Tag: M.W:100-200

HPLC of Formula: 53562-86-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Simplified preparation of chirally modified nickel catalyst for enantioselective hydrogenation: A step forward to industrial use.

A chirally modified nickel catalyst for the enantio-differentiating hydrogenation of β-ketoesters is conventionally prepared by immersing the pre-activated metallic nickel into an aqueous solution of enantiopure tartaric acid (so called “”modification step””). During the pre-activation step, nickel precursor is commonly treated with hydrogen gas at elevated temperatures of up to 473 K. The X-ray photoelectron spectral examinations of chirally modified nickel catalysts obtained under the different modification conditions revealed that the chiral modification process itself plays a major role in activating the nickel surface while the pre-activation procedure is a less important factor. The corresponding enantio-differentiating hydrogenations of Me acetoacetate in the liquid phase using the prepared chiral catalysts unambiguously confirmed this conclusion, providing quant. conversions and high enantioselectivities of up to 90%.

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Recommanded Product: 53562-86-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Determination of the absolute stereostructure of seco-macrosphelide E produced by a fungal strain from a sea hare.

Seco-Macrosphelide E (I) has been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Its absolute stereostructure, with the same configuration as that of macrosphelide E, have been elucidated on the basis of spectroscopic analyses and unambiguous synthesis.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Rh(III)-Catalyzed direct C-7 amination of indolines with anthranils, the main research direction is pyrimidylindoline anthranil preparation rhodium catalyst amination; pyrimidylindolinyl aminobenzaldehyde preparation.Quality Control of 5-Fluoroindoline.

An efficient and practical method for the C-7 amination of indolines via Rh(III)-catalyzed C-H activation was reported. This reaction afforded various C-7 aminated indolines in good to excellent yields by using readily available anthranils as the aminating agents. The corresponding indolines with an amino and a carbonyl group together provided an opportunity for the construction and modification of diverse indoles and indolines in the pharmaceutical industry.

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Safety of 1,10-Phenanthroline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Spectroscopic studies on DNA interaction and anticancer activities of pharmacologically active pyrimidine derivative mixed ligand Co(II) and Ni(II) complexes. Author is Nagaraj, Revathi; Murugesan, Sankarganesh; Jeyaraj, Dhaveethu Raja; Arumugam, Sakthivel; Shunmugasundaram, Gurusamy; Radhakrishnan, Nandini Asha.

This article reports the synthesis and its structural elucidation of pyrimidine based mixed ligand complexes [CoL(phen)](OAc) (1), [CoL(bpy)](OAc) (2), [NiL(phen)](OAc) (3) and [NiL(bpy)](OAc) (4), where, HL = 2-(4,6-dimethylpyrimidin-2-ylimino)methyl-4-nitrophenol, (phen) =1,10-phenanthroline, (bpy) = 2,2′-bipyridine and OAc = acetate. The prepared complexes are structurally pigeonholed by anal. and spectroscopic techniques. The hypothesized structure of prepared complexes has a square planar shape. This article deals with the spectroscopic, viscometric, and theor. investigation of binding between synthesized compounds and calf-thymus DNA (CT DNA). Spectroscopic (UV-Visible absorption and fluorescence) and viscometric measurements in combination with the mol. docking data reveal that produced compounds bind to DNA double helix in an intercalation mode. According to the in vitro anticancer activity data against various cancer cell lines (MCF-7, HeLa and HEp2), complexes 1-4 exhibit a modest anticancer impact. Investigation of the antioxidant property of prepared compounds showed that complexes 1-4 have a more antioxidant nature than Schiff base. A significant inhibition activity was predicted with complexes 1-4 against various bacterial inoculums typed as gram-pos. bacteria (S. aureus, S. pneumoniae, Stap. pneumoniae, B. subtilis) and gram-neg. bacteria (S. flexneri, S. typhi, K. pneumoniae, H. influenza) and various fungal inoculums such as A. niger, C. albicans, C. tropicalis, M. campestris. The chelating capacity of the Schiff base with Co(II) and Ni(II) ions indicated that complexes 1-4 are effective antimicrobial agents.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The configurational relationships between α hydroxy acids and β-hydroxy acids and between the latter and secondary alcohols》. Authors are Levene, P. A.; Haller, H. L..The article about the compound:(S)-Methyl 3-hydroxybutanoatecas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O).Name: (S)-Methyl 3-hydroxybutanoate. Through the article, more information about this compound (cas:53562-86-0) is conveyed.

It is proposed to study the relation between β-HO acids, α-HO acids and the secondary alcs. by means of the reactions RCH(OH)CH2CO2Et → RCH(OH)CH2NH2 → RCH(OH)CH2OH → RCH(OH)CO2H; RCH(OH)CH2NH2 → RCH(OH)CH2Cl → RCH(OH)CH2CH2CO2H → RCH(OH)Et; RCH(OH)CH2Cl → RCH(OH)Me. Levo-3-hydroxybutyric acid (J. Chem. Soc. 81, 1402(1902)) [α]D25 -24.5°, in H2O. Me Levo-3-hydroxybutyrate (cf. Fischer and Scheibler, C. A. 3, 2135), b17 70-2°, [α]D20 -20.9°, without solvent. Levo-3-hydroxybutyrylhydrazide, C4H10O2N2, m. 129-30°, [α]D31 -29.3°, in EtOH. sym-Dextro-2-hydroxypropylurea, C7H16O3N2, [α]D26.5 18.5°. Levo-2-hydroxypropylamine-HCl, C3H10ONCl, [α]D26.5 -31.2° in H2O, much less in N NaOH, (the last 3 substances were prepared according to methods of Levene and Scheidegger, C. A. 19, 1128, for inactive compounds). Levo-1,2-dihydroxypropane, from the amine, AgNO2 and HCl.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about A Bis-Steroidal Phosphine as New Chiral Hydrogenation Ligand, the main research direction is asym hydrogenation bissteroidal phosphine ligand preparation; stereoselective reduction ligand bissteroidal phosphine preparation.Synthetic Route of C5H10O3.

The new atropisomeric bissteroidal ligands R- and S-I are synthesized in 4 steps from the steroid precursor equilenin. The diastereomeric ligands are separable by column chromatog. and exhibit mirror image CD spectra. Likewise, they induce in the chiral reduction of acetophenone to enantiomeric 1-phenylethanols. The synthesis of the phosphine ligands R- and S-I is accomplished by a Ni-mediated cross coupling of the corresponding triflates with Ph2PH. The application of this new bissteroidal phosphine in the hydrogenation of Me acetoacetate, phenylcinnamic acid, and tiglic acid show that the in situ prepared chiral catalyst RuCl2(ligand)(DMF)2 is more active in terms of enantiomeric excess and/or conversion than the corresponding BINAP-derived catalyst.

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Formula: C5H10O3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about A kinetic study and application of a novel carbonyl reductase isolated from Rhodococcus erythropolis. Author is Zelinski, Thomas; Kula, Maria-Regina.

The newly described carbonyl reductase from Rhodococcus erythropolis (RECR) accepts a broad range of substrates. Based on the kinetic constants of a variety of Me and Et ketones a hypothetical model of the substrate-binding site is proposed. Whether a substrate of interest may be reduced by the RECR can be predicted from this model together with the kinetic data. A study of initial velocities and product inhibition is presented, which shows that the kinetics of the RECR follow a Theorell-Chance mechanism. The pro-R hydride of NADH is transferred by the enzyme to the re face of the carbonyl compounds yielding (S)-alcs. The reduction of Me 3-oxobutanoate and Et 4-chloro-3-oxobutanoate catalyzed by the oxidoreductase lead to the corresponding hydroxy compounds with high enantiomeric purity [enantiomeric excess (e.e.) ≥99%]. The synthesis of Et (2R,3S)-3-hydroxy-2-methylbutanoate was accomplished with high diastereoselectivity (diastereomeric excess = 95%) and enantioselectivity (e.e. ≥95%).

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Fluoroindoline( cas:2343-22-8 ) is researched.Quality Control of 5-Fluoroindoline.Pang, Shaofeng; Liu, Fangfang; Zhang, Yujing; Dong, Zhaowen; Su, Qiong; Wang, Wenfang; Li, Zhenhua; Zhou, Feng; Wang, Yanbin published the article 《Construction of Functional Superhydrophobic Biochars as Hydrogen Transfer Catalysts for Dehydrogenation of N-Heterocycles》 about this compound( cas:2343-22-8 ) in ACS Sustainable Chemistry & Engineering. Keywords: construction functional superhydrophobic biochars hydrogen transfer catalyst dehydrogenation nitrogen. Let’s learn more about this compound (cas:2343-22-8).

To endow metal-free materials with the high catalytic activity that is typically featured by a metal-based catalyst is yet a constant pursuit in the field of catalytic chem. In this work, novel functional biochars (DCNs) were prepared from wheat straw for the first time via a simple strategy of reconstructing the catalytic active sites in carbon precursors and subsequent controlled carbonization, which may be further applied in the oxidative dehydrogenation of N-heterocycles with ambient air as the oxidant. Whereas the superhydrophobicity of DCN-850 can effectively remove the only byproduct water to effectively reduce the possible effects of water on the catalyst, it also can decrease mass transfer resistance on active sites, thereby ensuring the reaction with high efficiencies and good generality. Especially, after several reuses, the activity and structures of DCN-850 remained unchanged in the catalytic system with water as a solvent. Furthermore, various characterization technologies and the model reaction were used to investigate the architectural attributes of DCNs, and the results show that there is a pos. correlation between the catalytic performance and hydrophobicity of DCNs, as well as reveal that the catalytic active sites may be made up of a five-membered-ring ketone or its enol form and possibly a phenolic unit, which could be encapsulated in internal structures of catalysts and promote the reaction via the recycling of -C-C-OH and -C-C=O groups by the pathway of catalytic hydrogen transfer.

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Application In Synthesis of (S)-Methyl 3-hydroxybutanoate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Durability enhancement of chirally modified metallic nickel catalysts for enantioselective hydrogenation. Author is Osawa, Tsutomu; Kizawa, Tomoko; Lee, I-Yin Sandy; Ikeda, Shinji; Kitamura, Takayuki; Inoue, Yoshihisa; Borovkov, Victor.

Metallic Ni catalysts co-modified with (R,R)-tartaric acid and NaBr showed high enantioselectivity and durability upon hydrogenation of Me acetoacetate to give Me 3-hydroxybutyrate. The chirally modified catalyst prepared from 3-μm Ni powder was highly robust to maintain the hydrogenation activity and enantiodifferentiating ability for ca. 3 mo under dry condition, which enables long-term storage and hence facilitates com. distribution and industrial application.

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SDS of cas: 66-71-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Two new Cu(II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity. Author is Xi, Yun-Hong; Yan, Xin; Bigdeli, Fahime; Zhang, Qianwen; Esrafili, Leili; Hanifehpour, Younes; Zhang, Wei-Bing; Hu, Mao-Lin; Morsali, Ali.

Two new Cu(II) complexes [Cu(bpy)2L1] BF4·CH3OH (Z3) and [Cu (phen)2L1] BF4·H2O (Z = 9), L1 = 5-Fluorouracil-1-yl Acetic Acid, were synthesized based on 5-Fluorouracil-1-yl Acetic Acid and 2,2′-Bipyridine or 1,10-phenanthroline ligands and their anticancer activity toward human cancer cell lines studied. The complexes were characterized by IR spectra, elemental anal., and x-ray crystallog. The interaction of the complexes with CT-DNA was studied by UV-visible absorption and fluorescence spectroscopies, and cyclic voltammetry; cell viability (%) was studied using the absorbance amount of the samples. The interaction mode of the complexes with DNA is electrostatic, and the complexes displayed good anticancer activity against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with best IC50 amount of 11.31 ± 0.74μM for Z = 9. The nature of the nitrogen-donor ligand is very effective in the anticancer activity of the complexes.

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