Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.

5625-67-2, STEP 1 Piperazin-2-one (1 g, 10 mmol) was dissolved in CH2C12 (40 ML), and BOC20 (2.4 g, 11 mmol, 1.1 eq), Et3N (2.02 g, 20 mmol, 2 eq) and DMAP (0.024 g, 0.2 mmol, 2 mol%) were added. After the mixture was stirred at RT for 16 h, it was acidified with 1 N HCI. The organic layer was separated, washed with saturated NAHC03, brine, dried (Na2SO4), and concentrated in vacuo to give the product (1.8 g, 90%) as a white SOLID. H NMR (CDCI3, 300 MHz) No. 6. 70 (1 H, bs), 4.08 (2H, s), 3.62 (2H, t, J = 6. 0 Hz), 3.37 (2H, m), 1.46 (9H, s).

The synthetic route of 5625-67-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/14540; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

Example 53: -r2-(4-methv.-piDerazin-1 -vn-ethvi1-3-r3-(5-thioDhen-3-vi-Dvrimidin-2-viamino)-Dhenvt1-urea; To a stirring solution of W (100 mg, 0.23 mmol) in CH2CI2 (20 mL) was added J (33 mg, 0.23 mmol) followed by triethylamine (32 muL, 0.23 mmol). The solution was stirred at room temperature for 12 hours where the reaction was diluted with CH2Cl2 (50 mL) and washed with 2N NaOH (2 x 50 mL), water (2 x 50 mL) and brine (2 x 50 mL). The organics were dried over Na2S04 and concentrated in vacuo. The residue was purified using column chromatography (silica gel, 5percent MeOH in CH2CI2). The fractions containing product were evaporated to dryness under vacuum to yield compound 53 in 45percent yield as a white solid. (at)H NMR (300 MHz, CD30D) No. 2.27 (s, 3H), 2.33-2.55 (m, 7.01-7.02 (m, 1H), 7.04-7.05 (m, 2H), 7.43 (d, 1 H), 7.45 (d, 1 H), 7.64 (d, 1 H), 7.86 (d, 1 H), 8.72 (s, 2H). MS m/z 438 [M++1].

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference：
Patent; SUGEN, INC.; WO2005/113548; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A solution of intermediate4a or 4b (1mmol), corresponding aliphatic amine (2mmol), K2CO3 (2mmol) in DMF was stirred at room temperature overnight. DMF was removed in vacuo and then H2O was added. The layer was extracted with CH2Cl2 (15mL×3). Organic layers were dried on Na2SO4 and the solvent was removed under pressure. Compounds were purified by column chromatography using dichloromethane/methanol as an eluent to give 5a-11a and 12b-21b.

21655-48-1, 21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Wang, Yu; Chen, Shaowei; Hu, Gang; Wang, Jiao; Gou, Wenfeng; Zuo, Daiying; Gu, Yucheng; Gong, Ping; Zhai, Xin; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 123 – 136;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

131.5 g of N-hydroxyethylpiperazine (purity 99%, about 1 mol)And 30% (mass concentration) aqueous sodium vinyl sulfonate solution (containing 1.05 mol of sodium vinyl sulfonate)Was added to a 1000 mL four-necked flask equipped with a reflux tube,The addition reaction is carried out with sufficient stirring;The reaction was carried out at 60 C for 1.0 hour,And then gradually heated to boiling reflux (about 100 ~ 120 , depending on the composition of the reaction and change)And continue to react for 2.0 hours;then,Cooled to give a reaction mother liquorcontaining 4-hydroxyethylpiperazineethanesulfonate.By high performance liquid chromatography,The yield of sodium 4-hydroxyethylpiperazineethanesulfonate was calculated to be 95.2%.A reaction mother liquor containing 0.5 mol HEPES-Na at a mass concentration of 40 wt% was placed in a 500 mL beaker,Under stirring,At room temperature,27.3 g of oxalic acid (99 wt%) was added slowly,Then stir,And acidified at 20 C for 1 hour.Into the low temperature thermostat,Cooling to 10 ,Cooling crystallization for 0.5 hours,The precipitated sodium oxalate was removed by filtration.The filtrate was placed in a beaker,Constantly stirring,1.0 g of Ba (OH) 2 was slowly added,Reaction for 1 hour,Remove the sulfate.Adding 5 g of activated carbon decolorization and filtering by filtration to obtain the filtrate,By rotary evaporation to anhydrous,To obtain a solid primary purified product.The solids were washed three times with 500 ml of ethanol,And then vacuum drying,Get high purity HEPES.

103-76-4, As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.

Reference：
Patent; Shandong University of Technology; Cui Hongyou; Wang Jiangang; Zhu Liwei; Liu Ransheng; Yang Yong; Wang Yang; (8 pag.)CN104803949; (2017); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of compound 9 (100mg, 0.23mmol) in CH2Cl2 (10ml) was added oxalyl chloride (0.04ml, 0.50mmol) at 0°C, the reaction mixture was stirred at 0°C for 0.5h and then at room temperature for another 3h. The mixture was added to a solution of various amines (2.2 eq) and Et3N (0.1ml, 0.72mmol) and stirred for 12hat room temperature. After the reaction completed, the mixture was washed by water (3×20ml), brine (2×20ml), dried over anhydrous Na2SO4 and concentrated, the residue was purified by silica gel chromatography (CH2Cl2/MeOH 30/1v/v) to give corresponding diamides 10?26.

4318-42-7, 4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Mao, Shi-Wei; Chen, Huang; Yu, Li-Fang; Lv, Fang; Xing, Ya-Jing; Liu, Ting; Xie, Jia; Tang, Jie; Yi, Zhengfang; Yang, Fan; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 574 – 583;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

In N2 Under protection, three-necked flask with stirring and the funnel was added dropwise and THF150ml 100mmol isopropyl piperazine, in an ice bath, was slowly added dropwise through a dropping funnel 100mmol butyllithium dropwise after l to room temperature, the reaction after 1h.Under a 71/92 then cooled to 0°C 100mmol cyclohexyl trimethoxysilane, after the completion of the dropwise addition the reaction at room temperature for 8h, and finally through G4Funnel, the solid residue was washed repeatedly with tetrahydrofuran and filtered, the filtrate was collected.With a rotary evaporator to tetrahydrofuran solvent, vacuum distillation, collecting 136 ~ 139°C / 100pa fraction.Vacuum distillation, collecting 136 ~ 139°C/ 100pa distillate, heavy 5.3g, 98.2percent yield,

As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.

Reference：
Patent; Institute of Chemistry Chinese Academy of Sciences; Li, Huayi; Chang, Hefei; Zhang, Liaoyun; Hu, Youliang; (19 pag.)CN102977133; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8,5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of compound 2 (0.55 mmol), 1-substituted piperazine (0.83 mmol) and pyridine (0.8 mmol) in 10 mL THF (tetrahydrofuran) was stirred at room temperature overnight. When the reaction was completed, the solvent was evaporated under reduced pressure. The residues were dissolved in ethyl acetate and washed with water and saturated sodium chloride solution. After drying over anhydrous Na2SO4, the solvent was removed under reduced pressure to get crude product. The pure products were obtained by recrystallizing from ethanol.

The synthetic route of 5308-25-8 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Wu, Zhilin; Ding, Na; Tang, Yuting; Ye, Jiao; Peng, Junmei; Hu, Aixi; Research on Chemical Intermediates; vol. 43; 8; (2017); p. 4833 – 4850;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

21655-48-1, EXAMPLE 24 Cis-3,5-dimethyl-1-(4-nitro-phenyl)-piperazine A suspension of 6.74 g (47.8 mmol) of 4-fluoro-nitro-benzene and 10.91 g (95.5 mmol) of cis-2,6-dimethyl-piperazine is heated at 45° C. for 1 hour. The reaction mixture is cooled and shaken with dichloromethane and water. The organic layer is dried (magnesium sulfate) and concentrated to give 11.62 g (>100percent) of the product as a solid.

21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Booth, Richard John; Dobrusin, Ellen Myra; Josyula, Vara Prasad Venkata Nagendra; McNamara, Dennis Joseph; Toogood, Peter Laurence; US2003/73668; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5271-27-2, 1-Methyl-3-phenylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5271-27-2

General procedure: A mixture of 1a-c (1.93 g, 10 mmol), 4 (1.76 g, 10mmol) and KF (18 mmol) were heated at 120-130 °C inDMF (30 mL) for 16 – 18 h. At the end of this period, thereaction mixture was cooled to room temperature and dilutedwith water (30 mL). The separated solid was filtered, washedand dried to obtain crude 5a-i. The obtained crude productwas then purified by recrystallization using ethanol

5271-27-2 1-Methyl-3-phenylpiperazine 2760009, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Darsi, S.S. Praveen Kumar; Kumar, K. Shiva; Devi, B. Rama; Naidu; Dubey; Letters in Organic Chemistry; vol. 11; 8; (2014); p. 551 – 555;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.,21043-40-3

Example 1 (General procedure A); 6-Chloro-2-(4-cyclopentylpiperazin-1-yl)benzothiazole, hydrochloride; A mixture of 2,6-dichlorobenzothiazole (0.39 g, 1.9 mmol), 1-cyclopentylpiperazine (0.22 g, 1.4 mmol) and dimethylsulfoxide (2.0 ml.) was stirred at 130 0C for 23 h. The reaction mixture was allowed to cool and water (50 ml.) and potassium carbonate (1 g) was added. The resulting mixture was extracted with a mixture of ethyl acetate and dichloromethane and filtered. The filtrate was separated and the organic extract was washed with brine (2 x) and dried (MgSO4). The volatiles were evaporated to give a solid residue which was dissolved into a mixture of ethanol (30 ml.) and 1 N hydrochloric acid (2.5 ml_). Toluene was added and the mixture was concentrated. Ethanol and toluene was added and the mixture was concentrated again. This afforded a solid which was treated with ethanol (50 ml.) and heated to reflux temperature. The resulting mixture was left overnight for crystallization. This afforded after filtration and drying 0.35 g (69 %) of 6-chloro-2-(4-cyclopentylpiperazin-1-yl)benzo- thiazole, hydrochloride.

The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NOVO NORDISK A/S; WO2007/110364; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics