Tag: M.W:100-200

Related Products of 66-71-7. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Synthesis, characterisation and biological activity of the ruthenium(II) complexes of the N4-tetradentate (N4-TL), 1,6-di(2′-pyridyl)-2,5-dibenzyl-2,5-diazahexane (picenBz2). Author is Bjelosevic, Aleksandra; Sakoff, Jennette; Gilbert, Jayne; Zhang, Yingjie; McGhie, Brondwyn; Gordon, Christopher; Aldrich-Wright, Janice R..

A series of complexes of the type rac-cis-β-[Ru(N4-TL)(N2-bidentates)]2+ (N4-TL = 1,6-di(2′-pyridyl)-2,5-dibenzyl-2,5-diazahexane) (picenBz2, N4-TL-2) and N2-bidentates = 1,10-phenanthroline (phen, Ru-2), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq, Ru-3), 7,8-dimethyl-dipyrido[3,2-a:2′,3′-c] phenazine (dppzMe2, Ru-4), 2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline (phenpyrBz, Ru-5), 2-(p-tolyl)-1H-imidazo[4,5-f][1,10]phenanthroline (phenpyrBzMe, Ru-6), 2-(4-nitrophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline (phenpyrBzNO2, Ru-7), were synthesized and characterized and x-ray crystallog. of Ru-5 obtained. The in vitro cytotoxicity assays revealed that Ru-6 was 5, 2 and 19-fold more potent than oxaliplatin, cisplatin, and carboplatin, resp. displaying an average GI50 value of ≈ 0.76 μM against a panel of 11 cancer cell lines.

Although many compounds look similar to this compound(66-71-7)Related Products of 66-71-7, numerous studies have shown that this compound(SMILES:C1=CC3=C(C2=NC=CC=C12)N=CC=C3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Homo- and heterometallic oxalate-based complexes obtained using [Cr(C2O4)3]3- building block – Two polymorphs of a solvate, published in 2022-01-01, which mentions a compound: 66-71-7, Name is 1,10-Phenanthroline, Molecular C12H8N2, Safety of 1,10-Phenanthroline.

Two heterometallic complex salts, as polymorphs of a solvate, consisting of three different mononuclear units, [CuCl(phen)2][Cu(H2O)(phen)2][Cr(C2O4)3]·nH2O [n = 5 (1) and n = 8 (2); phen = 1,10-phenanthroline] were obtained in reactions in which [Cr(C2O4)3]3- was used as a building unit. The polymorphs of a solvate are obtained in crystalline forms that differ in type or stoichiometry of included solvent mols., mostly obtained under different conditions. In this [CuIICrIII] system, the used solvents and crystallization method influence the final product, i.e., the formation of a specific solvatomorph. From the reaction of an aqueous solution of K3[Cr(C2O4)3]·3H2O and acetonitrile solutions containing phen and CuCl2·2H2O, compound 1 was formed when the layering technique is used; and compound 2 can be obtained from the mixture of these reactants, but using methanol instead of acetonitrile. Based on the index parameter for the degree of trigonality, τ, the geometry of copper(II) atoms of the [Cu(H2O)(phen)2]2+ cations in 1 and 2 are distorted from square pyramidal toward trigonal bipyramidal conformation, while those of [CuCl(phen)2]+ have a trigonal bipyramidal geometry. Interestingly, in the presence of [NBu4]+ cations, and applying slow liquid diffusion, partial decomposition of the building block [Cr(C2O4)3]3- occurred and the homobinuclear oxalate-bridged complex [{Cu(bpy)Cl}2(μ-C2O4)]·CH3OH (3; bpy = 2,2′-bipyridine) was formed. Consequently, the oxalate ligand released from the coordination sphere of CrIII was coordinated to CuII ions during the crystallization process. The obtained oxalate-based compounds 1-3 were characterized by IR spectroscopy and single-crystal x-ray diffraction.

Although many compounds look similar to this compound(66-71-7)Safety of 1,10-Phenanthroline, numerous studies have shown that this compound(SMILES:C1=CC3=C(C2=NC=CC=C12)N=CC=C3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Enantio-differentiating hydrogenation of methyl acetoacetate over modified Raney nickel catalysts prepared by two-step modifications.Computed Properties of C5H10O3.

Two-step modifications of Raney nickel were examined for the enantio-differentiating hydrogenation of Me acetoacetate. The combination of pre-modification with disodium tartrate and NaBr in water and in-situ modification with tartaric acid resulted in the highest optical yield (84%) of hydrogenation product. This modification process is greener [environmentally benign] process than conventional modification carried out under weakly acidic conditions, because this process generated almost no Ni2+ ions. The pre-modification with tartrate and NaBr preferentially eliminated Al3+ from Raney nickel surface.

Although many compounds look similar to this compound(53562-86-0)Computed Properties of C5H10O3, numerous studies have shown that this compound(SMILES:C[C@H](O)CC(OC)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,10-Phenanthroline(SMILESS: C1=CC3=C(C2=NC=CC=C12)N=CC=C3,cas:66-71-7) is researched.Computed Properties of C5H10O3. The article 《Intelligent graphene oxide membranes with pH tunable channels for water treatment》 in relation to this compound, is published in Chemical Engineering Journal (Amsterdam, Netherlands). Let’s take a look at the latest research on this compound (cas:66-71-7).

Adaptive membranes that can intelligently control their permeability or selectivity depending on the surrounding environments are of extraordinary importance in the separation technol. area. Herein, we report the pH responsive membranes through covalently grafting weak Polyelectrolytes (poly(acrylic acid) (PAA) or poly(4-vinylpyridine) (P4VP)) onto the regular two dimensional (2D) channels stacked by Graphene oxide (GO) nanosheets. Attributed to the reversible shrinking/stretching function of PAA (or P4VP) chains with the variation of external pH, the switchable 2D GO channels are thus established successfully. Correspondingly, the resulting PAA@GO and P4VP@GO 2D membranes show promising nano-gating ratios of ∼ 5 accompanied by satisfactory water permeances. Furthermore, the pH responsive 2D channels render these two types of membranes with the adaptive ability of rejecting different sized species according to separation requirements. For disposing industrial alk. (or acid) effluents, PAA@GO (or P4VP@GO) membranes exhibit outstanding alk. (or acid) recovery performance as well.

Although many compounds look similar to this compound(66-71-7)Related Products of 66-71-7, numerous studies have shown that this compound(SMILES:C1=CC3=C(C2=NC=CC=C12)N=CC=C3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C5H13NO. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies. Author is Tong, Lexian; Song, Pinrao; Jiang, Kailong; Xu, Lei; Jin, Tingting; Wang, Peipei; Hu, Xiaobei; Fang, Sui; Gao, Anhui; Zhou, Yubo; Liu, Tao; Li, Jia; Hu, Yongzhou.

Through virtual screening, we identified the lead compound MCL1020, which exhibited modest CHK1 inhibitory activity. Then a series of 5-(pyrimidin-2-ylamino)picolinonitrile derivatives as CHK1 inhibitors were discovered by further rational optimization. One promising mol., I, whose potency was one of the best, had an IC50 of 0.4 nM with remarkable selectivity (>4300-fold CHK1 vs. CHK2). Compound I effectively inhibited the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM) and displayed low affinity for hERG (IC50 > 40 μM). Moreover, I significantly suppressed the tumor growth in Z-138 cell inoculated xenograft model (20 mg/kg I.V., TGI = 90.29%) as a single agent with body weight unaffected. Taken together, our data demonstrated compound I could be a promising drug candidate for the treatment of hematol. malignancies.

Compounds in my other articles are similar to this one((S)-1-(Dimethylamino)propan-2-ol)Electric Literature of C5H13NO, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Studies of the effects of the modification conditions on the hydrogenation rate for the enantio-differentiating hydrogenation of methyl acetoacetate over a tartaric acid-NaBr-modified nickel catalyst, the main research direction is nickel tartaric acid sodium bromide catalyst enantioselectivity hydrogenation acetoacetate.SDS of cas: 53562-86-0.

The effects of modification conditions on the hydrogenation rate and the enantio-differentiating ability (e.d.a.) for hydrogenation of Me acetoacetate were studied, of (R,R)-tartaric acid-NaBr-in-situ-modified Ni catalyst. Tartaric acid treatment led to increased hydrogenation rate, irresp. of the presence of auxiliary modifier, NaBr. In the presence of tartaric acid, NaBr has two roles, i.e., Na+ activates the enantio-differentiating sites through interaction with tartaric acid, and Br- deactivates both the enantio-differentiating sites and non-enantio-differentiating sites. The e.d.a. and the hydrogenation rate are determined by the combination of these effects of Na+ and Br-.

Compounds in my other articles are similar to this one((S)-Methyl 3-hydroxybutanoate)SDS of cas: 53562-86-0, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Product Details of 53562-86-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Chiral biphenyl diphosphines for asymmetric catalysis: stereoelectronic design and industrial perspectives. Author is Jeulin, Severine; De Paule, Sebastien Duprat; Ratovelomanana-Vidal, Virginie; Genet, Jean-Pierre; Champion, Nicolas; Dellis, Philippe.

Both enantiomers of the chiral diphosphines I (SYNPHOS) and II (DIFLUORPHOS) are prepared on multigram scales; the electronic and steric characteristics of I and II and of rhodium complexes derived from them are determined, compared with previous diphosphine catalysts, and correlated with their activities and enantioselectivities in the hydrogenation of ketones and olefins. I and II are prepared in five steps from 6-bromo-2,3-dihydro-1,4-benzodioxane and 5-bromo-2,2-difluorobenzodioxole, resp.; lithium-metal exchange and addition to a phosphoryl or phosphinyl chloride followed by oxidation to yield phosphine oxides, regioselective lithiation and iodination, Ullman coupling of the aryl iodides, resolution (either by acid-base resolution with di-O-benzoyl-tartaric acid or by chiral HPLC), and reduction of the phosphine oxides yields I and II in 38% and 33% overall yield, resp. The bite angles of I and II are compared to those of other common diphosphine ligands such as BINAP and MeO-BIPHEP. The structure of diastereomeric chlorohydridoruthenium complexes of (S)-II with Me acetoacetate is determined The C-O stretching frequencies of chloro(carbonyl)rhodium diphosphine complexes containing I, II, BINAP, and MeO-BIPHEP are determined as a measure of the electronic demands of the diphosphine ligands. β-Keto ester, α-keto ester, 1,3-diketone, ketone, and olefin substrates are hydrogenated in the presence of nonracemic I, II, BINAP, and MeO-BIPHEP and bis(η3-methallyl)(η4-1,5-cyclooctadienyl)ruthenium; the enantioselectivities are correlated with the steric and electronic properties of the ligands. The stereoelectronic features of the ligand and the substrate deeply influence the enantioselectivities obtained in asym. hydrogenation; whereas the steric and electronic factors for I (as in other diphosphines) correlate well, the bite angle of II does not correlate to its electronic effects in asym. hydrogenation reactions, leading to complementary hydrogenation selectivities for ligands I and II.

Compounds in my other articles are similar to this one((S)-Methyl 3-hydroxybutanoate)Product Details of 53562-86-0, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ) is researched.COA of Formula: C5H10O3.Young, C. S.; Ward, O. P. published the article 《Studies of the reductive biotransformation of selected carbonyl compounds by whole cells and extracts of Baker’s yeast, Saccharomyces cerevisiae》 about this compound( cas:53562-86-0 ) in Biotechnology and Bioengineering. Keywords: carbonyl compound reduction bakers yeast; Saccharomyces citronellal benzoylformate acetoacetate reduction. Let’s learn more about this compound (cas:53562-86-0).

The progress of reductive biotransformations of a variety of carbonyl compounds by whole cells of baker’s yeast was monitored with time. Biotransformation rates ranged from 0.11 to 112.12 mg product formed per g dry yeast per h. While rapid biotransformations of citronellal and Et benzoylformate were observed, complete conversion of substrate to product did not occur. Reductive conversions of ethyl- and methyl-acetoacetate went to completion in 6 and 12 h resp. Et mandelate was produced stereoselectively, favoring the (R)-stereoisomer and ethyl- and methyl-3-hydroxybutyrate were produced with (S)-enantiospecificity. Yeast crude extract and resuspended pellet fractions converted citronellal to citronellol in the presence of NAD(P)H. Et benzoylformate and methyl- and ethyl-acetoacetate were preferentially reduced by yeast crude extract as compared to resuspended pellet and, in the case of the former two substrates, the reaction manifested a preference for NADPH over NADH.

Compounds in my other articles are similar to this one((S)-Methyl 3-hydroxybutanoate)COA of Formula: C5H10O3, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application of 66-71-7. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Cu-Catalyzed Intermolecular γ-Site C-H Amination of Cyclohexenone Derivatives: The Benefit of Bifunctional Ligands. Author is Zhao, Xin; Yang, Fang; Zou, Shao-Yu; Zhou, Qian-Qian; Chen, Zi-Sheng; Ji, Kegong.

Utilizing 1,10-phenanthroline-type bifunctional ligands, an efficient Cu-catalyzed intermol. site-selective remote C-H amination using cyclohexenone derivatives and anilines was realized. The amide group installed on the bifunctional ligand played a key role in stabilizing the N-centered radical generated in-situ to realize C-N-directed formation. Meanwhile, a useful catalytic system for site-selective intermol. remote γ-C-H amination to p-aminophenols and γ-aminated enones was established. This economical and practical approach using oxygen as the terminal oxidant was mild and environmentally friendly.

Although many compounds look similar to this compound(66-71-7)Application of 66-71-7, numerous studies have shown that this compound(SMILES:C1=CC3=C(C2=NC=CC=C12)N=CC=C3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mashima, Kazushi; Kusano, Kohhei; Ohta, Tetsuo; Noyori, Ryoji; Takaya, Hidemasa published the article 《Synthesis of new cationic BINAP-ruthenium(II) complexes and their use in asymmetric hydrogenation [BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl]》. Keywords: BINAP ruthenium arene cationic complex; crystal mol structure bisdiphenylphosphinobinaphthylruthenium complex; asym hydrogenation catalyst ruthenium BINAP.They researched the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2 ).Safety of (S)-1-(Dimethylamino)propan-2-ol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:53636-17-2) here.

Reaction of [RuX2(arene)]2 with (S)-BINAP gives cationic BINAP-ruthenium complexes I (X = Cl, Br, iodo; Z = Cl, Br, iodo, BF4, BPh4; arene = C6H6, p-MeC6H4CHMe2) which are efficient catalyst precursors for enantioselective hydrogenation of various prochiral alkenic and ketonic substrates; a crystal structure of I (X = Cl, Z = BF4) was obtained.

Although many compounds look similar to this compound(53636-17-2)Safety of (S)-1-(Dimethylamino)propan-2-ol, numerous studies have shown that this compound(SMILES:C[C@H](O)CN(C)C), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics