Tag: M.W:100-200

Application In Synthesis of 5-Fluoroindoline. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles. Author is Savych, Olena; Kuchkovska, Yuliya O.; Bogolyubsky, Andrey V.; Konovets, Anzhelika I.; Gubina, Kateryna E.; Pipko, Sergey E.; Zhemera, Anton V.; Grishchenko, Alexander V.; Khomenko, Dmytro N.; Brovarets, Volodymyr S.; Doroschuk, Roman; Moroz, Yurii S.; Grygorenko, Oleksandr O..

Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsym. thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chem. space covered by the method exceeded 7 million feasible compounds

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Delot, Marc; Carato, Pascal; Furman, Christophe; Lemoine, Amelie; Lebegue, Nicolas; Berthelot, Pascal; Yous, Said published the article 《Synthesis of 1,11-dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones with potential topoisomerase I inhibitory activity》. Keywords: dihydrooxazolo indenoquinolinone Friedlander preparation antitumor.They researched the compound: 6-Acetylbenzo[d]oxazol-2(3H)-one( cas:54903-09-2 ).Category: piperazines. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:54903-09-2) here.

A series of 1,11-dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones I (R1 = H, Me; R2 = H, Me, Ph, 4-Cl-Ph; R3 = H, MeO) were prepared by means of Friedlander condensations. The starting materials for the preparations were com. substituted 2-aminoacetophenones and various 5,6-dihydro-2H-indeno[5,6-d][1,3]oxazole-2,7(3H)-diones that were synthesized from 2(3H)-benzoxazolones or their N-Me analogs. Antitumor activity of the title compounds has been tested on DU145 human androgen-independent prostate cancer cells.

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Application In Synthesis of 6-Acetylbenzo[d]oxazol-2(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about 6-Acyl benzoxazolinones. II. Preparation of some transformation products. Author is Bonte, Jean P.; Lesieur, Daniel; Lespagnol, Charles; Cazin, Jean C.; Cazin, Micheline.

Alcs. I (R = H, R1 = MeCHOH, EtCHOH, PhCHOH, PhCH2CHOH) were prepared in 85-90% yield by reducing I (R = H, R1 = Ac, EtCO, Bz, Ph-CH2CO) and had analgesic activity comparable to that of I (R = R1 = H). Alk. hydrolysis of I (R = H, Me; R1 = HCO, Ac, EtCO, Bz, PhCH2CO, 2-thenoyl) gave 2,4-HO(R1)C6H3NHR with loss of analgesic activity. Reaction of I (R = H, R1 = Ac) with R2CHO (R2 = Ph, p-ClC6H4, p-MeOC6H4, m-MeOC6-H4, 2,3,4-HO2C(MeO)2C6H2, PhCH:CH, 2-thienyl, p-O2NC6H4, m-O2NC6H4) gave I (R = H, R1 = R2CH:CHCO), which were reduced to I (R = H, R1 = R2CH2CH2CO), both with loss of analgesic activity.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Anomerization in the preparation of 1-glycosylindoles by the dehydrogenation of 1-glycosylindolines.Synthetic Route of C8H8FN.

Dehydrogenation of 1-β-D-ribopyranosylfluoroindoline with 2,3-dichloro-5,6-dicyanobenzoquinone involved initial hydride elimination from the glycosyl C atom to give a planar carbonium ion, then proton elimination and H migration to the glycosyl center to give a mixture of α- and β-ribopyranosylfluoroindoles.

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De, Pinaki Bhusan; Pradhan, Sourav; Banerjee, Sonbidya; Punniyamurthy, Tharmalingam published the article 《Expedient cobalt(II)-catalyzed site-selective C7-arylation of indolines with arylboronic acids》. Keywords: phenyl pyrimidinyl indoline regioselective preparation; indoline arylboronic acid arylation cobalt catalyst.They researched the compound: 5-Fluoroindoline( cas:2343-22-8 ).HPLC of Formula: 2343-22-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2343-22-8) here.

A series of 7-phenyl-1-pyrimidin-2-yl-indolines I [R1 = H, 2-Me, 3-Cl, etc.; R2 = H, 5-OMe, 4-Br, etc.; R3 = H, 2-Me, 3-Me] was prepared via cobalt catalyzed site-selective C7-arylation of indolines with arylboronic acids using Mn(OAc)2·4H2O as an oxidant.

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Frelek, Jadwiga; Gorecki, Marcin; Jazwinski, Jaroslaw; Masnyk, Marek; Ruskowska, Patrycja; Szmigielski, Rafal published the article 《Configurational assignment of vic-amino alcohols from their circular dichroism spectra with dirhodium tetracetate as an auxiliary chromophore》. Keywords: configuration vic amino alc CD dirhodium tetracetate auxiliary chromophore.They researched the compound: (S)-1-(Dimethylamino)propan-2-ol( cas:53636-17-2 ).Recommanded Product: (S)-1-(Dimethylamino)propan-2-ol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:53636-17-2) here.

The CD spectra of a variety of vic-amino alcs. in the presence of dirhodium tetraacetate as an auxiliary chromophore were measured in ethanol as the solvent. The method was tested with several model compounds, representing both acyclic and cyclic amino alcs., including biol. important adrenergic drugs as well as amino sugars. The study demonstrated that the sign of the Cotton effects is determined by the preferred helicity of the O-C-C-N unit in the chiral complex formed in situ. The combined anal. of the CD, UV-vis, 1H and 13C NMR indicated predisposition to form chiral complexes by initial coordination of the amino alc. at the axial coordination site followed by migration to the equatorial position. Finally, after migration of the ligand to an equatorial position(s) a bridging or a chelating complex is formed. Hence, vic-amino alcs. in ethanol act as bidentate ligands in the end.

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Name: 5-Fluoroindoline. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1.

We present the design, synthesis and biol. activity of a new series of substituted 3-(2-(1H-indol-1-yl)ethyl)-1H-indoles and 1,2-di(1H-indol-1-yl)alkanes as selective inhibitors of CDK4/cyclin D1. The compounds were designed to explore the relationship between the connection mode of the indolyl moieties and their CDK inhibitory activities. We found all the above-mentioned designed compounds to be selective inhibitors of CDK4/cyclin D1 compared to the closely related CDK2/cyclin A, with IC50 for the best compounds 10m and 13a (I) being 39 and 37 μm, resp.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Methyl 3-hydroxybutanoate(SMILESS: C[C@H](O)CC(OC)=O,cas:53562-86-0) is researched.Quality Control of 2-(Thiophen-3-yl)-1,3-dioxolane. The article 《Difluorphos, an electron-poor diphosphane: A good match between electronic and steric features》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:53562-86-0).

Both enantiomers of difluorphos I were synthesized and their stereoelectronic features were evaluated in theor. and exptl. studies. The unusual π acidity of I explains the excellent results obtained with it in ruthenium-mediated asym. hydrogenation of fluorinated β-functionalized ketones. These results are better than those obtained with other biphenyl-based diphosphines.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 54903-09-2, is researched, Molecular C9H7NO3, about Aluminum trichloride-DMF reagent in the Friedel-Crafts reaction. Application to 2(3H)benzoxazolones in the Haworth reaction, the main research direction is Friedel Crafts benzoxazolone; Haworth benzoxazolone; benzoxazolone Friedel Crafts Haworth.COA of Formula: C9H7NO3.

Benzoxazolones I (R = H, Me) underwent the Haworth reaction to give cyclic ketone derivatives II and III (n = 1, 2, X = NR, Y = O; n = 1, 2, X = O, Y = NR). Friedel-Crafts acylation of I followed by reduction, and intramol. Friedel-Crafts reaction gave II. To shorten the sequence, I was reacted with γ-butyro- and δ-valerolactone in the presence of polyphosphoric acid to give III.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2343-22-8, is researched, SMILESS is FC1=CC2=C(NCC2)C=C1, Molecular C8H8FNJournal, Article, Angewandte Chemie, International Edition called Catalytic Enantioselective Intramolecular Aza-Diels-Alder Reactions, Author is Min, Chang; Lin, Chih-Tsung; Seidel, Daniel, the main research direction is secondary amine aldehyde dienophile; enantioselective intramol aza Diels Alder chiral bronsted acid catalyst; polycyclic amine stereoselective preparation; Brønsted acids; asymmetric catalysis; cycloaddition; ion pairs; organocatalysis.HPLC of Formula: 2343-22-8.

A readily available chiral Bronsted acid was identified as an efficient catalyst for intramol. Povarov reactions. Polycyclic amines containing three contiguous stereogenic centers were obtained with excellent stereocontrol in a single step from secondary anilines and aldehydes possessing a pendent dienophile. These transformations constitute the first examples of catalytic enantioselective intramol. aza-Diels-Alder reactions.

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