Tag: M.W:100-200

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Fluoroindoline( cas:2343-22-8 ) is researched.Quality Control of 5-Fluoroindoline.Pang, Shaofeng; Liu, Fangfang; Zhang, Yujing; Dong, Zhaowen; Su, Qiong; Wang, Wenfang; Li, Zhenhua; Zhou, Feng; Wang, Yanbin published the article 《Construction of Functional Superhydrophobic Biochars as Hydrogen Transfer Catalysts for Dehydrogenation of N-Heterocycles》 about this compound( cas:2343-22-8 ) in ACS Sustainable Chemistry & Engineering. Keywords: construction functional superhydrophobic biochars hydrogen transfer catalyst dehydrogenation nitrogen. Let’s learn more about this compound (cas:2343-22-8).

To endow metal-free materials with the high catalytic activity that is typically featured by a metal-based catalyst is yet a constant pursuit in the field of catalytic chem. In this work, novel functional biochars (DCNs) were prepared from wheat straw for the first time via a simple strategy of reconstructing the catalytic active sites in carbon precursors and subsequent controlled carbonization, which may be further applied in the oxidative dehydrogenation of N-heterocycles with ambient air as the oxidant. Whereas the superhydrophobicity of DCN-850 can effectively remove the only byproduct water to effectively reduce the possible effects of water on the catalyst, it also can decrease mass transfer resistance on active sites, thereby ensuring the reaction with high efficiencies and good generality. Especially, after several reuses, the activity and structures of DCN-850 remained unchanged in the catalytic system with water as a solvent. Furthermore, various characterization technologies and the model reaction were used to investigate the architectural attributes of DCNs, and the results show that there is a pos. correlation between the catalytic performance and hydrophobicity of DCNs, as well as reveal that the catalytic active sites may be made up of a five-membered-ring ketone or its enol form and possibly a phenolic unit, which could be encapsulated in internal structures of catalysts and promote the reaction via the recycling of -C-C-OH and -C-C=O groups by the pathway of catalytic hydrogen transfer.

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Piperazine – Wikipedia,
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Application In Synthesis of (S)-Methyl 3-hydroxybutanoate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Durability enhancement of chirally modified metallic nickel catalysts for enantioselective hydrogenation. Author is Osawa, Tsutomu; Kizawa, Tomoko; Lee, I-Yin Sandy; Ikeda, Shinji; Kitamura, Takayuki; Inoue, Yoshihisa; Borovkov, Victor.

Metallic Ni catalysts co-modified with (R,R)-tartaric acid and NaBr showed high enantioselectivity and durability upon hydrogenation of Me acetoacetate to give Me 3-hydroxybutyrate. The chirally modified catalyst prepared from 3-μm Ni powder was highly robust to maintain the hydrogenation activity and enantiodifferentiating ability for ca. 3 mo under dry condition, which enables long-term storage and hence facilitates com. distribution and industrial application.

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Piperazine – Wikipedia,
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SDS of cas: 66-71-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Two new Cu(II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity. Author is Xi, Yun-Hong; Yan, Xin; Bigdeli, Fahime; Zhang, Qianwen; Esrafili, Leili; Hanifehpour, Younes; Zhang, Wei-Bing; Hu, Mao-Lin; Morsali, Ali.

Two new Cu(II) complexes [Cu(bpy)2L1] BF4·CH3OH (Z3) and [Cu (phen)2L1] BF4·H2O (Z = 9), L1 = 5-Fluorouracil-1-yl Acetic Acid, were synthesized based on 5-Fluorouracil-1-yl Acetic Acid and 2,2′-Bipyridine or 1,10-phenanthroline ligands and their anticancer activity toward human cancer cell lines studied. The complexes were characterized by IR spectra, elemental anal., and x-ray crystallog. The interaction of the complexes with CT-DNA was studied by UV-visible absorption and fluorescence spectroscopies, and cyclic voltammetry; cell viability (%) was studied using the absorbance amount of the samples. The interaction mode of the complexes with DNA is electrostatic, and the complexes displayed good anticancer activity against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with best IC50 amount of 11.31 ± 0.74μM for Z = 9. The nature of the nitrogen-donor ligand is very effective in the anticancer activity of the complexes.

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Piperazine – Wikipedia,
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Formula: C8H8FN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Palladium-Catalyzed Remote 1,n-Arylamination of Unactivated Terminal Alkenes. Author is Han, Chunhua; Fu, Zhiyuan; Guo, Songjin; Fang, Xinxin; Lin, Aijun; Yao, Hequan.

A palladium-catalyzed remote 1,n-arylamination (from 1,3- to 1,11-arylamination) of unactivated terminal alkenes with aryl iodides and arylamines has been realized. This three-component reaction proceeded via Pd-catalyzed Heck arylation, alkene isomerization, and aza-Michael addition, exhibiting good regio- and chemoselectivity, and wide substrate scope. Preliminary mechanistic studies indicated that the in situ generated ortho/para-quinone methide intermediates served as the driving force for the alkene isomerization and promoted the rearomatization upon nucleophilic amination.

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Piperazine – Wikipedia,
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Formula: C8H8FN. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Oxidative Palladium(II)-Catalyzed C-7 Alkenylation of Indolines. Author is Jiao, Lin-Yu; Oestreich, Martin.

N-(dimethylcarbamoyl)indolines such as I underwent regioselective and stereoselective alkenylation with electron-deficient alkenes and styrenes RR1C:CHR2 [R = BuO2C, MeO2C, EtO2C, PhCH2O2C, MeCO, NC, (EtO)2P(:O), Ph, F5C6, 4-FC6H4, 4-ClC6H4, 2-ClC6H4, 2-BrC6H4; R1, R2 = H, Me] with 1,4-benzoquinone in acetic acid in the presence of Pd(OAc)2 and p-toluenesulfonic acid to give (E)-7-alkenylindolinecarboxamides such as II in 21-89% yield and all except II (R = MeO2C; R1 = H; R2 = Me) as the (E)-isomers in >98:2 dr. The tetrasubstituted urea moiety functioned as a directing group for directed alkenylation; non-urea directing groups either yielded alkenylation products in low (20%) yield or did not yield alkenylation products. An ethylcarbamoylindoline underwent alkenylation with Bu acrylate followed by cyclization to give oxoindolopyrimidineacetate III.

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Piperazine – Wikipedia,
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Safety of (S)-Methyl 3-hydroxybutanoate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Rhizopus arrhizus mediated asymmetric reduction of alkyl 3-oxobutanoates. Author is Salvi, Neeta A.; Chattopadhyay, Subrata.

Alkyl 3-oxobutanoates MeCOCH2CO2R (R = Me, Et, H2C:CHCH2, Me2CHCH2, Me3C) were reduced enantioselectively to the corresponding (S)-alcs. MeCH(OH)CH2CO2R by the fungus Rhizopus arrhizus and other Rhizopus sp. The best result obtained was with t-Bu 3-oxobutanoate, which was reduced by R. arrhizus with 99% enantiomeric excess and in 68% isolated yield.

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Piperazine – Wikipedia,
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Computed Properties of C8H8FN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Design, synthesis and biological evaluation of novel 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole triazole derivatives as potent TRPV1 antagonists. Author is Li, Jinyu; Nie, Cunbin; Qiao, Yue; Hu, Jing; Li, Qifei; Wang, Qiang; Pu, Xiaohui; Yan, Lin; Qian, Hai.

The design, synthesis, and pharmacol. evaluation of a class of TRPV1 antagonists constructed on 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole as A-region and triazole as B-region I (R = 2-Cl 2,5-Me2, 2-NO2-4-Cl, etc.) have been reported. The SAR anal. indicated that 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole analogs I displayed excellent antagonism of hTRPV1 activation by capsaicin and showed better potency compared to the corresponding dihydroindole analogs. Optimization of this design led to the eventual identification of compound I (R = 2-CF3), a potent TRPV1 antagonist. In vitro, using cells expressing recombinant human TRPV1 channels, I (R = 2-CF3) displayed potent antagonism activated by capsaicin (IC 50 = 0.075 μM) and only partially blocked acid activation of TRPV1. In vivo, I (R = 2-CF3) exhibited good efficacy in capsaicin-induced and heat-induced pain models and had almost no hyperthermia side-effect. Furthermore, pharmacokinetic studies revealed that compound I (R = 2-CF3) had a superior oral exposure after oral administration in rats. To understand its binding interactions with the receptor, the docking study of I (R = 2-CF3) was performed in rTRPV1 model and showed an excellent fit to the binding site. On the basis of its superior profiles, I (R = 2-CF3) could be considered as the lead candidate for the further development of antinociceptive drugs.

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Piperazine – Wikipedia,
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Synthetic Route of C12H8N2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Long-lived cyclometalated iridium complexes: Synthesis, structure, DFT and photocatalytic aspects. Author is Laha, Paltan; Chandra, Falguni; Husain, Ahmad; Koner, Apurba Lal; Patra, Srikanta.

Herein, authors present synthesis, photophys. and photocatalytic aspects of four mononuclear luminescent iridium complexes ([1]+-[4]+) incorporating cyclometalating benzimidazole-based (L1 and L2) and phenanthroline pyrazine-based (L3-L5) ligands. Several anal. techniques were used for the characterization of the complexes. The structural elucidation of [2]+ and [3]+ using x-ray crystallog. show a distorted Oh structure with nitrogen donors of cyclometalating ligands are in trans-direction. All the complexes are emitting in the orange-red region and displayed moderately good quantum yield. The complexes have also shown moderately good luminescence lifetime (τ = 80-1900 ns) in different solvents. Importantly, the complex [3]+ exhibits comparative longer emission lifetime (τ = 1800 ns) in water at ambient condition. The complexes have shown moderately good photocatalytic efficacy towards azo dyes degradation in aqueous solution The mechanistic investigation suggests that in the presence of light in aqueous medium the complexes induce the generation of (HO•/(O•2-)) species which is responsible for the photodecomposition of azo dyes.

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Piperazine – Wikipedia,
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Reference of (S)-Methyl 3-hydroxybutanoate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Highly Stereoselective Reagents for β-Keto Ester Reductions by Genetic Engineering of Baker’s Yeast. Author is Rodriguez, Sonia; Kayser, Margaret M.; Stewart, Jon D..

While whole cells of baker’s yeast (Saccharomyces cerevisiae) are a convenient biocatalytic reducing agent for a wide variety of carbonyl compounds, mixtures of stereoisomeric alcs. are often observed since the organism contains a large number of reductase enzymes with overlapping substrate specificities but differing stereoselectivities. We sought to improve the performance of baker’s yeast for β-keto ester reductions by using recombinant DNA techniques to alter the levels of three enzymes known to play important roles in these reactions (fatty acid synthase, Fasp; aldo-keto reductase, Ypr1p; α-acetoxy ketone reductase, Gre2p). A complete set of “”first-generation”” yeast strains that either lack or overexpress each of these three enzymes was created and tested for improvements in stereoselective reductions of a series of β-keto esters. On the basis of these results, multiply modified (“”second-generation””) strains were created that combined gene knockout and overexpression in single strains. In some cases, these addnl. modifications further improved the stereoselectivities of β-keto ester reductions, thereby making several β-hydroxy ester building blocks readily available by reactions that can be performed by nonspecialists. This work also revealed that addnl. yeast proteins participate in reducing β-keto esters, and further progress using this strategy will require either addnl. genetic manipulations or the expression of yeast reductases in hosts that lack enzymes with overlapping substrate specificity.

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Piperazine – Wikipedia,
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Khursheed, Salman; Tabassum, Sartaj; Arjmand, Farukh published the article 《Comprehensive biological {DNA/RNA binding profile, cleavage &cytotoxicity activity} of structurally well-characterized chromone-appended Cu(II)(L1-3)(phen) potential anticancer drug candidates》. Keywords: preparation copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; crystal structure copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; mol structure copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; DNA RNA interaction copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; anticancer activity copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; antimicrobial activity copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; cyclic voltammetry copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex.They researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Category: piperazines. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:66-71-7) here.

A series of chromone-appended copper(II)(phen) complexes (1-3) having the general formulas [Cu(L1)(phen)(H2O)2(NO3)] 1, [Cu(L2)(phen)(NO3)] 2 and [Cu(L3)(phen)(NO3)] 3, where L1 = 3-formylchromone, L2 = 6-fluoro-3-formylchromone, L3 = 6-bromo-3-formylchromone and phen = 1,10-phenanthroline were prepared to examine the effect of halogen on structure activity relation. The mol. solid state structure of (1-3) was fully characterized by employing various spectroscopic techiques, single crystal x-ray diffraction studies and DFT B3LYP (gas phase) computations. Comparative in vitro binding studies of (1-3) with ct-DNA and tRNA were conducted by using a battery of optical {UV-visible, fluorecence and circular dichoric} and electrochem. methods, which implicated strong binding through noncovalent π-π stacking intercalative binding mode. The order of binding is 3 > 2 > 1 as determined by Kb and Ksv values with bromo analog 3 exhibiting the strongest binding affinity for both ct-DNA and tRNA nucleobases, however, underlining more avid predisposed binding with tRNA as compared to ct-DNA. The cleavage activity of (1-3) was studied by electrophoretic assay using pBR322 DNA and tRNA, which exhibited efficient DNA cleaving ability at low micro molar concentrations The cleavage process was mediated by an oxidative pathway involving ROS species viz., singlet oxygen (1O2) and superoxide anions(O•-2), with more pronounced cleaving ability of bromo analog 3 as compared to unsubstituted 1 and fluoro 2 analog derivatives Furthermore, time and concentration dependence of tRNA cleavage was also observed The cytotoxicity activity of tested drug candidates 2 and 3 were evaluated on a panel of human cancer cell lines, viz., MCF-7, MDA-MB-231, AW13516, SiHa and Hop-62 using SRB assay which validated bromo analog 3 and 2 as good anticancer agents, broadly against all the tested cancerous strains (with GI50 values < 10) except with AW13516, SiHa and Hop-62 (GI50 values were found in the range18.00-36.8). Here is just a brief introduction to this compound(66-71-7)Category: piperazines, more information about the compound(1,10-Phenanthroline) is in the article, you can click the link below.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics