Tag: M.W:100-200

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about Gas chromatographic separation of some enantiomers on optically active copper(II) complexes.Synthetic Route of C5H13NO.

Gas chromatog. separation of optically active amino alcs., amines, amino esters, and alcs. was achieved using optically active Cu(II) complexes. The binuclear Cu(II) complex of either (R)-2-(salicylidenamino)-1,1-bis(5-tert-butyl-2-octyloxyphenyl)propan-1-ol or (S)-2-(salicylidenamino)-1,1-diphenylpropan-1-ol was incorporated into the stationary phase on both capillary and packed columns. Separation results for 13 compounds, using the carrier gas, are tabulated. Trimethylsilylation decreased the separation of amino alc. enantiomers, and acylation destroyed it entirely.

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Kluson, Petr; Stavarek, Petr; Penkavova, Vera; Vychodilova, Hana; Hejda, Stanislav; Bendova, Magdalena published an article about the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O ).Recommanded Product: (S)-Methyl 3-hydroxybutanoate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:53562-86-0) through the article.

Homogeneous asym. catalysts represented by organometallics of transition elements reveal very high activity and stereoselectivity in asym. hydrogenation of β-ketoesters. Recently, it appeared efficient to use ionic liquids of the [NR222][Tf2N] type for accommodation of the chiral catalytic complex. Even on the industrial scale it is becoming attractive to carry out hydrogenations with such immobilized complexes in a continuous regime in microreactors. Attention was paid to the stereoselective hydrogenation of methylacetoacetate (MAA) to isomeric (R)-(+) or (S)-(-)-methyl-3-hydroxybutanoates over a chiral ([RuCl((R)-BINAP)(p-cymene)]Cl) complex immobilized in the mixed [N8222][Tf2N]/methanol/water solvent phase, and performed inside of a microfluidic chip reactor. It was shown that the reaction could be successfully carried out in such an arrangement with a very high enantioselectivity (above 99%) and at very high conversion of MAA (above 97%). It was proven that the participation of a specific solvent (methanol or the mixture [N8222][Tf2N]/methanol/water) essentially influences the mechanism of the reaction. The solvents actively participate in the re-coordination of the catalytic complex in a series of reactions which is reflected in the values of reaction enthalpies. The specific process output was also evaluated.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 66-71-7, is researched, Molecular C12H8N2, about Design, Synthesis, Bioanalytical, Photophysical and Chemo-phototherapeutic Studies of Heteroleptic Cu(II) Complexes, the main research direction is copper complex thermodn property anticancer mol docking.Product Details of 66-71-7.

A broad investigation has been paid to design an alternative metal-based anticancer drug, bearing metal ions other than platinum, with more target specificity. In this regard, Cu(II) complexes showed a remarkable intercalation binding property with DNA which have received much attention in the development of efficient anticancer drugs. A series of mononuclear ternary Cu(II) complexes A, B and C were prepared with H2L and auxiliary ligand. The synthesized H2L and corresponding complexes were characterized using various electroanal. and physicochem. techniques. The thermodn. parameters were calculated using Gibb′s-Helmholtz, Arrhenius and Eyring equations. Morphol., binding energies of core electrons and crystallog. nature of the metal complexes were evaluated by SEM, XPS and PXRD techniques. Binding studies of the metal complexes with CT-DNA were conducted by absorption, fluorescence and viscometric methods. The pBR322 cleavage, antioxidant and mol. docking studies revealed the potent biol. activity of title complexes. In-vitro cytotoxicity of these biol. active biomaterials tested against HeLa and MCF-7 by MTT assay and DAPI staining revealed their anticancer activity. Such results are supportive for advanced studies which would come through insight for their possible applications.

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Piperazine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Challenging the scope of continuous, gas-phase reactions with supported ionic liquid phase (SILP) catalysts-Asymmetric hydrogenation of methyl acetoacetate.Quality Control of (S)-Methyl 3-hydroxybutanoate.

A supported ionic liquid phase (SILP) catalyst was tested in continuous gas phase asym. hydrogenation of Me acetoacetate (MAA); the catalyst is dibromo[3-(2,5-(2R,5R)-dimethylphospholanyl-1)-4-di-o-tolylphosphino-2,5-dimethylthiophene] ruthenium (RuLBr2). The ionic liquid is 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide [EMIMNTf2].

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C12H8N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Structure-Activity Studies Reveal Scope for Optimisation of Ebselen-Type Inhibition of SARS-CoV-2 Main Protease. Author is Thun-Hohenstein, Siegfried T. D.; Suits, Timothy F.; Malla, Tika R.; Tumber, Anthony; Brewitz, Lennart; Choudhry, Hani; Salah, Eidarus; Schofield, Christopher J..

The reactive organoselenium compound ebselen is being investigated for treatment of coronavirus disease 2019 (COVID-19) and other diseases. We report structure-activity studies on sulfur analogs of ebselen with the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), employing turnover and protein-observed mass spectrometry-based assays. The results reveal scope for optimization of ebselen/ebselen derivative- mediated inhibition of Mpro, particularly with respect to improved selectivity.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of the dibenzofuran-based diphosphine ligand BIFAP and its water-soluble derivative BIFAPS and their use in ruthenium-catalyzed asymmetric hydrogenation., published in 1999-09-30, which mentions a compound: 53562-86-0, Name is (S)-Methyl 3-hydroxybutanoate, Molecular C5H10O3, Application of 53562-86-0.

The syntheses of both enantiomers of the novel diphosphine ligand 2,2′-bis(diphenylphosphino)-1,1′-bidibenzofuranyl (BIFAP) and the water-soluble analog (-)-2,2′-bis(diphenylphosphino)-1,1′-bidibenzofuranyl-8,8′-disulfonic acid dipotassium salt (BIFAPS) are reported. Advantage is taken of the very high regioselectivity in ring functionalization of the 1,1′-bidibenzofuranyl backbone. These ligands were used in the Ru-catalyzed hydrogenation of Me acetoacetate and (Z)-acetamidocinnamic acid in MeOH and H2O. In MeOH both BIFAP and BIFAPS give the products in very high enantiomeric excess. With BIFAPS in H2O a slight drop in the ee of the products is observed When BIFAPS was used with either H2O or MeOH as the solvent the addition of a small amount of acid turns out to be essential for a fast reaction and high asym. induction.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 53562-86-0, is researched, Molecular C5H10O3, about Acclimatization of Baker’s Yeast for Asymmetric Reduction at High Substrate Concentration, the main research direction is Saccharomyces stereoselective reduction acclimatization high substrate.HPLC of Formula: 53562-86-0.

By gradually adding a low content of Me acetoacetate into a solid medium, a new yeast strain, called MAA yeast, was separated from com. baker’s yeast. The new yeast was used for catalyzing asym. reduction of Me acetoacetate in the aqueous phase, and results showed that it was more efficient than regular baker’s yeast in the asym. reduction of Me acetoacetate. The influence of external environment, pH, and temperature on MAA yeast was the same as on baker’s yeast. The yield of Me β-hydroxybutanoate with the new strain was about 13% higher than with baker’s yeast at 0.05 M Me acetoacetate. Similar results were also obtained in experiments, when MAA yeast was used to catalyze other systems, such as reducing Et 4-chloro-3-oxobutanoate to (S)-4-chloro-3-hydroxybutanoate and reducing Et acetoacetate to Et (S)-3-hydroxybutyrate. In addition, the main product was (S)-Me β-hydroxybutanoate at low substrate concentration; however, (R)-Me β-hydroxybutanoate would be obtained when the concentration of substrate exceeded 0.4 M. The morphol. of the new strain is the same as that of baker’s yeast.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

HPLC of Formula: 54903-09-2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Friedel-Crafts acylation of 2(3H)-benzoxazolone: investigation of the role of the catalyst and microwave activation. Author is Liacha, Messaoud; Yous, Said; Poupaert, Jacques H.; Depreux, Patrick; Aichaoui, Hocine.

To study the scope and limitations of the use of complexed species of AlCl3 in Friedel-Crafts reactions, we investigated the acetylation and benzoylation of 2(3H)-benzoxazolone and 3-methyl-2(3H)-benzoxazolone varying the amide complexing agent. We replaced DMF by N-methylformamide, dimethylacetamide, pyrrolidinone, N-methylpyrrolidinone, tetramethylurea, and DMSO. However, there was no particular advantage of substituting DMF by another amide ligand. This can probably be ascribed to the fact that the complex formed between AlCl3 and the complexing agent becomes too stable. Alternatively, a route using polyphosphoric acid and microwave activation was explored. The major advantage of running the reaction in a microwave oven was that a good yield was reached in a rather short period of time.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,10-Phenanthroline(SMILESS: C1=CC3=C(C2=NC=CC=C12)N=CC=C3,cas:66-71-7) is researched.Related Products of 15418-29-8. The article 《Improved singlet oxygen generation in rhenium(I) complexes functionalized with a pyridinyl selenoether ligand》 in relation to this compound, is published in Polyhedron. Let’s take a look at the latest research on this compound (cas:66-71-7).

The synthesis, characterization, electrochem. and photophys. properties of three novel polypyridine rhenium(I) complexes coordinated to an organoselenide ligand, 4-(phenylseleno)-pyridine (PhSepy), and structurally related polypyridine ligands, fac-[Re(CO)3(NN)(PhSepy)]+ NN = 1,10-phenanthroline (phen), 4,7-diphenyl-1,10-phenanthroline (ph2phen) and pyrazino[2,3-f]-1,10-phenanthroline (dpq), are reported. In addition, their ability to act as a photosensitizer agent for the generation of singlet oxygen was investigated. Cyclic and differential pulse voltammetry experiments showed an overlap of the redox waves characteristic of the 4-(phenylseleno)-pyridine ligand and the Re(I) complex. This finding is consistent with a strong contribution of the pyridine-based ligand on the HOMO levels of the three investigated complexes, further supported by quantum mech. calculations Moreover, the lowest energy band observed in the absorption spectra of the complexes was also influenced by the organoselenide ligand, with a combination of the usual MLCTRe→NN transition with a ligand-to-ligand charge transfer (LLCT) one. The three complexes showed typical emission spectra for this class of compounds ascribed to 3MLCTRe→NN, with excellent quantum yields for the singlet oxygen generation (ΦΔ = 0.65-070). Remarkably, these are significantly larger (15-29%) than those for structurally related complexes with non-functionalized pyridyl ligands, revealing a significant ability as a photosensitizer agent. Therefore, authors envisage this work to be of interest to those engaged in the development of novel rhenium(I) complexes for optoelectronic applications.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 2343-22-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Ruthenium-Catalyzed Dehydrogenation Through an Intermolecular Hydrogen Atom Transfer Mechanism. Author is Huang, Lin; Bismuto, Alessandro; Rath, Simon A.; Trapp, Nils; Morandi, Bill.

The direct dehydrogenation of alkanes is among the most efficient ways to access valuable alkene products. Although several catalysts have been designed to promote this transformation, they have unfortunately found limited applications in fine chem. synthesis. Here, we report a conceptually novel strategy for the catalytic, intermol. dehydrogenation of alkanes using a ruthenium catalyst. The combination of a redox-active ligand and a sterically hindered aryl radical intermediate has unleashed this novel strategy. Importantly, mechanistic investigations have been performed to provide a conceptual framework for the further development of this new catalytic dehydrogenation system.

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Piperazine – Wikipedia,
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