Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216144-45-5,4-(4-Methylpiperazin-1-yl)benzylamine,as a common compound, the synthetic route is as follows.

Example 280 6-(2,3-dimethylphenyl)-4-N-{[4-(4-m 2,4-diamine. A mixture of 4-chloro-6-(2,3-dimethylphenyl)pyrimidin-2-amine (23 mg, 0.10 mmol), [4-(4-methylpiperazin-1-yl)phenyl]methanamine (29 mg, 0.14 mmol) and Hunig’s base (35 muIota_, 0.20 mmol) in n-butanol (1.5 ml_) was heated in a sealed tube at 85C overnight. The reaction mixture was concentrated and purified by preparative HPLC. LCMS [M+H]+ 403.

216144-45-5, 216144-45-5 4-(4-Methylpiperazin-1-yl)benzylamine 2776493, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; HOMAN, Evert; HELLEDAY, Thomas; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; FISKESUND, Roland Julius Yu; (359 pag.)WO2015/187089; (2015); A1;,
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120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example C.4 Preparation of rac-4-(6-Carboxy-pyridin-3-yl)-2-methyl-piperazine-1 carboxylic acid tertbutylester A solution of 5-fluoropicolinic acid (0.47g, 3.33 mmol) and 2-methylpiperazine N1 Boc (1.00 g,5.00 mmol) in DMA (2.00 ml) was heated to 160C in a microwave reactor for 1 hour. Thesolvent was evaporated under high vacuum. The residue was taken in water and acidified to pH 3.The aqueous phase was extracted 3 times with ethyl acetate, dried and concentrated. The crudeproduct was purified with flash column chromatography on silica gel (Eluent: Heptane/ethyl acetate 0 to 20) to provide 1.17 g (100 %) of the title compound.

120737-78-2, As the paragraph descriping shows that 120737-78-2 is playing an increasingly important role.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; PTC THERAPEUTICS INC.; DAKKA, Amal; GREEN, Luke; KARP, Gary; NARASIMHAN, Jana; NARYSHKIN, Nikolai; PINARD, Emmanuel; QI, Hongyan; RATNI, Hasane; RISHER, Nicole; WEETALL, Marla; WOLL, Matthew; WO2014/209841; (2014); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.

A mixture of (R) -tert-butyl 3-methylpiperazine-1-carboxylate (250 mg, 1.25 mmol) , cyclopropanecarboxylic acid (130 mg, 1.50 mmol) , EDCI (480 mg, 2.50 mmol) and HOAT (254 mg, 1.87 mmol) in DCM (10 mL) was stirred at 0 , and DIPEA (0.65 mL, 3.74 mmol) was added dropwise. After the addition, the mixture was stirred at rt for 10 h and washed with water (10 mL × 3) . The organic layer was dried over anhydrous Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluted with Petroleum ether/EtOAc (v/v) 2/1 to give (R) -tert-butyl 4- (cyclopropanecarbonyl) -3-methylpiperazine-1-carboxylate as colorless oil (310 mg, 93) .1H NMR (400 MHz, CDCl3) : delta ppm 4.24-4.50 (m, 1H) , 3.78-4.07 (m, 2H) , 2.90-3.41 (m, 3H) , 2.81 (s, 6H) , 1.50 (s, 9H) , 1.12-1.36 (m, 4H) , 0.96-1.05 (m, 2H) , 0.74-0.82 (m, 2H) and MS-ESI: m/z 213.10 [M-55] +.

163765-44-4, The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
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5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5521-39-1, To a stirred solution of 21 3-(2,6-dichlorophenyl)-7-(methylthio)-2,3-dihydro-4H-pyrimido[5,4-e][1,3]oxazin-4-one (0.2 g, 0.58 mmol, 1.0 eq) in 5 mL 24 toluene 25 m-CPBA (0.251 g, 1.46 mmol, 2.5 eq) was added under stirring and resulting mixture was allowed to stir at rt for 30 min. Further, 604 2-(4-(4-aminophenyl)piperazin-1-yl)ethan-1-ol (0.129 g, 0.58 mmol, 1.0 eq) and 27 DIPEA (0.302 g, 2.33 mmol, 4 eq) were added and the reaction was allowed to stir at rt for 12 h. The reaction was monitored by LCMS. After completion reaction was quenched with 7 water and extracted with ethyl acetate (5 mL×3). The combined organic layer was washed with brine solution (10 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product which was purified by flash chromatography (MeOH: CH2Cl2 1-10%) to afford 607 3-(2,6-dichlorophenyl)-7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-2,3-dihydro-4H-pyrimido[5,4-e][1,3]oxazin-4-one (0.008 g, 10%) as white solid. (0628) LCMS: 515 [M+1]+ (0629) 1H NMR (400 MHz, DMSO-d6): delta 10.18 (s, 1H), 8.78 (s, 1H), 8.20 (s, 1H), 7.65 (d, J=8.33 Hz, 2H), 7.51 (d, J=7.45 Hz, 2H), 6.92 (d, J=8.33 Hz, 2H), 5.71 (br s, 2H), 4.43 (br s, 2H), 3.53 (d, J=6.14 Hz, 2H), 3.17 (d, J=5.26 Hz, 1H), 3.09 (br s, 1H), 1.23 (br s, 1H), 1.16 (d, J=10.09 Hz, 1H).

5521-39-1 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol 767100, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
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30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-(4-Trifluormethyl-phenyl)-piperazine (283 mg, 1 mmol) and triethylamine (220 muL, 2 mmol) were dissolved in dichloromethane (8 mL). Chloroacetyl chloride (110 muL, 1 mmol) was then slowly added under stirring. After stirring for an additional 10 min at room temperature, the mixture was diluted with dichloromethane (10 mL), washed with water (10 mL), and washed with saturated aqueous sodium hydrogencarbonate (10 mL). The organic layer was collected, dried over magnesium sulfate, filtered, and concentrated under vacuum. The desired product was isolated as a light yellow oil (292 mg, 95% yield).

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; INTERVET INTERNATIONAL B.V.; WO2009/77527; (2009); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

N-tert-butyloxycarbonyl-N’-(4-aminophenyl)-piperazine (138 mg) and 5-chloro-2-methoxyphenyl isocyanate (138 mg) were dissolved in anhydrous tetrahydrofuran (5 mL) and stirred at room temperature for 14.5 hours. After methanol was added to the reaction solution, the mixed solution was concentrated. The obtained solid was vigorously stirred in hexane/isopropyl ether (5:1), collected by filtration and dried under reduced pressure, and 206 mg (89%) of the title compound was obtained as a pale pink crystal. 1H-NMR spectrum (400MHz,DMSO-d6):delta(ppm)=9.15(1H, s), 8.27(1H, s), 8.21(1H, d, J=2.3Hz), 7.29(2H, d, J=9.0Hz), 7.00(1H, d, J=9.0Hz), 6.94(1H, dd, J=8.6 and 2.8Hz), 6.95(2H, d, J=2.8Hz), 3.87(3H, s), 3.44(4H, t, J=4.9Hz), 2.99(4H, t, J=5.1Hz), 1.42(9H, s). MS(FAB) m/z:461 (M + H)+. Melting point: 205C.

170911-92-9, 170911-92-9 tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 11011301, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Sankyo Company, Limited; EP1764360; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.848482-93-9,(S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

(EtOAc (200 mL x 2) and the acidic solution containing the desired mono-Boc product was then taken on in the synthesis. The aqueous acidic solution of 4-Boc-piperazine-2-carboxylic acid prepared above was basified to pH 9 with 50% NaOH. Sodium carbonate (10.6 g, 100 mmol) was added with stirring. A solution of 9-fluorenylmethyl chloro formate (15.27 g) in dioxane (50 mL) was added with an ice bath. The reaction was stirred at 0 0C for 5 hr. and at ambient temperature overnight. The reaction mixture was acidified to pH 2 and extracted with EtOAc twice. The combined organic layer was washed with brine and dried over Na2SO4. The solution was concentrated under vacuum to about 100 mL and hexane was added. The precipitate was collected and dried under vacuum to give 17.34 g (78% for 2 steps) of product as white solid.

848482-93-9, As the paragraph descriping shows that 848482-93-9 is playing an increasingly important role.

Reference：
Patent; XTL BIOPHARMACEUTICALS LTD; WO2008/48589; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 3-iodo-4-methylbenzoyl chloride obtained above in dry DCM (10mL) at 0C was added Et3N (0.28mL, 2.0mmol) and 4-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) aniline (328mg, 1.2mmol). The mixture was stirred at room temperature for 5h, and then the solvent was removed under reduced pressure. The residue was purified by using column chromatography to afford the corresponding product 6-1 (439mg, 2 steps yield: 85%).

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Liu, Yang; Peng, Xia; Guan, Xiaocong; Lu, Dong; Xi, Yong; Jin, Shiyu; Chen, Hui; Zeng, Limin; Ai, Jing; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 122 – 132;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound 9 (200mg, 0.8mmol), sodium iodine (289mg, 1.93mmol) and substituted amines (1.61mmol) in methanol (30mL) was stirred at 40C for 5h. After the reaction was completed (monitored by TLC), the solution was concentrated under vacuum. Then the crude residue was purified by column chromatography (dichloromethane/methanol), affording pure product 10.

208167-83-3, As the paragraph descriping shows that 208167-83-3 is playing an increasingly important role.

Reference：
Article; Liang, Yu-Kun; Yue, Zhi-Zhou; Li, Jia-Xin; Tan, Cun; Miao, Ze-Hong; Tan, Wen-Fu; Yang, Chun-Hao; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 505 – 515;,
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325145-35-5, (S)-tert-Butyl 2-ethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2-carboxyl-1H-benzo[d]immidazole-4-carboxamide (75 mg, 0.37 mmol), EDC (210 mg, 1.09 mmol), HOBt(147 mg, 1.09 mmol), Et3N (0.4 mL, 2.93 mmol) and N-Boc-aminopyrrolidine(202 mg, 1.09 mmol) in DMF (5 mL) was stirred atroom temperature for 20 h and then H2O was added to the mixture.The solutionwas extracted with the solvent mixture (ethyl acetate/methanol = 10:1) (30 mL x 3) and then the organic layer waswashed with brine (20 mL x 2). The combined organic layer wasdried over anhydrous MgSO4. After filtration and concentration, thecrude product was obtained and purified with column chromatography(methylene chloride/methanol 50:1 to 40:1) to givecompound 7a as a white solid (74 mg, 54.4percent).

325145-35-5, The synthetic route of 325145-35-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Zhou, Jie; Ji, Ming; Zhu, Zhixiang; Cao, Ran; Chen, Xiaoguang; Xu, Bailing; European Journal of Medicinal Chemistry; vol. 132; (2017); p. 26 – 41;,
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Piperazines – an overview | ScienceDirect Topics