Tag: M.W:100-200

55112-42-0, 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55112-42-0, Example 1: Preparation of Zopiclone in Ethyl acetate[0064] To a slurry of l-chlorocarbonyl-4-methyl piperazine hydrochloride(CMP) (52.96g) in Ethyl acetate (500 ml), mechanically stirred, was added tri-ethyl amine (Et3N) (46.12g) over 10 min. During Et3N addition, temperature rose by 2C. After Et3N addition ended, DMAP (4.62g) and 6-(5-chloro-2-pyridinyl]-6,7-dihydro- 7-hydroxy-5H-pyrrolo[3,4-b]pyrazine-5-one (7-OH-Py) (5Og) were added to the slurry. Then the slurry was heated to 6O0C. The slurry was stirred at 600C for 7.5 h. The heating was stopped and the slurry was cooled to room temperature. When the temperature reached the room temperature water was added (500 ml) and the slurry was stirred for 1 h. The obtained solid was filtered, washed with acetone (25 ml) and dried in vacuum oven at 400C overnight to give zopiclone product crude (7 Ig yield 90%; purity 99.22%). Zopiclone crude can be purified by crystallization to get zopiclone of a purity greater than 99.8%.

The synthetic route of 55112-42-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2008/2629; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57184-23-3, 1-(Cyclohexylmethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57184-23-3, 4-Cyclohexylmethyl-piperazine-1-carboxylic acid 4-(4-trifluoromethyl-phenoxy)-phenyl Ester The hydrochloride of the title compound was prepared from 4-(4-trifluoromethyl-phenoxy)-phenyl chloroformate and 1-cyclohexylmethyl-piperazine, yield 93%. White crystals, m.p. 256-258 C.; IR (KBr): nu 1715 (C=O) cm-1.

As the paragraph descriping shows that 57184-23-3 is playing an increasingly important role.

Reference£º
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5464-12-0, 1-(2-Hydroxyethyl)-4-methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step L: 2, 6-Dichloro-4-[ 4-chloro-6- ( 4-fluorophenyl) thienof 2, 3-dJpyrimidin-5-ylJ-3, 5- dimethyl-phenol and 4-f 4-bromo-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-5-yl]-2, 6- dichloro-3, 5 -dimethyl-phenol (0234) To a stirred solution of 700 mg compound of Step K above (1.50 mmol, 1.0 eq.) in 15 mL dichloromethane, 3.0 mL boron tribromide (1M in dichloromethane) (3.0 mmol, 2.0 eq.) was added at 0 ¡ãC and the mixture was allowed to warm up to room temperature and it was stirred until no further conversion was observed. The mixture was quenched with saturated aqueous NH4C1 and extracted with dichloromethane. The combined organic phases were dried over Na2S04 and concentrated under reduced pressure. The residue was purified via flash chromatography using heptane and ethyl acetate as eluents to obtain 2,6-dichloro-4- [4-chloro-6-(4-fluorophenyl)thieno[2,3-(i]pyrimidin-5-yl]-3,5-dimethyl-phenol and 4-[4- bromo-6-(4-fluorophenyl)thieno[2,3- ]pyrimidin-5-yl]-2,6-dichloro-3,5-dimethyl-phenol as a 37:63 mixture of products. (0235) 1H NMR (400 MHz, DMSO-d6): 10.14 (br s, 1H), 9.01 (s, 1H), 7.40-7.23 (m, 4H), 1.95 (s, 6H) and 10.14 (br s, 1H), 8.93 (s, 1H), 7.40-7.23 (m, 4H), 1.93 (s, 6H) (0236) HRMS (M+H)+ = 452.9800 and 496.9287 Step M: 4-Chloro-5-[3,5-dichloro-2,6-dimethyl-4-[2-(4-methylpiperazin-l- yl) ethoxy] phenyl] -6- ( 4-fluorophenyl) thienof 2, 3-dJpyrimidine and 4-bromo-5-[ 3, 5- dichloro-2, 6-dimethyl-4-[ 2- ( 4-methylpiperazin-l-yl) ethoxy] phenyl] -6- ( 4- fluorophenyl) thienof 2, 3-d]pyrimidine (0238) 300 mg mixture of 2,6-dichloro-4-[4-chloro-6-(4-fluorophenyl)thieno[2,3-5464-12-0, Big data shows that 5464-12-0 is playing an increasingly important role.

Reference£º
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; PACZAL, Attila; SZLAVIK, Zoltan; KOTSCHY, Andras; CHANRION, Maia; MARAGNO, Ana Leticia; GENESTE, Olivier; DEMARLES, Didier; BALINT, Balazs; SIPOS, Szabolcs; (81 pag.)WO2017/125224; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate (c) (1.82 g, 4.8 mmol), palladium acetate (52 mg, 0.24 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (240 mg, 0.48 mmol), cesium carbonate (2.32 g, 7.2 mmol) is dissolved in dioxane (15 ml), add 1-acetylpiperazine (0.92 g, 7.2 mmol), nitrogen protection, 100 C reflux stirring 6 hr, the reaction liquor is brown clear liquid. To the reaction solution to room temperature, add 15 ml water, ethyl acetate (10 ml ¡Á 3) extraction, the combined organic phase, dried with anhydrous sodium sulfate, filtered concentrated by reduced pressure distillation, column chromatography (PE: EtOAc=1:1), to obtain white solid 1.5 g, yield 75%.

13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Fudan University; Fu Wei; Sun Nannan; (18 pag.)CN108503584; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

34770-60-0, 4-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(iii) (S)- 1 -(4- 1 [2-Amino-4-( 1 -hvdroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl]methyl } -3- methoxyphenyl)-4-methylpiperazin-2-one To a solution of the product from step (ii) (126 mg, 0.240 mmol) in 1 ,4-dioxane (1 mL) was added Cul (46.0 mg, 0.240 mmol), N,N ‘-dimethyldiaminoethane (52.0 mu, 0.480 mmol), 4-methylpiperazin-2-one (55.0 mg, 0.480 mmol), and Cs2C03 (234 mg, 0.720 mmol). The mixture was heated to 100C and stirred for 1 Oh. After cooling, water was added and the resulting mixture was extracted with EtOAc. The combined organic solutions were washed with brine, and then dried (Na2S04). After removal of the solvent in vacuo, the crude residue was used for the next reaction without further purification. To the crude residue in THF (1.0 mL) was added tetra-rc-butylammonium fluoride (1.0 mL, 1M solution in THF) and the mixture was stirred at r.t.. After 5h, water was added and the resulting mixture was extracted with EtOAc. The combined organic solutions were washed with brine, and then dried(Na2S04). After removal of the solvent in vacuo, the crude residue was purified by silica gel column chromatography to give the title compound as a white amorphous solid (19.6 mg, 0.0430 mmol, 18%); NMR: 6.94 (1H , d), 6.86 (1 H, d), 6.75 (1H, dd), 5.07 (2H, br s), 4.90 (1H, d), 4.51 (1H, br s), 4.13 (1 H, m), 3.88 (3H, s), 3.69-3.65 (2H, m), 3.67 (2H, s,),3.31-3.26 (2H, m), 3.25 (2H, s), 2.78-2.76 (2H, m), 2.40 (3H, s), 2.35 (3H, s), 1.80-1.76 (1H, m), 1.44-1.1 1 (5H, m), 0.81 (3H, t); LC-MS: m/z = 457 [MH+] (T = 1.48).

34770-60-0, As the paragraph descriping shows that 34770-60-0 is playing an increasingly important role.

Reference£º
Patent; Dainippon Sumitomo Pharma Co., Ltd.; ASTRAZENECA AKTIEBOLAG; TOSAKI, Shinya; HORI, Seiji; WO2012/67268; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.

4-Nitropyrazole (2.81 g, 13.88 mmol) and 1-hydroxyethyl-4-methylpiperazine (1.0 g, 6.94 mmol) were dissolved in anhydrous tetrahydrofuran (50 mL), and a solution of triphenylphosphine (3.64 g, 13.88 mmol) and diisopropyl azodicarboxylate (2.81 g, 13.88 mmol) in anhydrous tetrahydrofuran (6 mL) was added dropwise under nitrogen gas atmosphere. The reaction solution was stirred at room temperature for 1 hour, and then 1N hydrochloric acid (30 mL) and water (50 mL) was added. The aqueous phase was extracted with ethyl acetate (50 mL*2). The combined organic phase was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated. The residue was purified by silica gel column chromatography (dichloromethane: methanol=10:1) to give compound 22-c (1.0 g, yield 60.2percent). LC-MS (ESI): m/z=240.2[M+H]+., 5464-12-0

As the paragraph descriping shows that 5464-12-0 is playing an increasingly important role.

Reference£º
Patent; GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.; XU, Zusheng; ZHANG, Nong; WANG, Tinghan; SUN, Qingrui; WANG, Yuguang; (90 pag.)US2018/208604; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148546-99-0,3-(4-Methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

Palladium acetate [Pd (OAc) 2] (10 mg, 0.022 mmol, 10%), (~)-BINAP (14 mg, 0.022 mmol, 10%) and dimethylformamide (4 mL) were charged in a round-bottom flask flushed with argon. The mixture was stirred under argon for 30 minutes. Then, 3- (4- METHYLPIPERAZIN-L-YL) phenylamine (84 mg, 0.44 mmol), 8-IODO-1-METHYL-N-[(LS)-2- morpholin-4-yl-1-phenylethyl]-4, 5-dihydro-1H-pyrazolo [4, 3-h]quinazoline-3- carboxamide (120 mg, 0.22 mmol), potassium carbonate (670 mg, 4.85 mmol) and dimethylformamide (1. 5 mL) were added. The resulting mixture was heated at 80C in an oil bath under argon with good stirring for 1.5 hours. After cooling to room temperature, the reaction mixture was poured into water and extracted with dichloromethane. The organic extracts were washed with brine and dried over NA2S04. The solvent was removed under vacuo, the crude was purified by flash chromatography on silica gel (eluant: dichloromethane/methanol 95: 5) to afford 40 mg (30% yield) of the title compound. IH NMR (400 MHz, DMSO-d6) 8 ppm 2.27 (s, 3 H) 2.52 (m, 8 H) 2.80 (t, 2 H) 2.94 (m, 4 H) 3. 13 (m, 4H) 3. 56 (m, 4H) 4. 39 (s, 3H) 5.16 (m, 1 H) 6. 59 (M, 1 H) 7. 14 (m, 1 H) 7.24 (m, 2 H) 7.33 (m, 2 H) 7.42 (m, 2 H) 8.39 (m, 2 H) 9.33 (s, 1 H)., 148546-99-0

As the paragraph descriping shows that 148546-99-0 is playing an increasingly important role.

Reference£º
Patent; PHARMACIA ITALIA S.P.A.; WO2004/104007; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5271-27-2, 1-Methyl-3-phenylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5271-27-2, General procedure: 4.2 General procedures: C. Reflux. Carried out under an inert atmosphere in the normal way.

5271-27-2 1-Methyl-3-phenylpiperazine 2760009, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Dubois, Nathalie; Glynn, Daniel; McInally, Thomas; Rhodes, Barrie; Woodward, Simon; Irvine, Derek J.; Dodds, Chris; Tetrahedron; vol. 69; 46; (2013); p. 9890 – 9897;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 128 4-Amino-2-[4-(cyclopropylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline N-(Cyclopropylcarbonyl)piperazine (3.08 g., 0.02 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (4.74 g., 0.02 mole) are reacted according to the procedure of Example 127(a). The crude product crystallized from ethanol affords analytically pure 4-amino-2-[4-(cyclopropylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline, m.p. 283.5 C. (corr.). Analysis, Calcd. for C18H23N5O3 (percent): C, 60.49; H, 6.49; N, 19.59. Found (percent): C, 60.56; H, 6.46; N, 19.41., 59878-57-8

The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Cell Pathways, Inc.; US6262059; (2001); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 6(4-Cvclopropyl-piperazin-1 -yl)-(4-morpholin-4-ylmethyl-phenyl)- methanone bis-hvdrochloride saltStep A: PreparationA 100-L glass-lined reactor was charged with toluene (45.00 kg) and stirred at ~20-25C. To the stirring toluene was added 4-(4- morpholinylmethyl)benzoic acid hydrochloride (6.50 kg, 93.5%, 24.04 mol), 1- hydroxybenzothazole monohydrate (2.32 kg, 15.13 mol), 1 – cyclopropylpiperazine (3.50 kg, 27.07 mol) and acetonitrile (9.00 kg). The resulting off-white slurry was stirred under N2 at ~20-25C for 40 minutes. N- (3-Dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (3.50 kg, 27.07 mol) was added, followed by an acetonitrile (1 .20 kg) rinse. After the addition, the reaction mixture was stirred at ~20-25C overnight. Water (32.50 kg) and aqueous saturated sodium carbonate (19.50 L) were then added to the stirring suspension. The suspension was stirred for an additional 30 minutes. The resulting biphasic solution was allowed to settle. The aqueous phase was discarded and the organic phase was washed with a 50% brine solution [water (19.50 L) / brine (19.50 L)]. To the stirred organic phase was then added anhydrous sodium sulfate (2.86 kg) and the resulting mixture was stirred at ~20-25C for 1.5 hours. The solid sodium sulfate was filtered off and the filter cake was washed with acetonitrile (15.30 kg). The filtrate was transferred to a clean 100-L glass-lined reactor and stirred at ~20-25C. Water (0.47 kg) and 5/6N HCI in 2-propanol were added to precipitate the title compound as the corresponding bis-hydrochloride salt as a solid. The solid was filtered, washed with acetonitrile (10.2 kg) and dried (60 Torr, ~40-45C) to a constant weight to yield the title compound as a white solid.Step B: PurificationIn a 50-L glass reactor, the white solid prepared as in Step A above (15.0 kg, 37.28 mol) was dissolved in 1 :1 (v/v) mixture of ethanol :water (15.0 L: 15.0 L) at ~20-25C. The resulting mixture was stirred for 45 minutes and polish filtered (to remove any foreign particles) into a clean 100-L glass-lined reactor. The filtrate was transferred to a clean reaction vessel. Upon stirring, (polish filtered) ethanol (75.0 L) was added and the title compound precipitated as a bis-HCLmono-hydrate salt. The resultant white slurry was stirred at -20- 25C overnight. The solid was filtered, washed with ethanol (7.5 L) and dried at ~20-25C under vacuum to yield the title compound as a monohydrate bis- hydrochloride salt as a white solid.Karl Fisher analysis showed 3.4-3.6% water present. Chromatographic Purity (%w/w) showed 96.6%, 20327-23-5

As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/76685; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics