Tag: M.W:200-300

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,30459-17-7

Dark brown solid; IR (KBr, cm-1): v 3282 (-NH), 3068-3076 (-CH str.), 2223 (CN), 1256 (C-O-C), 833 (s-triazine C-N str.), 749 (C-F). 1H NMR (400 MHz, Me2SO-d6): delta 9.18 (s, 1H, -NH, s-triazine to amino-benzonitrile linkage), 8.10 (d, J = 7.4 Hz, 1H, C8 proton of quinoline), 7.77 (t, J = 7.6 Hz, 1H, C7 proton of quinoline), 7.59 (d, J = 8.6 Hz, 1H, C5 proton of quinoline), 7.52 (t, J = 7.2 Hz, 1H, C6 proton of quinoline), 7.39 (s, 1H, C3 proton of quinoline), 7.26-6.93 (7H, m, Ar-H), 3.89 (4H, br s, piperazine), 3.77 (s, 3H, N-CH3), 3.51 (4H, br s, piperazine). 13C NMR (100 MHz, Me2SO-d6): delta 175.8 (1C, C-6, s-triazine, C-N at piperazine linkage), 167.5 (1C, C-4, s-triazine, C-O-C at quinoline linkage), 165.5, 163.6 (2C, 1C at C-2, s-triazine, C-NH at benzonitrile moiety and 1C of CO), 144.8-116.7 (22C, Ar. C including 2C-CF3 at 129.9, 130.4 and 2CF3 at 125.2, 125.7), 105.9 (1C, CN), 95.8 (1C, -C-CN), 48.2, 45.6 (4C, piperazine ring carbon atoms), 30.6 (1C, N-CH3). 19F NMR (400 MHz, CDCl3): delta -66.03, -63.29 (6F, s, -CF3 of piperazine moiety and -CF3 of amino benzonitrile moiety).

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Patel, Rahul V.; Kumari, Premlata; Rajani, Dhanji. P.; Chikhalia, Kishor H.; Journal of Fluorine Chemistry; vol. 132; 9; (2011); p. 617 – 627;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

262368-30-9, N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10.5 [G] (30.0 [MMOL)] of [1-ACETYL-3- (1-ETHOXY-1-PHENYLMETHYLENE)-6-METHOXYCARBONYL-2-] indolinone (for preparation see WO 01/27081 mentioned above) and 8.60 g (33.0 [MMOL)] [N- [ (4-METHYL-PIPERAZIN-1-YL)-METHYLCARBONYL]-N-METHYL-P-PHENYLENEDIAMINE] (for preparation see WO 01/27081 mentioned above) are dissolved in 80 mL of dimethylformamide and stirred for 1 hour at [80C.] After cooling 6.50 mL of piperidine are added and the mixture is stirred for another two hours at ambient temperature. Water is added, the precipitate formed is suction filtered and washed with a little water. The residue is suspended in 200 mL of methanol, suction filtered and washed with cold water and diethyl ether. The substance is [DRIED IN VACUO] at 110 [C.] Yield : 12.4 g (77% of theory), [IR SPECTRUM] : 1610,1655, 1711 cm-1 Tm. p. = [253C] [EMPIRICAL FORMULA : C31H33N504] [ESI] mass spectrum: m/z = 540 [M+H]+ Elemental analysis: calculated: C 68.99 [H-6.] 16 [N 12.] 98 found: C 68.32 H 6.29 N 12.85, 262368-30-9

The synthetic route of 262368-30-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2004/13099; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

342405-34-9, 4-(4-Methylpiperazino)benzyl Alcohol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,342405-34-9

General procedure: To a 25-mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mol, 5 mol%), DABCO (0.10 mol, 10 mol%), 4-HO-TEMPO (0.05 mmol, 5 mol%) were added. Substrates 1 (1 mmol) and NH3 (aq, 25-28%, 3 mmol, 3.0 equiv) in CH3CN (2 mL) were added subsequently. Then the reaction mixture was stirred at room temperature for 24 h in the presence of an air balloon. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4. Subsequently, the combined organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the corresponding products.

As the paragraph descriping shows that 342405-34-9 is playing an increasingly important role.

Reference：
Article; Hu, Yongke; Chen, Lei; Li, Bindong; Chinese Chemical Letters; vol. 29; 3; (2018); p. 464 – 466;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

EDAC.HCl (0.65 g, 3.37 mmol) was added to a stirred solution of compound 71 (0.62 g, 2.81 mmol), compound 72 (0.40 g, 2.81 mmol), HOBt (0.46 g, 3.37 mmol), and DIPEA (0.69 mL, 3.93 mmol) in CH2Cl2 (12 mL) at room temp. After 3 hr the reaction mixture was conc. and the residue was partitioned between EtOAc and 1N HCl. The organic phase was isolated, washed with 1N HCl, H2O, sat. NaHCO3, sat. NaCl, dried (MgSO4), and conc. to give 0.97 g (100percent) of compound 73., 31166-44-6

31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Bisacchi, Gregory S.; Sutton, James C.; Slusarchyk, William A.; Treuner, Uwe; Zhao, Guohua; US2004/147502; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-66-2,(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of (lambda)-3-hydroxymethyl-piperazine-l-carboxylic acid tert-butyl ester (795 mg, 3.68 mmol) in DCM (20 mL) was added triethylamine (1.53 mL, 11.04 mmol). The resulting mixture was cooled to 0 C before the dropwise addition of chloroacetyl chloride (325 muL, 4.05 mmol). The mixture was warmed to RT and stirred for 5 h. The reaction mixture was partitioned between a saturated aqueous solution OfNaHCO3 and DCM. The organic layer was separated and the aqueous layer extracted with DCM. The combined organic fractions were dried (Na2SO4) and concentrated in vacuo. The resulting residue was purified by column chromatography to give the title compound as a colourless oil which was a mixture of rotamers (710 mg, 66%).1H NMR (400 MHz, CDCl3): delta 1.48 (s, 9H), 2.80-2.92 (m, IH), 2.95-3.10 (m, 2H), 3.34-3.44 (m, 1AH), 3.60-3.74 (m, 21Z2H), 3.96-4.16 (m, 31AH), 4.22-4.30 (m, V2Yi), 4.32-4.40 (m, VJS) and 4.63 (bs, V2H)., 278788-66-2

As the paragraph descriping shows that 278788-66-2 is playing an increasingly important role.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; WO2009/53715; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

70261-82-4,70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2 k (0.21 g, 1 mmol) was dissolved in 10 mml of anhydrous dichloromethane,To this was added EDCI (0.38 g, 2 mmol)And DMAP (0.06 g, 0.5 mmol),Then, 12 g (0.21 g, 1 mmol) was added thereto,After 10 h, the reaction was completed, concentrated,Column chromatography gave 0.37 g of a pale yellow solid in 94% yield.

As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.

Reference：
Patent; Nantong University; Ling, Yong; Mou, Jiefei; Xu, Qibing; Feng, Jiao; Zhu, Peng; Liu, Ji; Wang, Tingting; Ge, Xiang; Liang, Shanshan; (26 pag.)CN106432235; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

674792-05-3, (S)-1-Boc-2-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,674792-05-3

The carboxylic acid was used directly in the next step without further purification. To a solution of the acid (340 mg, 1.5 mmol) in CH2Cl2 (15 mL), was added NEt3 (0.422 mL, 3 mmol), (2S)-N-Boc-2-Isopropyl-piperazine (350 mg, 1.5 mmol) and PyBroP (707 mg, 1.5 mmol). After stirring 18 h under nitrogen, the reaction mixture was diluted with CH2Cl2 (50 mL) and washed with a solution of HCl (0.1 M, 10 mL) and saturated NaHCO3 (10 mL). The organic layer was then dried with Na2SO4, filtered and concentrated under reduced pressure. The crude residue was purified by column chromatography (Hexane/AcOEt 1/0 to 6/4) and the desired piperazine adduct 13c was obtained as a pale yellow foam (452 mg, 1.04 mmol, 69%); HRMS: (ESI-TOF) C22H34N4O5H+ expected: 435.2602. found: 435.2598.

The synthetic route of 674792-05-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; The Scripps Research Institute; US2009/197895; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

373608-48-1, tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

373608-48-1, Example 94 4-{3-[4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-benzoylamino]-propyl}-piperazine-1-carboxylic acid tert-butyl ester (I-94) To a mixture of 0.105 g (0.23 mmole) of 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-benzoic acid (I-22), 0.0988 g (0.26 mmole) of 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxide hexafluorophosphate, 1 mL of dichloromethane, 0.2 mL of triethylamine was added followed by 0.0199 g (0.13 mmole) of 4-(3-amino-propyl)-piperazine-1-carboxylic acid tert-butyl ester. After stirring 1.5 hours, the mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluding with acetonitrile-water (gradient, 5:95-0:100) to give 0.0609 g of 4-{3-[4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-benzoylamino]-propyl}-piperazine-1-carboxylic acid tert-butyl ester (I-94).

373608-48-1 tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate 17750945, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Cai, Jianping; Chen, Shaoqing; Chu, Xin-Jie; Luk, Kin-Chun; Mischke, Steven Gregory; Sun, Hongmao; Wovkulich, Peter Michael; US2009/318408; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A vial was charged with 5-amino-3,6-dichloro-l,2,4-triazine (253.3 mg, 1.535 mmol), diisopropylethylamine (2.0 mL, 1 1.48 mmol), (S)-tert-butyl 2-(3- (hydroxymethyl)piperazin-l-yl)acetate (410.9 mg, 1.731 mmol) in dioxane (2 mL). The mixture was heated at 120 C for 5 h using microwave. The mixture was concentrated to remove all of solvent. The residue was dissolved in dichloromethane, washed with aqueous sodium bicarbonate solution. The organic solution was separated. The aqueous solution was mixed with brine, extracted with dichloromethane (2 x 35 mL). The combined organic solution was dried over anhydrous sodium sulfate, concentrated to afford a residue. The residue was dissolved into small amount of dichloromethane, filtered. The solid was collected the first batch of product. The solution was purified with flash column chromatography on silica using 1-10% methanol in dichloromethane to afford another batch of product. The product was slight yellow solid (343 mg) and the yield was 65%. NMR (500 MHz, Chloroform-d) delta 5.26 (br, 2H), 4.76 (s, lH), 4.43 (d, J = 13.3 Hz, lH), 4.23 – 3.92 (s, 2H), 3.65 (m, 2H), 3.16 – 2.90 (s, 4H), 1.47 (s, 9H). MS for Ci3H21ClN603: 345.0 (MH+)., 314741-40-7

As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.

Reference：
Patent; NEKTAR THERAPEUTICS (INDIA) PVT. LTD.; NEKTAR THERAPEUTICS; SHARMA, PANKAJ; KHATRI, VIJAY KUMAR; GU, XUYUAN; SONG, YUAN; SHEN, MICHAEL LIXIN; SAUTHIER, JENNIFER RIGGS; ANAND, NEEL K.; KOZLOWSKI, ANTONI; ODINECS, ALEKSANDRS; RILEY, TIMOTHY A.; REN, ZHONGXU; MU. YONGQI; SHEN, XIAOMING; YUAN. XUEJUN; AURRECOECHEA, NATALIA; O’MAHONY, DONOGH JOHN ROGER; WO2015/92819; (2015); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,694499-26-8

To a stirred solution of X (0.120 g, 0.33 mmol), V (0.090 g, 0.33 mmol) added HATU (0.255 g,0.67 mmol) and DIPEA (0.2 mL, 1.08 mmol) in DMF (2 mL). Reaction was allowed to stir at RT for 24 h.After completion of reaction, reaction mixture was diluted with water and extracted with ethyl acetate (15mL x 3). Brine washing was given to the organic layer and dried over anhydrous Na2SO4. Organic layerwas concentrated under vacuum to obtain crude which was purified by using reverse phase HPLC to obtain5 (0.021 g, 10%).LCMS: 613 [M+1]+1HNMR (400 MHz, DMSO) delta10.4 (s, 1H), 10.6 (s, 1H), 8.3 (s, 1H), 8.2 (d, 2H), 8.1 (d, 1H), 7.9 (t, 3H),7.8 (d, 1H), 7.7 (d, 1H), 7.6 (m, 3H), 7.2 (t, 1H), 3.6 (s, 2H), 2.3 (m, 8H), 2.1 (s, 3H).

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics