Tag: M.W=200-250

Kondo, Takashi published the artcileDesign and synthesis of DPP-IV inhibitors lacking the electrophilic nitrile group, Related Products of piperazines, the publication is Bioorganic & Medicinal Chemistry (2008), 16(4), 1613-1631, database is CAplus and MEDLINE.

A series of (4β-substituted)-L-prolylpyrrolidine analogs lacking the electrophilic nitrile function were synthesized and their dipeptidyl peptidase IV (DPP-IV) inhibitory activity and duration of ex vivo activity were evaluated. Structural optimization of the analog (I), which was found by high-speed analog synthesis, was carried out to improve the potency and duration of action. A representative compound (II) was evaluated to assess its effect on the plasma glucose level after the oGTT (oral glucose tolerance test) in normal rats. Structure-activity relationships (SAR) are also presented.

Bioorganic & Medicinal Chemistry published new progress about 113534-02-4. 113534-02-4 belongs to piperazines, auxiliary class Piperazine,Nitrile,Amide, name is tert-Butyl 4-cyanopiperazine-1-carboxylate, and the molecular formula is C10H17N3O2, Related Products of piperazines.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Amani, Amene published the artcileElectrochemical Synthesis Based on the Oxidation of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone in the Presence of Nucleophiles, Category: piperazines, the publication is Journal of Organic Chemistry (2012), 77(24), 11302-11306, database is CAplus and MEDLINE.

Electrochem. oxidation of piperazinylphenol I (R = R¹ = H) with 2-benzoxazolethiol or 2-benzothiazolethiol yielded the bis(benzoxazolethiyl)phenol I (R = R¹ = 2-benzoxazolylthio) and bis(benzothiazolethiyl)phenol I (R = R¹ = 2-benzothiazolylthio) in 87% and 93% yields, resp. Further electrochem. oxidation of I (R = R¹ = 2-benzothiazolylthio) in the presence of p-toluenesulfinic acid (TsH) gave (tosyl)(benzothiazolylthio)quinone II (Ts = 4-MeC₆H₄SO₂); attempted direct electrochem. synthesis of II from I (R = R¹ = H), 2-benzothiazolethiol, and TsH, from I (R = R¹ = 2-benzothiazolylthio) and TsH in the absence of elec. potential, and from I (R = Ts; R¹ = H) and 2-benzothiazolethiol were not successful. Cyclic voltammetric measurements during the reactions of I (R = H, 2-benzothiazolylthio, Ts; R¹ = H, 2-benzothiazolylthio) were used to delineate the mechanisms of formation of I (R = R¹ = 2-benzothiazolylthio) and II.

Journal of Organic Chemistry published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C12H16N2O2, Category: piperazines.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Amani, Amene published the artcileElectrochemical synthesis of new coumarin derivatives of potential biological significance, Quality Control of 67914-60-7, the publication is Journal of Electroanalytical Chemistry (2012), 11-15, database is CAplus.

Electrochem. synthesis of some new coumarin derivatives was carried out via the electrochem. oxidation of 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone (1) in the presence of 4-hydroxycoumarin and 4-hydroxy-6-methylcoumarin (2a,b). Electrogenerated p-quinone imine, participated in Michael type reaction with 2a,b and after hydrolysis reaction is converted to the corresponding coumarin derivatives This method provides a 1-pot procedure for the synthesis of new coumarin derivatives of potential biol. significance.

Journal of Electroanalytical Chemistry published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C12H16N2O2, Quality Control of 67914-60-7.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Amani, Ameneh published the artcileOne-pot electrochemical synthesis of highly symmetric and conjugated coumarin derivative, Synthetic Route of 67914-60-7, the publication is Journal of the Iranian Chemical Society (2018), 15(12), 2669-2674, database is CAplus.

A facile and one pot electrochem. synthesis of disubstituted hydroquinone generated from the electrochem. oxidation of 4-1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of 4-hydroxy-6,7-dimethylcoumarin was reported. The results revealed that p-quinone imine derived from oxidation of 4-1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone participated in Michael addition reactions with 4-hydroxy-6,7-dimethylcoumarin and followed by a hydrolysis reaction attain to the highly sym. and conjugated coumarin derivative A new product in good yield was derived based on controlled potential electrochem. oxidation at carbon electrode in a divided cell.

Journal of the Iranian Chemical Society published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C12H16N2O2, Synthetic Route of 67914-60-7.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Beiginejad, Hadi published the artcileEfficient factors on the hydrolysis reaction rate of some para-aminophenol derivatives in acidic pHs, Application of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, the publication is Journal of the Electrochemical Society (2013), 160(8), H469-H473, database is CAplus.

Electrochem. oxidation of some p-aminophenol derivatives (1-5) in acidic solutions was studied both exptl. and theor. to provide insight into the influence of some factors on the hydrolysis reaction rate. The result of this work shows that the electrogenerated p-quinoneimines participate in the hydrolysis reaction and are converted to the p-benzoquinone. The hydrolysis reaction rate strongly depends on the structure of the p-aminophenols and solution’s pH. The observed homogeneous rate constants of hydrolysis (k^obs_hyd) of p-quinoneimines were determined using digital simulation technique. The effect of different parameters such as: change of Gibbs free energy (ΔG) of the electrochem. oxidation of para-aminophenol derivatives (1-5), charge of reaction site, N-C₄ bond order (Wiberg Bond Indexes, WBIs) and the nature of substituted group, on the hydrolysis rate constant were also studied. All calculations were performed using D. Functional Theory (DFT) both BP86 and B3LYP levels of theory and 6-311G (p,d) basis set. The N-C₄ bond order and charge on the reaction site play significant roles in hydrolysis reaction’s rate.

Journal of the Electrochemical Society published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C12H16N2O2, Application of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Daneshyar, Anahita published the artcileElectrochemical synthesis of a new phosphonium betaine. Kinetic evaluation and antibacterial susceptibility, Quality Control of 67914-60-7, the publication is Electrochimica Acta (2019), 134893, database is CAplus.

Cyclic voltammetry, controlled-potential coulometry, chronoamperometry, chronocoulometry and chronopotentiometry methods were used for the electrochem. study of 1-acetyl-4-(4-hydroxyphenyl)piperazine (APIP) in the presence of PPh₃ (TPP) as a nucleophile. Electrochem. generated APIP_ox can serve as a Michael acceptor for nucleophilic attack by TPP to yield a new phosphonium betaine (APTP). The authors prepared a new product in good yield and purity by reaction of TPP with APIP_ox in an undivided cell equipped with C anode. Based on an EC mechanism, the observed homogeneous rate constant (k_obs) of the Michael addition reaction of APIP_ox with TPP were estimated by comparing the exptl. cyclic voltammograms with the digital simulated results. Also, electrochem. oxidation of APIP was studied both exptl. and theor. to provide insight into the influence of natural charge and thermodn. stability parameters on the type of chem. reaction which follows APIP_ox. The synthesized compound was evaluated for in vitro antibacterial.

Electrochimica Acta published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C12H16N2O2, Quality Control of 67914-60-7.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Salahifar, Eslam published the artcileRegioselective Green Electrochemical Approach to the Synthesis of Nitroacetaminophen Derivatives, Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, the publication is Organic Letters (2015), 17(19), 4666-4669, database is CAplus and MEDLINE.

A regioselective green synthesis of nitroacetaminophen derivatives e. g., I, was carried out by electrochem. oxidation of acetaminophen, N-(2-hydroxyphenyl)acetamide, and 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of nitrite ion as a nucleophile. The present work has led to the development of a reagentless green and facile electrochem. method for the synthesis of some nitroacetaminophen derivatives

Organic Letters published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C12H16N2O2, Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Mazzei, Mauro published the artcileActivity of Mannich bases of 7-hydroxycoumarin against Flaviviridae, Quality Control of 87179-40-6, the publication is Bioorganic & Medicinal Chemistry (2008), 16(5), 2591-2605, database is CAplus and MEDLINE.

Some Mannich bases of 7-hydroxycoumarin (2) and their simple derivatives (3 and 4) were prepared and tested against viruses containing single-stranded, pos.-sense RNA genomes (ssRNA⁺). This study was directed toward Flaviviridae and, in particular, HCV surrogate viruses (BVDV, YFV). The 7-hydroxy derivatives 2 were generally devoid of activity, but when position 7 was propylated, the resulting 7-propyloxy derivatives 3 were in some cases endowed with an interesting activity against BVDV. The formation of 7-benzoyl derivatives 4 gave compounds generally lacking in activity against Flaviviridae, whereas the appearance of activity against RSV has been observed Also some unsym. methylene derivatives 5-7 (namely coumarins bridged to chromones or indoles) were found moderately active in antiviral tests. Derivatives 3 were submitted to a mol. modeling study using DNA polymerase of HCV as a target. The good correlation between calculated mol. modeling IC₅₀ and exptl. EC₅₀ indicates that DNA polymerase is potentially involved in the inhibition of surrogate HCV viruses.

Bioorganic & Medicinal Chemistry published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Quality Control of 87179-40-6.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Kumar, J. Ranjith published the artcileSynthesis and antimicrobial activity of new series of piperazine containing chalcone derivatives, SDS of cas: 67914-60-7, the publication is PHARMANEST (2014), 5(2), 1943-1946, database is CAplus.

Treatment of 1-acetyl-4-(4-hydroxyphenyl)piperazine with aromatic or substituted aromatic aldehydes in presence of methanol and potassium hydroxide, formed 3-substituted phenyl-1-(4-(4-hydroxylphenyl)piperzin-1-yl)-prop-2-en-1-one derivatives I (R = Ph, 4-ClC₆H₄, 4-FC₆H₄, etc.). These are assayed for their antibacterial activity against Bacillus pumilus, Bacillus subtilis, Escherichia coli, Proteus vulgaris and for antifungal activity against Aspergillus niger, Candida albicans strains. Antibacterial assay revealed that Bacillus subtilis and Proteus vulgaris were the most sensitive bacterial strains to compounds I (R = 4-ClC₆H₄, 4-FC₆H₄, 4-O₂NC₆H₄, 2,4-di-MeOC₆H₃, 2,4-Cl₂C₆H₃) and in the antifungal assay, compounds I (R = Ph, 4-FC₆H₄, 2,4-Cl₂C₆H₃) were highly effective against Aspergillus niger when compared to other other investigated strains.

PHARMANEST published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C12H16N2O2, SDS of cas: 67914-60-7.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Raajaraman, BR. published the artcileInvestigation on 1-Acetyl-4-(4-hydroxyphenyl) piperazine an anti-fungal drug by spectroscopic, quantum chemical computations and molecular docking studies, Application of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, the publication is Journal of Molecular Structure (2018), 583-595, database is CAplus.

The title compound, 1-acetyl-4-(4-hydroxyphenyl)piperazine (1A4HP) has been examined by FT-Raman, FT-IR, ¹HNMR, ¹³CNMR and UV-Visible spectra range. By using the d. functional theory (DFT) by the method B3LYP and basis set 6-311++G(d,p) the optimized figure of 1A4HP, the vibrational modes, the IR penetration intensities and the working of Raman scattering were estimated The optimized mol. figure obtained by the DFT method and its bond length and bond angle computed values are same as the XRD exptl. values. AIM topol. anal. was done on the mol. The HOMO and LUMO energy results show that good exchange of charge happened inside the mol. NBO method was applied to study donor-acceptor interactions. ¹H and ¹³C chem. shift of NMR were estimated using the type gauge-independent AO (GIAO) and the results are related to the exptl. values. The hyperpolarizability computation shows the 1A4HP has very good NLO property. The anal. of Fukui function and Mol. electrostatic potential (MEP) studies were done. The essential thermodn. characters (entropy, enthalpy and heat capacity) of the 1A4HP estimated at various temperatures The best ligand-protein interactions are done by mol. docking with the various antifungal proteins and the ligand 1A4HP.

Journal of Molecular Structure published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C12H16N2O2, Application of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics