Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.

100g of concentrated hydrochloric acid (12mol / L) 250ml round bottom flask was placed in an ice bath, was slowly added 40g of anhydrous piperazine, the addition, the ice bath was removed, the reaction overnight at room temperature, filtered off with suction, the filter cake was placed It was dried in an oven, the resulting white solid, a piperazine dihydrochloride. o-fluorobenzoic acid was weighed 7g (0.05mol) dissolved in 20ml of dry tetrahydrofuran, was slowly added CDI 8.9g (0.055mol), after 4h the reaction was reacted at room temperature 4 h. Then a constant pressure dropping funnel was added dropwise a solution of piperazine dihydrochloride hydrochloride 20g (0.125mol), anhydrous piperazine 10g (0.125mol), 60ml of 14g of sodium chloride at room temperature after 5 hours the reaction solution is suction filtered, the filtrate was evaporated to dryness to remove THF, extracted with ethyl acetate again 10ml, NaOH saturated solution was adjusted to pH 10, and extracted 3 times with ethyl acetate and the combined organic phases, the organic phase was dried over anhydrous sodium sulfate overnight, filtration, rotary evaporation of ethyl acetate, the resulting white crystals which was 1- (2-fluorophenyl formyl) piperazine The crude product 4.7g, 45% yield.

142-64-3, As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.

Reference£º
Patent; XI’AN JIAOTONG UNIVERSITY; ZHANG, JIE; ZHANG, TAO; DONG, JINYUN; PAN, XIAOYAN; HE, LANGCHONG; LU, WEN; WANG, SICEN; SHI, YALING; (19 pag.)CN104262263; (2017); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.,115761-79-0

Take 50mL single-mouthed flask, was successively added 2-(1-(hydroxymethyl)cyclopropyl)methoxy-5-(methylsulfonyl)benzoic acid (150mg, 0.50mmol), 1-(2,4-difluorophenyl)piperazine (120mg, 0.60mmol), HATU (285mg, 0.75mmol), TEA (0.25mL, 1.5mmol), DMF (10mL), the reaction at room temperature overnight, saturated sodium chloride (20 mL), and extracted with ethyl acetate (20mL * 3). The organic phase was dried over anhydrous sodium sulfate and concentrated to dryness to give crude, the crude product was purified by preparative plate 130mg, yield: 55%.

The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Hansoh BioMedical Co., Ltd.; Jiangsu Stockhausen Pharmaceutical Group Co., Ltd.; Liao, Jianchun; Yu, Hongping; Xu, Yaochang; Chen, Jianghua; Zhang, Shaobao; Xiu, Wenhua; Liu, Zhaomin; (48 pag.)CN105712952; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

4- (4-Amino-2-fluorophenyl)-1, 2-dimethylpiperazine; 4- (2-Fluoro-4-nitrophenyl)-2-methylpiperazine; To rac-2-methylpiperazine (2.64 g, 23.1 mmol) in acetonitrile (50 mL) was added triethylamine (1.95 g, 2.7 mL, 19.2 mmol) followed by 3,4-difluoronitrobenzene (1 g, 7.7 mmol) dropwise over 5 min under a nitrogen atmosphere. The resulting yellow solution was allowed to stir at room temperature for 3 days. Excess acetonitrile was removed by evaporation under reduced pressure and the residue reconstituted in DCM (50mL), washed with water (2x50mL), dried (MgS04) and concentrated to afford the title compound as a yellow solid. LC-MS (UV 215nm) : 100%; m/z 240. 19; 0.91 min. IH NMR (CDC13) : 1.13 (3H, d, J6. 4), 2.56 (1H, dd, J 10.2 11.7), 2.91-2. 99 (1H, m), 3.00-3. 13 (3H, m), 3.52-3. 59 (2H, m), 6.91 (1H, t, J 8.8), 7.85-8. 01 (2H, m)., 109-07-9

109-07-9 2-Methylpiperazine 66057, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AMGEN INC.; WO2005/42518; (2005); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Example 126Atert-Butyl 3-methylpiperazine- 1 -carboxylate[00770] To a solution of 2-methyl-piperazine (2.0 g, 0.02 mol) and triethylamine (6 mL) in methylene chloride (15 mL) at 0 C was added (Boc O (4.14 g, 0.019 mol) dropwise. The mixture was stirred at room temperature for 1 hour, and then the solvent was removed by rotary evaporation. The residue was dissolved in methylene chloride, washed with saturated sodium bicarbonate and brine, dried over Na2S04, and purified by column chromatography on silica gel (DCM: MeOH:Et3N = 75 : 1 : 0.2) to give an white solid (1.65 g, 42%). LC-MS (ESI) m/z: 201 (M+l)+., 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; WO2011/130661; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.474711-89-2,Piperazine-1-carboxamide hydrochloride,as a common compound, the synthetic route is as follows.,474711-89-2

The compound (S) -5- (1 – ((tert-butoxycarbonyl) amino) ethyl) -2- (3- (cyclopropylmethoxy) -4-(difluoromethoxy) phenyl ) -oxazole-4-carboxylic Acid (300mg, 0.64mmol), piperazine-1-carboxamidecompound hydrochloride (127mg, 0.77mmol), 1- ethyl-3- (3-dimethylaminopropyl) carbon Carbodiimidehydrochloride (250mg, 1.3mmol) and N- hydroxy-7-aza-benzotriazole (130mg, 0.96mmol) was dissolved indichloromethane (15 mL), at 0 C conditions, to this solution was added dropwise N, Ndiisopropylethylamine(0.44mL, 2.56mmol), stirred at room temperature 5H, water (10mL ¡Á 3) washing theorganic phase was dried over anhydrous Na 2 SO 4, the solvent was removed concentrate was subjected tocolumn chromatography (eluent: DCM / MeOH (V / v) = 40/1), to give 250mg white solid, yield: 70%.

As the paragraph descriping shows that 474711-89-2 is playing an increasingly important role.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34770-60-0,4-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.

A mixture of 1 -bromo-4-iodobenzene (0.87 g, 3.1 mmol), 4-methylpiperazin-2- one (0.30 g, 2.6 mmol), 3P04 (1.1 g, 5.1 mmol), trans-N, N’-dimethylcyclohexane-l ,2-diamine (0.08 mL, 0.51 mmol) and dioxane (5 mL) was purged with argon gas for 10 min. Copper(I) iodide (0.049 g, 0.26 mmol) was added, the vial sealed and heated at 110 C in an oil bath for 22 h. The reaction was then allowed to cool to rt and was diluted with EtOAc and saturatedNaHC03 was added. The resulting mixture was extracted with EtOAc and the combined organic extracts were dried over MgS04 and concentrated to give the crude product. Purification by silica gel chromatography (MeOH/CH2Cl2, 5:95 to 1 :9) gave an inseparable 2: 1 mixture of the desired product and l-(4-bromophenyl)-4-methylpiperazin-2-one (200 mg). NMR (400 MHz, CDCI3) 6 7.66 (d, J = 8.0 Hz, 2H), 7.02 (d, J = 8.0 Hz, 2H), 3.64 (t, J = 5.0 Hz, 2H), 3.22 (s, 2H), 2.73 (t, J = 5.0 Hz, 2H), 2.35 (s, 3H); MS ESI 317.1 [M + H]+, calcd for [C, ,H|3IN20+ H]+ 317.01.

34770-60-0, As the paragraph descriping shows that 34770-60-0 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITY HEALTH NETWORK; PAULS, Heinz, W.; LI, Sze-Wan; SAMPSON, Peter Brent; FORREST, Bryan T.; WO2012/48411; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57184-25-5, 1-(Cyclopropylmethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57184-25-5, 4-Cyclopropylmethyl-piperazine-1-Carboxylic acid 4-(4,4-dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl Ester The title compound was prepared from 4-(4,4-dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl chloroformate and 1-cyclopropylmethyl-piperazine, preparative HPLC (Method C) (45%, off-white crystals). HPLC-MS m/z=400.3 (M+1), Rt: 1.83 min.

As the paragraph descriping shows that 57184-25-5 is playing an increasingly important role.

Reference£º
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.

Intermediate 9: 3-(4-Methylpiperazin-1-yl)-propan-1-ol. 1-Methylpiperazine (6.99 mL, 63 mol) was dissolved in toluene (30 mL). 3-Bromopropanol (2.62 mL, 30 mmol) was added slowly and the mixture was stirred overnight at r.t.. After heating to 80C for 2 h and cooling to r.t., the mixture was filtered and the filter cake was thoroughly washed with toluene. After removal of the solvent, the residue was subjected to Kugelrohr distillation (b.p., 180C / 2 mbar) to obtain a colourless oil (4.08 g, 25.8 mmol, 86 %). 1H NMR (CDCl3): delta = 1.70 (Psi-quint, J ? 5.8 Hz, 2 H), 2.26 (s, 3 H), 2.35-2.6 (m, 8 H), 2.60 (Psi-t, J = 5.8 Hz, 2 H), 3.77 (Psi-t, J ? 5.3 Hz, 2 H), 4.09 (s, br., 1 H).

109-01-3, 109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; 4SC AG; EP1674466; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.

55112-42-0, Example 3: Preparation of Zopiclone in Acetone[0066] l-Chlorocarbonyl-4-methyl piperazine hydrochloride (4.92g) in acetone (50 ml) was stirred mechanically at room temperature for 5 min. Then Et3N (4.42g) was added to the slurry over 10 min. During the tri-ethyl amine (Et3N) addition, the temperature rose slightly. After Et3N addition ended, DMAP (0.46g) was added to the slurry, and after 1-2 min of stirring, 7-OH-Py (5g) was added. The reaction mixture was heated to reflux and stirred at reflux for 4 h. After 4h at reflux, heating was stopped and the slurry was cooled to room temperature and ice (~50g) was added. Temperature dropped to -6C and the slurry was stirred till the temperature reached about 200C. The solid was filtered, washed with water (10 ml), and dried in vacuum oven at 400C overnight to obtain zopiclone crude product (6.95g yield 89%; purity 99.62% by HPLC).

55112-42-0 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride 3016934, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2008/2629; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

The starting material was prepared as follows: A suspension of 1-acetylpiperazine (3.85 g, 0.03 mol) and 3-bromopropan-1-ol (4 ml) containing potassium carbonate (8.3 g, 60 mmol) in acetonitrile (30 ml) was stirred at 80 C. for 5 hours. The solid was filtered and the filtrate was evaporated. The residue was purified by column chromatography eluding with ethanol/methylene chloride (1/9 followed by 3/7) to give 3-(4-acetylpiperazin-1-yl)propan-1-ol (3.15 g, 56%). 1H NMR Spectrum: (CDCl3) 1.75 (m, 2H), 2.05 (s, 3H), 2.4-2.5 (m, 4H), 2.6 (t, 2H), 3.45 (t, 2H), 3.6 (m, 2H), 3.8 (t, 2H), 4.6 (br s, 1H) MS: 187.4 (M+H)+, 13889-98-0

As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Patent; Hennequin, Laurent Francois Andre; US2003/212055; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics