Tag: M.W:200-300

34334-28-6, 4-(4-Methylpiperazin-1-yl)benzonitrile is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2-((4-chlorophenyl)thio)acetohydrazide 50(1.00 mmol), the suitably substituted nitrile (3.00 mmol), andK2CO3 (0.5 mmol) in n-BuOH (2 mL) was stirred for 16 h in a reusablesealed tube at 150 C, in an oil bath. The progress of the reactionwasmonitored by the disappearance of the hydrazide by TLCanalysis. The solvent was removed in vacuo and the residue obtainedwas purified by flash chromatography (hexanes/EtOAc 1:1).4.7. 5-(4-Chlorophenyl)-3-(((4-chlorophenyl)thio)methyl)-1H-1,2,4-triazole, 5White solid. M. p. 121e122 C. Yield: 51%. 1H-NMR (d, ppm):10.63 (bs, 1H, exc.), 7.93 (d, 2H, J 8.4 Hz), 7.42 (d, 2H, J 8.0 Hz),7.31e7.25 (m, 4H), 4.27 (s, 2H). 13C-NMR (d, ppm): 159.52, 156.95,136.28, 133.43, 132.72, 131.22, 129.41, 129.13, 128.54, 127.74, 127.49,30.34. HRMS (ESI) [M H] calculated for C15H11Cl2N3S: 335.0051,found: 335.0233., 34334-28-6

34334-28-6 4-(4-Methylpiperazin-1-yl)benzonitrile 763205, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; La Pietra, Valeria; Sartini, Stefania; Botta, Lorenzo; Antonelli, Alessandro; Ferrari, Silvia Martina; Fallahi, Poupak; Moriconi, Alessio; Coviello, Vito; Quattrini, Luca; Ke, Yi-Yu; Hsing-Pang, Hsieh; Da Settimo, Federico; Novellino, Ettore; La Motta, Concettina; Marinelli, Luciana; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 491 – 505;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3022-15-9,Piperazine-2-carboxylic acid dihydrochloride,as a common compound, the synthetic route is as follows.

EXAMPLE-6 2-Cyano-1-(4-isopropyl-2-piperazinyl)-carbonyl Pyrrolidine Trifluoroacetate (Compound No.2). Step-1 To an aqueous (100 ml) sodium hydroxide (4.0 g, 100 mmol) solution of piperazine-2-carboxylic acid dihydrochloride (5 g, 24.63 mmol) is added a solution of di-tert-butyl dicarbonate (11.0 g, 50.45 mmol) in dioxan (50 ml) at 0 C. over a period of half an hour. The reaction mixture is stirred at 0 C. for 1 hr. followed by stirring at room temperature (25 C.) for another 2 hrs. Neutralized (pH 6-7) with aqueous 2N HCl, extracted with ethyl acetate. Organic layer washed with brine solution, dried (Na2SO4) and evaporated in vacuo to yield an oil which solidifies on cooling. (Yield 8.02 g, 98.76%)., 3022-15-9

As the paragraph descriping shows that 3022-15-9 is playing an increasingly important role.

Reference：
Patent; TORRENT PHARMACEUTICALS LTD.; US2004/106802; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Z-rnethoxy4–(4-rnethyipiperazin- 1 -yl)aniline (10 g, 452 nunol) in toluene (230 mL) was added Di-tert-butyi dicarbonate (9.87 g, 45.2 mmol). The reaction mixture was stirred at 120 C for 6 hrs and concentrated under reduced pressure. The residue was purified by cohmm chromatography on silica gel (3:97 to 10:90, ammonia solution 7.0 N in methaiiolIdichioromethane) to afford title compound (12.5 g, 86% yield). Rt = 3.23 mm;?H NMR 600 MHz (DMSO-d6) d 7.62 (s, IH), 7.31 (/nc IH), 6.52 (d, .J 2.4 Hz, 1H), 6.38 (dci, J= 2.4 Hz, J= L0 Hz, 1H), 3.72 (s, 3H), 3.04 (in, 4H), 2.39 (in, 4H), 2.17 (s, 3H), 1.38 (r, 9H); MS ni/z: 321.99 [M+ii,., 122833-04-9

122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael; CHOI, Hwan Geun; TAN, Li; WO2015/6492; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1:The mixture of methyl (¡À)-4-Boc-piperazine-2-carboxylate (CAS: 129799-08-2, 2.44 g, 0.01 mol), TEA (1.52 g, 0.015 mol) in DCM (10 mL) was added to a solution of (4-nitrophenyl) carbonochloridate (2.42 g, 0.012 mol) in DCM (10 mL). After 1 hour at rt, the organic layer was washed with water and saturated sodium bicarbonate solution, dried over sodium sulfate. After removal of solvent, the crude product 67-B was obtained and used in the next step without purification. MS: calc’d 410 (MH+), measured 410 (MH+)., 129799-08-2

As the paragraph descriping shows that 129799-08-2 is playing an increasingly important role.

Reference£º
Patent; HOFFMANN-LA ROCHE INC.; Guo, Lei; Hu, Taishan; Kou, Buyu; Lin, Xianfeng; Shen, Hong; Shi, Houguang; Yan, Shixiang; Zhang, Weixing; Zhang, Zhisen; Zhou, Mingwei; Zhu, Wei; US2015/252057; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.955400-16-5,(S)-tert-Butyl 3-(methoxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,955400-16-5

A mixture of tert-butyl (3S)-3-(methoxymethyl)piperazine-1-carboxylate (633 mg), ethyl acrylate (0.39 mL), and ethanol (1.9 mL) was stirred at 80C for 3 hours under microwave irradiation. The reaction mixture was cooled to room temperature, and then was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain tert-butyl (3S)-4-(3-ethoxy-3-oxopropyl)-3-(methoxymethyl)piperazine-1-carboxylate (444 mg) as an oil.

The synthetic route of 955400-16-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Astellas Pharma Inc.; TAKAHASHI, Taisuke; TANAKA, Hiroaki; AKAIWA, Michinori; NEGORO, Kenji; MIHARA, Hisashi; FUJI, Hideyoshi; TAKAMATSU, Hajime; (133 pag.)EP3196200; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154590-35-9,tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Step 1: Cool in ice a solution of glycidol (0.63 g, 8.5 mmol) in ether (30 ml). Add DIPEA (1.6 ml, 8.5 mmol) and phosgene (1.85M in toluene, 5.8 ml, 10.8 mmol). Stir 2 h, filter, and concentrate. Dissolve in ether (50 ml) and add the product of Preparation 13, Step 3 (2.50 g, 7.7 mmol) and DIPEA (1.6 ml, 8.5 mmol). Stir 2 h, wash with sat. NaHCO3, dry (MgSO4), and concentrate to obtain the carbamate as a yellow solid

154590-35-9, The synthetic route of 154590-35-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schering Corporation; US2004/220194; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

630125-91-6, 4-((4-ethylpiperazin-l-yl)methyl)-3-(trifluoromethyl)benzeneamine (30.6 mg) in 1,4-dioxane (1 mNo.), was added 4-nitrophenylchloroformate (21.6 mg) at room temperature. After 60 0C at 1 h, them mixture was cooled to rt and ethyl 6-(3-aminophenyl)-lH-indazole-3-carboxylate (30 mg) was added. The mixture was stirred at 90 0Cf or 12 h. Ethyl acetate and water were added and the aqueous layer was extracted with ethyl acetate three times. The combined organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was triturated in ethyl acetate/hexane to give6-(3-(3-(4-((4-ethylpiperazin-l-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenyl)-l H-indazole-3-carboxylate (16.2 mg).[643] [644] 1H NMR (400 MHz, DMSOd6) 613.98 (s, IH), 9.09 (s, IH), 8.93 (s, IH), 8.15 (8.4 Hz, IH), 7.99 (s, IH), 7.93 (s, IH), 7.81 (s, IH), 7.62 (m, 3H), 7.43 (br d, J = 4.4 Hz, 2H), 7.28 (m, IH), 4.41 (q, J = 7.2 Hz, 2H), 3.54 (s, 2H), 2.49 (m, 10H), 1.39 (t, J = 7.2 Hz, 3H).

As the paragraph descriping shows that 630125-91-6 is playing an increasingly important role.

Reference£º
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; SIM, Tae Bo; SON, Jung Beom; KIM, Hwan; PARK, Dong Sik; CHOI, Hwan Geun; HAM, Young Jin; HAH, Jung Mi; YOO, Kyung Ho; OH, Chang Hyun; LEE, So Ha; HA, Jae Du; CHO, Sung Yun; KWON, Byoung-Mog; HAN, Dong Cho; WO2010/64875; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.219509-79-2,1-tert-Butyl 4-methyl piperazine-1,4-dicarboxylate,as a common compound, the synthetic route is as follows.

The compound 1-tert-butoxycarbonyl-2,4-piperazine carboxylate (0.18g, 0.61mmol) in dichloromethane(6mL) was added HCl in ethyl acetate solution (4M, 3mL), stirred at rt for 1h, the solvent was removed to give awhite solid 146mg: 1,3-piperazine compound Two carboxylate hydrochloride, yield: 99%., 219509-79-2

219509-79-2 1-tert-Butyl 4-methyl piperazine-1,4-dicarboxylate 11118267, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288851-44-5,4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-4-oxobutanoic acid,as a common compound, the synthetic route is as follows.

To a solution of Boc-piperazine (P/N: Lancaster L13363, 500 mg, 2.68 mmol) in DCM(30 ml) was added succinic anhydride (269 mg, 2.68 mmol). The reaction was stirred for 2 hours at ambient temperature. TLC analysis showed formation of succinylated Boc-piperazine (Rf= 0.50; 9:1:0.01 DCM-MeOH-AcOH, TLC developed by heating with 3% (w/v) solution of ninhydrin in EtOH). To this solution was added TFA (30 mL) and the mixture was then stirred for 1 h at ambient temperature. The volatile components of the mixture were removed under reduced pressure and the resulting oil dissolved in THF (30 mL) with minimum amount of water and adjustment of the pH to 9 by the addition of DIPEA. A solution of Fmoc-OSu (907 mg, 2.69 mmol) in THF (10 mL) was added and stirred for 1 h at ambient temperature. TLC analysis showed formation of a product (Rf = 0.55; 9:1:0.01 DCM-MeOH-AcOH, UV 254 nm, TLC developed by heating with 3% (w/v) solution of ninhydrin in EtOH). The volatile components of the mixture were then removed under reduced pressure and the resulting oil was dissolved in minimum volume of saturated NaHCO3. The aqueous solution was then extracted with Et2O (100 mL x 2), acidified (pH ~1) with HCI (1 M) and re-extracted with EtOAc (150 mL x 2). The combined EtOAc layers were dried over Na2SO4 and concentrated to give the product as colorless oil., 288851-44-5

The synthetic route of 288851-44-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; APPLERA CORPORATION; WO2007/87534; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

16154-62-4, 1-(2-Chloro-4-nitrophenyl)-4-methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Chloro-4-(4-methylpiperazin-l-yl)aniline (SG4-030): To a solution of SG4-029 (2.00 g, 7.82 mmol) in MeOH (32 niL, deoxygenated with Argon gas) was added PtC (18 mg, 0.0782 mmol). A balloon of hydrogen gas was attached to the flask via a septum cap. The mixture was stirred at room temperature for 5 h. The reaction mixture was filtered over Celite and the filtrate concentrated under reduced pressure to provide the title compound as a light yellow solid (1.741 g, 98%). NMR (400 MHz, DMSO-) delta: 6.85 (d, J= 8.5 Hz, 1H), 6.59 (d, J= 2.6 Hz, 1H), 6.45 (dd, J= 8.5, 2.6 Hz, 1H), 5.01 (s, 2H, disappeared on D2O shake), 2.81- 2.72 (m, 4H), 2.40 (brs, 4H), 2.18 (s, 3H). HPLC-MS (ESI+): m/z 228.2 [35%, (M37C1+H)+], 226.2 [100%, (M35C1+H)+].

16154-62-4, As the paragraph descriping shows that 16154-62-4 is playing an increasingly important role.

Reference£º
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas, J.; LAWRENCE, Harshani, R.; (257 pag.)WO2016/22460; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics