Tag: M.W:200-300

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Catalytic Enantio- and Diastereoselective Cyclopropanation of 2-Azadienes for the Synthesis of Aminocyclopropanes Bearing Quaternary Carbon Stereogenic Centers, published in 2019-09-20, which mentions a compound: 16004-15-2, mainly applied to enantioselective diastereoselective aminocyclopropane preparation cyclopropanation azadiene diazoester; terminal internal azadiene donor acceptor carbene diazoester cyclopropanation, Category: piperazines.

We report the catalytic enantio- and diastereoselective preparation of aminocyclopropanes by the cyclopropanation of terminal and (Z)-internal 2-azadienes with donor/acceptor carbenes derived from α-diazoesters. The resulting cyclopropanes bear quaternary carbon stereogenic centers vicinal to the amino-substituted carbon and are formed as a single diastereomer in up to 99:1 er and 97% yield with 0.5 mol % of Rh2(DOSP)4 and only 1.5 equiv of the diazo reagent. Transformations with internal azadienes afford cyclopropanes with three contiguous stereogenic centers.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 18583-60-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Potassiumtris(1-pyrazolyl)borohydride, is researched, Molecular C9H10BKN6, CAS is 18583-60-3, about Synthesis, characterization and investigation of [hydrotris(1-pyrazolyl)borato]trioxotechnetium(VII) and [hydrotris(3,5-dimethyl-1-pyrazolyl)borato]trioxotechnetium(VII). IX.

[HB(Pz)3]TcO3 (Pz = pyrazolyl) and [HB(3,5-Me2Pz)3]TcO3 were synthesized by reaction of Tc2O7 with K[HB(Pz)3] and Na[HB(3,5-Me2Pz)3] in THF. The IR, 1H NMR, UV, and mass spectra are reported and discussed.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Stauber, Julia M.; Qian, Elaine A.; Han, Yanxiao; Rheingold, Arnold L.; Kral, Petr; Fujita, Daishi; Spokoyny, Alexander M. published the article 《An organometallic strategy for assembling atomically precise hybrid nanomaterials》. Keywords: dodecaborane conjugate nanoparticle gold aminophosphine complex preparation thiolation; thioether conjugate dodecaborane preparation metalation gold aminophosphine.They researched the compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2 ).Product Details of 16004-15-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:16004-15-2) here.

Metalation of hypercloso-dodecaborane-appended aryl iodide B12(OCH2C6H4I)12 with Au(I) Me-DalPhos (L) complex LAuCl gives rise to Au(III)-functionalized cage [B12[OCH2C6H4Au(Cl)(Me-DalPhos)]12][SbF6]11 (1), which was converted into thioethers [B12[OCH2C6H4SR]12]2- (2-20) by reaction with thiols RSH and used for further layer-by-layer nanocluster growth. For decades, chemists have striven to mimic the intricate design and diverse functions of naturally occurring systems through the bioinspired synthesis of programmable inorganic nanomaterials. The development of thiol-capped gold nanoparticles (AuNPs) has driven advancement in this area; however, although versatile and readily accessible, hybrid AuNPs are rarely atomically precise, which limits control over their surface topol. and therefore the study of complex structure-function relationships. Here, we present a bottom-up approach to the systematic assembly of atomically precise hybrid nanoclusters employing a strategy that mimics the synthetic ease with which thiol-capped AuNPs are normally constructed, while producing well-defined covalent nanoscale assemblies with diverse surface topologies. For the first time, using a structurally characterized cluster-based organometallic building block, we demonstrate the systematic synthesis of nanoclusters with multivalent binding capabilities to complex protein targets.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2 ) is researched.Related Products of 16004-15-2.Tan, Fei; Pu, Maoping; He, Jun; Li, Jinzhao; Yang, Jian; Dong, Shunxi; Liu, Xiaohua; Wu, Yun-Dong; Feng, Xiaoming published the article 《Catalytic Asymmetric Homologation of Ketones with α-Alkyl α-Diazo Esters》 about this compound( cas:16004-15-2 ) in Journal of the American Chemical Society. Keywords: keto esters chemoselective regioselective enantioselective preparation; alkyl diazoester ketone scandium catalyst homologation chemoselective regioselective enantioselective. Let’s learn more about this compound (cas:16004-15-2).

The homologation of ketones with diazo compounds was a useful strategy to synthesize one-carbon chain-extended acyclic such as PhC(O)CMeCO2MeR [R = allyl, Bn, CH2(2-naphthyl), etc.] or ring-expanded cyclic ketones e.g., I. However, the asym. homologation of acyclic ketones with α-diazo esters remains a challenge due to the lower reactivity and complicated selectivity. Herein, the enantioselective catalytic homologation of acetophenone and related derivatives with α-alkyl α-diazo esters was reported utilizing a chiral scandium(III) N,N’-dioxide as the Lewis acid catalyst. This reaction supplies a highly chemo-, regio-, and enantioselective pathway for the synthesis of optically active β-keto esters with an all-carbon quaternary center through highly selective alkyl-group migration of the ketones. Moreover, the ring expansion of cyclic ketones was accomplished under slightly modified conditions, affording a series of enantioenriched cyclic β-keto esters. D. functional theory calculations was carried out to elucidate the reaction pathway and possible working models that could explain the observed regio- and enantioselectivity.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Dias, Maria C. F.; Gularte, Thiago Q.; Teixeira, Robson R.; Santos, Jorge A. N.; Pilau, Eduardo J.; Mendes, Tiago A. O.; Demuner, Antonio J.; dos Santos, Marcelo H. researched the compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2 ).Application of 16004-15-2.They published the article 《Synthesis of 1,2,3-triazole derivatives of 4,4′-dihydroxybenzophenone and evaluation of their elastase inhibitory activity》 about this compound( cas:16004-15-2 ) in Journal of the Brazilian Chemical Society. Keywords: benzophenone bis aryl triazolylmethoxy preparation elastase inhibitor docking. We’ll tell you more about this compound (cas:16004-15-2).

The synthesis of a series of novel triazole derivatives I (R = 4-iodophenyl, 2-methylphenyl, 2,6-dichlorophenyl, etc.) from 4,4′-dihydroxybenzophenone along with their elastase inhibitory activity has been described. The 1,2,3-triazoles I were obtained via the copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC), also known as click reaction, between bis(4-(prop-2-yn-1-yloxy))benzophenone and several benzyl azides RCH2N3. It was found that five derivatives exhibited significant inhibitory effects, presenting half maximal inhibitory concentration (IC50) values in the range of 16.6 to 72.1 μM. The most active compound, namely I (R = 4-iodophenyl) (IC50 = 16.6 ± 1.9 μM), was found to bind to elastase with the inhibition constant (Ki) of 11.12 μM, thereby illustrating competitive inhibitory behavior. Further, docking investigations provided insights on the possible binding mode of the most active compound with the elastase.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2 ) is researched.Synthetic Route of C7H6BrI.Pan, Ming; Shao, Ying-Bo; Zhao, Qun; Li, Xin published the article 《Asymmetric Synthesis of N-N Axially Chiral Compounds by Phase-Transfer-Catalyzed Alkylations》 about this compound( cas:16004-15-2 ) in Organic Letters. Keywords: alkyl bromide quinazolinone alkylation phase transfer catalyst; axially chiral quinazolinone preparation enantioselective DFT. Let’s learn more about this compound (cas:16004-15-2).

A wide range of N-N axially chiral quinazolinone derivatives I (R1 = Ph, prop-1-en-2-yl, 3-chlorphenyl, etc.; R2 = Ph, 1-naphthyl, prop-1-ynyl, etc.; R3 = Ph, t-Bu, 3-bromophenyl, etc.; R4 = H, 7-Me, 6-I, 5-Cl, etc.) were prepared by phase-transfer catalysis in high yields with excellent stereoselectivities. Furthermore, the synthetic utility of the protocol was proved by large-scale reaction and transformation of the product. D. functional theory calculations provide insight into the mechanism.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Structural modification on rupestonic acid leads to highly potent inhibitors against influenza virus.Product Details of 16004-15-2.

Influenza viruses are responsible for seasonal epidemics and occasional pandemics, which cause significant morbidity and mortality. Although several drugs (adamantanes and neuraminidase inhibitors) are available in the market, the worldwide spread of drug-resistant influenza strains poses an urgent need for novel antiviral drugs. Artemisia rupestris L. is a folk medicine used to treat cold. In this paper, we structurally modified rupestonic acid, a bioactive component of A. rupestris, to synthesize a series of 2-substituted rupestonic acid Me esters (3a-3o). Their structures were fully characterized by 1H NMR, 13C NMR, HRMS spectra. Among them, compounds 3b and 3c exhibited potent activities against influenza H1N1 with micromolar IC50 values and might serve as new lead compounds for the treatment of influenza.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of 4-Acylchromene via Highly Chemoselective Iodine-Catalyzed Cyclization of Alkynylarylether Dimethylacetals》. Authors are Rodphon, Warabhorn; Thongsornkleeb, Charnsak; Tummatorn, Jumreang; Ruchirawat, Somsak.The article about the compound:2-Bromopriopionaldehydediethylacetalcas:3400-55-3,SMILESS:CC(Br)C(OCC)OCC).Electric Literature of C7H15BrO2. Through the article, more information about this compound (cas:3400-55-3) is conveyed.

A metal-free method for the synthesis of 4-acylchromene derivatives I [R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.; R2 = H, 6-Cl, 7-OMe, etc.] and II [R3 = H, Me, CH2Cl; R4 = H, Me] via highly chemoselective iodine-catalyzed cyclization of alkynylarylether dimethylacetals was reported. A combination of acetone and catalytic I2 lead to selective activation of acetal in alkynylarylether dimethylacetal substrates while alkyne moiety remained intact. Also this method was a safe, cost-effective, convenient and environmentally-friendly.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Potassiumtris(1-pyrazolyl)borohydride, is researched, Molecular C9H10BKN6, CAS is 18583-60-3, about Synthesis and Reactivity of [TpRh(PPh3)2] (Tp = Hydridotris(pyrazol-1-yl)borate), the main research direction is rhodium hydridotris pyrazolylborate phosphine preparation reactivity; crystal structure hydridotrispyrazolylborate rhodium phosphine complex; mol structure hydridotrispyrazolylborate rhodium phosphine complex.Product Details of 18583-60-3.

The new complex [TpRh(PPh3)2] (I), readily obtained from [RhCl(PPh3)3] and KTp, is a particularly convenient and versatile entry point into the organometallic chem. of the “”TpRh”” fragment including complexes bearing alkyne, alkene, carbene, thiocarbamoyl, dithioalkoxycarbonyl, carbon disulfide, and vinyl ligands. Thus, reaction of I with di-Me acetylenedicarboxylate, N,N-dimethylthiocarbamoyl chloride, or carbon disulfide followed by chloroform chlorination gave [TpRh{η2-C2(CO2Me)2}(PPh3)], [TpRh(η2-SCNMe2)(PPh3)]Cl, and [TpRh{:C(SMe)2}Cl2] resp. which were characterized by x-ray crystal structure determination

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Potassiumtris(1-pyrazolyl)borohydride(SMILESS: [BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+],cas:18583-60-3) is researched.Related Products of 66-71-7. The article 《Stereo- and Regiocontrolled Construction of Trisubstituted Piperidines Using a TpMo(CO)2(Dihydropyridine) Scaffold (Tp = Hydridotrispyrazolylborate)》 in relation to this compound, is published in Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:18583-60-3).

Cationic TpMo(CO)2(dihydropyridine) complexes (Tp = hydridotrispyrazolylborate), readily generated from 3-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester, represent scaffolds from which (by judicious choice of demetalation conditions) either 2,3,6- or 2,5,6-trisubstituted-1,2,3,6-tetrahydropyridines can be prepared in a regio- and stereodefined way.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics