Tag: M.W:200-300

76003-29-7, 1-Boc-3-Oxopiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 27 (4.0 g, 20 mmol) in dichloromethane (50 mL) is added 28 (4.6 g, 24 mmol) at 25 C and then the reaction mixture is stirred at 25 C for 4 hours. The reaction mixture is concentrated under reduced pressure to give a residue 17 (5.0 g, crude) as yellow oil and used for the next without further processing., 76003-29-7

76003-29-7 1-Boc-3-Oxopiperazine 3157178, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; BIOVERSYS AG; BHATTACHARJEE, Ashoke; CHOWDHURY, Somenath; DUFFY, Erin, M.; IPPOLITO, Joseph, A.; KANYO, Zoltan, F.; LAU, Wan; TANG, Yuanqing; WU, Yusheng; (0 pag.)WO2019/234509; (2019); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3022-15-9,Piperazine-2-carboxylic acid dihydrochloride,as a common compound, the synthetic route is as follows.

a) 1,4-Bis(tert-butoxycarbonyl)-2-piperazinecarboxylic acid To a solution of piperazine-2-carboxylic acid dihydrochloride (5 g, 24.6 mmol) in 2M sodium hydroxide (40 mL) and ethanol (40 mL) was added di-tert-butyl dicarbonate (11.82 g, 54.1 mmol) and the reaction mixture stirred for 3 days. The organic solvent was removed in vacuo, the aqueous phase basified with 2M sodium hydroxide and extracted with diethyl ether to remove excess di-tert-butyl dicarbonate. The aqueous layer was adjusted to pH 3-4 and extracted with ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and evaporated to yield 1,4-bis(tert-butoxycarbonyl)-2-piperazinecarboxylic acid as a white solid., 3022-15-9

As the paragraph descriping shows that 3022-15-9 is playing an increasingly important role.

Reference：
Patent; Agejas-Chicharro, Javier; Belen Bueno Melendo, Ana; Camp, Nicholas Paul; Gilmore, Jeremy; Jimenez-Aguado, Alma Maria; Lamas-Peteira, Carlos; Marcos-Llorente, Alicia; Mazanetz, Michael Philip; Montero Salgado, Carlos; Timms, Graham Henry; Williams, Andrew Caerwyn; US2004/122001; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-38-0,2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.

REFERENCE EXAMPLE 19b 2-[4-(4-amino-phenyl)-piperazin-1-yl]-ethanol. 2-[4-(4-amino-phenyl)-piperazin-1-yl]-ethanol is prepared by catalytic hydrogenation of 2[4-(4-nitrophenyl)piperazine-1-yl]-ethanol (prepared as in Reference Example 19a) as described in Reference Example 13b, 5521-38-0

The synthetic route of 5521-38-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Chapdelaine, Marc; Davenport, Timothy; Haeberlein, Markus; Horchler, Carey; McCauley, John; Pierson, Edward; Sohn, Daniel; US2004/87575; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161357-89-7,1-(Methylsulfonyl)piperazine hydrochloride,as a common compound, the synthetic route is as follows.

To a suspension of Example 1285A (0.091 g, 0.21 1 mmol) and l-(methylsulfonyl)piperazine hydrochloride (0.057 g, 0.284 mmol) in 1,4-dioxane (1 mL), N-ethyl-N-isopropylpropan-2-amine (0.2 mL, 1.145 mmol) was added. The mixture was stirred for 72 hours at room temperature. The solvent was removed and the product was purified by flash chromatography on silica gel (AnaLogix IntelliFlash) eluting with a gradient of 0-50% ethyl acetate in heptanes to afford the title compound. MS (ESI+) m/z: 40.3.8 (M+H)+.

161357-89-7, As the paragraph descriping shows that 161357-89-7 is playing an increasingly important role.

Reference：
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; TONG, Yunsong; BRUNCKO, Milan; CLARK, Richard F.; CURTIN, Michael L.; FLORJANCIC, Alan S.; FREY, Robin R.; GONG, Jianchun; HANSEN, Todd M.; JI, Zhiqin; LAI, Chunqiu; MASTRACCHIO, Anthony; MICHAELIDES, Michael; MIYASHIRO, Juliem; RISI, Roberto M.; SONG, Xiaohong; TAO, Zhi-fu; WOODS, Keith W.; ZHU, Guidong; PENNING, Thomas; SOUERS, Andrew; GOSWAMI, Rajeev; IQUTURI, Omprakash Reddy; DABBEERU, Madhu Babu; WO2014/139328; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314741-39-4, (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 9; f8aS)-7V-Biphenyl-2-yl-2-[^r°?s-2-f4-chlorophenyl)cvclopropyll-l,3- dioxohexahydroimidazo [ 1 ,5-al pyrazine-7( lHVcarboxamide ( Eta5); Step 1 : ferf-Butyl (8a61-l,3-dioxohexahydroimidazo[l,5-alphalpyrazine-7(lH)-carboxylate (Hl); To a stirred solution of l-tert-buty 3-methyl (35)-piperazine-l,3-dicarboxylate (AA3) (1.0 eq.) and 6 N aq. HCl sol. (1.0 eq.) in 1,4-dioxane (1 M) was added a sol. of KOCN (2.0 eq.) in H2O (2 M). The reaction mixture was stirred at RT for 2 h, then the organic solvent was removed under reduced pressure. The desired product precipitated from H2O: it was filtered off, washed with cold water and dried at the high vacuum pump. Mother liquors were extracted with EtOAc, the organic phase was washed with brine, dried (Na2SO4), filtered and concentrated to dryness. The crude product was purified by flash chromatography on silica gel eluting with 10-100% EtO Ac/petroleum ether to afford the desired product (Hl) as a white powder which was combined with the previously isolated precipitate. 1H-NMR (300 MHz, DMSO-de, 300K) delta10.95 (IH, bs), 4.15-4.00 (2H, m), 3.97-3.75 (2H, m), 2.97-2.67 (3H, m), 1.42 (9H, s). MS (ES)CnHi7N3O4 requires: 255, found: 256 (M+H)+., 314741-39-4

The synthetic route of 314741-39-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; BRANCA, Danila; FERRIGNO, Federica; HERNANDO, Jose, Ignacio, Martin; JONES, Philip; KINZEL, Olaf; MALANCONA, Savina; MURAGLIA, Ester; PALUMBI, Maria, Cecilia; PESCATORE, Giovanna; SCARPELLI, Rita; WO2010/23480; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 58 te/f-Butyl 4-(4-(6-bromo-7-(4-((6-(trifluoromethyl)pyridin-3-yl)methyl)piperazin-1-yl)- 3H-imidazo[4,5-ib]pyridin-2-yl)phenyl)piperazine-1-carboxylateThis was prepared using the same procedure as for 4-(6-bromo-2-(4- (dimethylamino)phenyl)-3H-imidazo[4,5-/?]pyridin-7-yl)-lambda/-phenylpiperazine-1- carboxamide (example 39 of PCT/GB2006/004854), but here using 5-bromo-3-nitro- 4-(4-((6-(trifluoromethyl)pyridin-3-yl)methyl)piperazin-1-yl)pyridin-2-amine (75 mg, 0.16 mmol), DMF (0.2 mL), ethanol (1.3 ml_), 1 M Na2S2O4 (3 eq, 0.48 mmol, 0.48 ml_) and 4-(4-formylphenyl)piperazine-1-carboxylic acid tert-butyl ester (1.1 eq, 0.18 mmol, 52 mg). After 6 h, concentration in vacuo and purification by preparative tic (CH2CI2-MeOH, 95:5) gave the product (25 mg, 22%) as a colourless solid; deltaH (500 MHz, DMSO-d6) 1.42 (s, 9H, C(CH3J3), 2.63 (s, br, 4H, piperazine N(CH2J2), 3.26 (t, J = 4.4 Hz, 4H, piperazine N(CH2J2), 3.47 (s, br, 4H, piperazine N(CH2)2), 3.65 (s, br, 4H, piperazine N(CH2J2), 3.73 (s, 2H, NCH2), 7.07 (d, J = 9.0 Hz, 2H, phenyl H-3 & H- 5), 7.91 (d, J = 8.0 Hz, 1H, pyridine H-5), 8.04 (d, J = 8.8 Hz, 2H, phenyl H-2 & H-Q), 8.08 (dd, J = 8.1 , 1.4 Hz, 1 H, pyridine H-A), 8.18 (s, 1 H, imidazo[4,5-b]pyridine H-5), 8.77 (s, br, 1H, pyridine H-2), 13.28 (s, br, 1H, imidazo[4,5-6]pyridine NH); LC (Method B) – MS (ESI, m/z): Rt = 5.05 min – 701 , 703 [(M+H)+, Br isotopic pattern. ESI-HRMS: Found: 701.2167, calculated for C32H37BrF3N8O2 (M+H)+: 701.2170.

197638-83-8, As the paragraph descriping shows that 197638-83-8 is playing an increasingly important role.

Reference：
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5747-48-8,11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine,as a common compound, the synthetic route is as follows.

5747-48-8, Step 4 (E)-2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethanol:; A mixture of (E)-11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine (1.00 g, 3.385 mmol), 2-bromoethanol (0.500 g, 4.00 mmol), anhydrous potassium carbonate (0.468 g, 3.386 mmol), sodium iodide (0.250 g, 1.67 mmol) and 1-butanol (20 mL) was heated at reflux for about 24 hours. The reaction mixture was filtered and the solid was washed with methanol. The combined filtrate and washings were concentrated to provide a crude residue. The residue was purified by chromatography on neutral alumina (2% methanol in dichloromethane) to afford the title product as an off-white solid (0.990 g, 86%). m.p. 57-60 C.; 1H NMR (400 MHz, pyridine-d5, 60 C.) delta 2.53-2.60 (m, 2H), 2.63-2.70 (m, 2H), 2.67 (t, J=5.9 Hz, 2H), 3.46-3.68 (m, 4H), 3.89 (t, J=5.9 Hz, 2H), 6.86-7.59 (m, 8H); IR (film) nu 3134, 1598, 1405, 1265 cm-1; MS 340 (M+1).

The synthetic route of 5747-48-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; AUSPEX PHARMACEUTICALS, INC.; US2010/69356; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Compounds 1a-l and compounds 15-19 were synthesized in the same reaction: In a dichloromethane solution (2-3 mL) of chloroacetylchloride(1.1 eq), a dichloromethane solution (8-10 mL) of the appropriate piperazine (1 eq) and triethylamine (2.5 eq) was added dropwise and the reaction mixture was stirred overnight at room temperature under a nitrogen atmosphere. The reaction mixture was evaporated and the residue was extracted with ethylacetate-brine. The organic layer was dried over Na2SO4 and chromatographed on silica preparative TLC to give the desired products.When the reaction was run for 2 h, compounds 1a-l were the mainproducts (>90%).

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference：
Article; Papadopoulou, Maria V.; Bloomer, William D.; Rosenzweig, Howard S.; O’Shea, Ivan P.; Wilkinson, Shane R.; Kaiser, Marcel; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 325 – 334;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

78551-60-7, tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

78551-60-7, Preparation 46: (‘S)-2-[?S2S)-2-amino-l-hvdroxy-3-phenylpropyl”|-4-benzyl-3-oxo-piperazine-l- carboxylic acid t-butyl ester Step A: (S)-4-benzyl-2-|Tl S,2SV2-(dibenzylamino)-l-hvdroxy-3-phenylpropyl]-3-oxo-piperazine- 1-carboxylic acid t-butyl esterDsopropylamine (1.42 mL, 10.08 mmol) was dissolved in anhydrous tetrahydrofuran (10 mL) and the mixture was cooled to -78 C. n-butyl Miium (2.5 M n-hexane solution, 3.9 mL) was added dropwise to the resulting solution. The mixture was stirred for 5 min and then stirred on an ice bath for 30 min. The reaction mixture was cooled to -78 C, and a solution of t-butyl 4-benzyl- 3-oxopiperazine-l-carboxylate (B) (2.44 g, 8.40 mmol) in 15 mL of anhydrous tetrahydrofuran was added dropwise thereto, followed by stirring at that temperature for 1.5 hours. Thereafter, a solution of 2(S)-2-(dibenzylamino)-3-phenylpropanal (A) (2.99 g, 9.07 mmol) in anhydrous tetrahydrofuran (15 mL) was added to the reaction mixture which was gradually warmed to room temperature. After stirring at room temperature for 16 hours, the reaction was terminated with addition of water, followed by extraction with saturated ammonium chloride (aqueous) and diethyl ether. The organic layer was taken, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (EtOAc/n-Hex = 1/5) to afford the title compound (1.92 g, 24%).

The synthetic route of 78551-60-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; LG LIFE SCIENCES, LTD.; WO2009/38411; (2009); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

132710-90-8, 1-Boc-4-(3-hydroxypropyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Triphenylphosphine (2.059 g, 7.85 mmol), fert-butyl 4-(3- hydroxypropyl)piperazine-l-carboxylate ( 1.692 g, 6.93 mmol) and diisopropyl (E)- diazene-l,2-dicarboxylate (1.587 g, 7.85 mmol) were mixed in THF (20 mL) at 0 C, and then 4-chloro-3-hydroxy-5-nitrobenzamide (1 g, 4.62 mmol) was added. The reaction solution was maintained at RT for 16 hrs then the brown reaction solution was partitioned between sat. NaHCC (aq) and EtOAc. The organic layer was washed with brine, dried over MgSC , concentrated and purified on silica gel (20 %-80 % (3 : 1 EtOAc/EtOH) / Hexane, with 2% NH4OH; 330 g RediSep column). Desired fractions were combined and concentrated to give the title compound as a white solid (970 mg, 47 % yield). NMR (400 MHz, OMSO-de) delta ppm 8.30 (s, 1 H), 8.05 (d, J=1.77 Hz, 1 H), 7.88 (d, J=1.77 Hz, 1 H), 7.80 (s, 1 H), 4.28 (t, J=6.21 Hz, 2 H), 3.31 (br. s., 4 H), 2.48 (t, J=7.10 Hz, 2 H), 2.33 (t, J=4.94 Hz, 4 H), 1.96 (t, J=6.59 Hz, 2 H), 1.40 (s, 9 H). LCMS (LCMS Method K): Rt = 0.69 min, [M+H]+ = 443.4.

132710-90-8, The synthetic route of 132710-90-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; PESIRIDIS, George Scott; RAMANJULU, Joshi M.; TRAN, Jean-Luc; YANG, Jingsong; (157 pag.)WO2019/69275; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics