Tag: M.W:200-300

74852-62-3, 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

c) A solution of 400 g of 4-[4-(4-methoxyphenyl)-1-piperazinyl]benzenamine (prepared as described in example I of U.S. Pat. No. 4,267,179) in 1000 ml of tetrahydrothiophene 1,1-dioxide was stirred for 1 hour at 100 C. A solution of 382.8 g intermediate (2) in 200 ml of tetrahydrothiophene 1,1-dioxide, which was prepared by warming to 60 C., was added dropwise over 4 hours at 100 C. The mixture was stirred overnight at 100 C. and for 3 hours at 160 C. After cooling to 50 C., the precipitate was filtered off, washed with acetone and dried in vacuo at 60 C. under nitrogen, yielding 290 g (56%) of 2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-5-methyl-3H-1,2,4-triazol-3-one (interm. 3)., 74852-62-3

The synthetic route of 74852-62-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Janssen Pharmaceutica N.V.; US5254553; (1993); A;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16154-62-4,1-(2-Chloro-4-nitrophenyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of SG4-029 (2.00 g, 7.82 mmol) in MeOH (32 mL, deoxygenated with Argon gas) was added PtC (18 mg, 0.0782 mmol). A balloon of hydrogen gas was attached to the flask via a septum cap. The mixture was stirred at room temperature for 5 h. The reaction mixture was filtered over Celite and the filtrate concentrated under reduced pressure to provide the title compound as a light yellow solid (1.741 g, 98%). NMR (400 MHz, DMSO-ifc) delta: 6.85 (d, J = 8.5 Hz, 1H), 6.59 (d, / = 2.6 Hz, 1H), 6.45 (dd, / = 8.5, 2.6 Hz, 1H), 5.01 (s, 2H, disappeared on D20 shake), 2.81- 2.72 (m, 4H), 2.40 (brs, 4H), 2.18 (s, 3H). HPLC-MS (ESI+): m/z 228.2 [35%, (M37C1+H)+], 226.2 [100%, (M35C1+H)+]., 16154-62-4

The synthetic route of 16154-62-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas J.; LAWRENCE, Harshani R.; (293 pag.)WO2017/66428; (2017); A1;,
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197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

te/f-Butyl 4-(4-(6-chloro-7-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)-3H- imidazo[4,5-iotab]pyridin-2-yl)phenyl)piperazine-1-carboxylate To a mixture of 2-[4-(2-amino-5-chloro-3-nitro-pyridin-4-yl)-piperazin-1-yl]-lambda/-thiazol-2- yl-acetamide (0.048 g, 0.12 mmol) and EtOH (5 ml_) was added tert-butyl 4-(4- formylphenyl)piperazine-1-carboxylate (0.045 g, 0.16 mmol) followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.48 ml_, 0.48 mmol). The reaction mixture was stirred at 80 0C for 18 h, then allowed to cool to room temperature and concentrated in vacuo. The residue was absorbed on silica gel, the free-running powder was placed on a 10 g isolute silica column, and elution with a gradient of methanol (0 to 3%) in ethyl acetate / dichloromethane (v:v; 1 :1 ) afforded the title compound as a pale yellow solid (0.040 g, 53%).1 H-NMR (500 MHz, DMSO-d6) 1.43 (s, 9H, C(CHs)3), 2.77 (br t, 4H), 3.26 (br t obscured by water peak), 3.48 (br t, 4H), and 3.71 (br s, 4H) (piperazine N(CH2)2), 3.40 (s, 2H, NCH2CONH), 7.06 (d, J = 9.3 Hz, 2H) and 8.04 (d, J= 8.2Hz, 2H) (2,6-C6H4 and 3,5-C6H4), 7.23 (d, J = 3.5 Hz, 1 H) and 7.49 (d, J = 3.5 Hz, 1H), (thiazole 4-H, 5-H), 8.05 (s, 1 H, imidazo[4,5-]pyridine 5-H)1 11.87 (br s, 1H, CONH), 13.18 (br s, 1 H, imidazo[4,5-197638-83-8

197638-83-8 1-Boc-4-(4-Formylphenyl)piperazine 2795509, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
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Piperazines – an overview | ScienceDirect Topics

611225-86-6, 4-(4-Ethylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

611225-86-6, 104 mg (0.35 mMol) triphosgene are ^j-n’ ^ dissolved in13 ml ice-cooled CH2CI2. ^-/ ~~” Then a solution of 230 mg (1.05mMol) 4-(4-ethylpiperazin-1-O Hylmethyl)~aniline and 209 i (1.50 mMol) Et3N in 6 ml CH2CI2 is added during 8 min. After 3 additional minutes, the mixture is warmed up to rt by a water bath and then a solution of 1.0 mMol 5-(6-chloro-pyrimidin-4-yioxy)-2,3-dihydro-1H-indole (Step 14.1) and 139 jll. (1.00 mMol) Et3N in 6 ml CH2CI2 is added during 8 min. After 2 h at rt, the mixture is diluted with sat. Na2C03 solution / water 1:1 and EtOAc, the aqueous phase separated off and extracted twice with EtOAc. The organic layers are washed with water and brine, dried (Na2S04) and concentrated. Crystallization from DIPE gives the title compound: MS: [M+1]+= 493 / 495; TLC(CH2CI2/MeOH/NH3conc- 90:10:1): Rf = 0.24; HPLC: et_ = 10.5.

The synthetic route of 611225-86-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2006/34833; (2006); A1;,
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118753-66-5, tert-Butyl 4-aminopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of tert-hutyl 4-aminopiperazine-l-carboxylate (0.200 g, 0.99 mmol, 1.0 equiv) in DMF (05 mL) was added HATU (0.753 g, 1.98 mmol, 2.0 equiv) at RT and stirred for 10 minutes. Then 6-chloroquinoline-2-carboxylic acid (0.206 g, 0.99 mmol, 1.0 equiv) was added followed by the addition of DIPEA (0.6 mL, 2.97 mmol, 3.0 equiv). The resulting reaction mixture was allowed to stir at RT for overnight. Product formation was confirmed by LCMS The reaction mixture was diluted with water (50 mL) and extracted with EtOAc (50 mL * 2). The combined organic layer was washed with water (30mL x 3), brine solution (30 ml, c 2), dried over anhydrous sodium sulfate and concentrated under reduced pressure, to obtain tert-butyl 4-(6-chloroquinoline-2-carboxamido)piperazine-l-carboxylate (0.140 g, 36 % Yield) as a brown solid. LCMS 390 ] M 1 1 | : NMR (400MHz, DMSO-de) d 9.95 (br. s., 1 H), 8.53 (d, ./ 8.3 Hz, 1 H), 8.24 (br. s., 1 H), 8.15 (d, J= 5.3 Hz, 2 H), 7.88 (d, J = 7.5 Hz, 1 H), 3 45 (br. s., 4 H), 2.90 (d, J= 1 1.0 Hz, 4 H), 1.42 (s, 9 H).

118753-66-5, The synthetic route of 118753-66-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PRAXIS BIOTECH LLC; DELGADO OYARZO, Luz Marina; URETA DIAZ, Gonzalo Andres; PUJALA, Brahmam; PANPATIL, Dayanand; BERNALES, Sebastian; CHAKRAVARTY, Sarvajit; (0 pag.)WO2019/236710; (2019); A1;,
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Piperazines – an overview | ScienceDirect Topics

278788-66-2, (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Fluoro-2-methyl-3-(oxiran-2-yl)benzonitrile (prepared as described above for I-17A and I-17B, Method1, Steps A-C) (4.80 g, 27.1 mmol) and (R)-4-N-BOC-2-hydroxymethyl-piperazine (commercially available, e.g. fromAcesys Pharmatech, catalog A1612R; and also described in J. Org. Chem, 2007, 72(22), p. 8591-8592) (8.79g.40.6 mmol) were suspended in EtOH (30mL) and heated in a microwave apparatus at 150 C for 1 h. The reactionmixture was cooled and evaporated to dryness. The residue was purified by chromatography through a 330 g ISCORedi-sep column eluting with ethyl acetate to 5% MeOH/ ethyl acetate gradient to yield the title compound. LC-MS:M+1 = 394;

278788-66-2, 278788-66-2 (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate 24820286, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Merck Sharp & Dohme Corp.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; (128 pag.)EP2744499; (2016); B1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.187669-60-9,1-(4-(Methylsulfonyl)phenyl)piperazine,as a common compound, the synthetic route is as follows.

Example 80; 4-{2-[4-(4-Mcthancsulfonylphcnyl)pipcrazin-l-yl]-2-oxocthyl}pipcridinc-l- carboxylic acid ferf-butyl ester; To a solution of l-(4-methanesulfonylphenyl)piperazine (0.22 g, 0.91 mmol), 4-carboxy methylpiperidine-1-carboxylic acid tert-butyl ester (0.20 g, 0.80 mmol), HOBT.H2O (0.14 g, 0.91 mmol) and DIPEA (0.47 mL, 2.72 mmol) in DMF (5mL) was added EDCI (0.19 g, 0.99 mmol) and the mixture was stirred for 18h. The solvent was removed under vacuum and the resulting residue was partitioned between EtOAc and saturated NaHCO3 solution. The aqueous phase was re-extracted with EtOAc, the organic extracts were combined, washed with brine, dried (MgSO4) and adsorbed onto SiO2. The adsorbed sample was purified by flash chromatography eluting with 50:50 EtOAc:hexane to afford the title compound: RT = 3.26 min; m/z (ES+) = 466.33 [M+H]+., 187669-60-9

The synthetic route of 187669-60-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PROSIDION LIMITED; WO2007/3964; (2007); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.,76003-29-7

This compound was prepared as set out in step 1 of the scheme for example 4. NMR (300 MHz, CDC13) delta 9.09 (d, J= 2.1 Hz, 1H), 7.73 (d, J = 2.1 Hz, 1H), 7.53- 7.43 (m, 2H), 7.42-7.31 (m, 3H), 5.33 (s, 2H), 4.30 (s, 2H), 3.93-3.72(m, 7H), 1.51 (s, 9H)MS (ESI+) m/z 587 (M[Br79]+l), 589 (M[Br81]+l)

The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AVEXA LIMITED; SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (SIOC); RHODES, David, Ian; DEADMAN, John, Joseph; LE, Giang, Thanh; VAN DE GRAFF, Nicholas, Andrew; LONG, Lu; XINMING, Li; XIAO, Feng; CHANGJIANG, Yu; WO2012/6680; (2012); A1;,
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Piperazines – an overview | ScienceDirect Topics

3022-15-9, Piperazine-2-carboxylic acid dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of di-tert-butyldicarbonate (63 g, 290 mmol) in MeOH (100 mL) was added portionwise to a solution of piperazine-2-carboxyilic acid dihydrochloride (25.0 g, 123 mmol) and triethylamine (48 mL, 340 mmol) in MeOH (150 mL) over 30 minutes. Upon complete addition, the reaction mixture was heated to 50 0C for 2 h. Upon cooling to rt, the reaction mixture was concentrated under reduced pressure. The material was dissolved in water (300 mL) and the solution was brought to pH 2 with 1 M aqueous HCl. This was extracted with EtOAc (4 x 200 mL), and the combined extracts were dried over Na2SO4, filtered, and concentrated under reduced pressure until -100 mL EtOAc remained. The solution was diluted with hexanes (150 mL) and cooled to 0 0C. The resulting solid was collected by filtration, washed with hexanes (2 x) and air- dried. This gave 38.9 g (96%) of the title compound as a white solid. Analytical data: 1H NMR (400 MHz, DMSO-J6) delta 13.02-12.80 (br, IH), 4.50-4.24 (m, 2H)5 3.94-3.72 (br, IH), 3.66 (d, J= 12.8 Hz, IH), 3.22-2.92 (m, 2H), 2.90-2.68 (brs IH), 1.42-1.34, (m, 18H).

3022-15-9, As the paragraph descriping shows that 3022-15-9 is playing an increasingly important role.

Reference£º
Patent; CRITICAL THERAPEUTICS, INC.; WO2007/146066; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5753-26-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5753-26-4,1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride,as a common compound, the synthetic route is as follows.

[4-CYCLOPENTYLAMINO-6-HYDROXY-QUINAZOLINE-2-CARBONITRILE] (0. [4MMOL),] 1- (2-Chloro- ethyl) -4-methyl-piperazine dihydrochloride [(0.] [55MMOL)] and cesium carbonate [(4MMOL)] are stirred in DMF [(5ML)] at RT for 20 hours. The suspension is filtered, washed with little DMF and water is added to the filtrate until the solution gets turbide. The precipitate formed is filtered off, washed with water and dried (vacuum). A powder with mp. 110- [112C,] [RIF0.] 48 [(CH2CL2/MEOH=9] : 2) is obtained. [‘H-NMR] [(CDC13)] : 1.5-1. 9 [(M,] 6H), 2.2 [(M,] 2H), 2.35 (s, 3H), 2.4-2. 75 [(M,] 8H), 2.9 [(M,] [2H),] 4.25 [(M,] 2H), 4.6 [(M,] 1H), 6.85 (broad d, 1H), 7.05 (d, 1H), 7.45 (dd, 1H), 7.8 (d, [1H).]

5753-26-4 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride 11183940, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/20441; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics