Tag: M.W:100-200

Synthetic Route of C12H8N2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Long-lived cyclometalated iridium complexes: Synthesis, structure, DFT and photocatalytic aspects. Author is Laha, Paltan; Chandra, Falguni; Husain, Ahmad; Koner, Apurba Lal; Patra, Srikanta.

Herein, authors present synthesis, photophys. and photocatalytic aspects of four mononuclear luminescent iridium complexes ([1]+-[4]+) incorporating cyclometalating benzimidazole-based (L1 and L2) and phenanthroline pyrazine-based (L3-L5) ligands. Several anal. techniques were used for the characterization of the complexes. The structural elucidation of [2]+ and [3]+ using x-ray crystallog. show a distorted Oh structure with nitrogen donors of cyclometalating ligands are in trans-direction. All the complexes are emitting in the orange-red region and displayed moderately good quantum yield. The complexes have also shown moderately good luminescence lifetime (τ = 80-1900 ns) in different solvents. Importantly, the complex [3]+ exhibits comparative longer emission lifetime (τ = 1800 ns) in water at ambient condition. The complexes have shown moderately good photocatalytic efficacy towards azo dyes degradation in aqueous solution The mechanistic investigation suggests that in the presence of light in aqueous medium the complexes induce the generation of (HO•/(O•2-)) species which is responsible for the photodecomposition of azo dyes.

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Reference of (S)-Methyl 3-hydroxybutanoate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Highly Stereoselective Reagents for β-Keto Ester Reductions by Genetic Engineering of Baker’s Yeast. Author is Rodriguez, Sonia; Kayser, Margaret M.; Stewart, Jon D..

While whole cells of baker’s yeast (Saccharomyces cerevisiae) are a convenient biocatalytic reducing agent for a wide variety of carbonyl compounds, mixtures of stereoisomeric alcs. are often observed since the organism contains a large number of reductase enzymes with overlapping substrate specificities but differing stereoselectivities. We sought to improve the performance of baker’s yeast for β-keto ester reductions by using recombinant DNA techniques to alter the levels of three enzymes known to play important roles in these reactions (fatty acid synthase, Fasp; aldo-keto reductase, Ypr1p; α-acetoxy ketone reductase, Gre2p). A complete set of “”first-generation”” yeast strains that either lack or overexpress each of these three enzymes was created and tested for improvements in stereoselective reductions of a series of β-keto esters. On the basis of these results, multiply modified (“”second-generation””) strains were created that combined gene knockout and overexpression in single strains. In some cases, these addnl. modifications further improved the stereoselectivities of β-keto ester reductions, thereby making several β-hydroxy ester building blocks readily available by reactions that can be performed by nonspecialists. This work also revealed that addnl. yeast proteins participate in reducing β-keto esters, and further progress using this strategy will require either addnl. genetic manipulations or the expression of yeast reductases in hosts that lack enzymes with overlapping substrate specificity.

Here is just a brief introduction to this compound(53562-86-0)Reference of (S)-Methyl 3-hydroxybutanoate, more information about the compound((S)-Methyl 3-hydroxybutanoate) is in the article, you can click the link below.

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Piperazine – Wikipedia,
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Khursheed, Salman; Tabassum, Sartaj; Arjmand, Farukh published the article 《Comprehensive biological {DNA/RNA binding profile, cleavage &cytotoxicity activity} of structurally well-characterized chromone-appended Cu(II)(L1-3)(phen) potential anticancer drug candidates》. Keywords: preparation copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; crystal structure copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; mol structure copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; DNA RNA interaction copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; anticancer activity copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; antimicrobial activity copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex; cyclic voltammetry copper phenanthroline fluoroformylchromone bromoformylchromone nitrate complex.They researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Category: piperazines. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:66-71-7) here.

A series of chromone-appended copper(II)(phen) complexes (1-3) having the general formulas [Cu(L1)(phen)(H2O)2(NO3)] 1, [Cu(L2)(phen)(NO3)] 2 and [Cu(L3)(phen)(NO3)] 3, where L1 = 3-formylchromone, L2 = 6-fluoro-3-formylchromone, L3 = 6-bromo-3-formylchromone and phen = 1,10-phenanthroline were prepared to examine the effect of halogen on structure activity relation. The mol. solid state structure of (1-3) was fully characterized by employing various spectroscopic techiques, single crystal x-ray diffraction studies and DFT B3LYP (gas phase) computations. Comparative in vitro binding studies of (1-3) with ct-DNA and tRNA were conducted by using a battery of optical {UV-visible, fluorecence and circular dichoric} and electrochem. methods, which implicated strong binding through noncovalent π-π stacking intercalative binding mode. The order of binding is 3 > 2 > 1 as determined by Kb and Ksv values with bromo analog 3 exhibiting the strongest binding affinity for both ct-DNA and tRNA nucleobases, however, underlining more avid predisposed binding with tRNA as compared to ct-DNA. The cleavage activity of (1-3) was studied by electrophoretic assay using pBR322 DNA and tRNA, which exhibited efficient DNA cleaving ability at low micro molar concentrations The cleavage process was mediated by an oxidative pathway involving ROS species viz., singlet oxygen (1O2) and superoxide anions(O•-2), with more pronounced cleaving ability of bromo analog 3 as compared to unsubstituted 1 and fluoro 2 analog derivatives Furthermore, time and concentration dependence of tRNA cleavage was also observed The cytotoxicity activity of tested drug candidates 2 and 3 were evaluated on a panel of human cancer cell lines, viz., MCF-7, MDA-MB-231, AW13516, SiHa and Hop-62 using SRB assay which validated bromo analog 3 and 2 as good anticancer agents, broadly against all the tested cancerous strains (with GI50 values < 10) except with AW13516, SiHa and Hop-62 (GI50 values were found in the range18.00-36.8). Here is just a brief introduction to this compound(66-71-7)Category: piperazines, more information about the compound(1,10-Phenanthroline) is in the article, you can click the link below.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

HPLC of Formula: 53562-86-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Simplified preparation of chirally modified nickel catalyst for enantioselective hydrogenation: A step forward to industrial use.

A chirally modified nickel catalyst for the enantio-differentiating hydrogenation of β-ketoesters is conventionally prepared by immersing the pre-activated metallic nickel into an aqueous solution of enantiopure tartaric acid (so called “”modification step””). During the pre-activation step, nickel precursor is commonly treated with hydrogen gas at elevated temperatures of up to 473 K. The X-ray photoelectron spectral examinations of chirally modified nickel catalysts obtained under the different modification conditions revealed that the chiral modification process itself plays a major role in activating the nickel surface while the pre-activation procedure is a less important factor. The corresponding enantio-differentiating hydrogenations of Me acetoacetate in the liquid phase using the prepared chiral catalysts unambiguously confirmed this conclusion, providing quant. conversions and high enantioselectivities of up to 90%.

Here is just a brief introduction to this compound(53562-86-0)HPLC of Formula: 53562-86-0, more information about the compound((S)-Methyl 3-hydroxybutanoate) is in the article, you can click the link below.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: 53562-86-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Determination of the absolute stereostructure of seco-macrosphelide E produced by a fungal strain from a sea hare.

Seco-Macrosphelide E (I) has been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Its absolute stereostructure, with the same configuration as that of macrosphelide E, have been elucidated on the basis of spectroscopic analyses and unambiguous synthesis.

Here is just a brief introduction to this compound(53562-86-0)Recommanded Product: 53562-86-0, more information about the compound((S)-Methyl 3-hydroxybutanoate) is in the article, you can click the link below.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Rh(III)-Catalyzed direct C-7 amination of indolines with anthranils, the main research direction is pyrimidylindoline anthranil preparation rhodium catalyst amination; pyrimidylindolinyl aminobenzaldehyde preparation.Quality Control of 5-Fluoroindoline.

An efficient and practical method for the C-7 amination of indolines via Rh(III)-catalyzed C-H activation was reported. This reaction afforded various C-7 aminated indolines in good to excellent yields by using readily available anthranils as the aminating agents. The corresponding indolines with an amino and a carbonyl group together provided an opportunity for the construction and modification of diverse indoles and indolines in the pharmaceutical industry.

Here is just a brief introduction to this compound(2343-22-8)Quality Control of 5-Fluoroindoline, more information about the compound(5-Fluoroindoline) is in the article, you can click the link below.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Safety of 1,10-Phenanthroline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Spectroscopic studies on DNA interaction and anticancer activities of pharmacologically active pyrimidine derivative mixed ligand Co(II) and Ni(II) complexes. Author is Nagaraj, Revathi; Murugesan, Sankarganesh; Jeyaraj, Dhaveethu Raja; Arumugam, Sakthivel; Shunmugasundaram, Gurusamy; Radhakrishnan, Nandini Asha.

This article reports the synthesis and its structural elucidation of pyrimidine based mixed ligand complexes [CoL(phen)](OAc) (1), [CoL(bpy)](OAc) (2), [NiL(phen)](OAc) (3) and [NiL(bpy)](OAc) (4), where, HL = 2-(4,6-dimethylpyrimidin-2-ylimino)methyl-4-nitrophenol, (phen) =1,10-phenanthroline, (bpy) = 2,2′-bipyridine and OAc = acetate. The prepared complexes are structurally pigeonholed by anal. and spectroscopic techniques. The hypothesized structure of prepared complexes has a square planar shape. This article deals with the spectroscopic, viscometric, and theor. investigation of binding between synthesized compounds and calf-thymus DNA (CT DNA). Spectroscopic (UV-Visible absorption and fluorescence) and viscometric measurements in combination with the mol. docking data reveal that produced compounds bind to DNA double helix in an intercalation mode. According to the in vitro anticancer activity data against various cancer cell lines (MCF-7, HeLa and HEp2), complexes 1-4 exhibit a modest anticancer impact. Investigation of the antioxidant property of prepared compounds showed that complexes 1-4 have a more antioxidant nature than Schiff base. A significant inhibition activity was predicted with complexes 1-4 against various bacterial inoculums typed as gram-pos. bacteria (S. aureus, S. pneumoniae, Stap. pneumoniae, B. subtilis) and gram-neg. bacteria (S. flexneri, S. typhi, K. pneumoniae, H. influenza) and various fungal inoculums such as A. niger, C. albicans, C. tropicalis, M. campestris. The chelating capacity of the Schiff base with Co(II) and Ni(II) ions indicated that complexes 1-4 are effective antimicrobial agents.

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Piperazine – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The configurational relationships between α hydroxy acids and β-hydroxy acids and between the latter and secondary alcohols》. Authors are Levene, P. A.; Haller, H. L..The article about the compound:(S)-Methyl 3-hydroxybutanoatecas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O).Name: (S)-Methyl 3-hydroxybutanoate. Through the article, more information about this compound (cas:53562-86-0) is conveyed.

It is proposed to study the relation between β-HO acids, α-HO acids and the secondary alcs. by means of the reactions RCH(OH)CH2CO2Et → RCH(OH)CH2NH2 → RCH(OH)CH2OH → RCH(OH)CO2H; RCH(OH)CH2NH2 → RCH(OH)CH2Cl → RCH(OH)CH2CH2CO2H → RCH(OH)Et; RCH(OH)CH2Cl → RCH(OH)Me. Levo-3-hydroxybutyric acid (J. Chem. Soc. 81, 1402(1902)) [α]D25 -24.5°, in H2O. Me Levo-3-hydroxybutyrate (cf. Fischer and Scheibler, C. A. 3, 2135), b17 70-2°, [α]D20 -20.9°, without solvent. Levo-3-hydroxybutyrylhydrazide, C4H10O2N2, m. 129-30°, [α]D31 -29.3°, in EtOH. sym-Dextro-2-hydroxypropylurea, C7H16O3N2, [α]D26.5 18.5°. Levo-2-hydroxypropylamine-HCl, C3H10ONCl, [α]D26.5 -31.2° in H2O, much less in N NaOH, (the last 3 substances were prepared according to methods of Levene and Scheidegger, C. A. 19, 1128, for inactive compounds). Levo-1,2-dihydroxypropane, from the amine, AgNO2 and HCl.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about A Bis-Steroidal Phosphine as New Chiral Hydrogenation Ligand, the main research direction is asym hydrogenation bissteroidal phosphine ligand preparation; stereoselective reduction ligand bissteroidal phosphine preparation.Synthetic Route of C5H10O3.

The new atropisomeric bissteroidal ligands R- and S-I are synthesized in 4 steps from the steroid precursor equilenin. The diastereomeric ligands are separable by column chromatog. and exhibit mirror image CD spectra. Likewise, they induce in the chiral reduction of acetophenone to enantiomeric 1-phenylethanols. The synthesis of the phosphine ligands R- and S-I is accomplished by a Ni-mediated cross coupling of the corresponding triflates with Ph2PH. The application of this new bissteroidal phosphine in the hydrogenation of Me acetoacetate, phenylcinnamic acid, and tiglic acid show that the in situ prepared chiral catalyst RuCl2(ligand)(DMF)2 is more active in terms of enantiomeric excess and/or conversion than the corresponding BINAP-derived catalyst.

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Piperazine – Wikipedia,
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Formula: C5H10O3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about A kinetic study and application of a novel carbonyl reductase isolated from Rhodococcus erythropolis. Author is Zelinski, Thomas; Kula, Maria-Regina.

The newly described carbonyl reductase from Rhodococcus erythropolis (RECR) accepts a broad range of substrates. Based on the kinetic constants of a variety of Me and Et ketones a hypothetical model of the substrate-binding site is proposed. Whether a substrate of interest may be reduced by the RECR can be predicted from this model together with the kinetic data. A study of initial velocities and product inhibition is presented, which shows that the kinetics of the RECR follow a Theorell-Chance mechanism. The pro-R hydride of NADH is transferred by the enzyme to the re face of the carbonyl compounds yielding (S)-alcs. The reduction of Me 3-oxobutanoate and Et 4-chloro-3-oxobutanoate catalyzed by the oxidoreductase lead to the corresponding hydroxy compounds with high enantiomeric purity [enantiomeric excess (e.e.) ≥99%]. The synthesis of Et (2R,3S)-3-hydroxy-2-methylbutanoate was accomplished with high diastereoselectivity (diastereomeric excess = 95%) and enantioselectivity (e.e. ≥95%).

Compound(53562-86-0)Formula: C5H10O3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-Methyl 3-hydroxybutanoate), if you are interested, you can check out my other related articles.

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Piperazine – Wikipedia,
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