Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

40 mg of compound III and 56 mg of cyclopropylpiperazine, 2 drops of glacial acetic acid were added to 5 ml of anhydrous methanol, stirred, heated to 60 C, and reacted for 4 hours.Then, 50 mg of sodium cyanoborohydride (NaBH3CN) was added and reacted at room temperature for 12 hours.TLC monitoring, antiAfter completion, the solvent was evaporated, the reaction was poured into 100 mL of water, and extracted with ethyl acetate (20 mL¡Á3),The phases were washed with 5% NaHCO 3 (20 mL¡Á3), saturated brine (20 mL¡Á3), and dried over anhydrous magnesium sulfate.Filtration, removal of ethyl acetate under reduced pressure, followed by column chromatography V (dichloromethane):V (methanol) = 20:1 gave white solid compound C7 8 mg., 20327-23-5

As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.

Reference£º
Patent; Southern Medical University; Chen Jianjun; Cheng Binbin; (23 pag.)CN109503546; (2019); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Step 1: 2-Methylpiperazine (5.03 g) was dissolved in dichloromethane (200 mL) and a solution of di-tert-butyl-dicarbonate (10.96 g) in dichloromethane (100 mL) was added over 2.5 hours. The reaction was stirred at room temperature for 24 hours and concentrated to dryness giving 1-BOC-3-methylpiperazine. Yield=100percent, 109-07-9

109-07-9 2-Methylpiperazine 66057, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Millennium Pharmaceuticals, Inc.; US2003/153556; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59702-07-7, A mixture of 1-methylpiperazin-2-one (183 g, 1.6 mol) and diethyl ethoxymethylenemalonate (346 g, 1.6 mol) in toluene (12 L) was heated at 100 ¡ãC overnight. The resultant mixture was concentrated under vacuum. The residue was dissolved in anhydrous THF (8 L), brought to reflux under an atmosphere of nitrogen, and treated with a solution of lithium bis (trimethylsilyl)amide in THF (1 M, 1.05 eq). The reaction mixture was allowed to cool to room temperature and concentrated under vacuum. The residue was partitioned between methylene chloride and dilute aqueous HCI. The organic extract was washed with brine, dried over anhydrous magnesium sulfate, filtered, and concentrated under vacuum. The residue was triturated with ethyl acetate, cooled to -20 ¡ãC, and the solid precipitated was filtered to provide the title compound. 1H NMR (400 MHz, DMSO-d6) 8 8.50 (s, 1H), 7.33 (s, 1H), 4.18 (q, J = 7.1 Hz, 2H), 4.11 (t, J = 5.5 Hz, 2H), 3.59 (t, J = 5.5 Hz, 2H), 2.92 (s, 3H), 1.24 (t, J = 7.1 Hz, 3H). ES MS M+l = 239

The synthetic route of 59702-07-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK & CO., INC.; WO2005/110414; (2005); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

109384-27-2, To a mixture of 6-chloro-3-nitro-2-picoline (500 mg, 2.84 mmol) and 1-methyl-piperazin-2-one hydrochloride (535 mg, 3.55 mmol) in dioxane (15 ml) were added Cs2CO3 (1215 mg, 3.69 mmol) and xantphos (25.4 mg, 0.043 mmol). The mixture was degassed with Argon for 5 min, then Pd(OAc)2 (6.37 mg, 0.028 mmol) was added. The light brown suspension was heated up to 1 100C and stirred for 18h. The reaction mixture was concentrated then diluted in EtOAc/NaHCO3 aq. sat. soP. The aqueous layer was extracted twice with EtOAc. The combined organics were washed with brine, dried (Na2SO4) and after filtration, the solvent was removed under reduced pressure and the crude product was dried under high vacuum (500C). Purification was done by chromatography on silica gel (eluting with DCM / MeOH; 99/1 then 98/2) to obtain the title compound as a pink solid (347mg). (HPLC: tR 5.319 min (Method B); M+H = 251.2 MS-ES)

109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; FURET, Pascal; IMBACH, Patricia; MAH, Robert; STAUFFER, Frederic; WO2010/139747; (2010); A1;,
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59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59878-57-8, The active amide intermediate prepared in step 1 was dissolved in 10 ml of methylene chloride,The solution was cooled to 0 to 10 C and then added dropwise to a solution of 1-cyclopropylcarbamoylpiperazine (2.62 g, 17 mmol) and triethylamine (7.1 ml, 51 mmol) in 20 ml of dichloromethane for 1.5 hours at 0 to 10 C , Washed with 30 ml of water 3 times, the organic layer concentrated dry, add ethanol – water mixture (1: 2, v / v) 50 ml,And the filtrate was stirred at 0-5 C for 10 hours. The filtrate was filtered and dried to obtain 6.8 g of orapani. The yield was 92.0% and the purity was 99.87%.

The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Jin – yin Biological Technology Co., Ltd; Yang, Yinghua; Ji, Ye; Chen, Fangfang; Dai, Yi; (10 pag.)CN105503739; (2016); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485841-52-9,(S)-1,2-Dimethylpiperazine,as a common compound, the synthetic route is as follows.,485841-52-9

General procedure: To a solution of 53 (0.1 mmol, 1.0 eq.) in EtOH (2 mL) was addedEt3N (10.0 eq.) and corresponding amine (5.0 eq.). The reactionwasstirred at 85 C overnight, and then quenched with saturatedNaHCO3 aqueous solution. The aqueous layer was extracted withdichloromethane. The organic layer was dried over Na2SO4 andconcentrated. The residue was purified by silica gel column chromatography(dichloromethane/methanol 100/1) to give thedesired product.

The synthetic route of 485841-52-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Du, Qian; Fu, Chunyan; Ge, Wenxiang; He, Sudan; Li, Zhanhui; Luo, Lusong; Ma, Haikuo; Sun, Xiaotian; Tian, Sheng; Wang, Xu; Wang, Yujie; Zhang, Xiaohu; Zhang, Yi; Zheng, Jiyue; Zhu, Fang; European Journal of Medicinal Chemistry; (2019);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5317-33-9

DIAD (2.6 g, 13 mmol) was added dropwise to a solution of tert-butyl 4- (4-hydroxyphenyl) piperazine-1-carboxylate (3 g, 11 mmol) , 3- (4-methylpiperazin-1-yl) propan-1-ol (2.5 g, 16 mmol) and PPh3(4.3 g, 16 mmol) in THF (50 mL) . The resulting mixture was stirred at rt overnight. The solution was added with water (20 mL) , extracted with ethyl acetate (30 mL) and washed with brine (20 mL) . The organic layer was dried, concentrated and purified by column chromatography (DCM: MeOH = 15: 1) to get the desired product as a colorless oil (3.5 g, 78%) .1H NMR (400 MHz, DMSO-d6) delta 6.88 (d, J = 8.0Hz, 2H) , 6.81 (d, J = 8.0Hz, 2H) , 3.90 (t, J = 8.0Hz, 2H) , 3.44 (t, J = 4.0Hz, 4H) , 2.94 (t, J = 4.0Hz, 4H) , 2.38-2.30 (m, 10H) , 2.14 (s, 3H) , 1.82-1.79 (m, 2H) , 1.41 (s, 9H) ppm. MS: M/e 419 (M+1)+

The synthetic route of 5317-33-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BEIGENE, LTD.; ZHANG, Guoliang; SUN, Hanzi; ZHOU, Changyou; (253 pag.)WO2020/20097; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: In a 25 mL two necked round bottom flask, azole (1 mmol), amine (2.0 mmol), Cu(acac)2 (52.6 mg, 20 mol %), and 5 mL xylene were added. The above mixture was kept under reflux condition and then molecular oxygen was bubbled into the reaction mixture till the completion of reaction. The progress of reaction was monitored using gas chromatography. After completion of the reaction, the reaction mixture was filtered through celite bed. The organic solvent was removed under reduced pressure. The reaction mixture was analyzed using gas chromatography (Perkin Elmer, Clarus 400) equipped with a flame ionization detector (FID) and capillary column. The crude product was purified by column chromatography (silica gel, 100-200 mesh; petroleum ether/ethyl acetate, 90:10) to afford pure products. All the prepared compounds were confirmed by comparing with their authentic samples and were characterized by GC-MS (Shimadzu QP 2010), 1H NMR (Varian 500 MHz).

13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Wagh, Yogesh S.; Bhanage, Bhalchandra M.; Tetrahedron Letters; vol. 53; 48; (2012); p. 6500 – 6503,4;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5317-33-9,5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 6-substituted pyridazinone 9 (0.5 mmol) in DMF (10 mL) was added Cs2CO3 (0.55 mmol). An appropriately substituted nitro benzyl chloride (0.52 mmol) was added and the resulting mixture was stirred at 40-50 C for 3 h, the solvent was removed under reduced pressure and the residue was dissolved in EtOAc (30 mL), which was then washed with brine (3 ¡Á 10 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuo. The crude product, 2-nitrobenzyl-6-substituted-pyridazin-3(2H)-one (10), was used in the next step without further purification. To a solution of 10 in 95 % ethanol (50 mL) was added acetic acid (10 mmol) followed by slow addition of iron powder (2 mmol). The resulting mixture was stirred for 5 h at 100 C. The mixture was then filtered through celite and the filter cake was washed with 95 % ethanol (3 ¡Á 15 mL). The combined ethanol filtrates were evaporated in vacuo and the residue was re-dissolved in ethyl acetate (30 mL). The organic layer was washed with brine (3 ¡Á 10 mL) and 2 M NaOH (10 mL) sequentially. The organic layer was dried over anhydrous Na2SO4, evaporated in vacuo to afford 2-aminobenzyl-6-substituted-pyridazin-3(2H)-one (11) as a yellow solid, which was used without further purification. To a stirred solution of 11 and triphosgene (1 mmol) in dry dichloromethane (5 mL) was added triethylamine (2 mmol) under nitrogen atmosphere. A solution of the corresponding alcohol (1 mmol) in dichloromethane (5 mL) was added 5-10 min later and the mixture was stirred at room temperature overnight, diluted with dichloromethane (15 mL) and washed with water (3 ¡Á 20 mL). The organic phases were separated, combined, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by using column chromatography to afford the corresponding product.

As the paragraph descriping shows that 5317-33-9 is playing an increasingly important role.

Reference£º
Article; Xing, Weiqiang; Ai, Jing; Jin, Shiyu; Shi, Zhangxing; Peng, Xia; Wang, Lang; Ji, Yinchun; Lu, Dong; Liu, Yang; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 95; (2015); p. 302 – 312;,
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485841-52-9,485841-52-9, (S)-1,2-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (S)-1,3-Dimethylpiperazine dihydrochloride (0.16 g, 0.85 mmol) was added in oneportion to (2S)-2-bromo-N-(3-{2-[(3-methoxy-1-methyl-1 H-pyrazol-4-yl)amino]pyrimidin-4-yl}-1 Hindol-7-yl)propanamide (0.2 g, 0.43 mmol, Intermediate 32) and potassium carbonate (0.24 g, 1.7 mmol) in DMF (2 mL) at 0C. The resulting solution was stirred at 25C for 16 hours. The crude product was purified by preparative HPLC (X Bridge C18, 5 tim, 19×150 mm; Mobile Phase A: water0.05% TFA, Mobile Phase B: acetonitrile; Flow rate: 20 mLmin; Gradient: 20%B70%B in 10 mm; 254 nm) to afford (2R)-2-[(2S)-2,4-dimethylpiperazin-1-yl]-N-(3-{2-[(3-methoxy-i -methyl-i H-pyrazol-4-yl)amino]pyrimidin-4-yl}-i H-indol-7-yl)propanamide (49 mg, 23%, Example 1) as a white solid;

The synthetic route of 485841-52-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAND, Annika, Birgitta, Margareta; GRIMSTER, Neil, Patrick; KAWATKAR, Sameer; KETTLE, Jason, Grant; NILSSON, Magnus, K.; RUSTON, Linette, Lys; SU, Qibin; VASBINDER, Melissa, Marie; WINTER-HOLT, Jon, James; WU, Dedong; YANG, Wenzhan; GRECU, Tudor; MCCABE, James; WOESSNER, Richard, Donald; CHUAQUI, Claudio, Edmundo; (175 pag.)WO2017/50938; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics