Tag: M.W:100-200

Related Products of 2343-22-8. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers.

Compelling mol. biol. publications have reported the implication of phosphoinositide kinase PI3Kβ in PTEN-deficient cell line growth and proliferation. These findings supported a scientific rationale for the development of PI3Kβ-specific inhibitors for the treatment of PTEN-deficient cancers. This paper describes the discovery of 2-[2-(2,3-dihydro-indol-1-yl)-2-oxo-ethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one and the optimization of this new series of active and selective pyrimidone indoline amide PI3Kβ inhibitors. 2-[2-(2-Methyl-2,3-dihydro-indol-1-yl)-2-oxo-ethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one (I), identified following a carefully designed Me scan, displayed improved physicochem. and in vitro pharmacokinetic properties. Structural biol. efforts enabled the acquisition of the first x-ray cocrystal structure of p110β with the selective inhibitor compound I bound to the ATP site. The nonplanar binding mode described herein is consistent with observed structure-activity relationship for the series. Compound I demonstrated significant in vivo activity in a UACC-62 xenograft model in mice, warranting further preclin. investigation. Following successful development, compound 28 entered phase I/Ib clin. trial in patients with advanced cancer.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Quality Control of 1,10-Phenanthroline. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Application of molybdenum disulfide nanosheets adsorbent for simultaneous preconcentration and determination of Cd(II), Pb(II), Zn(II) and Ni(II) in water samples.

In this research, the two-dimensional molybdenum disulfide nanosheets (MoS2-NSH) were synthesized and successfully used as an effective adsorbent for preconcentration of trace amounts of four heavy metal ions (including, Cd, Ni, Zn and Pb) before measurements with flame at. absorption spectrometry (FAAS). The prepared MoS2-NSH was characterized by Fourier transform-IR spectroscopy (FT-IR), SEM (SEM), Energy-Dispersive X-Ray Spectroscopy (EDS) and transmission electron microscopy (TEM). The main anal. parameters which can influence the quant. recoveries of target analyte ions; such as solution pH, eluent type and its volume, adsorbent dosage and initial sample volume, were investigated. Under the optimized conditions, the recoveries of metal ions were > 90% at pH of 5.5, and the limits of detection values were found to be 0.37, 0.97, 0.76 and 1.09μg L-1 for Cd(II), Ni(II), Zn(II) and Pb(II), resp. The relative standard deviations (% RSD) for target ions were less than 5.3%. In addition, based on the exptl. data, the kinetics studies and adsorption isotherms were evaluated and the results showed that the pseudo-second-order kinetic model and Langmuir adsorption isotherm were well-fitted with the ions adsorption data. The suggested procedure has been successfully utilized in the anal. of some environmental water samples with satisfactory recoveries in the range of 93.6 to 107.2%.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Baker’s yeast reduction of β-keto esters in petrol, published in 1996-03-04, which mentions a compound: 53562-86-0, mainly applied to yeast reduction keto ester; hydroxy ester preparation, COA of Formula: C5H10O3.

A none fermenting suspension of Baker’s yeast in petrol containing a small amount of water reduces a variety of β-keto esters to the corresponding optically active β-hydroxy esters. E.g., RCOCH2CO2Et (R = Me, Et, Pr) gave (S)-RCH(OH)CH2CO2Et.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 53562-86-0, is researched, Molecular C5H10O3, about Assembling molecular guidance systems for heterogeneous enantioselective catalysis, the main research direction is review mol guidance system heterogeneous enantioselective catalysis; copper enantioselective catalysis chiral modification surface review; tartaric acid alanine surface modification catalyst chirality review.SDS of cas: 53562-86-0.

A review, on chirally-modified metal catalysts as means of imposing asymmetry on a non-chiral substrate. Surface science studies on inducing enantioselectivity by R,R-tartaric acid and S-alanine at (Cu(110)) surface are described. The chirality induction is illustrated by the hydrogenation of methylacetoacetate over Ni surface modified with the chiral agents to produce R- or S-methyl-3-hydroxybutyrate.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Molecular precursor route for the phase selective synthesis of α-MnS or metastable γ-MnS nanomaterials for magnetic studies and deposition of thin films by AACVD, the main research direction is manganese sulfide nanomaterial thin film chem vapor deposition.Recommanded Product: 1,10-Phenanthroline.

Heterocyclic dithiocarbamate complex of manganese and the adducts of the complex with 1,10-phenanthroline and 2,2-bipyridyl resp. were synthesized and characterized. The complexes were used as single-source precursors for the preparation of MnS nanoparticles via thermolysis in oleylamine (OLA) and dodecanethiol (DT). The optimized reaction parameters have resulted in the formation of α-MnS and γ-MnS nanoparticles depending on the dispersion medium and the nature of the precursor. The same precursors were also used for the deposition of MnS thin films by the aerosol-assisted chem. vapor deposition (AACVD) method in varying solvents and temperatures The morphol. and phase of the synthesized nanoparticles were shown to be affected by the precursor type and the nature of the surfactants. SEM images showed that the morphol. of the deposited thin films is affected by precursor type and the deposition temperature Worm-like to rod-like films were observed on TEM images at 350 °C, which changes to spherical or cubic films at 450 °C. Magnetic measurements at room temperature showed the α-MnS and γ-MnS nanoparticles in paramagnetic states due to Mn2+ moments. The susceptibility for the γ-phase is at least double that of the α-phase. Finite and small hysteretic effects in low fields are indicative of small ordered antiferromagnetic phases due to neg. exchange interaction between Mn2+ ions.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A General and Highly Selective Cobalt-Catalyzed Hydrogenation of N-Heteroarenes under Mild Reaction Conditions, published in 2017, which mentions a compound: 2343-22-8, Name is 5-Fluoroindoline, Molecular C8H8FN, Recommanded Product: 2343-22-8.

Herein, a general and efficient method for the homogeneous cobalt-catalyzed hydrogenation of N-heterocycles, under mild reaction conditions, is reported. Key to success is the use of the tetradentate ligand tris(2-(diphenylphosphino)phenyl)phosphine. This non-noble metal catalyst system allows the selective hydrogenation of heteroarenes in the presence of a broad range of other sensitive reducible groups.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Formula: C9H7NO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of derivatives of oximes, hydrazones, and dichloroacetamides. Study of antiparasitic properties. Author is Berthelot, P.; Vaccher, C.; Flouquet, N.; Viana, M. N.; Savel, J.; Debaert, M..

Title compounds I and II [X = NOH, NNHCSNH2, morpholinoimino; R = Me, CH2Ph, 2-(2-thienyl)vinyl, 2-(5-bromo-2-thienyl)vinyl; R1 = CH2CO2H, H, Me; R2 = H, COCHCl2] and R3C(:NOH)CH2CH2CR4:NOH (R3 = 2-thienyl, R4 = Me, Ph; R3 = tetrahydronaphthyl, R4 = Me, 4-ClC6H4; R3 = 4-phenylcyclohexyl, R4 = 4-ClC6H4) were prepared The products were devoid of protozoacidal activity.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity, Author is Hwang, Dong-Jin; He, Yali; Ponnusamy, Suriyan; Mohler, Michael L.; Thiyagarajan, Thirumagal; McEwan, Iain J.; Narayanan, Ramesh; Miller, Duane D., which mentions a compound: 2343-22-8, SMILESS is FC1=CC2=C(NCC2)C=C1, Molecular C8H8FN, Reference of 5-Fluoroindoline.

In our effort to find small-mol. treatments of advanced prostate cancers (PCs), a novel series of indolyl and indolinyl propanamides (series II and III) were discovered as selective androgen receptor degraders (SARDs). Initial studies of androgen receptor (AR) antagonist (1) and agonist (2) propanamides yielded a tertiary aniline (3) with novel SARD activity but poor metabolic stability. Cyclization to II and III produced submicromolar AR antagonism and protein degradation selective to AR and AR splice variant (AR SV). II and III maintained potency against enzalutamide-resistant (Enz-R) mutant ARs and PC cells and were efficacious in Enz-R xenografts, suggesting their potential to treat advanced PCs. Design, synthesis, and biol. activity of novel SARDs that could potentially be used for the treatment of a wide spectrum of PCs including castration-resistant, Enz-R, and/or AR SV-dependent advanced PCs that are often untreatable with known hormone therapies are discussed.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 53562-86-0, is researched, Molecular C5H10O3, about Studies of co-modifier and carboxylic acid for the enantio-differentiating hydrogenation of 2-octanone over a tartaric acid in situ modified nickel catalyst, the main research direction is hydrogenation octanone tartarate nickel catalyst sodium pivalate.Product Details of 53562-86-0.

The effects of a co-modifier and carboxylic acid on the hydrogenation rate and the enantio-differentiating ability (e.d.a.) were studied for the hydrogenation of 2-octanone and Me acetoacetate over a tartaric acid modified reduced nickel catalyst. For the hydrogenation of 2-octanone, tartaric acid, pivalic acid, and Na+ were necessary for the appearance of the predominant e.d.a. Sodium pivalate, instead of the typical co-modifier, NaBr, was appropriate for the in situ modification of reduced nickel. The use of sodium pivalate resulted in a higher hydrogenation rate and e.d.a.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Purification and characterization of a novel keto ester reductase from Candida parapsilosis, published in 1992, which mentions a compound: 53562-86-0, Name is (S)-Methyl 3-hydroxybutanoate, Molecular C5H10O3, Related Products of 53562-86-0.

The purification and characterization of a novel NADH-dependent keto ester reductase from Candida parapsilosis is reported and the applicability of this enzyme in a coupled enzyme system with cofactor regeneration is demonstrated. The system catalyzes the stereospecific reduction of Me acetoacetate.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics