 mmol) and N, N-diisopropylethylamine (4.2 mL, 23.9 mmol) in water (9.5 mL) in an ice-bath. After stirring overnight at room temperature, the reaction mixture was diluted with water and extracted with chloroform (4 times). The organic layer was washed with saturated sodium bicarbonate and water and then 1N HCl and water, dried over anhydrous sodium sulfate, filtered, and concentrated to afford piperazine-1,2, 4- tricarboxylic acid 4-tert-butyl ester 1- (9H-fluoren-9-ylmethyl) ester (4.3g)., 128019-59-0

The synthetic route of 128019-59-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2005/80386; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1217599-13-7,(R)-1-Boc-2-Isobutylpiperazine,as a common compound, the synthetic route is as follows.

(R)-tert-but l 4-(6-chloro-5-cyano-3-fluoropyridin-2-yl)-2-isobutylpiperazine-l-carboxylateA mixture of tert-butyl (2R)-2-isobutylpiperazine-l-carboxylate (515 mg, 2.13 mmol), 2,6- dichloro-5-fluoro-pyridine-3-carbonitrile (405.9 mg, 2.13 mmol) and DIPEA (274.6 mg, 370.1 mu, 2.13 mmol) in NMP was heated at 130 C for 20 minutes under microwave conditions. After this time, the reaction mixture was allowed to cool to ambient temperature and diluted with EtOAc and water. The organic layer was separated and washed with brine, dried ( a2S04), filtered and concentrated in vacuo. The crude mixture was purified by column chromatography (ISCO Companion, 120 g column, eluting with EtO Ac/Petroleum ether) to give the sub title compound (629.9 mg, 75% Yield). XH NMR (400 MHz, CDC13) delta 7.37 (d, J= 12.6 Hz, 1H), 4.55 – 4.23 (m, 3H), 4.1 1 (q, J= 7.2 Hz, 1H), 3.23 (dd, J= 13.4, 3.6 Hz, 1H), 3.08 (d, J= 9.4 Hz, 2H), 1.64 – 1.52 (m, 1H), 1.50 – 1.28 (m, 1 1H), 0.93 (d, J= 6.5 Hz, 6H).

1217599-13-7, As the paragraph descriping shows that 1217599-13-7 is playing an increasingly important role.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; JIMENEZ, Juan-Miguel; GOLEC, Julian, M.C.; SETTIMO, Luca; FRAYSSE, Damien; BRENCHLEY, Guy; BOYALL, Dean; TWIN, Heather; YOUNG, Stephen; MILLER, Andrew, W.; DAVIS, Christopher, John; WO2011/94283; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

1589082-06-3, (S)-tert-Butyl 3-(cyanomethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A reaction mixture of fert-butyl (3,51-3- (cyanomethyl)piperazine-l-carboxylate (850 mg, 3.77 mmol) and HCl/dioxane (4 M, 20 mL) was stirred at 15 C for 1 hour. Upon completion, the solvent was removed under vacuum to give 2-[(25)-piperazin-2-yl]acetonitrile (740 mg, 3.74 mmol, 99.0% yield, 2HC1) as a white solid. NMR (400MHz, METHANOLS) delta = 4.04 – 3.90 (m, 1H), 3.81 – 3.70 (m, 2H), 3.69 – 3.61 (m, 2H), 3.53 – 3.36 (m, 2H), 3.13 (d, J=6.4 Hz, 2H)., 1589082-06-3

As the paragraph descriping shows that 1589082-06-3 is playing an increasingly important role.

Reference£º
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; FISCHER, John, P.; FELL, Jay, Bradford; BLAKE, James, F.; HINKLIN, Ronald, Jay; MEJIA, Macedonio, J.; HICKEN, Erik, James; CHICARELLI, Mark, Joseph; GAUDINO, John, J.; VIGERS, Guy, P.A.; BURGESS, Laurence, E.; MARX, Matthew, Arnold; CHRISTENSEN, James, Gail; LEE, Matthew, Randolf; SAVECHENKOV, Pavel; ZECCA, Henry, J.; (529 pag.)WO2017/201161; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879896-50-1,2-(4-Methylpiperazin-1-ylmethyl)benzylamine,as a common compound, the synthetic route is as follows.,879896-50-1

Example 111 lambda/-Methoxy-4-methyl-3-[3-[[[2-[(4-methyl-1-piperazinyl)methyl]phenyl]methyl]amino]- 2-oxo-1(2H)-pyrazinyl]-benzamideTo a stirred solution of 3-(3,5-dibromo-2-oxo-2H-pyrazin-1-yl)-4-methyl-benzoic acid, methyl ester (Example 1 b, 0.1 g) in tetrahydrofuran (2 ml.) in a microwave vial was added triethylamine (250 mul_) and 2-[(4-methyl-1-piperazinyl)methyl]-benzenemethanamine (90 mg). The reaction was stirred overnight before the addition of O-methylhydroxylamine hydrochloride (83 mg) and cyclopentylmagnesium bromide (2M in diethyl ether, 2 ml.) dropwise. After stirring for 60 minutes, ethanol (2 ml.) was added followed by the addition of ammonium formate (0.4 g) and 10% palladium on carbon (40 mg). The reaction mixture was heated within a microwave for 30 minutes at 100C before being cooled to room temperature, filtered and washed with ethanol. The filtrate was concentrated in vacuo. Purification by preparative HPLC (Gemini column, 0.1 % trifluroacetic acid: acetonitrile eluent) afforded the title compound (13 mg). MS: APCI(+ve) 477 (M+H+).1H NMR delta(DMSO-d6, 400MHz) 7.77 (1 H, d), 7.67 (1 H, s), 7.51 (1 H, d), 7.41 (1 H, d), 7.33 – 7.27 (3H, m), 6.90 (1 H, d), 6.75 (1 H, d), 4.72 (1 H, d), 4.62 (1 H, d), 3.80 – 3.69 (2H, m), 3.69 (3H, s), 3.44 – 3.25 (4H, m), 2.70 (3H, s), 2.50 – 2.35 (2H, m), 2.12 (3H, s).

The synthetic route of 879896-50-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/1132; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5753-26-4,5753-26-4, 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) A mixture of 8.5 g of 9-acridanone, 180 ml of dimethylformamide and 3.3 g of sodium hydride is stirred for 0.5 hour, treated portionwise with 10.3 g of 2-[1-(4-methyl)-piperazinyl]ethyl chloride dihydrochloride, stirred at 80 for 3 days and evaporated. The residue is treated with water and extracted with methylene chloride. The extract is washed with water, dried over sodium sulfate and evaporated, whereupon the residue is recrystallized firstly from ether and then from ethyl acetate. There is obtained 10-[2-(4-methyl-1-piperazinyl)ethyl]-9-acridanone of melting point 156-157.

As the paragraph descriping shows that 5753-26-4 is playing an increasingly important role.

Reference£º
Patent; Hoffman-La Roche Inc.; US4711889; (1987); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128019-59-0,4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

61 (B) 4-Methyl-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester The crude piperazine-1, 3-dicarboxylic acid-1-tert-butyl ester (4.92 mmol), prepared as described in 62 (A), was suspended in dry acetonitrile (30 mL) under nitrogen atmosphere and formaldehyde (37% wt. aqueous solution, 367 mL, 4.92 mmol) and Na (OAc) 3BH (2.3 g, 10. 82 mmol) were added. The resulting mixture was stirred at R. T. for 3h, then a saturated aqueous solution of NaHC03 was slowly added until the pH was adjusted to 7. The mixture was concentrated to dryness under reduced pressure to give a yellow solid that was used without further purification for the next step. LCMS (Tr): 3.19 min (Method B); MS (ES+) gave m/z : 245.0., 128019-59-0

As the paragraph descriping shows that 128019-59-0 is playing an increasingly important role.

Reference£º
Patent; ADDEX PHARMACEUTICALS SA; WO2005/44797; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.623586-00-5,(R)-1-Cbz-3-methylpiperazine,as a common compound, the synthetic route is as follows.

623586-00-5, A mixture of (R)-benzyl 3-methylpiperazine-1-carboxylate (4.8 g, 20.5 mmol) from step (a) above, 1,3-bis(tertbutoxycarbonyl)-2-methylisothiourea (6.5 g, 23 mmol, Aldrich), and triethylamine (3.4 mL, 24.6 mmol, Aldrich) in DCM (140 mL) was added mercury(II)chloride (5.8 g, 21.6 mmol, Aldrich). The reaction mixture was stirred at RT for 16 h. Then, the mixture was filtered and the solid was washed with DCM (2*100 mL). The combined filtrates were concentrated in vacuo and the residue was purified on silica gel using ISCO Combiflash system with DCM/2M methanolic ammonia gradient to give the title compound as a white solid. MS (ESI, positive ion) m/z: 477 (M+1).

The synthetic route of 623586-00-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gore, Vijay Keshav; Ma, Vu Van; Norman, Mark H.; Ognyanov, Vassil I.; Xi, Ning; US2006/84640; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

185110-19-4, 2-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: (+/-)-Methyl {3-[4-(trifluoromethyl)phenyl]piperazin-l-yl} acetate; A mixture of the piperazine described in Step 2 above (2.1g, 9mmol), methyl bromoacetate (ImL, 9mmol) and potassium carbonate (2.4g, 18mmol) in acetonitrile (3OmL) was stirred overnight at room temperature. The mixture was filtered, evaporated and purified on silica using 25-50% ethyl acetate in z’s¡ã-hexane as eluant.1H NMR (500MHz, CDCl3): delta 2.22 (IH, t, J 10.6), 2.37-2.43 (IH, m), 2.93 (2H, t, J 9.4), 3.10- 3.17 (2H, m), 3.26 (2H, s), 3.72 (3H, s), 7.52 (2H, d, J 8.1), 7.58 (2H, d, J 8.2).

185110-19-4, The synthetic route of 185110-19-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME LIMITED; MERCK & CO., INC.; WO2007/125364; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

2031-23-4, 1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 3 4,6-Diamino-2-[3-(4-methyl-1-piperazinyl)propylthio]-5-(2-methoxybenzyl)pyrimidine trihydrochloride To a suspension of 6.0 g (20 mmoles) of 4,6-diamino-2-mercapto-5-(2-methoxybenzyl)pyrimidine potassium salt, 2.76 g (20 mmoles) of potassium carbonate and 0.33 g (2 mmoles) of potassium iodide in 100 ml of methyl alcohol, 5.0 g (20 mmoles) of 1-(3-chloropropyl)-4-methylpiperazine dihydrochloride are added, and the reaction mixture is boiled for 20 hours. The mixture is allowed to cool to room temperature, the inorganic salts are filtered, the filtrate is evaporated under reduced pressure, the oil obtained is crystallized from water, the crystalline substance is filtered and dried. The base obtained is reacted in ethyl alcohol with 3 equivalents of hydrogen chloride using isopropanol containing hydrogen chloride. Thus, 5.5 g (53.7%) of the title product are obtained. M.p.: above 280 C. Analysis: for C20H33Cl3N6OS (511.95) calculated: C, 46.92%; H, 6.50%; N, 16.42%; S, 6.26%; Cl, (ionic) 20.78%; found: C, 46.31%; H, 6.54%; N, 16.14%; S, 6.26%; Cl, (ionic) 20.44%., 2031-23-4

The synthetic route of 2031-23-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EGIS Gyogyszergyar Rt.; US6469168; (2002); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics