Tag: M.W:200-300

192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 24; N-(2-methanosulfonylethyl)-piperazine hydrochloride; Methanesulfonyl chloride (0.7 mL, 9.0 mmol) was added to a cooled solution of 4-(2-amino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (1.33 g, 5.8 mmol) in pyridine (25.0 mL). The reaction was stirred for 12 h and partitioned between partitioned between aqueous sodium bicarbonate and methylene chloride. The organic phase was washed with 1 M hydrochloric acid, aqueous sodium bicarbonate, and brine, dried over anhydrous magnesium sulfate and concentrated. Purification of the crude residue by chromatography over silica gel using 0-5percent methanol in methylene chloride gave 4-(2-methanesulfonylamino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (0.70 g, 70percent)., 192130-34-0

As the paragraph descriping shows that 192130-34-0 is playing an increasingly important role.

Reference：
Patent; Fotouhi, Nader; Haley, Gregory Jay; Simonsen, Klaus B.; Vu, Binh Thanh; Webber, Stephen Evan; US2006/211693; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

76003-29-7, 1-Boc-3-Oxopiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,76003-29-7

EXAMPLE 4 9-hydroxy-7-isopropyl-2- (quinolin-2-ylmethyl)-3, 4-dihydro-2H-pyrazino [1, 2-c] pyrimidine-1, 6,8 (7H) – trione Step 1 : 1- (2-Propenyl)-4-tert-butyloxycarbonyl-2-piperazinone To a stirred solution of 4-tert-butyloxycarbonyl-2-piperazinone (10 g, 50 mmol) and allyl bromide (7.25 g, 60 mmol) in DMF (75 mL) at 0 C was added sodium hydride (2.4 g of a 60% suspension in mineral oil, 60 mmol) in portions over a period of 10 min. The mixture was allowed to warm to ambient temperature and stirred for 18 h. The solvent was removed in vacuo and the residue was partitioned between EtOAc and water. The EtOAc layer was dried (MgS04), filtered, and the solvent was removed in vacuo. The residue was purified by silica gel column chromatography using a gradient elution of 33%, 40%, 50%, 60% EtOAc in hexanes. Concentration of product-containing fractions in vacuo gave the title compound as an oil. HPLC RT = 2.80 min (Method A), ES MS (M+H) = 241,’H NMR (400 MHz, CDC13) 8 5.76 (ddt, 1H), 5.2 (overlapping doublets, 2H), 4.10 (s, 2H), 4.04 (d, J = 6 Hz, 2H), 3.64 (t, J = 7 Hz, 2 H), 3.50 (t, J = 7 Hz, 2H), 1.47, (s, 9H).

The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK & CO., INC.; WO2005/92099; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.393781-71-0,1-Boc-2-Ethylpiperazine,as a common compound, the synthetic route is as follows.

Example 55A tert-butyl (2R)-4-[(6-{[5-(difluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]-2-ethylpiperazine-1-carboxylate The product from Example 14A (300 mg, 0.95 mmol) was subjected to the conditions described in Example 14B, substituting (R)-tert-butyl 2-ethylpiperazine-1-carboxylate for tert-butyl piperazine-1-carboxylate to give the titled compound (470 mg, 97%)., 393781-71-0

As the paragraph descriping shows that 393781-71-0 is playing an increasingly important role.

Reference：
Patent; AbbVie Inc.; Bogdan, Andrew; Cowart, Marlon D.; DeGoey, David A.; Jinkerson, Tammie K.; Koenig, John R.; Kort, Michael E.; Liu, Bo; Matulenko, Mark A.; Nelson, Derek W.; Patel, Meena V.; Peltier, Hillary; Scanio, Marc J.; Wakefield, Brian D.; US2015/218102; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of the product of EXAMPLE 5E (300 mg, 1.4 mmol), 2-methoxy-4-(4- methylpiperazin-l -yl)aniline (338 mg, 1 .53 mmol) and triethylamine (421 mg, 4.1 7 mmol) in 1 ,4-dioxane (30 mL) was stirred at 105C under nitrogen for 12 hours. The solvent was removed under vacuum and the residue was washed with sodium bicarbonate solution and ethanol. The crude product was recrystallized from l ;4-dioxane to give the title compound. ‘ H NMR (DMSO-t?) 6 ppm 12.66 (s, 1H), 1 1.35 (s, 1H), 8.31 (d, 7 = 9.0 Hz, 1H), 8.25 (s, 1H), 6.68 (d, J = 1.2 Hz, 1H), 6.54 (dd, J = 1.2, 9.0 Hz, 1 H), 3.89 (s, 3H), 3.21 -3.10 (m, 4H), 2.50-2.44 (m, 4H), 2.25 (s, 3H)., 122833-04-9

122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; ABBOTT LABORATORIES; VASUDEVAN, Anil; PENNING, Thomas, Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97479; (2012); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1403898-64-5,(2R,5R)-tert-Butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Tert-butyl (2R,5R)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate (770 mg, 3.34 mmol), 181 tert-butylchlorodimethylsilane (756 mg, 5.02 mmol), 132 triethylamine (677 mg, 6.69 mmol) and 182 N,N-dimethylpyridin-4-amine (41 mg, 0.33 mmol) were dissolved in 63 DCM (6 ml) and the mixture was stirred at room temperature for 2 hours. The reaction was quenched with saturated 152 aqueous NH4Cl and extracted with DCM (3×30 ml). The organic phase was washed with brine and dried. The solvent was removed under reduced pressure and the crude product was purified by flash chromatography on a silica gel, eluting from 0-30% (57 EtOAc in 148 petroleum ether). The fractions containing the desired product were evaporated to dryness to afford 183 tert-butyl (2R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-2-methylpiperazine-1-carboxylate (1.04 g, 90%) as a colourless oil. 1H NMR (Chloroform-d, 400 MHz) 0.08 (6H, d), 0.91 (9H, s), 1.30 (3H, d), 1.47 (9H, s), 2.56 (1H, dd), 2.96-3.05 (1H, m), 3.10 (1H, dd), 3.30 (1H, dd), 3.55 (1H, dd), 3.68-3.82 (2H, m), 4.15-4.25 (1H, m), (1 exchangeable proton not seen). m/z (ES+), [M+H]+=345., 1403898-64-5

The synthetic route of 1403898-64-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Synthesis of new compounds 1-4 and 7-9 was performed bynucleophilic substitution (alkylation of amines) following theprocedure previously reported with certain modifications [43].Briefly, the corresponding ferrocene haloalkane (1.0 mmol), thesubstituted amine (1.0 mmol) and K2CO3 or NaH (2.0 mmol) weredissolved in THF (20 mL). The reaction was stirred at room temperatureuntil TLC (CH2Cl2/methanol or hexane/ethyl acetate)proved that the reaction did not go (about 48 h). THF was removedand the residue was diluted in CH2Cl2. The organic phase waswashed with water, dried over anhydrous Na2SO4, filtered, andevaporated. The residue obtained was purified either by automatedflash chromatography, eluting in gradient with CH2Cl2/methanol, orby precipitation with cold diethyl ether. Compounds 5 and 6 werepreviously characterized and evaluated as antibacterial agents [48].So, the general procedure for their synthesis was followed asdescribed by Damljanovic et al. with slight modifications [48]. Amixture of i3 (1.0 mmol), the corresponding amine (1.5 mmol) andMontmorillonite K10 (100 mg) was irradiated by microwave (50W,1.5 min). TLC was used to follow the reaction. The crude wasextracted with CH2Cl2 and evaporated on the rotary evaporator. Theresidue obtained was purified by automated flash chromatography,eluting in gradient with hexane/ethyl acetate. The final compoundwas precipitated with cold diethyl ether in order to obtain an orangepowder.

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Paucar, Rocio; Martin-Escolano, Ruben; Moreno-Viguri, Elsa; Cirauqui, Nuria; Rodrigues, Carlos Rangel; Marin, Clotilde; Sanchez-Moreno, Manuel; Perez-Silanes, Silvia; Ravera, Mauro; Gabano, Elisabetta; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 569 – 582;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

1030377-21-9, (S)-1-Boc-2-(Hydroxymethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1030377-21-9

A suspension of 1-fluoro-4-nitrobenzene (1.305 g, 9.25 mmol), (S)-tert-butyl 2-(hydroxymethyl)piperazine-1-carboxylate (2.00 g, 9.25 mmol) and potassium carbonate (1.917 g, 13.87 mmol) in anhydrous DMF (10 mL) was heated to 50 C under a nitrogen atmosphere overnight. The reaction mixture was allowed to cool to room temperature, diluted with water (70 mL) and stirred at roomtemperature for 15 minutes. The precipitated solid was isolated by filtration, washed with water (50 mL), sucked dry and freeze-dried overnight to give the title compound as an orange solid (2.13 g, 68%) . ?H NMR (300 MHz, CDC13) 3 8.11 (dt, 2H), 6.78 (dt, 2H), 4.25 (br s, 1H), 3.85-4.04 (m, 2H), 3.61-3.80 (m, 3H), 3.25-3.43 (m, 2H), 3.18(ddd, 1H), 1.49 (s, 9H). LCMS (Method C): RT = 1.39 mm, m/z = 338 [M+H].

As the paragraph descriping shows that 1030377-21-9 is playing an increasingly important role.

Reference：
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161357-89-7,1-(Methylsulfonyl)piperazine hydrochloride,as a common compound, the synthetic route is as follows.

4-[5-(4-Methanesulfonyl-piperazin-1 -yl)-2-methyl-2,3-dihydro-furo[2,3-clpyridin-2-yl1- piperidine-1 -carboxylic acid tert-butyl ester4-(5-Chloro-2-methyl-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1 -carboxylic acid tert-butyl ester (100 mg) is added to a mixture of 1 -(methylsulfonyl)piperazine hydrochloride (70 mg), Pd2(dba)3 (65 mg), Xantphos (123 mg), and potassium tert- butylate (75 mg) in toluene (4 mL) under an argon atmosphere. The reaction mixture is stirred in an oil bath at 105C over night. After cooling to room temperature water is added and the mixture is extracted with ethyl acetate. The combined extracts are concentrated in vacuo and the residue is chromatographed on silica gel(cyclohexane/ethyl acetate 50:50? 0: 100) to give the title compound. LC (method 1 1 ): tR = 1 .03 min; Mass spectrum (EST): m/z = 481 [M+H]+.

161357-89-7, As the paragraph descriping shows that 161357-89-7 is playing an increasingly important role.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HIMMELSBACH, Frank; ECKHARDT, Matthias; HEINE, Niklas; LANGKOPF, Elke; NOSSE, Bernd; WO2012/80476; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 7-benzyl-2,4-dichloro-6,8-dihydro-5H-pyrido[3,4-d] pyrimidine (3.00 g, 10.2 mmol, 1.00 eq), 1-tert-butyl-3-methyl piperazine-1,3-dicarboxylate (2.62 g, 10.7 mmol, 1.05 eq), DIEA (3.30 g, 25.5 mmol, 4.45 mL, 2.50 eq) in DMSO (50.0 mL) was degassed and purged with nitrogen 3 times. The mixture was stirred at 100° C. for 12 hours under a nitrogen atmosphere. The reaction mixture was diluted with DCM (200 mL), washed with brine (3 50 mL), dried over Na 2SO 4, filtered and concentrated under reduced pressure to dryness. The residue was purified by column chromatography (SiO 2, Petroleum ether/Ethyl acetate=10:1 to 3:1) to give 1-tert-butyl 3-methyl 4-(7-benzyl-2-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)pipera- zine-1,3-dicarboxylate (2.10 g, 3.81 mmol, 37.4% yield, 91.0% purity) as a yellow oil. ESI MS m/z 502.1 [M+H] +.

129799-08-2, As the paragraph descriping shows that 129799-08-2 is playing an increasingly important role.

Reference：
Patent; Mirati Therapeutics, Inc.; Array BioPharma Inc.; Blake, James F.; Burgess, Laurence E.; Chicarelli, Mark Joseph; Christensen, James Gail; Cook, Adam; Fell, Jay Bradford; Fischer, John P.; Marx, Matthew Arnold; Mejia, Macedonio J.; Savechenkov, Pavel; Vigers, Guy P.A.; Smith, Christopher Ronald; Rodriguez, Martha E.; US2019/144444; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.192130-34-0,tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Preparation 20 tert-butyl 4-(2-{[(6′-{2-cyano-4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]phenoxy}-1,1′:3′,1″-terphenyl-3-yl)carbonyl]amino}ethyl)piperazine-1-carboxylate To a solution of 6′-{2-cyano-4-[(1 ,2,4-thiadiazol-5-ylamino)sulfonyl]phenoxy}-1 , 1′:3′, 1″- terphenyl-3-carboxylic acid (Preparation 21 , 100 mg, 0.18 mmol) in dimethylformamide (2.0 mL) was added 1 , T-carbonylbis(1 H-imidazole) (38 mg, 0.23 mmol) and N-ethyl-N- isopropylpropan-2-amine (35 mg, 0.27 mmol). The mixture was stirred at room temperature for 30 minutes, then tert-butyl 4-(2-aminoethyl)piperazine-1 -carboxylate (41.3 mg, 0.18 mmol) was added. The resulting reaction was stirred at room temperature for 3 days. The mixture was concentrated in vacuo to provide the title compound as an orange gum (204 mg, >100percent). This material was used in the next step without further purification. LCMS Rt = 2.40 minutes MS m/z 764 [M-H]”, 192130-34-0

The synthetic route of 192130-34-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; PFIZER INC.; SWAIN, Nigel Alan; BROWN, Alan Daniel; JONES, Lyn Howard; MARRON, Brian Edward; RAWSON, David James; RYCKMANS, Thomas; STORER, Robert Ian; WEST, Christopher William; WO2015/181797; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics